ATE195348T1 - Polysaccharide mit hohem anteil an iduronsäure - Google Patents

Polysaccharide mit hohem anteil an iduronsäure

Info

Publication number
ATE195348T1
ATE195348T1 AT95937026T AT95937026T ATE195348T1 AT E195348 T1 ATE195348 T1 AT E195348T1 AT 95937026 T AT95937026 T AT 95937026T AT 95937026 T AT95937026 T AT 95937026T AT E195348 T1 ATE195348 T1 AT E195348T1
Authority
AT
Austria
Prior art keywords
pct
polysaccharides
iduronic acid
sulfation
sec
Prior art date
Application number
AT95937026T
Other languages
English (en)
Inventor
Giorgio Zoppetti
Pasqua Oreste
Giovanni Cipolletti
Original Assignee
Inalco Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11369805&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE195348(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Inalco Spa filed Critical Inalco Spa
Application granted granted Critical
Publication of ATE195348T1 publication Critical patent/ATE195348T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
AT95937026T 1994-11-04 1995-10-30 Polysaccharide mit hohem anteil an iduronsäure ATE195348T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI942240A IT1271057B (it) 1994-11-04 1994-11-04 Polisaccaridi aventi un elevato contenuto di acido iduronico
PCT/EP1995/004241 WO1996014425A1 (en) 1994-11-04 1995-10-30 Polysaccharides having a high iduronic acid content

Publications (1)

Publication Number Publication Date
ATE195348T1 true ATE195348T1 (de) 2000-08-15

Family

ID=11369805

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95937026T ATE195348T1 (de) 1994-11-04 1995-10-30 Polysaccharide mit hohem anteil an iduronsäure

Country Status (13)

