ATE195348T1 - Polysaccharide mit hohem anteil an iduronsäure - Google Patents
Polysaccharide mit hohem anteil an iduronsäureInfo
- Publication number
- ATE195348T1 ATE195348T1 AT95937026T AT95937026T ATE195348T1 AT E195348 T1 ATE195348 T1 AT E195348T1 AT 95937026 T AT95937026 T AT 95937026T AT 95937026 T AT95937026 T AT 95937026T AT E195348 T1 ATE195348 T1 AT E195348T1
- Authority
- AT
- Austria
- Prior art keywords
- pct
- polysaccharides
- iduronic acid
- sulfation
- sec
- Prior art date
Links
- 150000004676 glycans Chemical class 0.000 title abstract 3
- 229920001282 polysaccharide Polymers 0.000 title abstract 3
- 239000005017 polysaccharide Substances 0.000 title abstract 3
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 title abstract 2
- AEMOLEFTQBMNLQ-HNFCZKTMSA-N L-idopyranuronic acid Chemical compound OC1O[C@@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-HNFCZKTMSA-N 0.000 title abstract 2
- 229920002971 Heparan sulfate Polymers 0.000 abstract 3
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 abstract 2
- 238000005670 sulfation reaction Methods 0.000 abstract 2
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 abstract 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 abstract 1
- 241000588724 Escherichia coli Species 0.000 abstract 1
- 239000007995 HEPES buffer Substances 0.000 abstract 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 1
- 102000004879 Racemases and epimerases Human genes 0.000 abstract 1
- 108090001066 Racemases and epimerases Proteins 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 230000000996 additive effect Effects 0.000 abstract 1
- 239000007853 buffer solution Substances 0.000 abstract 1
- 238000003381 deacetylation reaction Methods 0.000 abstract 1
- 238000006345 epimerization reaction Methods 0.000 abstract 1
- 229960002897 heparin Drugs 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 235000011164 potassium chloride Nutrition 0.000 abstract 1
- 239000001103 potassium chloride Substances 0.000 abstract 1
- 239000012429 reaction media Substances 0.000 abstract 1
- 230000019635 sulfation Effects 0.000 abstract 1
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Materials Engineering (AREA)
- Biotechnology (AREA)
- Polymers & Plastics (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI942240A IT1271057B (it) | 1994-11-04 | 1994-11-04 | Polisaccaridi aventi un elevato contenuto di acido iduronico |
| PCT/EP1995/004241 WO1996014425A1 (en) | 1994-11-04 | 1995-10-30 | Polysaccharides having a high iduronic acid content |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE195348T1 true ATE195348T1 (de) | 2000-08-15 |
Family
ID=11369805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95937026T ATE195348T1 (de) | 1994-11-04 | 1995-10-30 | Polysaccharide mit hohem anteil an iduronsäure |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5958899A (de) |
| EP (1) | EP0789777B1 (de) |
| JP (1) | JP3640259B2 (de) |
| CN (1) | CN1094977C (de) |
| AT (1) | ATE195348T1 (de) |
| AU (1) | AU3926195A (de) |
| CA (1) | CA2204366A1 (de) |
| DE (1) | DE69518333T2 (de) |
| DK (1) | DK0789777T3 (de) |
| ES (1) | ES2150589T3 (de) |
| IT (1) | IT1271057B (de) |
| PT (1) | PT789777E (de) |
| WO (1) | WO1996014425A1 (de) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1282994B1 (it) * | 1996-05-10 | 1998-04-03 | Inalco Spa | Derivati del polisaccaride k5 aventi elevata attivita' anticoagulante |
| SE9701454D0 (sv) * | 1997-04-18 | 1997-04-18 | Ulf Lindahl | new DNA sequences and a process for enzyme manufacture |
| US7223571B2 (en) * | 1998-04-02 | 2007-05-29 | The Board Of Regents Of The Universtiy Of Oklahoma | Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same |
| US8088604B2 (en) | 1998-04-02 | 2012-01-03 | The Board Of Regents Of The University Of Oklahoma | Production of defined monodisperse heparosan polymers and unnatural polymers with polysaccharide synthases |
