DE3751275T2 - Alkylesters of Heparin mit niedrigem Molecular Gewicht. - Google Patents

Alkylesters of Heparin mit niedrigem Molecular Gewicht.

Info

Publication number
DE3751275T2
DE3751275T2 DE3751275T DE3751275T DE3751275T2 DE 3751275 T2 DE3751275 T2 DE 3751275T2 DE 3751275 T DE3751275 T DE 3751275T DE 3751275 T DE3751275 T DE 3751275T DE 3751275 T2 DE3751275 T2 DE 3751275T2
Authority
DE
Germany
Prior art keywords
heparin
molecular weight
low molecular
activity
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3751275T
Other languages
English (en)
Other versions
DE3751275D1 (de
Inventor
Kevin Michael Foley
Charles Campbell Griffin
Eduardo Amaya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Miami
Original Assignee
University of Miami
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/898,124 external-priority patent/US4745107A/en
Priority claimed from US06/898,130 external-priority patent/US4745105A/en
Priority claimed from US06/898,431 external-priority patent/US4942156A/en
Priority claimed from US06/898,436 external-priority patent/US4745106A/en
Priority claimed from US06/898,127 external-priority patent/US4745108A/en
Application filed by University of Miami filed Critical University of Miami
Publication of DE3751275D1 publication Critical patent/DE3751275D1/de
Application granted granted Critical
Publication of DE3751275T2 publication Critical patent/DE3751275T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Materials Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
DE3751275T 1986-08-20 1987-08-18 Alkylesters of Heparin mit niedrigem Molecular Gewicht. Expired - Lifetime DE3751275T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US06/898,124 US4745107A (en) 1986-08-20 1986-08-20 Heparin derivatives with improved permeability
US06/898,130 US4745105A (en) 1986-08-20 1986-08-20 Low molecular weight heparin derivatives with improved permeability
US06/898,431 US4942156A (en) 1986-08-20 1986-08-20 Low molecular weight heparin derivatives having improved anti-Xa specificity
US06/898,436 US4745106A (en) 1986-08-20 1986-08-20 Heparin derivatives having improved anti-Xa specificity
US06/898,127 US4745108A (en) 1986-08-20 1986-08-20 Heparin derivatives having decreased anti-Xa specificity

Publications (2)

Publication Number Publication Date
DE3751275D1 DE3751275D1 (de) 1995-06-08
DE3751275T2 true DE3751275T2 (de) 1995-09-07

Family

ID=27542290

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3751275T Expired - Lifetime DE3751275T2 (de) 1986-08-20 1987-08-18 Alkylesters of Heparin mit niedrigem Molecular Gewicht.

Country Status (8)

Country Link
EP (1) EP0256880B1 (de)
JP (1) JP2643950B2 (de)
AT (1) ATE122059T1 (de)
CA (1) CA1312861C (de)
DE (1) DE3751275T2 (de)
DK (1) DK175087B1 (de)
ES (1) ES2071608T3 (de)
NO (1) NO172803C (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3821271A1 (de) * 1988-06-23 1989-12-28 Solco Basel Ag Derivatisiertes heparin, verfahren zu dessen herstellung und arzneimittel, welches dieses enthaelt
US5011919A (en) * 1989-01-30 1991-04-30 Ajorca S.A. Modified heparins and obtention process
IT1243300B (it) * 1990-12-20 1994-05-26 Fidia Spa Derivati dell'eparina
IT1286510B1 (it) * 1996-11-29 1998-07-15 Cooperativa Centro Ricerche Po Esteri butirrici ad attivita' antiproliferativa e composizioni farmaceutiche che li contengono
JP4964577B2 (ja) * 2006-12-15 2012-07-04 有限会社応用糖質化学研究所 親脂質性ヘパリン修飾体、その製造方法及び毛髪成長促進剤
CN102516416A (zh) * 2011-12-28 2012-06-27 蚌埠医学院 一种肝素酯化物的合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1355036A (en) * 1970-04-14 1974-06-05 Ici Ltd Articles of plastic film
JPS52111983A (en) * 1976-03-18 1977-09-20 Teijin Ltd Preparation of heparin derivatives
JPS55158055A (en) * 1979-05-25 1980-12-09 Teijin Ltd Preparation of antithrombus medical material
US4331697A (en) * 1980-09-02 1982-05-25 Teijin Limited Novel heparin derivative, method for production thereof, and method for rendering biomedical materials antithrombotic by use of the novel heparin derivative
CA1195322A (en) * 1982-07-19 1985-10-15 Eduardo Amaya Process for manufacturing low molecular weight heparins by depolymerization of normal heparin

Also Published As

Publication number Publication date
JP2643950B2 (ja) 1997-08-25
NO873501L (no) 1988-02-22
DK434587A (da) 1988-02-21
NO172803B (no) 1993-06-01
DK175087B1 (da) 2004-05-24
EP0256880A3 (en) 1988-12-14
EP0256880B1 (de) 1995-05-03
DE3751275D1 (de) 1995-06-08
NO172803C (no) 1993-09-08
JPS6366202A (ja) 1988-03-24
DK434587D0 (da) 1987-08-20
ES2071608T3 (es) 1995-07-01
EP0256880A2 (de) 1988-02-24
CA1312861C (en) 1993-01-19
NO873501D0 (no) 1987-08-19
ATE122059T1 (de) 1995-05-15

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Legal Events

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