DE3834636C2 - - Google Patents
Info
- Publication number
- DE3834636C2 DE3834636C2 DE3834636A DE3834636A DE3834636C2 DE 3834636 C2 DE3834636 C2 DE 3834636C2 DE 3834636 A DE3834636 A DE 3834636A DE 3834636 A DE3834636 A DE 3834636A DE 3834636 C2 DE3834636 C2 DE 3834636C2
- Authority
- DE
- Germany
- Prior art keywords
- dna
- primer
- primers
- dna sequence
- chain reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 claims abstract description 49
- 108091028043 Nucleic acid sequence Proteins 0.000 claims abstract description 48
- 108020004414 DNA Proteins 0.000 claims abstract description 44
- 238000003752 polymerase chain reaction Methods 0.000 claims abstract description 20
- 230000000295 complement effect Effects 0.000 claims abstract description 9
- 238000003786 synthesis reaction Methods 0.000 claims abstract description 9
- 239000000047 product Substances 0.000 claims abstract description 8
- 230000015572 biosynthetic process Effects 0.000 claims abstract description 7
- 239000007795 chemical reaction product Substances 0.000 claims abstract description 7
- 238000006116 polymerization reaction Methods 0.000 claims abstract description 5
- 238000004925 denaturation Methods 0.000 claims abstract description 4
- 230000036425 denaturation Effects 0.000 claims abstract description 4
- 239000002773 nucleotide Substances 0.000 claims description 21
- 125000003729 nucleotide group Chemical group 0.000 claims description 21
- 238000004458 analytical method Methods 0.000 claims description 15
- 108091034117 Oligonucleotide Proteins 0.000 claims description 12
- 102000054765 polymorphisms of proteins Human genes 0.000 claims description 10
- 238000012360 testing method Methods 0.000 claims description 10
- 230000002285 radioactive effect Effects 0.000 claims description 4
- 238000001514 detection method Methods 0.000 claims description 3
- 239000003550 marker Substances 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 238000000163 radioactive labelling Methods 0.000 claims description 3
- 108090000790 Enzymes Proteins 0.000 claims description 2
- 102000004190 Enzymes Human genes 0.000 claims description 2
- 238000002372 labelling Methods 0.000 claims description 2
- 238000000926 separation method Methods 0.000 claims description 2
- 241000251468 Actinopterygii Species 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 239000011550 stock solution Substances 0.000 claims 1
- 239000001226 triphosphate Substances 0.000 claims 1
- 235000011178 triphosphate Nutrition 0.000 claims 1
- 125000002264 triphosphate group Chemical class [H]OP(=O)(O[H])OP(=O)(O[H])OP(=O)(O[H])O* 0.000 claims 1
- 238000000137 annealing Methods 0.000 abstract description 4
- 239000013615 primer Substances 0.000 description 32
- 239000012634 fragment Substances 0.000 description 17
- 241000255581 Drosophila <fruit fly, genus> Species 0.000 description 11
- 238000006243 chemical reaction Methods 0.000 description 11
- 239000000499 gel Substances 0.000 description 11
- 238000009396 hybridization Methods 0.000 description 7
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 6
- 230000003321 amplification Effects 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 238000003199 nucleic acid amplification method Methods 0.000 description 6
- 230000000875 corresponding effect Effects 0.000 description 5
- 239000000523 sample Substances 0.000 description 5
- 238000012163 sequencing technique Methods 0.000 description 5
- 108091008146 restriction endonucleases Proteins 0.000 description 4
- 238000007894 restriction fragment length polymorphism technique Methods 0.000 description 4
- 208000034454 F12-related hereditary angioedema with normal C1Inh Diseases 0.000 description 3
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 3
- 208000037065 Subacute sclerosing leukoencephalitis Diseases 0.000 description 3
- 206010042297 Subacute sclerosing panencephalitis Diseases 0.000 description 3
- 208000016861 hereditary angioedema type 3 Diseases 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 238000009666 routine test Methods 0.000 description 3
- 241000282412 Homo Species 0.000 description 2
- 108090001061 Insulin Proteins 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 238000003776 cleavage reaction Methods 0.000 description 2
- 238000004590 computer program Methods 0.000 description 2
- 238000012217 deletion Methods 0.000 description 2
- 230000037430 deletion Effects 0.000 description 2
- 230000002068 genetic effect Effects 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 230000007017 scission Effects 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
- 108010085238 Actins Proteins 0.000 description 1
- 108700028369 Alleles Proteins 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 102000053602 DNA Human genes 0.000 description 1
- 239000003155 DNA primer Substances 0.000 description 1
- 230000006820 DNA synthesis Effects 0.000 description 1
- 241000255601 Drosophila melanogaster Species 0.000 description 1
- 241000283086 Equidae Species 0.000 description 1
- 241000701959 Escherichia virus Lambda Species 0.000 description 1
- 241001524679 Escherichia virus M13 Species 0.000 description 1
- 208000026350 Inborn Genetic disease Diseases 0.000 description 1
- 108091092919 Minisatellite Proteins 0.000 description 1
- 108020005196 Mitochondrial DNA Proteins 0.000 description 1
- 101100314144 Mus musculus Tnip1 gene Proteins 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 108020004511 Recombinant DNA Proteins 0.000 description 1
- 108010006785 Taq Polymerase Proteins 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 238000009223 counseling Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001502 gel electrophoresis Methods 0.000 description 1
- 208000016361 genetic disease Diseases 0.000 description 1
- 230000008297 genomic mechanism Effects 0.000 description 1
- 238000003505 heat denaturation Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 230000002438 mitochondrial effect Effects 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 238000003793 prenatal diagnosis Methods 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6858—Allele-specific amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3834636A DE3834636A1 (de) | 1988-10-11 | 1988-10-11 | Verfahren zur analyse von laengenpolymorphismen in dna-bereichen |
| JP51115289A JP3218318B2 (ja) | 1988-10-11 | 1989-10-11 | Ｄｎａ領域における長さ多型を分析する方法 |
| HK98103477.9A HK1004341B (en) | 1988-10-11 | 1989-10-11 | Process for analysing length polymorphisms in dna domains |
| EP89912096A EP0438512B2 (de) | 1988-10-11 | 1989-10-11 | Verfahren zur analyse von längenpolymorphismen in dna-bereichen |
| AT89912096T ATE161585T1 (de) | 1988-10-11 | 1989-10-11 | Verfahren zur analyse von längenpolymorphismen in dna-bereichen |
| DE58909827T DE58909827D1 (de) | 1988-10-11 | 1989-10-11 | Verfahren zur analyse von längenpolymorphismen in dna-bereichen |
| PCT/EP1989/001203 WO1990004040A1 (de) | 1988-10-11 | 1989-10-11 | Verfahren zur analyse von längenpolymorphismen in dna-bereichen |
| US08/145,617 US5766847A (en) | 1988-10-11 | 1993-11-04 | Process for analyzing length polymorphisms in DNA regions |
| US09/591,383 USRE37984E1 (en) | 1988-10-11 | 2000-06-09 | Process for analyzing length polymorphisms in DNA regions |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3834636A DE3834636A1 (de) | 1988-10-11 | 1988-10-11 | Verfahren zur analyse von laengenpolymorphismen in dna-bereichen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3834636A1 DE3834636A1 (de) | 1990-04-19 |
| DE3834636C2 true DE3834636C2 (show.php) | 1992-02-20 |
Family
ID=6364896
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE3834636A Granted DE3834636A1 (de) | 1988-10-11 | 1988-10-11 | Verfahren zur analyse von laengenpolymorphismen in dna-bereichen |
