DE3418187A1 - Verfahren zur herstellung von aminoglykosid-antibiotica enthaltenden gaerbruehen - Google Patents

Verfahren zur herstellung von aminoglykosid-antibiotica enthaltenden gaerbruehen

Info

Publication number
DE3418187A1
DE3418187A1 DE19843418187 DE3418187A DE3418187A1 DE 3418187 A1 DE3418187 A1 DE 3418187A1 DE 19843418187 DE19843418187 DE 19843418187 DE 3418187 A DE3418187 A DE 3418187A DE 3418187 A1 DE3418187 A1 DE 3418187A1
Authority
DE
Germany
Prior art keywords
strains
protoplasts
streptomyces
nebramycin
weight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19843418187
Other languages
German (de)
English (en)
Other versions
DE3418187C2 (https=
Inventor
Gábor Dr. Budapest Ambrus
Lajos Dr. Ferenczy
Tibor Dr. Budapest Láng
Antal Szeged Mai
István Dr. Ott
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Works PLC
Original Assignee
Teva Pharmaceutical Works PLC
Biogal Gyogyszergyar Rt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Works PLC, Biogal Gyogyszergyar Rt filed Critical Teva Pharmaceutical Works PLC
Publication of DE3418187A1 publication Critical patent/DE3418187A1/de
Application granted granted Critical
Publication of DE3418187C2 publication Critical patent/DE3418187C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/02—Preparation of hybrid cells by fusion of two or more cells, e.g. protoplast fusion
    • C12N15/03—Bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/46—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin
    • C12P19/48—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin the cyclohexyl radical being substituted by two or more nitrogen atoms, e.g. destomycin, neamin
    • C12P19/485—Having two saccharide radicals bound through only oxygen to non-adjacent ring carbons of the cyclohexyl radical, e.g. gentamycin, kanamycin, sisomycin, verdamycin, mutamycin, tobramycin, nebramycin, antibiotics 66-40B, 66-40D, XK-62-2, 66-40, G-418, G-52
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE19843418187 1983-05-16 1984-05-16 Verfahren zur herstellung von aminoglykosid-antibiotica enthaltenden gaerbruehen Granted DE3418187A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU831678A HU194306B (en) 1983-05-16 1983-05-16 Process for influencing biosynthesis of antibiotics with in vivo genetical recombination

Publications (2)

Publication Number Publication Date
DE3418187A1 true DE3418187A1 (de) 1985-03-28
DE3418187C2 DE3418187C2 (https=) 1991-12-19

Family

ID=10955644

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19843418187 Granted DE3418187A1 (de) 1983-05-16 1984-05-16 Verfahren zur herstellung von aminoglykosid-antibiotica enthaltenden gaerbruehen

Country Status (8)

Country Link
US (1) US4729951A (https=)
BE (1) BE899661A (https=)
CH (1) CH662582A5 (https=)
DE (1) DE3418187A1 (https=)
FI (1) FI79551C (https=)
FR (1) FR2546180B1 (https=)
GB (1) GB2146015B (https=)
HU (1) HU194306B (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5149639A (en) * 1986-03-24 1992-09-22 Abbott Laboratories Biologically pure cultures of streptomyces and use thereof in macrolide antibiotic production
US5670350A (en) * 1990-08-20 1997-09-23 Novartis Finance Corporation Genomic DNA encoding a pseudomonas global transcriptional activation element and its use in activating gene expression
US5639949A (en) * 1990-08-20 1997-06-17 Ciba-Geigy Corporation Genes for the synthesis of antipathogenic substances
US5662898A (en) * 1990-08-20 1997-09-02 Ciba-Geigy Corporation Genes for the synthesis of antipathogenic substances
USD343510S (en) 1992-05-29 1994-01-25 Langlois Andrew R Tank strap
US6117670A (en) * 1994-06-08 2000-09-12 Novartis Finance Corporation Pyrrolnitrin biosynthesis genes and uses thereof
US5888744A (en) * 1995-08-24 1999-03-30 The United States Of America, As Represented By The Secretary Of Agriculture Detection and separation of aminoglycosides by binding to immobilized lysozyme or α-lactalbumin
EP1717322B1 (en) 1997-01-17 2012-07-18 Codexis Mayflower Holdings, LLC Evolution of whole cells and organisms by recursive sequence recombination
US6326204B1 (en) 1997-01-17 2001-12-04 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
US7148054B2 (en) 1997-01-17 2006-12-12 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
CN113403299A (zh) * 2021-07-21 2021-09-17 大连工业大学 一种选育高产抗菌脂肽的枯草芽孢杆菌的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE868473A (fr) * 1977-07-01 1978-12-27 Lilly Co Eli Procede permettant de faciliter l'echange genetique dans les genres streptomyces et nocardia, par fusion des protoplastes
BE868472A (fr) * 1977-07-01 1978-12-27 Lilly Co Eli Procede d'obtention de protoplastes de streptomyces susceptibles de regeneration efficace de cellules viables

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU184125B (en) * 1978-11-13 1984-07-30 Gyogyszerkutato Intezet New genetic process for preparing antibiotic producing micromono spora strains

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE868473A (fr) * 1977-07-01 1978-12-27 Lilly Co Eli Procede permettant de faciliter l'echange genetique dans les genres streptomyces et nocardia, par fusion des protoplastes
BE868472A (fr) * 1977-07-01 1978-12-27 Lilly Co Eli Procede d'obtention de protoplastes de streptomyces susceptibles de regeneration efficace de cellules viables

Also Published As

Publication number Publication date
US4729951A (en) 1988-03-08
FI79551B (fi) 1989-09-29
FI841951L (fi) 1984-11-17
FR2546180A1 (fr) 1984-11-23
FI841951A0 (fi) 1984-05-15
HUT34235A (en) 1985-02-28
DE3418187C2 (https=) 1991-12-19
FR2546180B1 (fr) 1987-05-29
FI79551C (fi) 1990-01-10
CH662582A5 (de) 1987-10-15
BE899661A (fr) 1984-11-16
GB8412364D0 (en) 1984-06-20
HU194306B (en) 1988-01-28
GB2146015B (en) 1987-03-25
GB2146015A (en) 1985-04-11

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
8125 Change of the main classification

Ipc: C12P 1/04

D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee