DE3322783A1 - Verfahren zur herstellung von 1-aethoxycarbonyloxyaethylestern von penicillinen, 6-aminopenicillansaeure oder cephalosporinen - Google Patents

Verfahren zur herstellung von 1-aethoxycarbonyloxyaethylestern von penicillinen, 6-aminopenicillansaeure oder cephalosporinen

Info

Publication number
DE3322783A1
DE3322783A1 DE3322783A DE3322783A DE3322783A1 DE 3322783 A1 DE3322783 A1 DE 3322783A1 DE 3322783 A DE3322783 A DE 3322783A DE 3322783 A DE3322783 A DE 3322783A DE 3322783 A1 DE3322783 A1 DE 3322783A1
Authority
DE
Germany
Prior art keywords
group
acid
hours
reaction
carried out
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE3322783A
Other languages
German (de)
English (en)
Other versions
DE3322783C2 (enEXAMPLES
Inventor
Derek Reginald Heswall Merseyside Palmer
Luigi Bergamo Ratti
Robert Graham Prestatyn Clwyd Tyson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astra Lakemedel AB
AstraZeneca AB
Original Assignee
Astra AB
Astra Lakemedel AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT22141/82A external-priority patent/IT1190897B/it
Priority claimed from GB838300331A external-priority patent/GB8300331D0/en
Application filed by Astra AB, Astra Lakemedel AB filed Critical Astra AB
Priority to DE3348300A priority Critical patent/DE3348300C2/de
Publication of DE3322783A1 publication Critical patent/DE3322783A1/de
Application granted granted Critical
Publication of DE3322783C2 publication Critical patent/DE3322783C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C68/00—Preparation of esters of carbonic or haloformic acids
    • C07C68/02—Preparation of esters of carbonic or haloformic acids from phosgene or haloformates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/96—Esters of carbonic or haloformic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE3322783A 1982-06-29 1983-06-24 Verfahren zur herstellung von 1-aethoxycarbonyloxyaethylestern von penicillinen, 6-aminopenicillansaeure oder cephalosporinen Granted DE3322783A1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE3348300A DE3348300C2 (de) 1982-06-29 1983-06-24 Verwendung von alpha-Bromdiethylcarbonat

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IT22141/82A IT1190897B (it) 1982-06-29 1982-06-29 Procedimento per la preparazione dell'estere 1-etossicarbonilossietilico dell'acido 6-(d(-)-alfa aminoalfa fenilacetamido)-penicillanico
GB8226751 1982-09-20
GB8228622 1982-10-06
GB8232629 1982-11-16
GB838300331A GB8300331D0 (en) 1983-01-07 1983-01-07 Preparation of bromo carbonates

Publications (2)

Publication Number Publication Date
DE3322783A1 true DE3322783A1 (de) 1984-02-09
DE3322783C2 DE3322783C2 (enEXAMPLES) 1991-01-31

Family

ID=27516485

Family Applications (2)

Application Number Title Priority Date Filing Date
DE3348299A Expired - Lifetime DE3348299C2 (enEXAMPLES) 1982-06-29 1983-06-24
DE3322783A Granted DE3322783A1 (de) 1982-06-29 1983-06-24 Verfahren zur herstellung von 1-aethoxycarbonyloxyaethylestern von penicillinen, 6-aminopenicillansaeure oder cephalosporinen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE3348299A Expired - Lifetime DE3348299C2 (enEXAMPLES) 1982-06-29 1983-06-24

Country Status (23)

Country Link
JP (2) JPH0819052B2 (enEXAMPLES)
AT (1) AT383128B (enEXAMPLES)
AU (1) AU566803B2 (enEXAMPLES)
BG (3) BG38336A3 (enEXAMPLES)
CH (2) CH656377A5 (enEXAMPLES)
CY (2) CY1520A (enEXAMPLES)
DD (1) DD211561A5 (enEXAMPLES)
DE (2) DE3348299C2 (enEXAMPLES)
DK (3) DK160039C (enEXAMPLES)
FI (1) FI79115C (enEXAMPLES)
FR (1) FR2543957B1 (enEXAMPLES)
GB (3) GB2168050A (enEXAMPLES)
GR (1) GR78585B (enEXAMPLES)
HU (1) HU191534B (enEXAMPLES)
IE (1) IE56712B1 (enEXAMPLES)
IL (1) IL68992A (enEXAMPLES)
IS (1) IS1361B6 (enEXAMPLES)
NL (1) NL194081C (enEXAMPLES)
NO (3) NO157696C (enEXAMPLES)
NZ (1) NZ204736A (enEXAMPLES)
PT (1) PT76944B (enEXAMPLES)
SE (2) SE454879B (enEXAMPLES)
YU (2) YU43926B (enEXAMPLES)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2573756B1 (fr) * 1984-11-23 1987-01-16 Poudres & Explosifs Ste Nale Procede de preparation des carbonates de bromo-1 ethyle et d'hydrocarbyle et nouveaux carbonates de bromo-1 ethyle et d'hydrocarbyle

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2144457A1 (enEXAMPLES) * 1970-09-17 1972-03-30
DE2345236A1 (de) * 1973-02-19 1974-08-22 Astra Laekemedel Ab Quaternaere ammoniumverbindungen, verfahren zu deren herstellung und sie enthaltende arzneimittel
DE2656062A1 (de) * 1975-12-13 1977-06-23 Beecham Group Ltd Verfahren zur herstellung von penicillinestern mittels phasentransfer-katalyse
DE3323462A1 (de) * 1982-06-30 1984-01-12 Glaxo Group Ltd., London Cephalosporin-antibiotika
EP0108547A2 (en) * 1982-11-04 1984-05-16 Astra Lakemedel Aktiebolag Process for the preparation of the 1'-ethoxycarbonyloxyethyl ester of benzylpenicillin

