ATE548393T1 - Mischungen von aus heparin hergestellten oligosacchariden, deren herstellung und diese enthaltenden pharmazeutischen zusammensetzungen - Google Patents
Mischungen von aus heparin hergestellten oligosacchariden, deren herstellung und diese enthaltenden pharmazeutischen zusammensetzungenInfo
- Publication number
- ATE548393T1 ATE548393T1 AT03807882T AT03807882T ATE548393T1 AT E548393 T1 ATE548393 T1 AT E548393T1 AT 03807882 T AT03807882 T AT 03807882T AT 03807882 T AT03807882 T AT 03807882T AT E548393 T1 ATE548393 T1 AT E548393T1
- Authority
- AT
- Austria
- Prior art keywords
- heparin
- activity
- hexasaccharide
- mixtures
- production
- Prior art date
Links
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title abstract 3
- 229920000669 heparin Polymers 0.000 title abstract 3
- 229960002897 heparin Drugs 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 229920001542 oligosaccharide Polymers 0.000 title abstract 2
- 150000002482 oligosaccharides Chemical class 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 230000000694 effects Effects 0.000 abstract 6
- 230000001858 anti-Xa Effects 0.000 abstract 4
- 150000004676 glycans Chemical class 0.000 abstract 3
- 229920001282 polysaccharide Polymers 0.000 abstract 3
- 239000005017 polysaccharide Substances 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 239000003513 alkali Substances 0.000 abstract 2
- 150000001720 carbohydrates Chemical group 0.000 abstract 2
- 239000002184 metal Substances 0.000 abstract 2
- 150000003839 salts Chemical group 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
- C08B37/0078—Degradation products
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biochemistry (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Physical Education & Sports Medicine (AREA)
- Molecular Biology (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0212584A FR2845686B1 (fr) | 2002-10-10 | 2002-10-10 | Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant |
| PCT/FR2003/002960 WO2004033503A1 (fr) | 2002-10-10 | 2003-10-08 | Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE548393T1 true ATE548393T1 (de) | 2012-03-15 |
Family
ID=32039597
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03807882T ATE548393T1 (de) | 2002-10-10 | 2003-10-08 | Mischungen von aus heparin hergestellten oligosacchariden, deren herstellung und diese enthaltenden pharmazeutischen zusammensetzungen |
Country Status (35)
| Country | Link |
|---|---|
| EP (1) | EP1556414B1 (de) |
| JP (2) | JP5021898B2 (de) |
| CN (6) | CN1798771A (de) |
| AT (1) | ATE548393T1 (de) |
| AU (1) | AU2003300161B2 (de) |
| BR (1) | BR0315149A (de) |
| CA (1) | CA2501546C (de) |
| CY (1) | CY1112808T1 (de) |
| DK (1) | DK1556414T3 (de) |
| EC (1) | ECSP055722A (de) |
| ES (1) | ES2383597T3 (de) |
| FR (1) | FR2845686B1 (de) |
| GT (1) | GT200300181A (de) |
| HN (1) | HN2003000312A (de) |
| IL (1) | IL167868A (de) |
| MA (1) | MA27398A1 (de) |
| MX (1) | MXPA05003321A (de) |
| MY (1) | MY142376A (de) |
| NI (1) | NI200300087A (de) |
| NO (1) | NO20052170L (de) |
| NZ (1) | NZ539229A (de) |
| OA (1) | OA12940A (de) |
| PA (1) | PA8584201A1 (de) |
| PE (1) | PE20040507A1 (de) |
| PT (1) | PT1556414E (de) |
| RS (1) | RS20050274A (de) |
| RU (1) | RU2332424C2 (de) |
| SI (1) | SI1556414T1 (de) |
| SV (1) | SV2004001626A (de) |
| TN (1) | TNSN05101A1 (de) |
| TW (1) | TWI332010B (de) |
| UA (1) | UA81925C2 (de) |
| UY (1) | UY28016A1 (de) |
| WO (1) | WO2004033503A1 (de) |
| ZA (1) | ZA200502787B (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2845686B1 (fr) * | 2002-10-10 | 2013-08-30 | Aventis Pharma Sa | Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant |
| FR2857971B1 (fr) * | 2003-07-24 | 2005-08-26 | Aventis Pharma Sa | Melanges d'oligosaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant |
| CN101495517B (zh) * | 2006-05-25 | 2012-10-10 | 莫曼塔医药品有限公司 | 低分子量肝素及其用途 |
| EP1994934A4 (de) | 2006-12-05 | 2010-03-10 | Glycoscience Lab Inc | Therapeutisches mittel gegen degenerative arthritis |
| CA2750188C (en) * | 2009-02-02 | 2016-11-29 | Otsuka Chemical Co., Ltd. | Low-molecular polysulfated hyaluronic acid derivative and compositions containing same |
| EP2233145A1 (de) | 2009-03-19 | 2010-09-29 | Sanofi-Aventis | AVE5026-Dosis zur Behandlung von venöser Thromboembolie bei Patienten mit starker Nierenfunktionsstörung |
| EP2399591A1 (de) | 2010-06-25 | 2011-12-28 | Aventis Pharma S.A. | Semuloparin zur Prävention eines Mortalitäts- und/oder Morbiditätsereignisses bei einem Patienten, an dem ein schwerer chirurgischer Eingriff vorgenommen wird |
| EP2399592A1 (de) | 2010-06-25 | 2011-12-28 | Aventis Pharma S.A. | Semuloparin zur Prävention eines Mortalitäts- und/oder Morbiditätsereignisses bei einem Patienten, an dem ein schwerer chirurgischer Eingriff vorgenommen wird |
| EP2399590A1 (de) | 2010-06-25 | 2011-12-28 | Aventis Pharma S.A. | Semuloparin zur Prävention eines Mortalitäts- und/oder Morbiditätsereignisses bei einem Patienten, an dem ein schwerer chirurgischer Eingriff vorgenommen wird |
| EP2399593A1 (de) | 2010-06-28 | 2011-12-28 | Aventis Pharma S.A. | Semuloparin zur Prävention eines Mortalitäts- und/oder Morbiditätsereignisses bei einem Patienten, an dem ein schwerer chirurgischer Eingriff vorgenommen wird |
| JP2012046511A (ja) * | 2010-07-30 | 2012-03-08 | Otsuka Chem Co Ltd | 低分子量多硫酸化ヒアルロン酸誘導体を含有する医薬 |
| EP3144325B1 (de) * | 2010-09-14 | 2020-11-04 | University Of Miyazaki | Hochreines heparin und herstellungsverfahren dafür |
| WO2012055843A1 (en) | 2010-10-28 | 2012-05-03 | Aventis Pharma S.A. | Semuloparin for the prevention of major venous thromboembolism in a patient undergoing major abdominal surgery |
| EP2446891A1 (de) | 2010-10-28 | 2012-05-02 | Aventis Pharma S.A. | Semuloparin für Verwendung als eine antithrombotische Behandlung in den großen Bauchoperation mit verbesserter Sicherheit in Bezug auf klinisch relevante Blutungen und starken Blutungen |
| WO2012072799A1 (en) | 2010-12-02 | 2012-06-07 | Aventis Pharma S.A. | New methods for the in vitro measurement of the biological activity of an ultra low molecular weight heparin sample |
| AR085961A1 (es) * | 2011-04-11 | 2013-11-06 | Sanofi Sa | Polisacaridos que poseen dos sitios de union a la antitrombina iii, metodo para prepararlos y composiciones farmaceuticas que los contienen |
| EP2548561A1 (de) | 2011-07-22 | 2013-01-23 | Aventis Pharma S.A. | Semuloparin zur Verbesserung der Überlebenschancen von Patienten mit örtlich fortgeschrittenem Krebs |
| WO2013044793A1 (zh) * | 2011-09-26 | 2013-04-04 | Xu Meiying | 一种高纯度肝素苄酯盐及其制法和应用 |
| CN102633908A (zh) * | 2012-05-02 | 2012-08-15 | 雷晓刚 | 一种高品质超低分子量肝素的制备方法 |
| ES2445494B1 (es) * | 2012-08-02 | 2015-03-06 | Rovi Lab Farmaceut Sa | Procedimiento de obtención de heparinas de bajo y muy bajo peso molecular |
| US9873712B2 (en) * | 2014-10-03 | 2018-01-23 | Amphastar Pharmaceuticals, Inc. | Method of purifying idraparinux sodium |
| WO2017113197A1 (zh) * | 2015-12-30 | 2017-07-06 | 深圳市海普瑞药业集团股份有限公司 | 硫酸化肝素寡糖及其制备方法和应用 |
| CZ308106B6 (cs) * | 2016-06-27 | 2020-01-08 | Contipro A.S. | Nenasycené deriváty polysacharidů, způsob jejich přípravy a jejich použití |
| CN110917208B (zh) * | 2019-12-27 | 2021-02-12 | 浙江医院 | 硫酸化甘露葡萄糖醛酸六糖在防治动脉粥样硬化中的应用 |
| CN117534776A (zh) * | 2023-09-26 | 2024-02-09 | 南京健友生化制药股份有限公司 | 一种依诺酯化反应液的除杂方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL61201A (en) * | 1979-10-05 | 1984-09-30 | Choay Sa | Oligosaccharides having no more than 8 saccharide moieties,their obtention from heparin and pharmaceutical compositions containing them |
| FR2482611B1 (fr) * | 1980-05-14 | 1986-03-07 | Pharmindustrie | Nouveaux polysaccharides sulfates, procedes pour leur preparation et leur utilisation comme medicaments |
| FR2504928A1 (fr) * | 1981-04-29 | 1982-11-05 | Choay Sa | Oligosaccharides a chaines courtes possedant des proprietes biologiques, leur preparation et leurs applications en tant que medicaments |
| FR2584728B1 (fr) * | 1985-07-12 | 1987-11-20 | Choay Sa | Procede de sulfatation de glycosaminoglycanes et de leurs fragments |
| FR2584606A1 (fr) * | 1985-07-12 | 1987-01-16 | Dropic | Utilisation de poly- et oligosaccharides pour l'obtention de medicaments actifs dans les pathologies du tissu conjonctif |
| FR2669932B1 (fr) * | 1990-12-03 | 1994-07-01 | Sanofi Sa | Nouvel heparosane-n,o-sulfate, son procede de preparation et les compositions pharmaceutiques qui le contiennent. |
| JP4897991B2 (ja) * | 1999-07-23 | 2012-03-14 | ラボラトリオス ファルマセウティコス ロビ ソシエダッド アノニマ | 超低分子量ヘパリン組成物 |
| ES2161615B1 (es) * | 1999-07-23 | 2003-03-16 | Rovi Lab Farmaceut Sa | Composiciones de heparinas de muy bajo peso molecular. |
| FR2807043B1 (fr) * | 2000-03-28 | 2002-11-22 | Aventis Pharma Sa | Composition pharmaceutique contenant des oligosaccharides, les nouveaux oligosaccharides et leur preparation |
| FR2811992B1 (fr) * | 2000-07-21 | 2003-07-04 | Aventis Pharma Sa | Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant |
| FR2845686B1 (fr) * | 2002-10-10 | 2013-08-30 | Aventis Pharma Sa | Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant |
-
2002
- 2002-10-10 FR FR0212584A patent/FR2845686B1/fr not_active Expired - Fee Related
-
2003
- 2003-08-10 UA UAA200504331A patent/UA81925C2/uk unknown
- 2003-08-26 GT GT200300181A patent/GT200300181A/es unknown
- 2003-09-18 NI NI200300087A patent/NI200300087A/es unknown
- 2003-09-24 SV SV2003001626A patent/SV2004001626A/es not_active Application Discontinuation
- 2003-10-01 PA PA20038584201A patent/PA8584201A1/es unknown
- 2003-10-06 PE PE2003001005A patent/PE20040507A1/es not_active Application Discontinuation
- 2003-10-08 SI SI200332145T patent/SI1556414T1/sl unknown
- 2003-10-08 CN CNA2003801009925A patent/CN1798771A/zh active Pending
- 2003-10-08 CA CA2501546A patent/CA2501546C/fr not_active Expired - Fee Related
- 2003-10-08 MX MXPA05003321A patent/MXPA05003321A/es active IP Right Grant
- 2003-10-08 CN CN201010147528A patent/CN101812189A/zh active Pending
- 2003-10-08 WO PCT/FR2003/002960 patent/WO2004033503A1/fr not_active Ceased
- 2003-10-08 BR BR0315149-2A patent/BR0315149A/pt not_active IP Right Cessation
- 2003-10-08 CN CN201010147509A patent/CN101810637A/zh active Pending
- 2003-10-08 RU RU2005113987/04A patent/RU2332424C2/ru not_active IP Right Cessation
- 2003-10-08 PT PT03807882T patent/PT1556414E/pt unknown
- 2003-10-08 AT AT03807882T patent/ATE548393T1/de active
- 2003-10-08 ES ES03807882T patent/ES2383597T3/es not_active Expired - Lifetime
- 2003-10-08 HN HN2003000312A patent/HN2003000312A/es unknown
- 2003-10-08 OA OA1200500102A patent/OA12940A/fr unknown
