DE3203957A1 - Verfahren zur herstellung von feinporigen kollagenschwaemmen - Google Patents
Verfahren zur herstellung von feinporigen kollagenschwaemmenInfo
- Publication number
- DE3203957A1 DE3203957A1 DE19823203957 DE3203957A DE3203957A1 DE 3203957 A1 DE3203957 A1 DE 3203957A1 DE 19823203957 DE19823203957 DE 19823203957 DE 3203957 A DE3203957 A DE 3203957A DE 3203957 A1 DE3203957 A1 DE 3203957A1
- Authority
- DE
- Germany
- Prior art keywords
- collagen
- production
- fine
- water
- pore
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 20
- 238000000034 method Methods 0.000 title claims abstract description 19
- 239000000515 collagen sponge Substances 0.000 title claims description 5
- 239000011148 porous material Substances 0.000 title abstract description 4
- 102000008186 Collagen Human genes 0.000 claims abstract description 67
- 108010035532 Collagen Proteins 0.000 claims abstract description 67
- 229920001436 collagen Polymers 0.000 claims abstract description 67
- 239000000463 material Substances 0.000 claims abstract description 42
- 239000000835 fiber Substances 0.000 claims abstract description 29
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 24
- 230000008961 swelling Effects 0.000 claims abstract description 14
- 239000000126 substance Substances 0.000 claims abstract description 12
- 239000002994 raw material Substances 0.000 claims abstract description 7
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000003513 alkali Substances 0.000 claims abstract description 6
- 239000000316 bone substitute Substances 0.000 claims abstract description 6
- 239000001506 calcium phosphate Substances 0.000 claims abstract description 5
- 229910000389 calcium phosphate Inorganic materials 0.000 claims abstract description 5
- 235000011010 calcium phosphates Nutrition 0.000 claims abstract description 5
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims abstract description 5
- 241000283690 Bos taurus Species 0.000 claims abstract description 4
- 239000004753 textile Substances 0.000 claims abstract description 4
- 102000035195 Peptidases Human genes 0.000 claims abstract description 3
- 108091005804 Peptidases Proteins 0.000 claims abstract description 3
- 239000002253 acid Substances 0.000 claims abstract description 3
- 150000007513 acids Chemical class 0.000 claims abstract description 3
- 239000011260 aqueous acid Substances 0.000 claims abstract description 3
- 238000010790 dilution Methods 0.000 claims abstract description 3
- 239000012895 dilution Substances 0.000 claims abstract description 3
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims abstract description 3
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims abstract description 3
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 claims abstract description 3
- 239000007787 solid Substances 0.000 claims abstract 2
- 238000007710 freezing Methods 0.000 claims description 20
- 230000008014 freezing Effects 0.000 claims description 20
- 239000003431 cross linking reagent Substances 0.000 claims description 17
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 14
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
- 150000001408 amides Chemical class 0.000 claims description 7
- 229910052757 nitrogen Inorganic materials 0.000 claims description 7
- 238000010521 absorption reaction Methods 0.000 claims description 2
- 230000001143 conditioned effect Effects 0.000 claims description 2
- 239000007858 starting material Substances 0.000 claims description 2
- 241000243142 Porifera Species 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000002452 interceptive effect Effects 0.000 claims 1
- 235000012461 sponges Nutrition 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 abstract description 4
- 239000013543 active substance Substances 0.000 abstract description 2
- 238000007865 diluting Methods 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 239000000047 product Substances 0.000 description 10
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 9
- 238000004108 freeze drying Methods 0.000 description 6
- 239000012267 brine Substances 0.000 description 5
- 238000004132 cross linking Methods 0.000 description 5
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 4
- 239000000654 additive Substances 0.000 description 4
- 235000015278 beef Nutrition 0.000 description 4
- 239000000084 colloidal system Substances 0.000 description 4
- LEQAOMBKQFMDFZ-UHFFFAOYSA-N glyoxal Chemical compound O=CC=O LEQAOMBKQFMDFZ-UHFFFAOYSA-N 0.000 description 4
- 239000010985 leather Substances 0.000 description 4
