ITMI20032498A1 - Polisaccaridi antitrombotici a basso peso molecolare e - Google Patents

Polisaccaridi antitrombotici a basso peso molecolare e

Info

Publication number
ITMI20032498A1
ITMI20032498A1 IT002498A ITMI20032498A ITMI20032498A1 IT MI20032498 A1 ITMI20032498 A1 IT MI20032498A1 IT 002498 A IT002498 A IT 002498A IT MI20032498 A ITMI20032498 A IT MI20032498A IT MI20032498 A1 ITMI20032498 A1 IT MI20032498A1
Authority
IT
Italy
Prior art keywords
sulfate
epik5
lmw
depolymerized
sulfation
Prior art date
Application number
IT002498A
Other languages
English (en)
Inventor
Pasqua Anna Oreste
Giorgio Zoppetti
Original Assignee
Pasqua Anna Oreste
Giorgio Zoppetti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pasqua Anna Oreste, Giorgio Zoppetti filed Critical Pasqua Anna Oreste
Priority to IT002498A priority Critical patent/ITMI20032498A1/it
Priority to US10/868,359 priority patent/US20050027117A1/en
Priority to AT04806349T priority patent/ATE388169T1/de
Priority to PT04806349T priority patent/PT1694714E/pt
Priority to ES04806349T priority patent/ES2302065T3/es
Priority to JP2006544586A priority patent/JP4975443B2/ja
Priority to DE602004012314T priority patent/DE602004012314T2/de
Priority to PCT/IB2004/004128 priority patent/WO2005058976A2/en
Priority to US10/582,687 priority patent/US7812151B2/en
Priority to EP04806349A priority patent/EP1694714B8/en
Publication of ITMI20032498A1 publication Critical patent/ITMI20032498A1/it
Priority to US12/120,167 priority patent/US8513407B2/en
Priority to US13/465,495 priority patent/US20120253029A1/en
Priority to US14/328,271 priority patent/US9346893B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IT002498A 2000-12-18 2003-12-17 Polisaccaridi antitrombotici a basso peso molecolare e ITMI20032498A1 (it)

Priority Applications (13)

Application Number Priority Date Filing Date Title
IT002498A ITMI20032498A1 (it) 2003-12-17 2003-12-17 Polisaccaridi antitrombotici a basso peso molecolare e
US10/868,359 US20050027117A1 (en) 2000-12-18 2004-06-16 Anticoagulant and antithrombotic LMW-glycosaminoglycans derived from K5 polysaccharide and process for their preparation
JP2006544586A JP4975443B2 (ja) 2003-12-17 2004-12-15 抗血栓活性を有する低分子量多糖
PT04806349T PT1694714E (pt) 2003-12-17 2004-12-15 Novos polissacáridos com pequena massa molecular possuindo actividade anti -trombótica
ES04806349T ES2302065T3 (es) 2003-12-17 2004-12-15 Polisacaridos de bajo peso molecular que tienen actividad antitrombotica.
AT04806349T ATE388169T1 (de) 2003-12-17 2004-12-15 Niedermolekulare polysaccharide mit antithrombotischer wirkung
DE602004012314T DE602004012314T2 (de) 2003-12-17 2004-12-15 Niedermolekulare polysaccharide mit antithrombotischer wirkung
PCT/IB2004/004128 WO2005058976A2 (en) 2003-12-17 2004-12-15 Low molecular polysaccharides having antithrombotic activity
US10/582,687 US7812151B2 (en) 2003-12-17 2004-12-15 Low molecular weight polysaccharides having antithrombotic activity
EP04806349A EP1694714B8 (en) 2003-12-17 2004-12-15 Low molecular weight polysaccharides having antithrombotic activity
US12/120,167 US8513407B2 (en) 2002-06-18 2008-05-13 Process for the preparation of N-acyl-(epi)K5-amine-O-sulfate-derivatives and products thus obtained
US13/465,495 US20120253029A1 (en) 2002-06-18 2012-05-07 Process for the preparation of highly o-sulfated epimerized derivatives of k5 polysaccharide and intermediates therein
US14/328,271 US9346893B2 (en) 2002-06-18 2014-07-10 Process for the preparation of highly O-sulfated, epimerized derivatives of K5 polysacchride and intermediates therein

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT002498A ITMI20032498A1 (it) 2003-12-17 2003-12-17 Polisaccaridi antitrombotici a basso peso molecolare e

Publications (1)

Publication Number Publication Date
ITMI20032498A1 true ITMI20032498A1 (it) 2005-06-18

Family

ID=34685622

Family Applications (1)

Application Number Title Priority Date Filing Date
IT002498A ITMI20032498A1 (it) 2000-12-18 2003-12-17 Polisaccaridi antitrombotici a basso peso molecolare e

Country Status (9)

Country Link
US (1) US7812151B2 (it)
EP (1) EP1694714B8 (it)
JP (1) JP4975443B2 (it)
AT (1) ATE388169T1 (it)
DE (1) DE602004012314T2 (it)
ES (1) ES2302065T3 (it)
IT (1) ITMI20032498A1 (it)
PT (1) PT1694714E (it)
WO (1) WO2005058976A2 (it)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20032498A1 (it) 2003-12-17 2005-06-18 Pasqua Anna Oreste Polisaccaridi antitrombotici a basso peso molecolare e
ITMI20010397A1 (it) * 2001-02-27 2002-08-27 Giorgio Zoppetti Derivati altamente n,o-solfatati del polisaccaride k5 e loro preparazione
CA2489870A1 (en) * 2002-06-18 2003-12-24 Glycores 2000 S.R.L. Low molecular weight oversulfated polysaccharide
US8513407B2 (en) * 2002-06-18 2013-08-20 Glycores 2000 S.R.L. Process for the preparation of N-acyl-(epi)K5-amine-O-sulfate-derivatives and products thus obtained
US20120253029A1 (en) 2002-06-18 2012-10-04 Pasqua Anna Oreste Process for the preparation of highly o-sulfated epimerized derivatives of k5 polysaccharide and intermediates therein
EP1872791A1 (en) * 2006-06-30 2008-01-02 Institut Pasteur Use of bacterial polysaccharides for biofilm inhibition
ES2947291T3 (es) * 2015-12-28 2023-08-04 Ajinomoto Kk Heparán sulfato que presenta una elevada tasa de 3-O-sulfatación en los residuos de glucosamina
CN110776578B (zh) * 2019-11-12 2021-01-29 苏州颐华生物医药技术股份有限公司 低分子海参糖胺聚糖及其应用
CN111875714B (zh) * 2020-08-05 2022-05-20 青岛海洋生物医药研究院股份有限公司 低分子量硫酸半乳聚糖及其制备方法和应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1141483B (it) 1980-04-18 1986-10-01 Crinos Industria Farmaco Resina poliamminica per la separazione selettiva di eparina da altri glucosamminoglicani e procedimento per la sua preparazione
ES2059321T3 (es) 1986-05-16 1994-11-16 Italfarmaco Spa Heparinas, fracciones y fragmentos de heparinas libres de edta, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
FR2684385B1 (fr) * 1991-11-28 1997-08-01 Sanofi Elf Heparosanes-n,o-sulfates de haute masse moleculaire, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
IT1271057B (it) 1994-11-04 1997-05-26 Inalco Spa Polisaccaridi aventi un elevato contenuto di acido iduronico
IT1282994B1 (it) * 1996-05-10 1998-04-03 Inalco Spa Derivati del polisaccaride k5 aventi elevata attivita' anticoagulante
IT1289613B1 (it) 1997-02-07 1998-10-15 Inalco Spa Polisaccaridi batterici o-solfatati
IT1318432B1 (it) 2000-03-30 2003-08-25 Inalco Spa Glicosaminoglicani derivati dal polisaccaride k5 aventi elevataattivita' anticoagulante ed antitrombotica e processo per la loro
US20020062019A1 (en) * 2000-03-30 2002-05-23 Pasqua Oreste Glycosaminoglycans derived from K5 polysaccharide having high anticoagulant and antithrombotic activities and process for their preparation
ITMI20032498A1 (it) 2003-12-17 2005-06-18 Pasqua Anna Oreste Polisaccaridi antitrombotici a basso peso molecolare e
US20050027117A1 (en) 2000-12-18 2005-02-03 Pasqua Oreste Anticoagulant and antithrombotic LMW-glycosaminoglycans derived from K5 polysaccharide and process for their preparation
ITMI20010397A1 (it) 2001-02-27 2002-08-27 Giorgio Zoppetti Derivati altamente n,o-solfatati del polisaccaride k5 e loro preparazione
ITMI20011633A1 (it) 2001-07-27 2003-01-27 San Raffaele Centro Fond Uso di polisaccaridi batterici supersolfatati inibitori dell'hiv
ITMI20012200A1 (it) 2001-10-22 2003-04-22 Ibsa Inst Biochimique Sa Processo per la preparazione di condroitin solfati dal polisaccaride k4 e prodotti ottenuti
CA2489870A1 (en) 2002-06-18 2003-12-24 Glycores 2000 S.R.L. Low molecular weight oversulfated polysaccharide
ITMI20032614A1 (it) 2003-12-30 2005-06-30 Altergon Sa Nuova composizione comprendente cs

