ES2004443A6 - Procedimiento de preparacion del acido 1-(3-bromo-(2s)-metilpropionil)-pirrolidin-(2s)-carboxilico - Google Patents
Procedimiento de preparacion del acido 1-(3-bromo-(2s)-metilpropionil)-pirrolidin-(2s)-carboxilicoInfo
- Publication number
- ES2004443A6 ES2004443A6 ES8701951A ES8701951A ES2004443A6 ES 2004443 A6 ES2004443 A6 ES 2004443A6 ES 8701951 A ES8701951 A ES 8701951A ES 8701951 A ES8701951 A ES 8701951A ES 2004443 A6 ES2004443 A6 ES 2004443A6
- Authority
- ES
- Spain
- Prior art keywords
- pyrrolidine
- bromo
- methyl
- formula
- image
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22B—PRODUCTION AND REFINING OF METALS; PRETREATMENT OF RAW MATERIALS
- C22B9/00—General processes of refining or remelting of metals; Apparatus for electroslag or arc remelting of metals
- C22B9/02—Refining by liquating, filtering, centrifuging, distilling, or supersonic wave action including acoustic waves
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Acoustics & Sound (AREA)
- Manufacturing & Machinery (AREA)
- Physics & Mathematics (AREA)
- Mechanical Engineering (AREA)
- Metallurgy (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
LA INVENCION SE REFIERE A UN PROCEDIMIENTO DE PREPARACION DEL ACIDO 1-(3-BROMO-(2S)-METILPROPIONIL)-PIRROLIDIN-(2S)-CARBOXILICO DE LA FORMULAO SU MONOHIDRATO QUE ES UN INTERMEDIO UTIL PARA LA SINTESIS DE CAPTOPRIL, UN AGENTE ANTIHIPERTENSIVO VALIOSO.DE ACUERDO CON LA INVENCION, SE HACE REACCIONAR LA SAL DE LA FORMULACON UN AGENTE DE CONDENSACION EN UN DISOLVENTE INERTE, SE DESBENCILA EL 1-(3-BROMO-(2S)-METILPROPIONIL)-PIRROLIDIN-(2S)-CARBOXILATO BENCILICO OBTENIDO DE LA FORMULAPOR MEDIO DE LA HIDROGENACION CATALITICA PARA DAR EL PRODUCTO DE LA FORMULA (I) Y, SI SE DESEA, SE RECRISTALIZA EL PRODUCTO A PARTIR DE AGUA PARA OBTENER EL MONOHIDRATO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU862811A HU196368B (en) | 1986-07-04 | 1986-07-04 | Process for production of 1-/3-brom-/25/-methil-prophionil/-pirrolidin-/25/-carbonic acid |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2004443A6 true ES2004443A6 (es) | 1989-01-01 |
Family
ID=10961203
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES8701951A Expired ES2004443A6 (es) | 1986-07-04 | 1987-07-03 | Procedimiento de preparacion del acido 1-(3-bromo-(2s)-metilpropionil)-pirrolidin-(2s)-carboxilico |
Country Status (19)
Country | Link |
---|---|
JP (1) | JPS6322557A (es) |
KR (1) | KR880001589A (es) |
CN (1) | CN87104582A (es) |
AT (1) | AT387382B (es) |
CH (1) | CH672786A5 (es) |
CS (1) | CS262693B2 (es) |
DD (1) | DD263984A5 (es) |
DE (1) | DE3722278A1 (es) |
DK (1) | DK343587A (es) |
ES (1) | ES2004443A6 (es) |
FI (1) | FI872966A (es) |
GR (1) | GR871051B (es) |
HU (1) | HU196368B (es) |
IT (1) | IT1221952B (es) |
NO (1) | NO872796L (es) |
PL (1) | PL150350B1 (es) |
PT (1) | PT85256B (es) |
SE (1) | SE8702753L (es) |
YU (1) | YU118087A (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL8802849A (nl) * | 1988-11-18 | 1990-06-18 | Stamicarbon | Werkwijze voor de enantioselectieve bereiding van d-(-)-3-hal-methylpropionzuur of derivaten daarvan en de bereiding van captopril daaruit. |
CN103086939A (zh) * | 2011-10-28 | 2013-05-08 | 华中药业股份有限公司 | 1-(3-溴-2-d-甲基丙酰基)吡咯烷-2-羧酸的重结晶方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU184082B (en) * | 1979-12-29 | 1984-06-28 | Egyt Gyogyszervegyeszeti Gyar | Process for preparing 1-3-/3mercapto-/2s/-methyl-propinyl/-pyrrolidine-/2s/-carboxylic acid |
IE50839B1 (en) * | 1980-02-26 | 1986-07-23 | Wyeth John & Brother Ltd | Novel processes for preparing proline derivatives and analogous compounds |
-
1986
- 1986-07-04 HU HU862811A patent/HU196368B/hu unknown
-
1987
- 1987-06-24 YU YU01180/87A patent/YU118087A/xx unknown
- 1987-07-02 CH CH2523/87A patent/CH672786A5/de not_active IP Right Cessation
- 1987-07-03 SE SE8702753A patent/SE8702753L/xx not_active Application Discontinuation
- 1987-07-03 IT IT21179/87A patent/IT1221952B/it active
- 1987-07-03 ES ES8701951A patent/ES2004443A6/es not_active Expired
- 1987-07-03 DD DD87304596A patent/DD263984A5/de not_active IP Right Cessation
- 1987-07-03 PL PL1987266620A patent/PL150350B1/pl unknown
- 1987-07-03 PT PT85256A patent/PT85256B/pt not_active IP Right Cessation
- 1987-07-03 CS CS875051A patent/CS262693B2/cs unknown
- 1987-07-03 NO NO872796A patent/NO872796L/no unknown
- 1987-07-03 GR GR871051A patent/GR871051B/el unknown
- 1987-07-03 JP JP62166755A patent/JPS6322557A/ja active Pending
- 1987-07-03 DK DK343587A patent/DK343587A/da not_active Application Discontinuation
- 1987-07-03 FI FI872966A patent/FI872966A/fi not_active Application Discontinuation
- 1987-07-03 CN CN198787104582A patent/CN87104582A/zh active Pending
- 1987-07-03 AT AT0168087A patent/AT387382B/de not_active IP Right Cessation
- 1987-07-04 KR KR1019870007155A patent/KR880001589A/ko not_active Application Discontinuation
- 1987-07-06 DE DE19873722278 patent/DE3722278A1/de not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
SE8702753D0 (sv) | 1987-07-03 |
CS505187A2 (en) | 1988-08-16 |
DE3722278A1 (de) | 1988-01-07 |
PT85256A (en) | 1987-08-01 |
CS262693B2 (en) | 1989-03-14 |
PL266620A1 (en) | 1988-07-07 |
SE8702753L (sv) | 1988-01-05 |
HUT44491A (en) | 1988-03-28 |
NO872796D0 (no) | 1987-07-03 |
ATA168087A (de) | 1988-06-15 |
CH672786A5 (es) | 1989-12-29 |
HU196368B (en) | 1988-11-28 |
PT85256B (pt) | 1990-03-30 |
CN87104582A (zh) | 1988-01-20 |
DK343587D0 (da) | 1987-07-03 |
DD263984A5 (de) | 1989-01-18 |
GR871051B (en) | 1987-11-09 |
IT1221952B (it) | 1990-08-31 |
FI872966A0 (fi) | 1987-07-03 |
JPS6322557A (ja) | 1988-01-30 |
IT8721179A0 (it) | 1987-07-03 |
FI872966A (fi) | 1988-01-05 |
DK343587A (da) | 1988-01-05 |
PL150350B1 (en) | 1990-05-31 |
NO872796L (no) | 1988-01-05 |
YU118087A (en) | 1988-06-30 |
KR880001589A (ko) | 1988-04-25 |
AT387382B (de) | 1989-01-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
SA6 | Expiration date (snapshot 920101) |
Free format text: 2007-07-03 |
|
FD1A | Patent lapsed |
Effective date: 20040503 |