DE3722278A1 - Verfahren zur herstellung von 1-(3'-(brom)-(2's)-(methyl)-propionyl) -pyrrolidin-(2s)-carbonsaeure oder ihres monohydrates - Google Patents

Verfahren zur herstellung von 1-(3'-(brom)-(2's)-(methyl)-propionyl) -pyrrolidin-(2s)-carbonsaeure oder ihres monohydrates

Info

Publication number
DE3722278A1
DE3722278A1 DE19873722278 DE3722278A DE3722278A1 DE 3722278 A1 DE3722278 A1 DE 3722278A1 DE 19873722278 DE19873722278 DE 19873722278 DE 3722278 A DE3722278 A DE 3722278A DE 3722278 A1 DE3722278 A1 DE 3722278A1
Authority
DE
Germany
Prior art keywords
methyl
pyrrolidine
bromine
carboxylic acid
propionyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19873722278
Other languages
German (de)
English (en)
Inventor
Janos Toempe
Janos Dr Fischer
Laszlo Dobay
Laszlo Koncz
Mihaly Major
Geb Gallo Petenyi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Egyt Gyogyszervegyeszeti Gyar
Egis Pharmaceuticals PLC
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Egis Pharmaceuticals PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar, Egis Pharmaceuticals PLC filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of DE3722278A1 publication Critical patent/DE3722278A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22B—PRODUCTION AND REFINING OF METALS; PRETREATMENT OF RAW MATERIALS
    • C22B9/00—General processes of refining or remelting of metals; Apparatus for electroslag or arc remelting of metals
    • C22B9/02—Refining by liquating, filtering, centrifuging, distilling, or supersonic wave action including acoustic waves

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Acoustics & Sound (AREA)
  • Manufacturing & Machinery (AREA)
  • Physics & Mathematics (AREA)
  • Mechanical Engineering (AREA)
  • Metallurgy (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE19873722278 1986-07-04 1987-07-06 Verfahren zur herstellung von 1-(3'-(brom)-(2's)-(methyl)-propionyl) -pyrrolidin-(2s)-carbonsaeure oder ihres monohydrates Withdrawn DE3722278A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU862811A HU196368B (en) 1986-07-04 1986-07-04 Process for production of 1-/3-brom-/25/-methil-prophionil/-pirrolidin-/25/-carbonic acid

Publications (1)

Publication Number Publication Date
DE3722278A1 true DE3722278A1 (de) 1988-01-07

Family

ID=10961203

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19873722278 Withdrawn DE3722278A1 (de) 1986-07-04 1987-07-06 Verfahren zur herstellung von 1-(3'-(brom)-(2's)-(methyl)-propionyl) -pyrrolidin-(2s)-carbonsaeure oder ihres monohydrates

Country Status (19)

Country Link
JP (1) JPS6322557A (ko)
KR (1) KR880001589A (ko)
CN (1) CN87104582A (ko)
AT (1) AT387382B (ko)
CH (1) CH672786A5 (ko)
CS (1) CS262693B2 (ko)
DD (1) DD263984A5 (ko)
DE (1) DE3722278A1 (ko)
DK (1) DK343587A (ko)
ES (1) ES2004443A6 (ko)
FI (1) FI872966A (ko)
GR (1) GR871051B (ko)
HU (1) HU196368B (ko)
IT (1) IT1221952B (ko)
NO (1) NO872796L (ko)
PL (1) PL150350B1 (ko)
PT (1) PT85256B (ko)
SE (1) SE8702753L (ko)
YU (1) YU118087A (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0369553A1 (en) * 1988-11-18 1990-05-23 Dsm N.V. Process for the enantioselective preparation of D-(-)-3-hal-2-methylpropionic acid or derivatives thereof and the preparation of captopril therefrom

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103086939A (zh) * 2011-10-28 2013-05-08 华中药业股份有限公司 1-(3-溴-2-d-甲基丙酰基)吡咯烷-2-羧酸的重结晶方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4349480A (en) * 1980-02-26 1982-09-14 John Wyeth & Brother Limited Process for preparing 1-(3-bromo-2-alkylpropanoyl-L-proline derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU184082B (en) * 1979-12-29 1984-06-28 Egyt Gyogyszervegyeszeti Gyar Process for preparing 1-3-/3mercapto-/2s/-methyl-propinyl/-pyrrolidine-/2s/-carboxylic acid

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4349480A (en) * 1980-02-26 1982-09-14 John Wyeth & Brother Limited Process for preparing 1-(3-bromo-2-alkylpropanoyl-L-proline derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0369553A1 (en) * 1988-11-18 1990-05-23 Dsm N.V. Process for the enantioselective preparation of D-(-)-3-hal-2-methylpropionic acid or derivatives thereof and the preparation of captopril therefrom