- 239000002002 slurry Substances 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- 238000010306 acid treatment Methods 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 238000010382 chemical cross-linking Methods 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 230000003750 conditioning effect Effects 0.000 description 3
- 230000029087 digestion Effects 0.000 description 3
- 125000005442 diisocyanate group Chemical group 0.000 description 3
- 235000013372 meat Nutrition 0.000 description 3
- 210000003739 neck Anatomy 0.000 description 3
- 230000002378 acidificating effect Effects 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 229940015043 glyoxal Drugs 0.000 description 2
- 238000000265 homogenisation Methods 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 230000006641 stabilisation Effects 0.000 description 2
- 238000011105 stabilization Methods 0.000 description 2
- RINCXYDBBGOEEQ-UHFFFAOYSA-N succinic anhydride Chemical compound O=C1CCC(=O)O1 RINCXYDBBGOEEQ-UHFFFAOYSA-N 0.000 description 2
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 102000006395 Globulins Human genes 0.000 description 1
- 108010044091 Globulins Proteins 0.000 description 1
- 239000005057 Hexamethylene diisocyanate Substances 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 102000016611 Proteoglycans Human genes 0.000 description 1
- 108010067787 Proteoglycans Proteins 0.000 description 1
- 229920000297 Rayon Polymers 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 210000001361 achilles tendon Anatomy 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 229940030225 antihemorrhagics Drugs 0.000 description 1
- 238000004380 ashing Methods 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 239000011243 crosslinked material Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000035617 depilation Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 238000001879 gelation Methods 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 150000002337 glycosamines Chemical class 0.000 description 1
- 239000002874 hemostatic agent Substances 0.000 description 1
- RRAMGCGOFNQTLD-UHFFFAOYSA-N hexamethylene diisocyanate Chemical compound O=C=NCCCCCCN=C=O RRAMGCGOFNQTLD-UHFFFAOYSA-N 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000006855 networking Effects 0.000 description 1
- 239000012875 nonionic emulsifier Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000015277 pork Nutrition 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N urea group Chemical group NC(=O)N XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- -1 wool Polymers 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
- C08J9/26—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof by elimination of a solid phase from a macromolecular composition or article, e.g. leaching out
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00365—Proteins; Polypeptides; Degradation products thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2201/00—Foams characterised by the foaming process
- C08J2201/04—Foams characterised by the foaming process characterised by the elimination of a liquid or solid component, e.g. precipitation, leaching out, evaporation
- C08J2201/048—Elimination of a frozen liquid phase
- C08J2201/0484—Elimination of a frozen liquid phase the liquid phase being aqueous
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2389/00—Characterised by the use of proteins; Derivatives thereof
- C08J2389/04—Products derived from waste materials, e.g. horn, hoof or hair
- C08J2389/06—Products derived from waste materials, e.g. horn, hoof or hair derived from leather or skin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Botany (AREA)
- Inorganic Chemistry (AREA)
- Composite Materials (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Materials For Medical Uses (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19823203957 DE3203957A1 (de) | 1982-02-05 | 1982-02-05 | Verfahren zur herstellung von feinporigen kollagenschwaemmen |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19823203957 DE3203957A1 (de) | 1982-02-05 | 1982-02-05 | Verfahren zur herstellung von feinporigen kollagenschwaemmen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3203957A1 true DE3203957A1 (de) | 1983-08-18 |
| DE3203957C2 DE3203957C2 (enrdf_load_stackoverflow) | 1989-12-07 |
Family
ID=6154882
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19823203957 Granted DE3203957A1 (de) | 1982-02-05 | 1982-02-05 | Verfahren zur herstellung von feinporigen kollagenschwaemmen |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE3203957A1 (enrdf_load_stackoverflow) |
Cited By (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3616365A1 (de) * | 1985-05-15 | 1986-11-20 | Mitsubishi Mining & Cement Co. Ltd., