ES2129037T3 - Heparosanos-n,o-sulfatados de alta masa molecular, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. - Google Patents

Heparosanos-n,o-sulfatados de alta masa molecular, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.

Info

Publication number
ES2129037T3
ES2129037T3 ES92403180T ES92403180T ES2129037T3 ES 2129037 T3 ES2129037 T3 ES 2129037T3 ES 92403180 T ES92403180 T ES 92403180T ES 92403180 T ES92403180 T ES 92403180T ES 2129037 T3 ES2129037 T3 ES 2129037T3
Authority
ES
Spain
Prior art keywords
molecular mass
high molecular
heparosanes
sulphates
contain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92403180T
Other languages
English (en)
Inventor
Jean-Claude Lormeau
Bruno Chevallier
Marc Louis Victor Salome
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Application granted granted Critical
Publication of ES2129037T3 publication Critical patent/ES2129037T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Molecular Biology (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

LA INVENCION SE REFIERE A NUEVOS HEPAROSANOS-N,O-SULFATADOS DE ALTA MASA MOLECULAR, CONSTITUIDOS POR CADENAS O POR MEZCLAS DE CADENAS DE MASA MOLECULAR ENTRE 1,5.104 Y 4,0.106 DA, CARACTERIZADOS POR UNA ESTRUCTURA DISACARIDICA REPETIDA DE FORMULA I: EN LA QUE, E REPRESENTA, EN 0 A 80% DE LAS UNIDADES DISACARIDICAS DE DICHO HEPAROSANO-N,O-SULFATADO, UN GRUPO ACETILO, Y EN LAS UNIDADES DISACARIDICAS RESTANTES, UN GRUPO SULFATO Y EVENTUALMENTE UN ATOMO DE HIDROGENO. G REPRESENTA UN ATOMO DE HIDROGENO Y UN GRUPO SULFATO, Y LAS SALES FARMACEUTICAMENTE ACEPTABLES HEPAROSANOS-N,O-SULFATADOS. MEDICAMENTO.
ES92403180T 1991-11-28 1992-11-25 Heparosanos-n,o-sulfatados de alta masa molecular, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. Expired - Lifetime ES2129037T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9114725A FR2684385B1 (fr) 1991-11-28 1991-11-28 Heparosanes-n,o-sulfates de haute masse moleculaire, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Publications (1)

Publication Number Publication Date
ES2129037T3 true ES2129037T3 (es) 1999-06-01

Family

ID=9419448

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92403180T Expired - Lifetime ES2129037T3 (es) 1991-11-28 1992-11-25 Heparosanos-n,o-sulfatados de alta masa molecular, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.

Country Status (11)

