DE4213919A1 - Cyclische iminoderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel - Google Patents

Cyclische iminoderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Info

Publication number
DE4213919A1
DE4213919A1 DE4213919A DE4213919A DE4213919A1 DE 4213919 A1 DE4213919 A1 DE 4213919A1 DE 4213919 A DE4213919 A DE 4213919A DE 4213919 A DE4213919 A DE 4213919A DE 4213919 A1 DE4213919 A1 DE 4213919A1
Authority
DE
Germany
Prior art keywords
group
carbon atoms
methyl
substituted
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE4213919A
Other languages
German (de)
English (en)
Inventor
Frank Dipl Chem Dr Himmelsbach
Volkhard Dipl Chem Dr Austel
Helmut Dipl Chem Dr Pieper
Guenter Dipl Chem Dr Linz
Johannes Dipl Che Weisenberger
Thomas Dipl Chem Dr Mueller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Priority to DE4213919A priority Critical patent/DE4213919A1/de
Priority to TW082101712A priority patent/TW232006B/zh
Priority to DK93106724T priority patent/DK0567966T3/da
Priority to US08/053,037 priority patent/US5576444A/en
Priority to DE59308940T priority patent/DE59308940D1/de
Priority to ES93106724T priority patent/ES2121888T3/es
Priority to AT93106724T priority patent/ATE170509T1/de
Priority to EP93106724A priority patent/EP0567966B1/de
Priority to MX9302448A priority patent/MX9302448A/es
Priority to CA002095009A priority patent/CA2095009A1/en
Priority to NO931526A priority patent/NO180045C/no
Priority to HU9301222A priority patent/HUT70039A/hu
Priority to IL105517A priority patent/IL105517A0/xx
Priority to KR1019930007059A priority patent/KR940005569A/ko
Priority to PL29871793A priority patent/PL298717A1/xx
Priority to JP09993093A priority patent/JP3315463B2/ja
Priority to NZ247512A priority patent/NZ247512A/en
Priority to FI931880A priority patent/FI931880A7/fi
Priority to AU38222/93A priority patent/AU662223B2/en
Publication of DE4213919A1 publication Critical patent/DE4213919A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE4213919A 1992-04-28 1992-04-28 Cyclische iminoderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel Withdrawn DE4213919A1 (de)

Priority Applications (19)

Application Number Priority Date Filing Date Title
DE4213919A DE4213919A1 (de) 1992-04-28 1992-04-28 Cyclische iminoderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
TW082101712A TW232006B (enExample) 1992-04-28 1993-03-09
DK93106724T DK0567966T3 (da) 1992-04-28 1993-04-26 Cykliske aminoderivater, fremgangsmåder til deres fremstilling og lægemidler indeholdende disse forbindelser
US08/053,037 US5576444A (en) 1992-04-28 1993-04-26 Cyclic imino derivatives, processes for preparing them and pharmaceutical compositions containing these compounds
DE59308940T DE59308940D1 (de) 1992-04-28 1993-04-26 Cyclische Iminoderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
ES93106724T ES2121888T3 (es) 1992-04-28 1993-04-26 Derivados iminicos ciclicos, procedimientos para su preparacion y medicamentos que contienen a estos compuestos.
AT93106724T ATE170509T1 (de) 1992-04-28 1993-04-26 Cyclische iminoderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
EP93106724A EP0567966B1 (de) 1992-04-28 1993-04-26 Cyclische Iminoderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
MX9302448A MX9302448A (es) 1992-04-28 1993-04-27 Derivados iminicos ciclicos, procedimientos para su preparacion y medicamentos que contienen estos compuestos.
CA002095009A CA2095009A1 (en) 1992-04-28 1993-04-27 Cyclic imino derivatives
NO931526A NO180045C (no) 1992-04-28 1993-04-27 Cykliske iminoderivater, og legemiddelpreparater inneholdende dem
HU9301222A HUT70039A (en) 1992-04-28 1993-04-27 Cyclic imino derivatives, process for preparing tkereof, and the pharmaceutical compositions comprising same compounds
IL105517A IL105517A0 (en) 1992-04-28 1993-04-27 Cyclic imino derivatives,their preparation and pharmaceutical compositions containing them
KR1019930007059A KR940005569A (ko) 1992-04-28 1993-04-27 사이클릭 이미노 유도체, 이의 제조방법 및 이를 함유하는 약제학적 조성물
PL29871793A PL298717A1 (en) 1992-04-28 1993-04-27 Cyclic imine derivatives, method of obtaining them and therapeutic agents containing such compounds
JP09993093A JP3315463B2 (ja) 1992-04-28 1993-04-27 環状イミノ誘導体、それらの調製法及びこれらの化合物を含む医薬組成物
NZ247512A NZ247512A (en) 1992-04-28 1993-04-27 Cyclic imino derivatives and pharmaceutical compositions
FI931880A FI931880A7 (fi) 1992-04-28 1993-04-27 Sykliset iminojohdokset, menetelmä niiden valmistamiseksi ja näitä yhdisteitä sisältävät lääkeaineet
AU38222/93A AU662223B2 (en) 1992-04-28 1993-04-28 Cyclic imino derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4213919A DE4213919A1 (de) 1992-04-28 1992-04-28 Cyclische iminoderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Publications (1)