Country Link
US (1) US5958899A (de)
EP (1) EP0789777B1 (de)
JP (1) JP3640259B2 (de)
CN (1) CN1094977C (de)
AT (1) ATE195348T1 (de)
AU (1) AU3926195A (de)
CA (1) CA2204366A1 (de)
DE (1) DE69518333T2 (de)
DK (1) DK0789777T3 (de)
ES (1) ES2150589T3 (de)
IT (1) IT1271057B (de)
PT (1) PT789777E (de)
WO (1) WO1996014425A1 (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1282994B1 (it) * 1996-05-10 1998-04-03 Inalco Spa Derivati del polisaccaride k5 aventi elevata attivita' anticoagulante
SE9701454D0 (sv) 1997-04-18 1997-04-18 Ulf Lindahl new DNA sequences and a process for enzyme manufacture
US20080108110A1 (en) * 1998-04-02 2008-05-08 Deangelis Paul L Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
US8088604B2 (en) 1998-04-02 2012-01-03 The Board Of Regents Of The University Of Oklahoma Production of defined monodisperse heparosan polymers and unnatural polymers with polysaccharide synthases
US7223571B2 (en) * 1998-04-02 2007-05-29 The Board Of Regents Of The Universtiy Of Oklahoma Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
US20060188966A1 (en) * 1998-04-02 2006-08-24 Deangelis Paul L Natural, chimeric and hybrid glycosaminoglycan polymers and methods of making and using same
US20040197868A1 (en) * 2001-05-08 2004-10-07 Deangelis Paul L. Heparin/heparosan synthase from P. multocida, soluble and single action catalysts thereof and methods of making and using same
CN1098354C (zh) * 1998-11-12 2003-01-08 武汉大学 双酶催化法合成1－β－D－呋喃核糖苷－1，2，4－三氮唑－3－甲酰胺
US6608042B2 (en) 2000-03-28 2003-08-19 Aventis Pharma, S.A. Pharmaceutical compositions containing oligosaccharides, the novel oligosaccharides and preparation thereof
US20020062019A1 (en) 2000-03-30 2002-05-23 Pasqua Oreste Glycosaminoglycans derived from K5 polysaccharide having high anticoagulant and antithrombotic activities and process for their preparation
IT1318432B1 (it) * 2000-03-30 2003-08-25 Inalco Spa Glicosaminoglicani derivati dal polisaccaride k5 aventi elevataattivita' anticoagulante ed antitrombotica e processo per la loro
US8227449B2 (en) 2000-03-30 2012-07-24 Glycores 2000 S.R.L. Glycosaminoglycans derived from K5 polysaccharide having high anticoagulant and antithrombotic activities and process for their preparation
AU2002217174B2 (en) 2000-12-08 2006-06-22 Biotie Therapies Corp. Glucuronyl C5-epimerase, DNA encoding the same and uses thereof
ITMI20032498A1 (it) 2003-12-17 2005-06-18 Pasqua Anna Oreste Polisaccaridi antitrombotici a basso peso molecolare e
ITMI20010397A1 (it) * 2001-02-27 2002-08-27 Giorgio Zoppetti Derivati altamente n,o-solfatati del polisaccaride k5 e loro preparazione
WO2002089742A2 (en) * 2001-05-08 2002-11-14 The Board Of Regents Of The University Of Oklahoma Heparin/heparosan synthase and methods of making and using same
US8580290B2 (en) * 2001-05-08 2013-11-12 The Board Of Regents Of The University Of Oklahoma Heparosan-based biomaterials and coatings and methods of production and use thereof
AU2003225724A1 (en) * 2002-03-11 2003-09-29 Momenta Pharmaceuticals, Inc. Analysis of sulfated polysaccharides
CN1675250B (zh) * 2002-06-18 2012-11-14 格利考斯2000有限公司 硫酸盐化程度非常高的k5多糖的差向异构衍生物
US8513407B2 (en) * 2002-06-18 2013-08-20 Glycores 2000 S.R.L. Process for the preparation of N-acyl-(epi)K5-amine-O-sulfate-derivatives and products thus obtained
US20120253029A1 (en) 2002-06-18 2012-10-04 Pasqua Anna Oreste Process for the preparation of highly o-sulfated epimerized derivatives of k5 polysaccharide and intermediates therein
GB0216861D0 (en) * 2002-07-19 2002-08-28 Univ Birmingham Saccharide libraries
US20040171819A1 (en) 2002-10-10 2004-09-02 Aventis Pharma S.A. Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
ITMI20031618A1 (it) * 2003-08-06 2005-02-07 Inalco Spa Derivati polisaccaridici dotati di alta attivita'
FI20065035A (fi) * 2006-01-19 2007-07-20 Polysackaridforskning I Uppsal Olennaisesti puhdas entsyymi
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
WO2009014715A2 (en) * 2007-07-23 2009-01-29 The University Of North Carolina At Chapel Hill Enzymatic synthesis of sulfated polysaccharides without iduronic acid residues
US9925209B2 (en) 2008-03-19 2018-03-27 The Board Of Regents Of The University Of Oklahoma Heparosan-polypeptide and heparosan-polynucleotide drug conjugates and methods of making and using same
US9687559B2 (en) * 2008-03-19 2017-06-27 The Board Of Regents Of The University Of Oklahoma Heparosan polymers and methods of making and using same for the enhancement of therapeutics
CN101591401A (zh) * 2009-02-27 2009-12-02 江南大学 一种制备高活性低分子量肝素的方法
ES2817779T3 (es) * 2010-01-19 2021-04-08 Momenta Pharmaceuticals Inc Evaluación de preparaciones de heparina
US11203772B2 (en) 2010-12-23 2021-12-21 The University Of North Carolina At Chapel Hill Chemoenzymatic synthesis of structurally homogeneous ultra-low molecular weight heparins
US9068957B2 (en) 2011-02-21 2015-06-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
WO2013149161A1 (en) 2012-03-30 2013-10-03 Deangelis Paul L High molecular weight heparosan polymers and methods of production and use thereof
WO2014204929A2 (en) 2013-06-17 2014-12-24 The University Of North Carolina At Chapel Hill Reversible heparin molecules and methods of making and using the same
WO2016159296A1 (ja) * 2015-03-31 2016-10-06 生化学工業株式会社 グリコサミノグリカンの硫酸化方法
WO2018165656A1 (en) 2017-03-10 2018-09-13 The University Of North Carolina At Chapel Hill Short-acting heparin-based anticoagulant compounds and methods
US11993627B2 (en) 2017-07-03 2024-05-28 The University Of North Carolina At Chapel Hill Enzymatic synthesis of homogeneous chondroitin sulfate oligosaccharides
CN111601603A (zh) 2017-11-03 2020-08-28 北卡罗来纳大学查珀尔希尔分校 具有抗炎活性的硫酸化寡糖
CN108486187A (zh) * 2018-02-02 2018-09-04 南京微构医药科技有限公司 一种艾杜糖醛酸的制备工艺
CN112437667B (zh) 2018-06-20 2024-05-28 北卡罗来纳大学查珀尔希尔分校 细胞保护方法和组合物
CN110577559B (zh) * 2019-08-19 2023-02-17 江西科技师范大学 α-L-艾杜糖醛酸酶测定用荧光糖苷酶底物的合成方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2286193A (en) * 1991-03-28 1995-08-09 Italfarmaco Spa Anticoagulants and processes for preparing such