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH516593A (de) * 1967-09-29 1971-12-15 Leo Pharm Prod Ltd Verfahren zur Herstellung von neuen Estern von a-Aminobenzyl-penicillin
IE35648B1 (en) * 1970-09-25 1976-04-14 Beecham Group Ltd Penicillins
DE2161420A1 (de) * 1970-12-30 1972-07-27 Toyama Chemical Co. Ltd., Tokio Penicillinderivate und Verfahren zu deren Herstellung
BE784800A (fr) * 1971-06-15 1972-10-02 Yamanouchi Pharma Co Ltd Procede de preparation de nouveaux derives esters oxymethyliques de la penicilline et de la cephalosporine
IL41313A (en) * 1972-02-15 1976-08-31 Harrison Ltd Preparation of the lh-and fsh-releasing hormone and compositions containing it
GB1425571A (en) * 1972-03-13 1976-02-18 Astra Laekemedel Ab Penicillins and cephaosporins
GB1426869A (en) * 1972-03-13 1976-03-03 Astra Laekemedel Ab Penicillins
GB1426717A (en) * 1972-03-13 1976-03-03 Astra Laekemedel Ab Penicillins
GB1598568A (en) * 1977-04-19 1981-09-23 Glaxo Lab Ltd Esters of(6r,7r)-3-carbamoyloxymethyl-7-((z)-2-(fur-2-yl)-2-methoxyiminoacetamido)-ceph-3-em-4-carboxylic acid
JPS5444694A (en) * 1977-09-06 1979-04-09 Kou Kamata Aminobenzylpenicillin derivative

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2144457A1 (enEXAMPLES) * 1970-09-17 1972-03-30
DE2345236A1 (de) * 1973-02-19 1974-08-22 Astra Laekemedel Ab Quaternaere ammoniumverbindungen, verfahren zu deren herstellung und sie enthaltende arzneimittel
DE2656062A1 (de) * 1975-12-13 1977-06-23 Beecham Group Ltd Verfahren zur herstellung von penicillinestern mittels phasentransfer-katalyse
DE3323462A1 (de) * 1982-06-30 1984-01-12 Glaxo Group Ltd., London Cephalosporin-antibiotika
EP0108547A2 (en) * 1982-11-04 1984-05-16 Astra Lakemedel Aktiebolag Process for the preparation of the 1'-ethoxycarbonyloxyethyl ester of benzylpenicillin

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GREENE, T.W.: Protective Groups in Organic Synthesis, Wiley 1981, S. 278

Also Published As

Publication number Publication date
DK105990A (da) 1990-04-30
GB8528958D0 (en) 1986-01-02
GB2169287A (en) 1986-07-09
DK159821B (da) 1990-12-10
FI79115C (fi) 1989-11-10
GB8522826D0 (en) 1985-10-23
GB2168050A (en) 1986-06-11
NO851255L (no) 1983-12-30
AU1632883A (en) 1984-01-05
ATA238483A (de) 1986-10-15
NL194081B (nl) 2001-02-01
SE454879B (sv) 1988-06-06
DK159821C (da) 1991-04-29
NO851254L (no) 1983-12-30
NO832351L (no) 1983-12-30
PT76944B (en) 1986-04-09
YU141583A (en) 1986-06-30
HU191534B (en) 1987-03-30
FI832363L (fi) 1983-12-30
CY1520A (en) 1990-11-16
IS1361B6 (is) 1989-05-25
CH656377A5 (de) 1986-06-30
IE56712B1 (en) 1991-11-20
DE3348299C2 (enEXAMPLES) 1990-12-20
DK105990D0 (da) 1990-04-30
JPH0730082B2 (ja) 1995-04-05
PT76944A (en) 1983-07-01
DK296683D0 (da) 1983-06-28
BG38335A3 (en) 1985-11-15
YU21886A (en) 1987-10-31
SE9100548L (sv) 1991-02-26
GB2168699A (en) 1986-06-25
DK167807B1 (da) 1993-12-20
GB2169287B (en) 1987-04-08
DK106090D0 (da) 1990-04-30
GB8522827D0 (en) 1985-10-23
NO157696C (no) 1988-05-04
CH657620B (enEXAMPLES) 1986-09-15
AU566803B2 (en) 1987-10-29
GR78585B (enEXAMPLES) 1984-09-27
IS2825A7 (is) 1984-07-08
SE9100548D0 (sv) 1991-02-26
FI832363A0 (fi) 1983-06-28
DD211561A5 (de) 1984-07-18
DK160039C (da) 1991-06-10
GB2168699B (en) 1987-04-15
JPH0819052B2 (ja) 1996-02-28
YU43926B (en) 1989-12-31
FR2543957A1 (fr) 1984-10-12
DE3322783C2 (enEXAMPLES) 1991-01-31
DK106090A (da) 1990-04-30
AT383128B (de) 1987-05-25
NL8302286A (nl) 1984-01-16
IE831445L (en) 1983-12-29
NL194081C (nl) 2001-06-05
SE503843C2 (sv) 1996-09-16
NO157696B (no) 1988-01-25
SE8303414D0 (sv) 1983-06-15
IL68992A (en) 1991-06-10
JPH0543583A (ja) 1993-02-23
DK160039B (da) 1991-01-21
NZ204736A (en) 1986-11-12
JPH0717918A (ja) 1995-01-20
SE8303414L (sv) 1983-12-30
YU43693B (en) 1989-10-31
BG37527A3 (en) 1985-06-14
FI79115B (fi) 1989-07-31
CY1519A (en) 1990-11-16
BG38336A3 (en) 1985-11-15
DK296683A (da) 1983-12-30
FR2543957B1 (fr) 1986-10-24

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