Publication Number Publication Date
DE4213919A1 true DE4213919A1 (de) 1993-11-04

Family

ID=6457638

Family Applications (2)

Application Number Title Priority Date Filing Date
DE4213919A Withdrawn DE4213919A1 (de) 1992-04-28 1992-04-28 Cyclische iminoderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE59308940T Expired - Fee Related DE59308940D1 (de) 1992-04-28 1993-04-26 Cyclische Iminoderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE59308940T Expired - Fee Related DE59308940D1 (de) 1992-04-28 1993-04-26 Cyclische Iminoderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel

Country Status (18)

Country Link
US (1) US5576444A (enExample)
EP (1) EP0567966B1 (enExample)
JP (1) JP3315463B2 (enExample)
KR (1) KR940005569A (enExample)
AT (1) ATE170509T1 (enExample)
AU (1) AU662223B2 (enExample)
CA (1) CA2095009A1 (enExample)
DE (2) DE4213919A1 (enExample)
DK (1) DK0567966T3 (enExample)
ES (1) ES2121888T3 (enExample)
FI (1) FI931880A7 (enExample)
HU (1) HUT70039A (enExample)
IL (1) IL105517A0 (enExample)
MX (1) MX9302448A (enExample)
NO (1) NO180045C (enExample)
NZ (1) NZ247512A (enExample)
PL (1) PL298717A1 (enExample)
TW (1) TW232006B (enExample)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993018058A1 (en) * 1992-03-06 1993-09-16 G.D. Searle & Co. Peptides mimics useful as platelet aggregation inhibitors
DE4241632A1 (de) * 1992-12-10 1994-06-16 Thomae Gmbh Dr K Carbonsäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
ATE195117T1 (de) * 1993-03-31 2000-08-15 Searle & Co 1-amdinophenyl-pyrrolidone/piperidinone als blutblättchen-aggregations inhibitoren
DE59409322D1 (de) * 1993-12-03 2000-06-08 Hoffmann La Roche Essigsäurederivate als Arzneimittel
EE9700141A (et) * 1994-12-23 1997-12-15 Dr. Karl Thomae Gmbh Piperasiinderivaadid, neid sisaldavad ravimid, nende kasutamine ja valmistamise meetod
US5691364A (en) * 1995-03-10 1997-11-25 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
ES2208737T3 (es) * 1995-03-10 2004-06-16 Berlex Laboratories, Inc. Derivados de benzamidina, su preparacion y su utilizacion como anticoagulantes.
US5612363A (en) * 1995-06-02 1997-03-18 Berlex Laboratories, Inc. N,N-di(aryl) cyclic urea derivatives as anti-coagulants
US5849759A (en) * 1995-12-08 1998-12-15 Berlex Laboratories, Inc. Naphthyl-substituted benzimidazole derivatives as anti-coagulants
US5994375A (en) * 1996-02-12 1999-11-30 Berlex Laboratories, Inc. Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants
WO1997033576A1 (en) * 1996-03-12 1997-09-18 Bristol-Myers Squibb Company Carbamyl guanidine and amidine prodrugs
US5753635A (en) * 1996-08-16 1998-05-19 Berlex Laboratories, Inc. Purine derivatives and their use as anti-coagulants
US5693641A (en) * 1996-08-16 1997-12-02 Berlex Laboratories Inc. Bicyclic pyrimidine derivatives and their use as anti-coagulants
CN1234798A (zh) 1996-09-12 1999-11-10 舍林股份公司 环状氨基酸和环状羟基羧酸衍生物取代的苄脒衍生物和它们用作抗凝剂的用途
US6008234A (en) * 1996-09-12 1999-12-28 Berlex Laboratories, Inc. Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives and their use as anti-coagulants
US6004985A (en) 1996-10-09 1999-12-21 Berlex Laboratories, Inc. Thio acid derived monocylic N-heterocyclics as anticoagulants
US7109326B2 (en) * 1997-04-15 2006-09-19 Genentech, Inc. Halo-alkoxycarbonyl prodrugs
US6686364B2 (en) 1997-12-08 2004-02-03 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
US6140351A (en) * 1997-12-19 2000-10-31 Berlex Laboratories, Inc. Ortho-anthranilamide derivatives as anti-coagulants
DK1040108T3 (da) 1997-12-19 2004-05-24 Schering Ag Orthoanthranilamidderivater som antikoagulanter
EP1060166A1 (de) * 1998-02-03 2000-12-20 Boehringer Ingelheim Pharma KG 5-gliedrige benzokondensierte heterocyclen als antithrombotika
US6114532A (en) * 1998-02-03 2000-09-05 Boehringer Ingelheim Pharma Kg Bicyclic heterocycles, the preparation thereof, and their use as pharmaceuticals
DE19844787A1 (de) * 1998-09-30 2000-04-13 Boehringer Ingelheim Pharma Disubstituierte Pyrrolidinone, diese Verbindung enthaltende Arzneimittel und deren Verwendung sowie ihre Herstellung
US6262088B1 (en) 1998-11-19 2001-07-17 Berlex Laboratories, Inc. Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants
US6127376A (en) * 1998-12-04 2000-10-03 Berlex Laboratories, Inc. Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants
US6350761B1 (en) 1999-07-30 2002-02-26 Berlex Laboratories, Inc. Benzenamine derivatives as anti-coagulants
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7232924B2 (en) 2001-06-11 2007-06-19 Xenoport, Inc. Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
JP5440976B2 (ja) * 2009-01-14 2014-03-12 ホクト株式会社 血小板凝集抑制剤

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2123288A (en) * 1982-07-16 1984-02-01 Wellcome Found Anti-thrombotic agent
EP0194548A3 (de) * 1985-03-12 1988-08-17 Dr. Karl Thomae GmbH Neue Sulfonylaminoäthylverbindungen, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
PT82200B (pt) * 1985-03-16 1990-02-08 Wellcome Found Processo para a preparacao de novos derivados do acido hidroxamico e de composicoes farmaceuticas que os contem
DE3823299A1 (de) * 1988-07-07 1990-01-11 Schering Ag Substituierte phenyl-pyrrolidin-2-one, -oxazolidin-2-one und -imidazolidin-2-one, ihre herstellung sowie verwendung in arzneimitteln
JPH02247166A (ja) * 1989-03-17 1990-10-02 Taisho Pharmaceut Co Ltd ３―ピロリン―２―オン誘導体
DE3932403A1 (de) * 1989-05-12 1991-04-11 Thomae Gmbh Dr K Neue arylsulfonamide, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US5026861A (en) * 1989-07-17 1991-06-25 Merrell Dow Pharmaceuticals Substituted 1,5-dihydro-4-(N-methylhydroxylamino)-2H-pyrrol-2-ones
DE4035961A1 (de) * 1990-11-02 1992-05-07 Thomae Gmbh Dr K Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE4107857A1 (de) * 1991-03-12 1992-09-17 Thomae Gmbh Dr K Cyclische harnstoffderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE4124942A1 (de) * 1991-07-27 1993-01-28 Thomae Gmbh Dr K 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE4127404A1 (de) * 1991-08-19 1993-02-25 Thomae Gmbh Dr K Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
FI931880L (fi) 1993-10-29
JP3315463B2 (ja) 2002-08-19
NO931526D0 (no) 1993-04-27
IL105517A0 (en) 1993-08-18
DK0567966T3 (da) 1999-05-31
AU662223B2 (en) 1995-08-24
EP0567966A1 (de) 1993-11-03
CA2095009A1 (en) 1993-10-29
HUT70039A (en) 1995-09-28
NO180045B (no) 1996-10-28
ATE170509T1 (de) 1998-09-15
TW232006B (enExample) 1994-10-11
JPH0673001A (ja) 1994-03-15
FI931880A0 (fi) 1993-04-27
DE59308940D1 (de) 1998-10-08
ES2121888T3 (es) 1998-12-16
US5576444A (en) 1996-11-19
PL298717A1 (en) 1994-01-24
NZ247512A (en) 1995-12-21
FI931880A7 (fi) 1993-10-29
EP0567966B1 (de) 1998-09-02
NO931526L (no) 1993-10-29
NO180045C (no) 1997-02-05
MX9302448A (es) 1993-10-01
AU3822293A (en) 1993-11-04
KR940005569A (ko) 1994-03-21
HU9301222D0 (en) 1993-07-28

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