BE1003228A4 - Procede de synthese de la vinblastine et de la vincristine - Google Patents

Procede de synthese de la vinblastine et de la vincristine Download PDF

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Publication number
BE1003228A4
BE1003228A4 BE8800908A BE8800908A BE1003228A4 BE 1003228 A4 BE1003228 A4 BE 1003228A4 BE 8800908 A BE8800908 A BE 8800908A BE 8800908 A BE8800908 A BE 8800908A BE 1003228 A4 BE1003228 A4 BE 1003228A4
Authority
BE
Belgium
Prior art keywords
vinblastine
vincristine
synthesis
dihydro
indole
Prior art date
Application number
BE8800908A
Other languages
English (en)
French (fr)
Inventor
P Kutney James
S L Choi Lewis
Nakano Jun
Tsukamoto Hiroki
A Boulet Camille
Mchugh Michael
Original Assignee
Univ British Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ British Columbia filed Critical Univ British Columbia
Application granted granted Critical
Publication of BE1003228A4 publication Critical patent/BE1003228A4/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
BE8800908A 1987-08-06 1988-08-05 Procede de synthese de la vinblastine et de la vincristine BE1003228A4 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA000543832A CA1341262C (en) 1987-08-06 1987-08-06 A new process of the synthesis of 3',4'-anhydrovinblastine, vinblastine and vincristine

Publications (1)

Publication Number Publication Date
BE1003228A4 true BE1003228A4 (fr) 1992-02-04

Family

ID=4136214

Family Applications (1)

Application Number Title Priority Date Filing Date
BE8800908A BE1003228A4 (fr) 1987-08-06 1988-08-05 Procede de synthese de la vinblastine et de la vincristine

Country Status (12)

Country Link
JP (1) JPH0613532B2 (it)
AU (1) AU617342B2 (it)
BE (1) BE1003228A4 (it)
CA (1) CA1341262C (it)
CH (1) CH676711A5 (it)
DE (1) DE3826412A1 (it)
GB (1) GB2215331B (it)
HU (1) HU208829B (it)
IT (1) IT1227155B (it)
NL (1) NL8801966A (it)
SE (1) SE467875B (it)
ZA (1) ZA885765B (it)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5047528A (en) * 1987-01-22 1991-09-10 University Of Bristish Columbia Process of synthesis of vinblastine and vincristine
USRE37449E1 (en) 1987-02-06 2001-11-13 University Of British Columbia Process of synthesis of 3′,4′-anhydrovinblastine, vinblastine and vincristine
US5432279A (en) * 1989-03-04 1995-07-11 Mitsui Petrochemical Industries, Inc. Process for the preparation of binary indole alkaloids
DE69131444T2 (de) * 1990-11-30 1999-12-23 Fujirebio Inc., Tokio/Tokyo Optisch aktive 1,4-Dihydropyridinderivate sowie Verfahren zu ihrer Herstellung
JP3010151U (ja) * 1994-04-26 1995-04-25 スミ子 片山 切込みのついた筒形食器収納ケース。
FR2779146B1 (fr) * 1998-06-02 2002-01-18 Roowin Nouveaux derives de vinca-alcaloides et procedes de preparation

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4144237A (en) * 1975-05-30 1979-03-13 The United States Of America As Represented By The Department Of Health, Education And Welfare Synthetic vinblastine and vincristine derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU195513B (en) * 1984-10-16 1988-05-30 Richter Gedeon Vegyeszet Process for producing stable solutions of alkaloides with bis-indole skeleton
JPS62502684A (ja) * 1985-03-12 1987-10-15 ザ・ユニバ−シテイ・オブ・バ−モント・アンド・ステイト・アグリカルチユラル・カレツジ ビンブラスチン及びビンクリスチン型化合物の合成
CA1341261C (en) * 1987-01-22 2001-06-26 James P. Kutney Process for the synthesis of 3',4'-anhydrovinblastine, vinblastine and vincristine

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4144237A (en) * 1975-05-30 1979-03-13 The United States Of America As Represented By The Department Of Health, Education And Welfare Synthetic vinblastine and vincristine derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEMISTRY AND INDUSTRY, 2 avril 1977, pages 277-278; T. MAKINO et al.: "Asymmetric reduction of aplha,beta-unsaturated iminium salt with N-glucopyranosyl-1,4-dihydronicotinamides" *

Also Published As

Publication number Publication date
HU208829B (en) 1994-01-28
AU617342B2 (en) 1991-11-28
AU2051288A (en) 1989-02-09
GB2215331B (en) 1992-01-02
HUT50351A (en) 1990-01-29
IT8821678A0 (it) 1988-08-05
JPH01151590A (ja) 1989-06-14
SE8802813D0 (sv) 1988-08-03
JPH0613532B2 (ja) 1994-02-23
ZA885765B (en) 1989-09-27
CH676711A5 (it) 1991-02-28
GB8818765D0 (en) 1988-09-07
CA1341262C (en) 2001-06-26
DE3826412A1 (de) 1989-02-16
GB2215331A (en) 1989-09-20
SE8802813L (sv) 1989-02-07
SE467875B (sv) 1992-09-28
IT1227155B (it) 1991-03-19
NL8801966A (nl) 1989-03-01

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: THE UNIVERSITY OF BRITISH COLUMBIA

Effective date: 19990831