CA2378586C - Replication-competent anti-cancer vectors - Google Patents
Replication-competent anti-cancer vectors Download PDFInfo
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- CA2378586C CA2378586C CA2378586A CA2378586A CA2378586C CA 2378586 C CA2378586 C CA 2378586C CA 2378586 A CA2378586 A CA 2378586A CA 2378586 A CA2378586 A CA 2378586A CA 2378586 C CA2378586 C CA 2378586C
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- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C12N15/09—Recombinant DNA-technology
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- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- C12N15/86—Viral vectors
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- C12N2710/10011—Adenoviridae
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- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
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- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
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- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/351,778 US7589069B1 (en) | 1999-07-12 | 1999-07-12 | Replication-competent anti-cancer vectors |
| US09/351,778 | 1999-07-12 | ||
| PCT/US2000/018971 WO2001004282A2 (en) | 1999-07-12 | 2000-07-12 | Replication-competent anti-cancer vectors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2378586A1 CA2378586A1 (en) | 2001-01-18 |
| CA2378586C true CA2378586C (en) | 2011-05-03 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2378586A Expired - Fee Related CA2378586C (en) | 1999-07-12 | 2000-07-12 | Replication-competent anti-cancer vectors |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US7589069B1 (enExample) |
| EP (1) | EP1196616B1 (enExample) |
| JP (1) | JP4361708B2 (enExample) |
| AT (1) | ATE286139T1 (enExample) |
| AU (1) | AU780613B2 (enExample) |
| CA (1) | CA2378586C (enExample) |
| DE (1) | DE60017141T2 (enExample) |
| ES (1) | ES2231281T3 (enExample) |
| WO (1) | WO2001004282A2 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US7589069B1 (en) * | 1999-07-12 | 2009-09-15 | Saint Louis University | Replication-competent anti-cancer vectors |
| WO2002068627A2 (en) | 2001-02-23 | 2002-09-06 | Novartis Ag | Vector constucts |
| US8163892B2 (en) * | 2002-07-08 | 2012-04-24 | Oncolys Biopharma, Inc. | Oncolytic virus replicating selectively in tumor cells |
| WO2004087930A1 (en) * | 2003-03-28 | 2004-10-14 | Saint Louis University | Adenovirus replication-competent vectors expressing trail |
| US7815902B2 (en) | 2003-07-09 | 2010-10-19 | Henry Ford Health System | Methods and compositions for cancer therapy using a novel adenovirus |
| KR100903729B1 (ko) * | 2003-07-09 | 2009-06-19 | 헨리 포드 헬쓰 시스템 | 신규한 아데노바이러스를 이용한 암 치료 방법 및 조성물 |
| WO2005049094A1 (en) * | 2003-11-13 | 2005-06-02 | Advantagene, Inc. | A mixed complementary viral vector for gene therapy |
| WO2008136213A1 (ja) * | 2007-04-27 | 2008-11-13 | Oncolys Biopharma Inc. | 放射線増感増強剤 |
| US8696544B2 (en) | 2009-02-05 | 2014-04-15 | Coloplast A/S | Minimally invasive adjustable support |
| WO2011146885A2 (en) * | 2010-05-21 | 2011-11-24 | Virxsys Corporation | Compositions and methods for lentiviral expression of apoa-1 or variants thereof using spliceosome mediated rna trans-splicing |
| JP6576326B2 (ja) | 2013-03-14 | 2019-09-18 | ソーク インスティテュート フォー バイオロジカル スタディーズ | 腫瘍溶解性アデノウイルス組成物 |
| JP7054527B2 (ja) | 2016-02-23 | 2022-04-14 | ソーク インスティテュート フォー バイオロジカル スタディーズ | アデノウイルスの複製動態を測定するための高スループットアッセイ |
| KR20220163505A (ko) | 2016-02-23 | 2022-12-09 | 솔크 인스티튜트 포 바이올로지칼 스터디즈 | 바이러스 동역학에 미치는 영향 최소화를 위한 치료용 아데노바이러스의 외인성 유전자 발현 |
| JP2019536468A (ja) | 2016-12-12 | 2019-12-19 | ソーク インスティテュート フォー バイオロジカル スタディーズ | 腫瘍を標的にする合成アデノウイルスおよびその使用 |
| JP2020510624A (ja) | 2016-12-12 | 2020-04-09 | マルチビア インコーポレイテッド | がんおよび感染性疾患の治療および予防のための、ウイルス遺伝子治療および免疫チェックポイント阻害剤を含む方法および組成物 |
| WO2020036635A2 (en) | 2018-03-19 | 2020-02-20 | Multivir Inc. | Methods and compositions comprising tumor suppressor gene therapy and cd122/cd132 agonists for the treatment of cancer |
| AU2019251356B2 (en) * | 2018-04-09 | 2025-06-12 | Salk Institute For Biological Studies | Oncolytic adenovirus compositions with enhanced replication properties |
| WO2021113644A1 (en) | 2019-12-05 | 2021-06-10 | Multivir Inc. | Combinations comprising a cd8+ t cell enhancer, an immune checkpoint inhibitor and radiotherapy for targeted and abscopal effects for the treatment of cancer |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5801029A (en) | 1993-02-16 | 1998-09-01 | Onyx Pharmaceuticals, Inc. | Cytopathic viruses for therapy and prophylaxis of neoplasia |
| US5631236A (en) * | 1993-08-26 | 1997-05-20 | Baylor College Of Medicine | Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk |
| US6254862B1 (en) | 1997-03-03 | 2001-07-03 | Calydon, Inc. | Adenovirus vectors specific for cells expressing alpha-fetoprotein and methods of use thereof |
| US6197293B1 (en) * | 1997-03-03 | 2001-03-06 | Calydon, Inc. | Adenovirus vectors specific for cells expressing androgen receptor and methods of use thereof |
| US6627190B2 (en) * | 1999-07-12 | 2003-09-30 | Saint Louis University | Recombinant adenovirus vectors that are replication-competent in tert-expressing cells |
| US7589069B1 (en) * | 1999-07-12 | 2009-09-15 | Saint Louis University | Replication-competent anti-cancer vectors |
-
1999
- 1999-07-12 US US09/351,778 patent/US7589069B1/en not_active Expired - Fee Related
-
2000
- 2000-07-12 AT AT00975153T patent/ATE286139T1/de not_active IP Right Cessation
- 2000-07-12 ES ES00975153T patent/ES2231281T3/es not_active Expired - Lifetime
- 2000-07-12 AU AU13244/01A patent/AU780613B2/en not_active Ceased
- 2000-07-12 EP EP00975153A patent/EP1196616B1/en not_active Expired - Lifetime
- 2000-07-12 JP JP2001509486A patent/JP4361708B2/ja not_active Expired - Fee Related
- 2000-07-12 WO PCT/US2000/018971 patent/WO2001004282A2/en not_active Ceased
- 2000-07-12 DE DE60017141T patent/DE60017141T2/de not_active Expired - Lifetime
- 2000-07-12 CA CA2378586A patent/CA2378586C/en not_active Expired - Fee Related
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2005
- 2005-10-13 US US11/249,873 patent/US7608255B2/en not_active Expired - Fee Related
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2009
- 2009-09-16 US US12/561,016 patent/US8658610B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1196616B1 (en) | 2004-12-29 |
| AU1324401A (en) | 2001-01-30 |
| CA2378586A1 (en) | 2001-01-18 |
| JP2003504052A (ja) | 2003-02-04 |
| DE60017141D1 (de) | 2005-02-03 |
| WO2001004282A2 (en) | 2001-01-18 |
| WO2001004282A3 (en) | 2001-09-13 |
| EP1196616A2 (en) | 2002-04-17 |
| US20100034776A1 (en) | 2010-02-11 |
| US20060029596A1 (en) | 2006-02-09 |
| US7589069B1 (en) | 2009-09-15 |
| US7608255B2 (en) | 2009-10-27 |
| US8658610B2 (en) | 2014-02-25 |
| DE60017141T2 (de) | 2005-12-29 |
| ES2231281T3 (es) | 2005-05-16 |
| ATE286139T1 (de) | 2005-01-15 |
| AU780613B2 (en) | 2005-04-07 |
| JP4361708B2 (ja) | 2009-11-11 |
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