JP2008308430A5 - - Google Patents

Info

Publication number

JP2008308430A5

JP2008308430A5 JP2007156997A JP2007156997A JP2008308430A5 JP 2008308430 A5 JP2008308430 A5 JP 2008308430A5 JP 2007156997 A JP2007156997 A JP 2007156997A JP 2007156997 A JP2007156997 A JP 2007156997A JP 2008308430 A5 JP2008308430 A5 JP 2008308430A5

Authority

JP

Japan

Prior art keywords

hyaluronic acid

acid

vivo

glucuronic acid

addition

Prior art date

2007-06-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 229920002674 hyaluronan Polymers 0.000 description 8
• 229960003160 hyaluronic acid Drugs 0.000 description 8
• MAKUBRYLFHZREJ-JWBQXVCJSA-M sodium;(2S,3S,4R,5R,6R)-3-[(2S,3R,5S,6R)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylate Chemical compound [Na+].CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@H](O)[C@H]1O MAKUBRYLFHZREJ-JWBQXVCJSA-M 0.000 description 8
• 229940097043 Glucuronic Acid Drugs 0.000 description 6
• AEMOLEFTQBMNLQ-QIUUJYRFSA-N β-D-glucuronic acid Chemical group O[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-QIUUJYRFSA-N 0.000 description 6
• OVRNDRQMDRJTHS-FMDGEEDCSA-N N-Acetylglucosamine Chemical group CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 description 3
• 210000003491 Skin Anatomy 0.000 description 3
• 230000015572 biosynthetic process Effects 0.000 description 3
• 238000003786 synthesis reaction Methods 0.000 description 3
• 230000002194 synthesizing Effects 0.000 description 3
• 229950002441 Glucurolactone Drugs 0.000 description 2
• UYUXSRADSPPKRZ-SKNVOMKLSA-N Glucuronolactone Chemical compound O=C[C@H](O)[C@H]1OC(=O)[C@@H](O)[C@H]1O UYUXSRADSPPKRZ-SKNVOMKLSA-N 0.000 description 2
• 229950006780 N-Acetylglucosamine Drugs 0.000 description 2
• 229940053049 glucuronolactone Drugs 0.000 description 2
• 235000013402 health food Nutrition 0.000 description 2
• 238000004519 manufacturing process Methods 0.000 description 2
• 150000003839 salts Chemical class 0.000 description 2
• 239000011780 sodium chloride Substances 0.000 description 2
• 239000000126 substance Substances 0.000 description 2
• 206010003246 Arthritis Diseases 0.000 description 1
• AEMOLEFTQBMNLQ-YMDCURPLSA-N D-Galacturonic acid Chemical compound OC1O[C@H](C(O)=O)[C@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-YMDCURPLSA-N 0.000 description 1
• 210000001503 Joints Anatomy 0.000 description 1
• 210000001179 Synovial Fluid Anatomy 0.000 description 1
• 210000004127 Vitreous Body Anatomy 0.000 description 1
• 230000032683 aging Effects 0.000 description 1
• 230000021615 conjugation Effects 0.000 description 1
• 239000002537 cosmetic Substances 0.000 description 1
• 210000004748 cultured cells Anatomy 0.000 description 1
• 125000000600 disaccharide group Chemical group 0.000 description 1
• 239000003814 drug Substances 0.000 description 1
• 230000002708 enhancing Effects 0.000 description 1
• 239000000284 extract Substances 0.000 description 1
• 239000012530 fluid Substances 0.000 description 1
• 239000002778 food additive Substances 0.000 description 1
• 235000013373 food additive Nutrition 0.000 description 1
• 235000010987 pectin Nutrition 0.000 description 1
• 229920001277 pectin Polymers 0.000 description 1
• 239000001814 pectin Substances 0.000 description 1
• OZAIFHULBGXAKX-UHFFFAOYSA-N precursor Substances N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 description 1
• 210000001519 tissues Anatomy 0.000 description 1