Also Published As

Publication number Publication date
US20070155694A1 (en) 2007-07-05
ATE388169T1 (de) 2008-03-15
EP1694714B8 (en) 2009-04-01
PT1694714E (pt) 2008-05-09
JP2007514817A (ja) 2007-06-07
DE602004012314T2 (de) 2009-03-19
JP4975443B2 (ja) 2012-07-11
DE602004012314D1 (de) 2008-04-17
EP1694714B1 (en) 2008-03-05
EP1694714A2 (en) 2006-08-30
WO2005058976A3 (en) 2005-08-04
ES2302065T3 (es) 2008-07-01
US7812151B2 (en) 2010-10-12
WO2005058976A2 (en) 2005-06-30

Similar Documents

Publication Publication Date Title
ITMI20032498A1 (it) Polisaccaridi antitrombotici a basso peso molecolare e
ATE548393T1 (de) Mischungen von aus heparin hergestellten oligosacchariden, deren herstellung und diese enthaltenden pharmazeutischen zusammensetzungen
KR900018129A (ko) 콘드로이틴 황산염, 데르마탄황산염 및 히알루론산의 술포아미노 유도체와 그 약제학적 성질
WO2002018448A3 (en) Percarboxylated polysaccharides, and a process for their preparation
ATE430558T1 (de) Herstellung von mikrokügelchen
ATE195348T1 (de) Polysaccharide mit hohem anteil an iduronsäure
IT1282994B1 (it) Derivati del polisaccaride k5 aventi elevata attivita' anticoagulante
DE50310724D1 (de) Herstellung von suspension hydrophober oxidpartikel
ATE517550T1 (de) Verwendung von polysaccharide als brotverbesserungsmittel
JP2015500388A5 (it)
CN103524759B (zh) 动物角蛋白基高分子水凝胶的制备方法及作为药物载体的应用
PL405074A1 (pl) Zastosowanie alpha-cyklodrkstryny do wytwarzania leku do obnizenia poziomów trójglicerydów
CN103774287B (zh) 一种通过光聚合反应增强壳聚糖衍生物纳米纤维的方法
ATE315049T1 (de) Hochsulfatierte derivate von k5-polysacchariden und ihre herstellung
AU2235802A (en) Glycosaminoglycans derived from k5 polysaccharide having high antithrombin activity and process for their preparation
HUP0004365A2 (hu) Eljárás igen alacsony maradékmonomer-tartalmú, vízben oldódó, illetve vízzel duzzasztható polimerizátumok előállítására, az eljárás szerint előállított termékek és alkalmazásuk
MXPA05009109A (es) Modificacion de reologia de revestimiento de papel.
RU2216548C2 (ru) Смесь линейных олигосахаридов, полученная из дерматансульфата, фармацевтическая композиция, обладающая антитромботическим действием, и способ лечения
CN106519060A (zh) 一种羧甲基可得然胶的制备
IL165808A0 (en) Low molecular weight k5-n,o-oversulfated polysaccharide process for the preparation thereof and pharmaceutical compositions containing the same
JP2004210715A5 (it)
JP4897991B2 (ja) 超低分子量ヘパリン組成物
Ruggiero et al. Increased calcium affinity of a fucosylated chondroitin sulfate from sea cucumber
WO2005007114A3 (en) Method of treating diabetes type ii
JP2008308430A5 (it)