ES2004443A6 - Procedimiento de preparacion del acido 1-(3-bromo-(2s)-metilpropionil)-pirrolidin-(2s)-carboxilico - Google Patents

Procedimiento de preparacion del acido 1-(3-bromo-(2s)-metilpropionil)-pirrolidin-(2s)-carboxilico

Info

Publication number
ES2004443A6
ES2004443A6 ES8701951A ES8701951A ES2004443A6 ES 2004443 A6 ES2004443 A6 ES 2004443A6 ES 8701951 A ES8701951 A ES 8701951A ES 8701951 A ES8701951 A ES 8701951A ES 2004443 A6 ES2004443 A6 ES 2004443A6
Authority
ES
Spain
Prior art keywords
pyrrolidine
bromo
methyl
formula
image
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8701951A
Other languages
English (en)
Inventor
Janos Tompe
Janos Fischer
Laszlo Obay
Laszlo Koncz
Nihaly Major
Gallo Eva Peternyinee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Egyt Gyogyszervegyeszeti Gyar
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of ES2004443A6 publication Critical patent/ES2004443A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22B—PRODUCTION AND REFINING OF METALS; PRETREATMENT OF RAW MATERIALS
    • C22B9/00—General processes of refining or remelting of metals; Apparatus for electroslag or arc remelting of metals
    • C22B9/02—Refining by liquating, filtering, centrifuging, distilling, or supersonic wave action including acoustic waves

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Acoustics & Sound (AREA)
  • Manufacturing & Machinery (AREA)
  • Physics & Mathematics (AREA)
  • Mechanical Engineering (AREA)
  • Metallurgy (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA INVENCION SE REFIERE A UN PROCEDIMIENTO DE PREPARACION DEL ACIDO 1-(3-BROMO-(2S)-METILPROPIONIL)-PIRROLIDIN-(2S)-CARBOXILICO DE LA FORMULAO SU MONOHIDRATO QUE ES UN INTERMEDIO UTIL PARA LA SINTESIS DE CAPTOPRIL, UN AGENTE ANTIHIPERTENSIVO VALIOSO.DE ACUERDO CON LA INVENCION, SE HACE REACCIONAR LA SAL DE LA FORMULACON UN AGENTE DE CONDENSACION EN UN DISOLVENTE INERTE, SE DESBENCILA EL 1-(3-BROMO-(2S)-METILPROPIONIL)-PIRROLIDIN-(2S)-CARBOXILATO BENCILICO OBTENIDO DE LA FORMULAPOR MEDIO DE LA HIDROGENACION CATALITICA PARA DAR EL PRODUCTO DE LA FORMULA (I) Y, SI SE DESEA, SE RECRISTALIZA EL PRODUCTO A PARTIR DE AGUA PARA OBTENER EL MONOHIDRATO.
ES8701951A 1986-07-04 1987-07-03 Procedimiento de preparacion del acido 1-(3-bromo-(2s)-metilpropionil)-pirrolidin-(2s)-carboxilico Expired ES2004443A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU862811A HU196368B (en) 1986-07-04 1986-07-04 Process for production of 1-/3-brom-/25/-methil-prophionil/-pirrolidin-/25/-carbonic acid

Publications (1)

Publication Number Publication Date
ES2004443A6 true ES2004443A6 (es) 1989-01-01

Family

ID=10961203

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8701951A Expired ES2004443A6 (es) 1986-07-04 1987-07-03 Procedimiento de preparacion del acido 1-(3-bromo-(2s)-metilpropionil)-pirrolidin-(2s)-carboxilico

Country Status (19)

Country Link
JP (1) JPS6322557A (es)
KR (1) KR880001589A (es)
CN (1) CN87104582A (es)
AT (1) AT387382B (es)
CH (1) CH672786A5 (es)
CS (1) CS262693B2 (es)
DD (1) DD263984A5 (es)
DE (1) DE3722278A1 (es)
DK (1) DK343587A (es)
ES (1) ES2004443A6 (es)
FI (1) FI872966A (es)
GR (1) GR871051B (es)
HU (1) HU196368B (es)
IT (1) IT1221952B (es)
NO (1) NO872796L (es)
PL (1) PL150350B1 (es)
PT (1) PT85256B (es)
SE (1) SE8702753L (es)
YU (1) YU118087A (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8802849A (nl) * 1988-11-18 1990-06-18 Stamicarbon Werkwijze voor de enantioselectieve bereiding van d-(-)-3-hal-methylpropionzuur of derivaten daarvan en de bereiding van captopril daaruit.
CN103086939A (zh) * 2011-10-28 2013-05-08 华中药业股份有限公司 1-(3-溴-2-d-甲基丙酰基)吡咯烷-2-羧酸的重结晶方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU184082B (en) * 1979-12-29 1984-06-28 Egyt Gyogyszervegyeszeti Gyar Process for preparing 1-3-/3mercapto-/2s/-methyl-propinyl/-pyrrolidine-/2s/-carboxylic acid
IE50839B1 (en) * 1980-02-26 1986-07-23 Wyeth John & Brother Ltd Novel processes for preparing proline derivatives and analogous compounds

Also Published As

Publication number Publication date
CH672786A5 (es) 1989-12-29
HUT44491A (en) 1988-03-28
SE8702753D0 (sv) 1987-07-03
DK343587D0 (da) 1987-07-03
GR871051B (en) 1987-11-09
DD263984A5 (de) 1989-01-18
PT85256B (pt) 1990-03-30
JPS6322557A (ja) 1988-01-30
KR880001589A (ko) 1988-04-25
DE3722278A1 (de) 1988-01-07
FI872966A0 (fi) 1987-07-03
FI872966A (fi) 1988-01-05
PT85256A (en) 1987-08-01
HU196368B (en) 1988-11-28
IT1221952B (it) 1990-08-31
IT8721179A0 (it) 1987-07-03
CS505187A2 (en) 1988-08-16
CS262693B2 (en) 1989-03-14
AT387382B (de) 1989-01-10
YU118087A (en) 1988-06-30
DK343587A (da) 1988-01-05
CN87104582A (zh) 1988-01-20
PL266620A1 (en) 1988-07-07
NO872796L (no) 1988-01-05
SE8702753L (sv) 1988-01-05
PL150350B1 (en) 1990-05-31
ATA168087A (de) 1988-06-15
NO872796D0 (no) 1987-07-03

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Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2007-07-03

FD1A Patent lapsed

Effective date: 20040503