| US20060188966A1 (en) * | 1998-04-02 | 2006-08-24 | Deangelis Paul L | Natural, chimeric and hybrid glycosaminoglycan polymers and methods of making and using same |
| US20080108110A1 (en) * | 1998-04-02 | 2008-05-08 | Deangelis Paul L | Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same |
| US20040197868A1 (en) * | 2001-05-08 | 2004-10-07 | Deangelis Paul L. | Heparin/heparosan synthase from P. multocida, soluble and single action catalysts thereof and methods of making and using same |
| CN1098354C (zh) * | 1998-11-12 | 2003-01-08 | 武汉大学 | 双酶催化法合成1－β－D－呋喃核糖苷－1，2，4－三氮唑－3－甲酰胺 |
| US6608042B2 (en) | 2000-03-28 | 2003-08-19 | Aventis Pharma, S.A. | Pharmaceutical compositions containing oligosaccharides, the novel oligosaccharides and preparation thereof |
| US8227449B2 (en) | 2000-03-30 | 2012-07-24 | Glycores 2000 S.R.L. | Glycosaminoglycans derived from K5 polysaccharide having high anticoagulant and antithrombotic activities and process for their preparation |
| IT1318432B1 (it) * | 2000-03-30 | 2003-08-25 | Inalco Spa | Glicosaminoglicani derivati dal polisaccaride k5 aventi elevataattivita' anticoagulante ed antitrombotica e processo per la loro |
| US20020062019A1 (en) | 2000-03-30 | 2002-05-23 | Pasqua Oreste | Glycosaminoglycans derived from K5 polysaccharide having high anticoagulant and antithrombotic activities and process for their preparation |
| SK286819B6 (sk) | 2000-12-08 | 2009-06-05 | Biotie Therapies Corporation | Izolovaný polynukleotid, izolovaný C5-epimerázový polypeptid, spôsob produkcie proteínu a spôsob zvýšenia aktivity C5-epimerázy |
| ITMI20032498A1 (it) | 2003-12-17 | 2005-06-18 | Pasqua Anna Oreste | Polisaccaridi antitrombotici a basso peso molecolare e |
| ITMI20010397A1 (it) * | 2001-02-27 | 2002-08-27 | Giorgio Zoppetti | Derivati altamente n,o-solfatati del polisaccaride k5 e loro preparazione |
| US8580290B2 (en) * | 2001-05-08 | 2013-11-12 | The Board Of Regents Of The University Of Oklahoma | Heparosan-based biomaterials and coatings and methods of production and use thereof |
| EP1392843B1 (de) * | 2001-05-08 | 2017-12-13 | The Board of Regents of the University of Oklahoma | Heparin/heparosan-synthase und verfahren zu ihrer herstellung und verwendung |
| JP4828795B2 (ja) * | 2002-03-11 | 2011-11-30 | モメンタ ファーマシューティカルズ インコーポレイテッド | 硫酸化多糖類の分析 |
| US20120253029A1 (en) | 2002-06-18 | 2012-10-04 | Pasqua Anna Oreste | Process for the preparation of highly o-sulfated epimerized derivatives of k5 polysaccharide and intermediates therein |
| AU2003242881A1 (en) * | 2002-06-18 | 2003-12-31 | Glycores 2000 S.R.L. | Low molecular weight oversulfated polysaccharide |
| US8513407B2 (en) * | 2002-06-18 | 2013-08-20 | Glycores 2000 S.R.L. | Process for the preparation of N-acyl-(epi)K5-amine-O-sulfate-derivatives and products thus obtained |
| GB0216861D0 (en) * | 2002-07-19 | 2002-08-28 | Univ Birmingham | Saccharide libraries |
| US20040171819A1 (en) | 2002-10-10 | 2004-09-02 | Aventis Pharma S.A. | Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them |
| ITMI20031618A1 (it) * | 2003-08-06 | 2005-02-07 | Inalco Spa | Derivati polisaccaridici dotati di alta attivita' |
| FI20065035A7 (fi) * | 2006-01-19 | 2007-07-20 | Polysackaridforskning I Uppsal | Olennaisesti puhdas entsyymi |
| US9139876B1 (en) | 2007-05-03 | 2015-09-22 | Momenta Pharmacueticals, Inc. | Method of analyzing a preparation of a low molecular weight heparin |
| US20090035787A1 (en) * | 2007-07-23 | 2009-02-05 | The University Of North Carolina At Chapel Hill | Enzymatic synthesis of sulfated polysaccharides without iduronic acid residues |
| US9687559B2 (en) | 2008-03-19 | 2017-06-27 | The Board Of Regents Of The University Of Oklahoma | Heparosan polymers and methods of making and using same for the enhancement of therapeutics |