Also Published As

Publication number Publication date
JPH10508204A (ja) 1998-08-18
EP0789777B1 (de) 2000-08-09
CN1094977C (zh) 2002-11-27
DE69518333D1 (en) 2000-09-14
DK0789777T3 (da) 2000-11-06
JP3640259B2 (ja) 2005-04-20
CA2204366A1 (en) 1996-05-17
DE69518333T2 (de) 2001-02-22
CN1162339A (zh) 1997-10-15
AU3926195A (en) 1996-05-31
US5958899A (en) 1999-09-28
ITMI942240A1 (it) 1996-05-04
PT789777E (pt) 2001-01-31
EP0789777A1 (de) 1997-08-20
ITMI942240A0 (it) 1994-11-04
IT1271057B (it) 1997-05-26
ES2150589T3 (es) 2000-12-01
WO1996014425A1 (en) 1996-05-17

Similar Documents

Publication Publication Date Title
ATE195348T1 (de) Polysaccharide mit hohem anteil an iduronsäure
Linhardt et al. Polysaccharide lyases
ATE94554T1 (de) Oligosaccharide, verwendbar als haarwuchsmittel.
KR840006812A (ko) 해중합된 과황산염 헤파린의 제조방법
PL167668B1 (pl) Sposób wytwarzania mieszaniny N,O-siarczanów heparosanów PL PL PL
AU3026597A (en) Derivatives of k5 polysaccharide having high anticoagulant activity
JPH07501684A (ja) 抗凝固剤およびその調製方法
EP1654288B1 (de) Polysaccharidderivate mit antithrombotischer wirkung im plasma
Pejler et al. Basement-membrane heparan sulphate with high affinity for antithrombin synthesized by normal and transformed mouse mammary epithelial cells
AU2235802A (en) Glycosaminoglycans derived from k5 polysaccharide having high antithrombin activity and process for their preparation
JPS63191801A (ja) 多糖類の制御された解重合方法
Linker et al. The hyaluronidase of the leech: an endoglucuronidase
EA199800778A1 (ru) Способ окисления полисахарида
Pinhal et al. Antithrombotic agents stimulate the synthesis and modify the sulfation pattern of a heparan sulfate proteoglycan from endothelial cells
Göhler et al. Purification and characterization of 3′‐phosphoadenylylsulfate: N‐desulfoheparan sulfate sulfotransferase from arterial tissue
KR910007532A (ko) 항트롬보 활성을 지닌 설페이트화 글리코 사미노글리큐로난
Mirelman et al. The location of the D-alanyl ester in the ribitol teichoic acid of Staphylococcusaureus
Hannesson Bacterial polysaccharides as substrates for D-glucuronyl C-5 epimerases in studies of glycosaminoglycan biosynthesis.
Lohse The heparin lyases of Flavobacterium heparinum
Steel et al. A highly specific growth-inhibitory factor produced by certain Acetobacter species
JPWO2021007429A5 (de)
FR2831553B1 (fr) Milieu de culture solide pour micro-organismes et cellules eucaryotes ainsi que son procede d'obtention
Kusche O-Sulfotransferase reactions in the biosynthesis of mast cell glycosaminoglycans.
RU95110112A (ru) Способ получения хитозан-глюканового комплекса
JPH06113873A (ja) 微生物セルロースの製造方法

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee