DE3712768C2 - - Google Patents
Info
- Publication number
- DE3712768C2 DE3712768C2 DE3712768A DE3712768A DE3712768C2 DE 3712768 C2 DE3712768 C2 DE 3712768C2 DE 3712768 A DE3712768 A DE 3712768A DE 3712768 A DE3712768 A DE 3712768A DE 3712768 C2 DE3712768 C2 DE 3712768C2
- Authority
- DE
- Germany
- Prior art keywords
- oil
- polysaccharide
- adjuvant
- emulsion
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/852,118 US4803070A (en) | 1986-04-15 | 1986-04-15 | Immunological emulsion adjuvants for polysaccharide vaccines |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3712768A1 DE3712768A1 (de) | 1987-10-22 |
DE3712768C2 true DE3712768C2 (US08066781-20111129-C00013.png) | 1992-01-16 |
Family
ID=25312539
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19873712768 Granted DE3712768A1 (de) | 1986-04-15 | 1987-04-15 | Immunologisches adjuvans fuer polysaccharid-impfstoffe |
Country Status (9)
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0832637B2 (ja) * | 1985-02-14 | 1996-03-29 | アクゾ・エヌ・ヴエー | 合成免疫原 |
US5554372A (en) * | 1986-09-22 | 1996-09-10 | Emory University | Methods and vaccines comprising surface-active copolymers |
EP0324455A3 (en) * | 1988-01-15 | 1991-03-27 | Hans O. Ribi | Novel polymeric immunological adjuvants |
HU212924B (en) * | 1989-05-25 | 1996-12-30 | Chiron Corp | Adjuvant formulation comprising a submicron oil droplet emulsion |
FR2649012B1 (fr) * | 1989-07-03 | 1991-10-25 | Seppic Sa | Emulsions multiphasiques injectables |
FR2649013B1 (fr) * | 1989-07-03 | 1991-10-25 | Seppic Sa | Vaccins et vecteurs de principes actifs fluides contenant une huile metabolisable |
US5268454A (en) * | 1991-02-08 | 1993-12-07 | La Jolla Pharmaceutical Company | Composition for inducing humoral anergy to an immunogen comprising a t cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic carrier |
DE4007315A1 (de) * | 1990-03-08 | 1991-09-12 | Behringwerke Ag | Verwendung von zink-calciumhydroxid, lecithin und pao zur adjuvierung von antigenloesungen und auf diese weise adjuvierte antigenloesungen |
US5091188A (en) * | 1990-04-26 | 1992-02-25 | Haynes Duncan H | Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs |
US5246707A (en) * | 1990-04-26 | 1993-09-21 | Haynes Duncan H | Sustained release delivery of water-soluble bio-molecules and drugs using phospholipid-coated microcrystals, microdroplets and high-concentration liposomes |
AU662146B2 (en) | 1991-03-19 | 1995-08-24 | Cytrx Corporation | Polyoxypropylene/polyoxyethylene copolymers with improved biological activity |
US6048531A (en) * | 1991-04-15 | 2000-04-11 | Albany Medical College | Immunogenic composites capable of stimulating production of anti-peptide antibodies, pharmaceutical compositions employing these composites and methods of selectively inducing production of anti-peptide antibodies |
US5688761A (en) * | 1991-04-19 | 1997-11-18 | Lds Technologies, Inc. | Convertible microemulsion formulations |
ES2136620T3 (es) * | 1991-04-19 | 1999-12-01 | Lds Technologies Inc | Formulaciones de microemulsiones convertibles. |
US5462735A (en) * | 1993-06-10 | 1995-10-31 | The United States Of America As Represented By The Secretary Of Agriculture | Pasteurella haemolytica subunit vaccine containing capsular polysaccharide and muramyl dipeptide |
US5961970A (en) * | 1993-10-29 | 1999-10-05 | Pharmos Corporation | Submicron emulsions as vaccine adjuvants |
KR100372375B1 (ko) | 1993-12-23 | 2003-04-21 | 머클한스피터 | 면역반응의강화방법 |
US20070231402A1 (en) | 1994-08-02 | 2007-10-04 | Immunopath Profile, Inc. | Therapeutic stem cell composition and stimulant, facilitator, accelerator, and synergizer thereof, growth factor, anti-inflammatory composition and uses thereof |
US5718904A (en) * | 1995-06-02 | 1998-02-17 | American Home Products Corporation | Adjuvants for viral vaccines |
US6576264B1 (en) | 1995-10-17 | 2003-06-10 | Skyepharma Canada Inc. | Insoluble drug delivery |
US7255877B2 (en) * | 1996-08-22 | 2007-08-14 | Jagotec Ag | Fenofibrate microparticles |
US6465016B2 (en) | 1996-08-22 | 2002-10-15 | Research Triangle Pharmaceuticals | Cyclosporiine particles |
DE69908304T2 (de) * | 1998-02-11 | 2004-02-19 | Rtp Pharma Corp. | Ungesättigte fettsäure und steroide enthaltende kombinationspräparate zur behandlung von entzündungen |
US6979456B1 (en) | 1998-04-01 | 2005-12-27 | Jagotec Ag | Anticancer compositions |
US8415329B1 (en) | 1998-05-29 | 2013-04-09 | Jagotec Ag | Thermoprotected compositions and process for terminal steam sterilization of microparticle preparations |
AU759641B2 (en) * | 1998-08-19 | 2003-04-17 | Skyepharma Canada Inc. | Injectable aqueous dispersions of propofol |
KR20010073232A (ko) | 1998-11-20 | 2001-07-31 | 추후제출 | 분산성 인지질로 안정화된 마이크로입자 |
AU769539B2 (en) * | 1999-01-29 | 2004-01-29 | Zoetis Services Llc | Adjuvants for use in vaccines |
EP1574210B1 (en) | 1999-02-26 | 2016-04-06 | Novartis Vaccines and Diagnostics, Inc. | Microemulsions with adsorbed macromolecules |
WO2001021154A2 (en) * | 1999-09-21 | 2001-03-29 | Rtp Pharma Inc. | Surface modified particulate compositions of biologically active substances |
CA2407027C (en) | 2000-04-20 | 2011-02-15 | Rtp Pharma Inc. | Improved water-insoluble drug particle process |
EP1313451B1 (en) | 2000-08-31 | 2009-03-11 | Jagotec AG | Milled particles |
US8586094B2 (en) * | 2000-09-20 | 2013-11-19 | Jagotec Ag | Coated tablets |
AU2001255515A1 (en) * | 2000-09-20 | 2002-04-02 | Skyepharma Canada Inc. | Stabilised fibrate microparticles |
GB0031430D0 (en) | 2000-12-22 | 2001-02-07 | Norsk Hydro As | Polypeptides |
TWI288000B (en) * | 2001-02-22 | 2007-10-11 | Rtp Pharma Inc | Fibrate-statin combinations with reduced fed-fasted effects |
AU2004226591B2 (en) * | 2003-04-04 | 2009-06-04 | Zoetis Services Llc | Microfluidized oil-in-water emulsions and vaccine compositions |
FR2873386B1 (fr) | 2004-07-22 | 2011-01-14 | Agence Francaise De Securite Sanitaire Des Aliments Afssa | Composition vaccinale contre le rhodococcus equi |
US20060210590A1 (en) | 2005-02-03 | 2006-09-21 | Alk-Abello A/S | Minor allergen control to increase safety of immunotherapy |
CN101313216A (zh) * | 2005-09-22 | 2008-11-26 | 普洛茨股份有限公司 | 酵母突变体中产生的糖基化多肽及其使用方法 |
ES2588705T3 (es) * | 2007-09-27 | 2016-11-04 | Immunovaccine Technologies Inc. | Uso de liposomas en un vehículo que comprende una fase hidrófoba continua para la entrega de polinucleótidos in vivo |
US20100209452A1 (en) * | 2007-10-03 | 2010-08-19 | Immunovaccine Technologies, Inc | Compositions comprising an antigen, an amphipathic compound and a hydrophobic carrier, and uses thereof |
BRPI0818545A2 (pt) * | 2007-10-19 | 2017-07-04 | Novartis Ag | formulações de vacinais meningocócicas |
ES2524699T3 (es) | 2008-06-05 | 2014-12-11 | Immunovaccine Technologies Inc. | Composiciones que comprenden liposomas, un antígeno, un polinucleótido y un vehículo que comprende una fase continua de una sustancia hidrófoba |
SG11201401177WA (en) | 2011-10-06 | 2014-04-28 | Immunovaccine Technologies Inc | Liposome compositions comprising an adjuvant that activates or increases the activity of tlr2 and uses thereof |
WO2014055825A1 (en) * | 2012-10-04 | 2014-04-10 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | A formulation of mycobacterial components as an adjuvant for inducing th17 responses |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2160326B1 (US08066781-20111129-C00013.png) * | 1971-11-19 | 1975-02-07 | Anvar | |
US4185090A (en) * | 1972-02-02 | 1980-01-22 | Abbott Laboratories | Chemically modified endotoxin immunizing agent |
GB1506563A (en) * | 1974-04-25 | 1978-04-05 | Williams J | Immunosuppressive agents |
US4338334A (en) * | 1977-12-29 | 1982-07-06 | Merck & Co., Inc. | 1-[4-(4-Sulfanilyl)phenyl] urea and derivatives in compositions and methods of treating rheumatoid arthritis and immune complex diseases |
ES483541A1 (es) * | 1979-08-21 | 1980-03-01 | Benlloch Llorach Alfredo | Perfeccionamientos en los colectores de aparatos captadores de la energia solar. |
US4307229A (en) * | 1979-11-07 | 1981-12-22 | Avraham Liav | 6,6'-Diesters of trehalose and process for the synthesis thereof |
US4340588A (en) | 1980-03-28 | 1982-07-20 | Research Corporation | Brucellosis vaccine for cattle containing mycolate esters of trehalose |
US4436728A (en) * | 1982-05-26 | 1984-03-13 | Ribi Immunochem Research, Inc. | Refined detoxified endotoxin product |
US4505900A (en) * | 1982-05-26 | 1985-03-19 | Ribi Immunochem Research, Inc. | Refined detoxified endotoxin product |
CA1206416A (en) * | 1982-06-30 | 1986-06-24 | John L. Cantrell | Pyridine soluble extract of a microorganism |
NL8301996A (nl) * | 1983-06-06 | 1985-01-02 | Duphar Int Res | Werkwijze ter bereiding van geadjuveerde levende vaccins en aldus verkregen geadjuveerde levende vaccins. |
US4606918A (en) * | 1983-08-22 | 1986-08-19 | Syntex (U.S.A.) Inc. | Polyoxypropylene-polyoxyethylene block polymer based adjuvants |
CA1225592A (en) * | 1983-08-26 | 1987-08-18 | Ribi Immunochem Research Inc. | Refined detoxified endotoxin |
JPS6292947A (ja) * | 1985-10-19 | 1987-04-28 | Fuji Photo Film Co Ltd | ハロゲン化銀カラ−写真感光材料の処理方法 |
US4806352A (en) * | 1986-04-15 | 1989-02-21 | Ribi Immunochem Research Inc. | Immunological lipid emulsion adjuvant |
-
1986
- 1986-04-15 US US06/852,118 patent/US4803070A/en not_active Expired - Lifetime
-
1987
- 1987-04-15 CH CH1511/87A patent/CH675076A5/de not_active IP Right Cessation
- 1987-04-15 CA CA000534736A patent/CA1322333C/en not_active Expired - Lifetime
- 1987-04-15 IT IT47856/87A patent/IT1205820B/it active
- 1987-04-15 BE BE8700410A patent/BE1001630A4/fr not_active IP Right Cessation
- 1987-04-15 JP JP62092948A patent/JP2648305B2/ja not_active Expired - Lifetime
- 1987-04-15 NL NL8700892A patent/NL194603C/nl not_active IP Right Cessation
- 1987-04-15 GB GB8709124A patent/GB2189143B/en not_active Expired - Lifetime
- 1987-04-15 DE DE19873712768 patent/DE3712768A1/de active Granted
Also Published As
Publication number | Publication date |
---|---|
JP2648305B2 (ja) | 1997-08-27 |
IT8747856A0 (it) | 1987-04-15 |
CH675076A5 (US08066781-20111129-C00013.png) | 1990-08-31 |
GB8709124D0 (en) | 1987-05-20 |
US4803070A (en) | 1989-02-07 |
BE1001630A4 (fr) | 1989-12-27 |
CA1322333C (en) | 1993-09-21 |
GB2189143B (en) | 1990-07-25 |
NL194603B (nl) | 2002-05-01 |
IT1205820B (it) | 1989-03-31 |
NL194603C (nl) | 2002-09-03 |
GB2189143A (en) | 1987-10-21 |
NL8700892A (nl) | 1987-11-02 |
DE3712768A1 (de) | 1987-10-22 |
JPS6322029A (ja) | 1988-01-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
OP8 | Request for examination as to paragraph 44 patent law | ||
D2 | Grant after examination | ||
8364 | No opposition during term of opposition |