| DE58909827T Expired - Lifetime DE58909827D1 (de) | 1988-10-11 | 1989-10-11 | Verfahren zur analyse von längenpolymorphismen in dna-bereichen |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE58909827T Expired - Lifetime DE58909827D1 (de) | 1988-10-11 | 1989-10-11 | Verfahren zur analyse von längenpolymorphismen in dna-bereichen |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | USRE37984E1 (show.php) |
| EP (1) | EP0438512B2 (show.php) |
| JP (1) | JP3218318B2 (show.php) |
| AT (1) | ATE161585T1 (show.php) |
| DE (2) | DE3834636A1 (show.php) |
| WO (1) | WO1990004040A1 (show.php) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6238863B1 (en) | 1998-02-04 | 2001-05-29 | Promega Corporation | Materials and methods for indentifying and analyzing intermediate tandem repeat DNA markers |
| US7008771B1 (en) | 1994-09-30 | 2006-03-07 | Promega Corporation | Multiplex amplification of short tandem repeat loci |
| WO2018011101A1 (en) | 2016-07-12 | 2018-01-18 | Mautner Martín Eduardo | Methods for using long ssdna polynucleotides as primers in pcr assays |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL9002259A (nl) * | 1990-10-17 | 1992-05-18 | Eurodiagnostics B V | Werkwijze voor het bepalen van een genotype door het vergelijken van de nucleotidensequentie van leden van een genfamilie, alsmede kit voor het opsporen van genetische variaties. |
| US5364759B2 (en) * | 1991-01-31 | 1999-07-20 | Baylor College Medicine | Dna typing with short tandem repeat polymorphisms and identification of polymorphic short tandem repeats |
| WO1992013968A1 (en) * | 1991-02-07 | 1992-08-20 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Monolocus-specific hypervariable probes |
| US6207373B1 (en) | 1998-02-25 | 2001-03-27 | Nanogen, Inc. | Methods for determining nature of repeat units in DNA |
| JPH10509594A (ja) * | 1994-11-28 | 1998-09-22 | イー・アイ・デユポン・ドウ・ヌムール・アンド・カンパニー | 遺伝的多型の検出のための複合ミクロサテライトプライマー |
| EP1007730A4 (en) | 1996-08-30 | 2004-04-28 | Invitrogen Corp | METHODS OF IDENTIFYING AND ISOLATING SPECIFIC NUCLEOTIDE SEQUENCES IN cDNA AND GENOMIC DNA |
| US6306588B1 (en) | 1997-02-07 | 2001-10-23 | Invitrogen Corporation | Polymerases for analyzing or typing polymorphic nucleic acid fragments and uses thereof |
| GB9713597D0 (en) * | 1997-06-28 | 1997-09-03 | Sec Dep Of The Home Department | Improvements in and relating to forensic identification |
| JP3738268B2 (ja) | 2003-02-24 | 2006-01-25 | 森永乳業株式会社 | インターロイキン−６産生抑制剤 |
| KR20050109979A (ko) | 2003-03-14 | 2005-11-22 | 메이지 데어리즈 코포레이션 | 항로타바이러스 감염 조성물 및 그의 제법 |
| AU2003225410A1 (en) | 2003-03-21 | 2004-10-11 | Academisch Ziekenhuis Leiden | Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure |
| US20050112591A1 (en) * | 2003-11-25 | 2005-05-26 | Applera Corporation | Novel method for isolating single stranded product |
| WO2007123391A1 (en) | 2006-04-20 | 2007-11-01 | Academisch Ziekenhuis Leiden | Therapeutic intervention in a genetic disease in an individual by modifying expression of an aberrantly expressed gene. |
| EP1857548A1 (en) | 2006-05-19 | 2007-11-21 | Academisch Ziekenhuis Leiden | Means and method for inducing exon-skipping |
| DK2049664T3 (da) | 2006-08-11 | 2012-01-02 | Prosensa Technologies Bv | Enkeltstrengede oligonukleotider, som er komplementære til repetitive elementer, til behandling af med DNA-repetitiv-ustabilitet associerede lidelser |
| AU2008273094B2 (en) | 2007-07-12 | 2013-05-09 | Prosensa Technologies B.V. | Molecules for targeting compounds to various selected organs, tissues or tumor cells |
| AU2008273096B2 (en) | 2007-07-12 | 2013-05-02 | Academisch Ziekenhuis Leiden | Molecules for targeting compounds to various selected organs or tissues |
| USRE48468E1 (en) | 2007-10-26 | 2021-03-16 | Biomarin Technologies B.V. | Means and methods for counteracting muscle disorders |
| CN101896186A (zh) | 2007-10-26 | 2010-11-24 | 莱顿教学医院 | 对抗肌肉病症的方式和方法 |
| JP2011510678A (ja) | 2008-02-08 | 2011-04-07 | プロセンサ ホールディング ビーブイ | Ｄｎａ反復不安定性関連遺伝性障害を治療するための方法及び手段 |
| EP2119783A1 (en) | 2008-05-14 | 2009-11-18 | Prosensa Technologies B.V. | Method for efficient exon (44) skipping in Duchenne Muscular Dystrophy and associated means |