| US9925209B2 (en) | 2008-03-19 | 2018-03-27 | The Board Of Regents Of The University Of Oklahoma | Heparosan-polypeptide and heparosan-polynucleotide drug conjugates and methods of making and using same |
| CN101591401A (zh) * | 2009-02-27 | 2009-12-02 | 江南大学 | 一种制备高活性低分子量肝素的方法 |
| US8435795B2 (en) * | 2010-01-19 | 2013-05-07 | Momenta Pharmaceuticals, Inc. | Evaluating heparin preparations |
| EP2655421B1 (de) | 2010-12-23 | 2022-02-09 | The University of North Carolina At Chapel Hill | Chemoenzymatische synthese von strukturell homogenen heparinen mit ultra-niedrigem molekulargewicht |
| WO2012115952A1 (en) | 2011-02-21 | 2012-08-30 | Momenta Pharmaceuticals, Inc. | Evaluating heparin preparations |
| PL2831237T3 (pl) | 2012-03-30 | 2018-06-29 | The Board Of Regents Of The University Of Oklahoma | Polimery heparosanu o wysokiej masie cząsteczkowej i sposoby ich wytwarzania i zastosowania |
| EP3011043B1 (de) | 2013-06-17 | 2022-05-11 | The University of North Carolina At Chapel Hill | Umkehrbare heparinmoleküle |
| EP3279220B1 (de) * | 2015-03-31 | 2024-12-04 | Seikagaku Corporation | Verfahren zur sulfatierung von glykosaminoglykan |
| US11903963B2 (en) | 2017-03-10 | 2024-02-20 | The University Of North Carolina At Chapel Hill | Short-acting heparin-based anticoagulant compounds and methods |
| WO2019010216A1 (en) | 2017-07-03 | 2019-01-10 | The University Of North Carolina At Chapel Hill | ENZYMATIC SYNTHESIS OF HOMOGENEOUS CHONDROITIN SULFATE OLIGOSACCHARIDES |
| EP3691653B1 (de) | 2017-11-03 | 2025-03-12 | The University Of North Carolina At Chapel Hill | Sulfatierte oligosaccharide mit entzündungshemmender wirkung |
| CN108486187A (zh) * | 2018-02-02 | 2018-09-04 | 南京微构医药科技有限公司 | 一种艾杜糖醛酸的制备工艺 |
| EP3810152A4 (de) | 2018-06-20 | 2022-04-27 | The University of North Carolina at Chapel Hill | Zellschutzverfahren und zusammensetzungen |
| CN110577559B (zh) * | 2019-08-19 | 2023-02-17 | 江西科技师范大学 | α-L-艾杜糖醛酸酶测定用荧光糖苷酶底物的合成方法 |
| EP4041251A4 (de) | 2019-11-13 | 2023-11-29 | The University of North Carolina at Chapel Hill | Heparansulfat(hs)-oligosaccharid-wirkung in leberischämie-reperfusionsverletzung |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2254083A (en) * | 1991-03-28 | 1992-09-30 | Italfarmaco Spa | Anticoagulants from e.coli saccharide |
-
1994
- 1994-11-04 IT ITMI942240A patent/IT1271057B/it active IP Right Grant
-
1995
- 1995-10-30 DK DK95937026T patent/DK0789777T3/da active
- 1995-10-30 AT AT95937026T patent/ATE195348T1/de not_active IP Right Cessation
- 1995-10-30 AU AU39261/95A patent/AU3926195A/en not_active Abandoned
- 1995-10-30 ES ES95937026T patent/ES2150589T3/es not_active Expired - Lifetime
- 1995-10-30 CA CA002204366A patent/CA2204366A1/en not_active Abandoned
- 1995-10-30 US US08/628,690 patent/US5958899A/en not_active Expired - Fee Related
- 1995-10-30 EP EP95937026A patent/EP0789777B1/de not_active Expired - Lifetime
- 1995-10-30 WO PCT/EP1995/004241 patent/WO1996014425A1/en not_active Ceased
- 1995-10-30 PT PT95937026T patent/PT789777E/pt unknown
- 1995-10-30 JP JP51501996A patent/JP3640259B2/ja not_active Expired - Fee Related
- 1995-10-30 CN CN95196040A patent/CN1094977C/zh not_active Expired - Fee Related
- 1995-10-30 DE DE69518333T patent/DE69518333T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2204366A1 (en) | 1996-05-17 |
| ITMI942240A1 (it) | 1996-05-04 |
| EP0789777A1 (de) | 1997-08-20 |
| DK0789777T3 (da) | 2000-11-06 |
| DE69518333D1 (en) | 2000-09-14 |
| IT1271057B (it) | 1997-05-26 |
| ITMI942240A0 (it) | 1994-11-04 |
| PT789777E (pt) | 2001-01-31 |
| DE69518333T2 (de) | 2001-02-22 |
| AU3926195A (en) | 1996-05-31 |
| WO1996014425A1 (en) | 1996-05-17 |
| CN1094977C (zh) | 2002-11-27 |
| JPH10508204A (ja) | 1998-08-18 |
| JP3640259B2 (ja) | 2005-04-20 |
| CN1162339A (zh) | 1997-10-15 |
| US5958899A (en) | 1999-09-28 |
| EP0789777B1 (de) | 2000-08-09 |
| ES2150589T3 (es) | 2000-12-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |