DE69228362T2 - Hochmolekulare, N,O-sulfatierte Heparosane; Verfahren zu deren Herstellung und diese enthaltende Arzneimittel - Google Patents

Hochmolekulare, N,O-sulfatierte Heparosane; Verfahren zu deren Herstellung und diese enthaltende Arzneimittel

Info

Publication number
DE69228362T2
DE69228362T2 DE69228362T DE69228362T DE69228362T2 DE 69228362 T2 DE69228362 T2 DE 69228362T2 DE 69228362 T DE69228362 T DE 69228362T DE 69228362 T DE69228362 T DE 69228362T DE 69228362 T2 DE69228362 T2 DE 69228362T2
Authority
DE
Germany
Prior art keywords
high molecular
preparation
molecular weight
products containing
medicinal products
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69228362T
Other languages
English (en)
Other versions
DE69228362D1 (de
Inventor
Jean-Claude Lormeau
Bruno Chevallier
Marc Louis Victor Salome
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Application granted granted Critical
Publication of DE69228362D1 publication Critical patent/DE69228362D1/de
Publication of DE69228362T2 publication Critical patent/DE69228362T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69228362T 1991-11-28 1992-11-25 Hochmolekulare, N,O-sulfatierte Heparosane; Verfahren zu deren Herstellung und diese enthaltende Arzneimittel Expired - Fee Related DE69228362T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9114725A FR2684385B1 (fr) 1991-11-28 1991-11-28 Heparosanes-n,o-sulfates de haute masse moleculaire, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Publications (2)

Publication Number Publication Date
DE69228362D1 DE69228362D1 (de) 1999-03-18
DE69228362T2 true DE69228362T2 (de) 1999-09-09

Family

ID=9419448

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69228362T Expired - Fee Related DE69228362T2 (de) 1991-11-28 1992-11-25 Hochmolekulare, N,O-sulfatierte Heparosane; Verfahren zu deren Herstellung und diese enthaltende Arzneimittel

Country Status (11)

Country Link
US (2) US5314876A (de)
EP (1) EP0544592B1 (de)
JP (1) JPH05271305A (de)
AT (1) ATE176484T1 (de)
CA (1) CA2083576A1 (de)
DE (1) DE69228362T2 (de)
DK (1) DK0544592T3 (de)
ES (1) ES2129037T3 (de)
FR (1) FR2684385B1 (de)
HU (2) HUT64087A (de)
MX (1) MX9206783A (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2684385B1 (fr) * 1991-11-28 1997-08-01 Sanofi Elf Heparosanes-n,o-sulfates de haute masse moleculaire, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
IT1270823B (it) * 1993-06-04 1997-05-13 Italfarmaco Spa Polisaccaridi ad elevata attivita' antitrombotica e anticoagulante
AU3596797A (en) 1996-07-09 1998-02-02 Keith A. Crutcher Methods for the treatment of apolipoprotein e related diseases
US20060188966A1 (en) * 1998-04-02 2006-08-24 Deangelis Paul L Natural, chimeric and hybrid glycosaminoglycan polymers and methods of making and using same
US7223571B2 (en) * 1998-04-02 2007-05-29 The Board Of Regents Of The Universtiy Of Oklahoma Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
US20080108110A1 (en) * 1998-04-02 2008-05-08 Deangelis Paul L Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
US8088604B2 (en) 1998-04-02 2012-01-03 The Board Of Regents Of The University Of Oklahoma Production of defined monodisperse heparosan polymers and unnatural polymers with polysaccharide synthases
US20040197868A1 (en) * 2001-05-08 2004-10-07 Deangelis Paul L. Heparin/heparosan synthase from P. multocida, soluble and single action catalysts thereof and methods of making and using same
ITMI20032498A1 (it) * 2003-12-17 2005-06-18 Pasqua Anna Oreste Polisaccaridi antitrombotici a basso peso molecolare e
EP1353556A4 (de) * 2001-01-23 2009-09-09 Massachusetts Inst Technology Fest- und flüssigphasen-synthese von heparin und anderen glykosaminoglykanen
US8580290B2 (en) * 2001-05-08 2013-11-12 The Board Of Regents Of The University Of Oklahoma Heparosan-based biomaterials and coatings and methods of production and use thereof
WO2002089742A2 (en) * 2001-05-08 2002-11-14 The Board Of Regents Of The University Of Oklahoma Heparin/heparosan synthase and methods of making and using same
ITMI20011633A1 (it) * 2001-07-27 2003-01-27 San Raffaele Centro Fond Uso di polisaccaridi batterici supersolfatati inibitori dell'hiv
US8513407B2 (en) 2002-06-18 2013-08-20 Glycores 2000 S.R.L. Process for the preparation of N-acyl-(epi)K5-amine-O-sulfate-derivatives and products thus obtained
CN1675250B (zh) * 2002-06-18 2012-11-14 格利考斯2000有限公司 硫酸盐化程度非常高的k5多糖的差向异构衍生物
JP2006291028A (ja) * 2005-04-11 2006-10-26 Q P Corp 低分子ヘパリンまたはその塩、ならびにその製造方法
US20060287512A1 (en) * 2005-05-04 2006-12-21 Novozymes Biopolymer A/S Method of controlling the content of selected component(s) from polymer(s) using molecular sieve(s)
JP5091119B2 (ja) * 2005-05-04 2012-12-05 ノボザイムス バイオファーマ デーコー アクティーゼルスカブ 分子篩を用いてポリマーからの選択された成分の含有率を調節するための方法
EP1872791A1 (de) 2006-06-30 2008-01-02 Institut Pasteur Verwendung von Polysacchariden bakteriellen Ursprungs zur Hemmung der Bildung von Biofilmen
ES2292351B1 (es) * 2006-07-14 2009-03-01 Laboratorios Farmaceuticos Rovi, S.A. Procedimiento nuevo de despolimerizacion de la heparina.
US9925209B2 (en) 2008-03-19 2018-03-27 The Board Of Regents Of The University Of Oklahoma Heparosan-polypeptide and heparosan-polynucleotide drug conjugates and methods of making and using same
US9687559B2 (en) * 2008-03-19 2017-06-27 The Board Of Regents Of The University Of Oklahoma Heparosan polymers and methods of making and using same for the enhancement of therapeutics
JP5830464B2 (ja) * 2009-09-01 2015-12-09 レンセラー ポリテクニック インスティチュート Ｋ５ヘパロサン発酵および精製
WO2013149161A1 (en) 2012-03-30 2013-10-03 Deangelis Paul L High molecular weight heparosan polymers and methods of production and use thereof
WO2016159296A1 (ja) * 2015-03-31 2016-10-06 生化学工業株式会社 グリコサミノグリカンの硫酸化方法
CN111662394B (zh) * 2019-03-05 2022-11-04 中国医学科学院药物研究所 硫酸软骨素多糖半合成制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4818817A (en) * 1983-11-30 1989-04-04 Petroleum Fermentations N.V. Enzymatic degradation of lipopolysaccharide bioemulsifiers
FR2584728B1 (fr) * 1985-07-12 1987-11-20 Choay Sa Procede de sulfatation de glycosaminoglycanes et de leurs fragments
EP0333243A3 (de) * 1988-03-10 1989-09-27 Akzo N.V. Sulphatiertes K5-Antigen und seine Fragmente
FR2669932B1 (fr) * 1990-12-03 1994-07-01 Sanofi Sa Nouvel heparosane-n,o-sulfate, son procede de preparation et les compositions pharmaceutiques qui le contiennent.
GB2286193A (en) * 1991-03-28 1995-08-09 Italfarmaco Spa Anticoagulants and processes for preparing such
FR2684385B1 (fr) * 1991-11-28 1997-08-01 Sanofi Elf Heparosanes-n,o-sulfates de haute masse moleculaire, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
CA2083576A1 (en) 1993-05-29
US5384398A (en) 1995-01-24
HUT64087A (en) 1993-11-29
ES2129037T3 (es) 1999-06-01
FR2684385B1 (fr) 1997-08-01
EP0544592A3 (en) 1993-11-18
US5314876A (en) 1994-05-24
ATE176484T1 (de) 1999-02-15
JPH05271305A (ja) 1993-10-19
DE69228362D1 (de) 1999-03-18
HU9203757D0 (en) 1993-03-29
MX9206783A (es) 1994-05-31
EP0544592A2 (de) 1993-06-02
EP0544592B1 (de) 1999-02-03
FR2684385A1 (fr) 1993-06-04
DK0544592T3 (da) 1999-09-20

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee
8327 Change in the person/name/address of the patent owner

Owner name: SANOFI-SYNTHELABO, PARIS, FR