| CA2759899A1 (en) | 2009-04-24 | 2010-10-28 | Prosensa Technologies B.V. | Oligonucleotide comprising an inosine for treating dmd |
| ES2616561T3 (es) | 2009-12-24 | 2017-06-13 | Biomarin Technologies B.V. | Molécula para tratar un trastorno inflamatorio |
| BR112014018427B1 (pt) | 2012-01-27 | 2021-11-03 | Biomarin Technologies B.V. | Oligonucleotídeos moduladores de rna com características melhoradas para o tratamento da distrofia muscular de duchenne e becker |
| GB201418980D0 (en) | 2014-10-24 | 2014-12-10 | Univ Portsmouth | Cell assay kit and method |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0342717A3 (en) | 1984-11-12 | 1990-04-25 | THE LISTER INSTITUTE OF PREVENTIVE MEDICINE Royal National Orthopaedic Hospital | Polynucleotide probes |
| IS1355B6 (is) | 1984-11-12 | 1989-04-19 | Lister Institute Of Preventive Medicine | Fjölkjarna kannar |
| DK171161B1 (da) * | 1985-03-28 | 1996-07-08 | Hoffmann La Roche | Fremgangsmåde til påvisning af forekomst eller fravær af mindst én specifik nukleinsyresekvens i en prøve eller til skelnen mellem to forskellige nukleinsyresekvenser i denne prøve |
| CA1284931C (en) * | 1986-03-13 | 1991-06-18 | Henry A. Erlich | Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids |
| US4987066A (en) | 1986-11-07 | 1991-01-22 | Max Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Process for the detection of restriction fragment length polymorphisms in eukaryotic genomes |
| EP0402400B1 (en) | 1988-02-18 | 1999-09-08 | University of Utah | Genetic identification employing dna probes of variable number tandem repeat loci |
| US5075217A (en) | 1989-04-21 | 1991-12-24 | Marshfield Clinic | Length polymorphisms in (dC-dA)n ·(dG-dT)n sequences |
| US5364759B2 (en) | 1991-01-31 | 1999-07-20 | Baylor College Medicine | Dna typing with short tandem repeat polymorphisms and identification of polymorphic short tandem repeats |
-
1988
- 1988-10-11 DE DE3834636A patent/DE3834636A1/de active Granted
-
1989
- 1989-10-11 AT AT89912096T patent/ATE161585T1/de not_active IP Right Cessation
- 1989-10-11 JP JP51115289A patent/JP3218318B2/ja not_active Expired - Lifetime
- 1989-10-11 WO PCT/EP1989/001203 patent/WO1990004040A1/de not_active Ceased
- 1989-10-11 DE DE58909827T patent/DE58909827D1/de not_active Expired - Lifetime
- 1989-10-11 EP EP89912096A patent/EP0438512B2/de not_active Expired - Lifetime
-
2000
- 2000-06-09 US US09/591,383 patent/USRE37984E1/en not_active Expired - Lifetime
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7008771B1 (en) | 1994-09-30 | 2006-03-07 | Promega Corporation | Multiplex amplification of short tandem repeat loci |
| US6238863B1 (en) | 1998-02-04 | 2001-05-29 | Promega Corporation | Materials and methods for indentifying and analyzing intermediate tandem repeat DNA markers |
| US6767703B2 (en) | 1998-02-04 | 2004-07-27 | Promega Corporation | Materials and methods for identifying and analyzing intermediate tandem repeat DNA markers |
| EP2287307A2 (en) | 1998-02-04 | 2011-02-23 | Promega Corporation | Materials and methods for identifying and analyzing intermediate tandem repeat DNA markers |
| EP2287308A2 (en) | 1998-02-04 | 2011-02-23 | Promega Corporation | Materials and methods for identifying and analyzing intermediate tandem repeat DNA markers |
| WO2018011101A1 (en) | 2016-07-12 | 2018-01-18 | Mautner Martín Eduardo | Methods for using long ssdna polynucleotides as primers in pcr assays |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0438512B2 (de) | 2005-07-27 |
| WO1990004040A1 (de) | 1990-04-19 |
| JP3218318B2 (ja) | 2001-10-15 |
| JPH04501207A (ja) | 1992-03-05 |
| EP0438512A1 (de) | 1991-07-31 |
| EP0438512B1 (de) | 1997-12-29 |
| HK1004341A1 (en) | 1998-11-20 |
| USRE37984E1 (en) | 2003-02-11 |
| ATE161585T1 (de) | 1998-01-15 |
| DE3834636A1 (de) | 1990-04-19 |
| DE58909827D1 (de) | 1998-02-05 |
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| OP8 | Request for examination as to paragraph 44 patent law | ||
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