Country Link
US (2) US5314876A (es)
EP (1) EP0544592B1 (es)
JP (1) JPH05271305A (es)
AT (1) ATE176484T1 (es)
CA (1) CA2083576A1 (es)
DE (1) DE69228362T2 (es)
DK (1) DK0544592T3 (es)
ES (1) ES2129037T3 (es)
FR (1) FR2684385B1 (es)
HU (2) HU9203757D0 (es)
MX (1) MX9206783A (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2684385B1 (fr) * 1991-11-28 1997-08-01 Sanofi Elf Heparosanes-n,o-sulfates de haute masse moleculaire, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
IT1270823B (it) * 1993-06-04 1997-05-13 Italfarmaco Spa Polisaccaridi ad elevata attivita' antitrombotica e anticoagulante
US6245751B1 (en) 1996-07-09 2001-06-12 University Of Cincinnati Methods for the treatment of apolipoprotein E related diseases
US20060188966A1 (en) * 1998-04-02 2006-08-24 Deangelis Paul L Natural, chimeric and hybrid glycosaminoglycan polymers and methods of making and using same
US8088604B2 (en) 1998-04-02 2012-01-03 The Board Of Regents Of The University Of Oklahoma Production of defined monodisperse heparosan polymers and unnatural polymers with polysaccharide synthases
US7223571B2 (en) * 1998-04-02 2007-05-29 The Board Of Regents Of The Universtiy Of Oklahoma Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
US20080108110A1 (en) * 1998-04-02 2008-05-08 Deangelis Paul L Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
US20040197868A1 (en) * 2001-05-08 2004-10-07 Deangelis Paul L. Heparin/heparosan synthase from P. multocida, soluble and single action catalysts thereof and methods of making and using same
ITMI20032498A1 (it) * 2003-12-17 2005-06-18 Pasqua Anna Oreste Polisaccaridi antitrombotici a basso peso molecolare e
AU2002243630A1 (en) 2001-01-23 2002-08-06 Massachusetts Institute Of Technology Solid- and solution -phase synthesis of heparin and other glycosaminoglycans
EP1392843B1 (en) * 2001-05-08 2017-12-13 The Board of Regents of the University of Oklahoma Heparin/heparosan synthase and methods of making and using same
US8580290B2 (en) * 2001-05-08 2013-11-12 The Board Of Regents Of The University Of Oklahoma Heparosan-based biomaterials and coatings and methods of production and use thereof
ITMI20011633A1 (it) * 2001-07-27 2003-01-27 San Raffaele Centro Fond Uso di polisaccaridi batterici supersolfatati inibitori dell'hiv
CA2489870A1 (en) * 2002-06-18 2003-12-24 Glycores 2000 S.R.L. Low molecular weight oversulfated polysaccharide
US8513407B2 (en) 2002-06-18 2013-08-20 Glycores 2000 S.R.L. Process for the preparation of N-acyl-(epi)K5-amine-O-sulfate-derivatives and products thus obtained
JP2006291028A (ja) * 2005-04-11 2006-10-26 Q P Corp 低分子ヘパリンまたはその塩、ならびにその製造方法
CA2606877C (en) * 2005-05-04 2013-09-03 Novozymes Biopolymer A/S Method of controlling the content of selected component(s) from polymer(s) using molecular sieve(s)
US20060287512A1 (en) * 2005-05-04 2006-12-21 Novozymes Biopolymer A/S Method of controlling the content of selected component(s) from polymer(s) using molecular sieve(s)
EP1872791A1 (en) * 2006-06-30 2008-01-02 Institut Pasteur Use of bacterial polysaccharides for biofilm inhibition
ES2292351B1 (es) * 2006-07-14 2009-03-01 Laboratorios Farmaceuticos Rovi, S.A. Procedimiento nuevo de despolimerizacion de la heparina.
US9925209B2 (en) 2008-03-19 2018-03-27 The Board Of Regents Of The University Of Oklahoma Heparosan-polypeptide and heparosan-polynucleotide drug conjugates and methods of making and using same
US9687559B2 (en) 2008-03-19 2017-06-27 The Board Of Regents Of The University Of Oklahoma Heparosan polymers and methods of making and using same for the enhancement of therapeutics
CN102712942B (zh) * 2009-09-01 2014-05-14 伦斯勒理工学院 K5肝素前体的发酵和纯化
PL2831237T3 (pl) * 2012-03-30 2018-06-29 The Board Of Regents Of The University Of Oklahoma Polimery heparosanu o wysokiej masie cząsteczkowej i sposoby ich wytwarzania i zastosowania
CN107406525B (zh) * 2015-03-31 2020-06-12 生化学工业株式会社 糖胺聚糖的硫酸化方法
CN111662394B (zh) * 2019-03-05 2022-11-04 中国医学科学院药物研究所 硫酸软骨素多糖半合成制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4818817A (en) * 1983-11-30 1989-04-04 Petroleum Fermentations N.V. Enzymatic degradation of lipopolysaccharide bioemulsifiers
FR2584728B1 (fr) * 1985-07-12 1987-11-20 Choay Sa Procede de sulfatation de glycosaminoglycanes et de leurs fragments
EP0333243A3 (en) * 1988-03-10 1989-09-27 Akzo N.V. Sulphated k5 antigen and sulphated k5 antigen fragments
FR2669932B1 (fr) * 1990-12-03 1994-07-01 Sanofi Sa Nouvel heparosane-n,o-sulfate, son procede de preparation et les compositions pharmaceutiques qui le contiennent.
GB2254083A (en) * 1991-03-28 1992-09-30 Italfarmaco Spa Anticoagulants from e.coli saccharide
FR2684385B1 (fr) * 1991-11-28 1997-08-01 Sanofi Elf Heparosanes-n,o-sulfates de haute masse moleculaire, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
EP0544592B1 (fr) 1999-02-03
FR2684385A1 (fr) 1993-06-04
US5384398A (en) 1995-01-24
HUT64087A (en) 1993-11-29
JPH05271305A (ja) 1993-10-19
MX9206783A (es) 1994-05-31
FR2684385B1 (fr) 1997-08-01
DE69228362D1 (de) 1999-03-18
EP0544592A3 (en) 1993-11-18
HU9203757D0 (en) 1993-03-29
US5314876A (en) 1994-05-24
DE69228362T2 (de) 1999-09-09
EP0544592A2 (fr) 1993-06-02
DK0544592T3 (da) 1999-09-20
ATE176484T1 (de) 1999-02-15
CA2083576A1 (en) 1993-05-29

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