DE60017141T2 - Replikationskompetente anti-krebs-vektoren - Google Patents
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- DE60017141T2 DE60017141T2 DE60017141T DE60017141T DE60017141T2 DE 60017141 T2 DE60017141 T2 DE 60017141T2 DE 60017141 T DE60017141 T DE 60017141T DE 60017141 T DE60017141 T DE 60017141T DE 60017141 T2 DE60017141 T2 DE 60017141T2
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 239000000439 tumor marker Substances 0.000 description 1
- 239000000225 tumor suppressor protein Substances 0.000 description 1
- 230000005760 tumorsuppression Effects 0.000 description 1
- 241001529453 unidentified herpesvirus Species 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
- 230000006656 viral protein synthesis Effects 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
- 238000002424 x-ray crystallography Methods 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
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- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10332—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
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- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
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- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
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- Zoology (AREA)
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- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
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- Biomedical Technology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
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- Molecular Biology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US351778 | 1999-07-12 | ||
| US09/351,778 US7589069B1 (en) | 1999-07-12 | 1999-07-12 | Replication-competent anti-cancer vectors |
| PCT/US2000/018971 WO2001004282A2 (en) | 1999-07-12 | 2000-07-12 | Replication-competent anti-cancer vectors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60017141D1 DE60017141D1 (de) | 2005-02-03 |
| DE60017141T2 true DE60017141T2 (de) | 2005-12-29 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60017141T Expired - Lifetime DE60017141T2 (de) | 1999-07-12 | 2000-07-12 | Replikationskompetente anti-krebs-vektoren |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US7589069B1 (enExample) |
| EP (1) | EP1196616B1 (enExample) |
| JP (1) | JP4361708B2 (enExample) |
| AT (1) | ATE286139T1 (enExample) |
| AU (1) | AU780613B2 (enExample) |
| CA (1) | CA2378586C (enExample) |
| DE (1) | DE60017141T2 (enExample) |
| ES (1) | ES2231281T3 (enExample) |
| WO (1) | WO2001004282A2 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7589069B1 (en) * | 1999-07-12 | 2009-09-15 | Saint Louis University | Replication-competent anti-cancer vectors |
| WO2002068627A2 (en) | 2001-02-23 | 2002-09-06 | Novartis Ag | Vector constucts |
| US8163892B2 (en) * | 2002-07-08 | 2012-04-24 | Oncolys Biopharma, Inc. | Oncolytic virus replicating selectively in tumor cells |
| WO2004087930A1 (en) * | 2003-03-28 | 2004-10-14 | Saint Louis University | Adenovirus replication-competent vectors expressing trail |
| US7815902B2 (en) | 2003-07-09 | 2010-10-19 | Henry Ford Health System | Methods and compositions for cancer therapy using a novel adenovirus |
| KR100903729B1 (ko) * | 2003-07-09 | 2009-06-19 | 헨리 포드 헬쓰 시스템 | 신규한 아데노바이러스를 이용한 암 치료 방법 및 조성물 |
| WO2005049094A1 (en) * | 2003-11-13 | 2005-06-02 | Advantagene, Inc. | A mixed complementary viral vector for gene therapy |
| WO2008136213A1 (ja) * | 2007-04-27 | 2008-11-13 | Oncolys Biopharma Inc. | 放射線増感増強剤 |
| US8696544B2 (en) | 2009-02-05 | 2014-04-15 | Coloplast A/S | Minimally invasive adjustable support |
| WO2011146885A2 (en) * | 2010-05-21 | 2011-11-24 | Virxsys Corporation | Compositions and methods for lentiviral expression of apoa-1 or variants thereof using spliceosome mediated rna trans-splicing |
| JP6576326B2 (ja) | 2013-03-14 | 2019-09-18 | ソーク インスティテュート フォー バイオロジカル スタディーズ | 腫瘍溶解性アデノウイルス組成物 |
| JP7054527B2 (ja) | 2016-02-23 | 2022-04-14 | ソーク インスティテュート フォー バイオロジカル スタディーズ | アデノウイルスの複製動態を測定するための高スループットアッセイ |
| KR20220163505A (ko) | 2016-02-23 | 2022-12-09 | 솔크 인스티튜트 포 바이올로지칼 스터디즈 | 바이러스 동역학에 미치는 영향 최소화를 위한 치료용 아데노바이러스의 외인성 유전자 발현 |
| JP2019536468A (ja) | 2016-12-12 | 2019-12-19 | ソーク インスティテュート フォー バイオロジカル スタディーズ | 腫瘍を標的にする合成アデノウイルスおよびその使用 |
| JP2020510624A (ja) | 2016-12-12 | 2020-04-09 | マルチビア インコーポレイテッド | がんおよび感染性疾患の治療および予防のための、ウイルス遺伝子治療および免疫チェックポイント阻害剤を含む方法および組成物 |
| WO2020036635A2 (en) | 2018-03-19 | 2020-02-20 | Multivir Inc. | Methods and compositions comprising tumor suppressor gene therapy and cd122/cd132 agonists for the treatment of cancer |
| AU2019251356B2 (en) * | 2018-04-09 | 2025-06-12 | Salk Institute For Biological Studies | Oncolytic adenovirus compositions with enhanced replication properties |
| WO2021113644A1 (en) | 2019-12-05 | 2021-06-10 | Multivir Inc. | Combinations comprising a cd8+ t cell enhancer, an immune checkpoint inhibitor and radiotherapy for targeted and abscopal effects for the treatment of cancer |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5801029A (en) | 1993-02-16 | 1998-09-01 | Onyx Pharmaceuticals, Inc. | Cytopathic viruses for therapy and prophylaxis of neoplasia |
| US5631236A (en) * | 1993-08-26 | 1997-05-20 | Baylor College Of Medicine | Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk |
| US6254862B1 (en) | 1997-03-03 | 2001-07-03 | Calydon, Inc. | Adenovirus vectors specific for cells expressing alpha-fetoprotein and methods of use thereof |
| US6197293B1 (en) * | 1997-03-03 | 2001-03-06 | Calydon, Inc. | Adenovirus vectors specific for cells expressing androgen receptor and methods of use thereof |
| US6627190B2 (en) * | 1999-07-12 | 2003-09-30 | Saint Louis University | Recombinant adenovirus vectors that are replication-competent in tert-expressing cells |
| US7589069B1 (en) * | 1999-07-12 | 2009-09-15 | Saint Louis University | Replication-competent anti-cancer vectors |
-
1999
- 1999-07-12 US US09/351,778 patent/US7589069B1/en not_active Expired - Fee Related
-
2000
- 2000-07-12 AT AT00975153T patent/ATE286139T1/de not_active IP Right Cessation
- 2000-07-12 ES ES00975153T patent/ES2231281T3/es not_active Expired - Lifetime
- 2000-07-12 AU AU13244/01A patent/AU780613B2/en not_active Ceased
- 2000-07-12 EP EP00975153A patent/EP1196616B1/en not_active Expired - Lifetime
- 2000-07-12 JP JP2001509486A patent/JP4361708B2/ja not_active Expired - Fee Related
- 2000-07-12 WO PCT/US2000/018971 patent/WO2001004282A2/en not_active Ceased
- 2000-07-12 DE DE60017141T patent/DE60017141T2/de not_active Expired - Lifetime
- 2000-07-12 CA CA2378586A patent/CA2378586C/en not_active Expired - Fee Related
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2005
- 2005-10-13 US US11/249,873 patent/US7608255B2/en not_active Expired - Fee Related
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2009
- 2009-09-16 US US12/561,016 patent/US8658610B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2378586C (en) | 2011-05-03 |
| EP1196616B1 (en) | 2004-12-29 |
| AU1324401A (en) | 2001-01-30 |
| CA2378586A1 (en) | 2001-01-18 |
| JP2003504052A (ja) | 2003-02-04 |
| DE60017141D1 (de) | 2005-02-03 |
| WO2001004282A2 (en) | 2001-01-18 |
| WO2001004282A3 (en) | 2001-09-13 |
| EP1196616A2 (en) | 2002-04-17 |
| US20100034776A1 (en) | 2010-02-11 |
| US20060029596A1 (en) | 2006-02-09 |
| US7589069B1 (en) | 2009-09-15 |
| US7608255B2 (en) | 2009-10-27 |
| US8658610B2 (en) | 2014-02-25 |
| ES2231281T3 (es) | 2005-05-16 |
| ATE286139T1 (de) | 2005-01-15 |
| AU780613B2 (en) | 2005-04-07 |
| JP4361708B2 (ja) | 2009-11-11 |
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