DE3826412A1 - Verfahren fuer die synthese von vinblastin und vincristin - Google Patents

Verfahren fuer die synthese von vinblastin und vincristin

Info

Publication number
DE3826412A1
DE3826412A1 DE3826412A DE3826412A DE3826412A1 DE 3826412 A1 DE3826412 A1 DE 3826412A1 DE 3826412 A DE3826412 A DE 3826412A DE 3826412 A DE3826412 A DE 3826412A DE 3826412 A1 DE3826412 A1 DE 3826412A1
Authority
DE
Germany
Prior art keywords
formula
enamine
alkyl
alk
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE3826412A
Other languages
German (de)
English (en)
Inventor
James P Kutney
Lewis S L Choi
Jun Nakano
Hiroki Tsukamoto
Camille A Boulet
Michael Mchugh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of British Columbia
Original Assignee
University of British Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of British Columbia filed Critical University of British Columbia
Publication of DE3826412A1 publication Critical patent/DE3826412A1/de
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE3826412A 1987-08-06 1988-08-03 Verfahren fuer die synthese von vinblastin und vincristin Ceased DE3826412A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA000543832A CA1341262C (en) 1987-08-06 1987-08-06 A new process of the synthesis of 3',4'-anhydrovinblastine, vinblastine and vincristine

Publications (1)

Publication Number Publication Date
DE3826412A1 true DE3826412A1 (de) 1989-02-16

Family

ID=4136214

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3826412A Ceased DE3826412A1 (de) 1987-08-06 1988-08-03 Verfahren fuer die synthese von vinblastin und vincristin

Country Status (12)

Country Link
JP (1) JPH0613532B2 (it)
AU (1) AU617342B2 (it)
BE (1) BE1003228A4 (it)
CA (1) CA1341262C (it)
CH (1) CH676711A5 (it)
DE (1) DE3826412A1 (it)
GB (1) GB2215331B (it)
HU (1) HU208829B (it)
IT (1) IT1227155B (it)
NL (1) NL8801966A (it)
SE (1) SE467875B (it)
ZA (1) ZA885765B (it)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5047528A (en) * 1987-01-22 1991-09-10 University Of Bristish Columbia Process of synthesis of vinblastine and vincristine
EP0488345A1 (en) * 1990-11-30 1992-06-03 Fujirebio Inc. 1,4-Dihydropyridine derivatives and methods of producing the same
FR2779146A1 (fr) * 1998-06-02 1999-12-03 Roowin Nouveaux derives de vinca-alcaloides et procedes de preparation
USRE37449E1 (en) 1987-02-06 2001-11-13 University Of British Columbia Process of synthesis of 3′,4′-anhydrovinblastine, vinblastine and vincristine

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5432279A (en) * 1989-03-04 1995-07-11 Mitsui Petrochemical Industries, Inc. Process for the preparation of binary indole alkaloids
JP3010151U (ja) * 1994-04-26 1995-04-25 スミ子 片山 切込みのついた筒形食器収納ケース。

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3801450A1 (de) * 1987-01-22 1988-08-18 Univ British Columbia Verfahren fuer die synthese von vinblastin und vincristin

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4279817A (en) * 1975-05-30 1981-07-21 The United States Of America As Represented By The Department Of Health & Human Services Method for producing dimer alkaloids
HU195513B (en) * 1984-10-16 1988-05-30 Richter Gedeon Vegyeszet Process for producing stable solutions of alkaloides with bis-indole skeleton
JPS62502684A (ja) * 1985-03-12 1987-10-15 ザ・ユニバ−シテイ・オブ・バ−モント・アンド・ステイト・アグリカルチユラル・カレツジ ビンブラスチン及びビンクリスチン型化合物の合成

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3801450A1 (de) * 1987-01-22 1988-08-18 Univ British Columbia Verfahren fuer die synthese von vinblastin und vincristin

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5047528A (en) * 1987-01-22 1991-09-10 University Of Bristish Columbia Process of synthesis of vinblastine and vincristine
USRE37449E1 (en) 1987-02-06 2001-11-13 University Of British Columbia Process of synthesis of 3′,4′-anhydrovinblastine, vinblastine and vincristine
EP0488345A1 (en) * 1990-11-30 1992-06-03 Fujirebio Inc. 1,4-Dihydropyridine derivatives and methods of producing the same
US5367081A (en) * 1990-11-30 1994-11-22 Fujirebio Inc. 1,4-dihydropyridine derivatives
FR2779146A1 (fr) * 1998-06-02 1999-12-03 Roowin Nouveaux derives de vinca-alcaloides et procedes de preparation
WO1999062912A1 (fr) * 1998-06-02 1999-12-09 Roowin S.A. Nouveaux derives de vinca-alcaloides et procedes de preparation
US6365735B1 (en) 1998-06-02 2002-04-02 Roowin S.A. Vinca-alkaloid derivatives and preparation method

Also Published As

Publication number Publication date
HU208829B (en) 1994-01-28
AU617342B2 (en) 1991-11-28
AU2051288A (en) 1989-02-09
GB2215331B (en) 1992-01-02
HUT50351A (en) 1990-01-29
IT8821678A0 (it) 1988-08-05
JPH01151590A (ja) 1989-06-14
SE8802813D0 (sv) 1988-08-03
BE1003228A4 (fr) 1992-02-04
JPH0613532B2 (ja) 1994-02-23
ZA885765B (en) 1989-09-27
CH676711A5 (it) 1991-02-28
GB8818765D0 (en) 1988-09-07
CA1341262C (en) 2001-06-26
GB2215331A (en) 1989-09-20
SE8802813L (sv) 1989-02-07
SE467875B (sv) 1992-09-28
IT1227155B (it) 1991-03-19
NL8801966A (nl) 1989-03-01

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
8131 Rejection