- 2003-10-08 AU AU2003300161A patent/AU2003300161B2/en not_active Ceased
- 2003-10-08 CN CN201010147539A patent/CN101812139A/zh active Pending
- 2003-10-08 RS YUP-2005/0274A patent/RS20050274A/sr unknown
- 2003-10-08 CN CN201010147549A patent/CN101812190A/zh active Pending
- 2003-10-08 DK DK03807882.0T patent/DK1556414T3/da active
- 2003-10-08 NZ NZ539229A patent/NZ539229A/en not_active IP Right Cessation
- 2003-10-08 JP JP2004542566A patent/JP5021898B2/ja not_active Expired - Fee Related
- 2003-10-08 EP EP03807882A patent/EP1556414B1/de not_active Expired - Lifetime
- 2003-10-08 CN CN201010120370A patent/CN101817940A/zh active Pending
- 2003-10-09 TW TW092128028A patent/TWI332010B/zh not_active IP Right Cessation
- 2003-10-09 MY MYPI20033852A patent/MY142376A/en unknown
- 2003-10-10 UY UY28016A patent/UY28016A1/es unknown
-
2005
- 2005-04-01 MA MA28192A patent/MA27398A1/fr unknown
- 2005-04-05 IL IL167868A patent/IL167868A/en not_active IP Right Cessation
- 2005-04-06 ZA ZA200502787A patent/ZA200502787B/en unknown
- 2005-04-07 TN TNP2005000101A patent/TNSN05101A1/fr unknown
- 2005-04-08 EC EC2005005722A patent/ECSP055722A/es unknown
- 2005-05-03 NO NO20052170A patent/NO20052170L/no not_active Application Discontinuation
-
2011
- 2011-10-21 JP JP2011231218A patent/JP5389140B2/ja not_active Expired - Fee Related
-
2012
- 2012-05-30 CY CY20121100489T patent/CY1112808T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1112808T1 (el) | Μειγματα ολιγοσακχαριτων προερχομενων απο την ηπαρινη, η παρασκευη τους και φαρμακευτικες συνθεσεις που τα περιεχουν | |
| US4791195A (en) | Novel oligosaccharides having pharmacological properties by depolymerization of heparin | |
| ES2269943T5 (es) | Polímeros solubles de glucosa altamente ramificados y su procedimiento de obtención | |
| HRP20180124T1 (hr) | Glikozaminoglikani koji nisu antikoagulanti koji sadrže ponavljajuću jedinicu disaharida i njihova medicinska upotreba | |
| SI2794667T1 (en) | Low anticoagulant heparins | |
| KR830006333A (ko) | 의약용 신규의 황산화 다당류 제조방법 | |
| US6197943B1 (en) | Glycosaminoglycans having high antithrombotic activity | |
| IT1282994B1 (it) | Derivati del polisaccaride k5 aventi elevata attivita' anticoagulante | |
| EP0973526A1 (de) | Sulfatierte oligosaccharide die anticoagulierende und antithrombotische reigenschaften besitzen | |
| DE69813216T2 (de) | Oligosaccharidemischungen mit antithrombotischer wirkung | |
| HRP20230820T1 (hr) | Heparan-sulfat, s visokom stopom 3-o-sulfatiranja u glukozaminskim ostacima | |
| JP2004210715A5 (de) | ||
| JP3218039B2 (ja) | 硫酸化多糖類，それらの調製法，医薬組成物および使用 | |
| EP1561760A3 (de) | Salz von Heparin mit niedrigem Molekulargewicht mit Triethanolamin | |
| JPH10218902A5 (de) | ||
| IL165807A (en) | Process for preparing epimerized derivatives of k5 polysaccharide with a very high degree of sulfation and new epi k5-n,o-sulfated polysaccharide derivatives thus obtained | |
| ATE388169T1 (de) | Niedermolekulare polysaccharide mit antithrombotischer wirkung | |
| TW200704403A (en) | Dilution resistant viscoelastic compositions | |
| Sinaÿ | Recent advances in the study of the binding site of heparin to antithrombin | |
| AR041555A1 (es) | Mezclas de polisacaridos derivados de heparina, su preparacion y las composiciones farmaceuticas que las contienen | |
| TH68733A (th) | ของผสมของพอลิแซคคาไรด์ที่มาจากเฮพาริน การเตรียมและสารผสมทางเภสัชกรรมที่มีของผสมนั้น | |
| AU6284898A (en) | Sulfated oligosaccharides having anticoagulant/antithrombotic activity |