Also Published As

Publication number Publication date
DK343587D0 (da) 1987-07-03
DD263984A5 (de) 1989-01-18
AT387382B (de) 1989-01-10
CS262693B2 (en) 1989-03-14
NO872796L (no) 1988-01-05
PL266620A1 (en) 1988-07-07
JPS6322557A (ja) 1988-01-30
KR880001589A (ko) 1988-04-25
HUT44491A (en) 1988-03-28
SE8702753D0 (sv) 1987-07-03
ATA168087A (de) 1988-06-15
CH672786A5 (ko) 1989-12-29
ES2004443A6 (es) 1989-01-01
HU196368B (en) 1988-11-28
FI872966A (fi) 1988-01-05
GR871051B (en) 1987-11-09
IT1221952B (it) 1990-08-31
FI872966A0 (fi) 1987-07-03
IT8721179A0 (it) 1987-07-03
YU118087A (en) 1988-06-30
PT85256B (pt) 1990-03-30
CS505187A2 (en) 1988-08-16
PL150350B1 (en) 1990-05-31
CN87104582A (zh) 1988-01-20
DK343587A (da) 1988-01-05
PT85256A (en) 1987-08-01
SE8702753L (sv) 1988-01-05
NO872796D0 (no) 1987-07-03

Similar Documents

Publication Publication Date Title
DE102006059317A1 (de) Verfahren zur Herstellung von β-Amino-α-hydroxy-carbonsäureamiden
DE3049273A1 (de) Verfahren zur herstellung von 1-(3-mercapto-(2s)-methyl-n-propionyl) -pyrrolidin-(2's)-carbonsaeure
EP0206993A1 (de) Neue Sulfonsäureester
DE3729729A1 (de) Verfahren zur herstellung von statin und verwandten verbindungen
CH542202A (de) Verfahren zur Herstellung von Indolinderivaten
DE3722278A1 (de) Verfahren zur herstellung von 1-(3'-(brom)-(2's)-(methyl)-propionyl) -pyrrolidin-(2s)-carbonsaeure oder ihres monohydrates
DE2219120A1 (de) Verfahren zur Herstellung von Nitrobenzylalkoholmesylaten und tosylaten
EP0543343A2 (de) Verfahren zur Herstellung von alpha-Hydroxy-beta-aminocarbonsäuren
EP0692471A1 (de) Verfahren zur Herstellung optisch aktiver 3-Hydroxy-Pyrrolidine mit hoher Enantiomerenreinheit
DE2558508C3 (de) Verfahren zur Racematspaltung von DL-Pantolacton
DE69221733T3 (de) Beta-phenylisoserin-(2r,3s), ihre salze, herstellung und verwendung
AT395148B (de) Verfahren zur herstellung von 1-(3-mercapto-(2s)methyl-1-oxo-propyl)-l-prolin
DE3721430A1 (de) Verfahren zur herstellung von 1-(3'-(mercapto)-(2's)-(methyl)-propionyl)-pyrrolidin-(2s)-carbonsaeure oder ihren salzen
CH662117A5 (de) Carbapenemderivate und verfahren zu ihrer herstellung.
DE949232C (de) Verfahren zur Herstellung therapeutisch wertvoller basischer substituierter Essigsaeureester
DE3310174C2 (de) Verfahren zur Herstellung von Hydroxyäthyltetrazolthiol
DE4115540A1 (de) Verfahren zur herstellung von 2,2-di-(methyl)-5-(2',5'-di-(methyl)-phenoxy) -pentansaeure sowie di-(halogencarbonsaeure)-ester von mehrwertigen alkoholen und verfahren zur herstellung der letzteren
DE60024540T2 (de) Synthese von alpha-amino-alpha',alpha'-dihaloketonen und verfahren zur herstellung von beta)-aminosäurederivaten durch verwendung derselben
CH622488A5 (en) Process for the preparation of N-cyclohexyl-N-methyl-N-(2-amino-3,5-dibromobenzyl)amine
EP0027956A1 (de) Verfahren zur Herstellung von (1-(4-Chlorbenzoyl)-5-methoxy-2-methyl-3-indol)acetoxyessigsäure
DE2737195A1 (de) Benzolsulfonamidderivate und verfahren zu ihrer herstellung
DE4123214A1 (de) 2-methyl)-3-(rhodanido)-propionsaeure und verfahren zu ihrer herstellung
EP0824512B1 (de) Synthese von optisch aktivem aminoindanol
EP0692470A1 (de) Verfahren zur Herstellung optisch aktiver 1-substituierter 2-(Aminomethyl)pyrrolidinderivaten
EP0025935A1 (de) Verfahren zur Herstellung von 5-(2,2,2-Trihalogenethyl)-dialkyl-tetrahydrofuran-2-onen

Legal Events

Date Code Title Description
8101 Request for examination as to novelty
8105 Search report available
8139 Disposal/non-payment of the annual fee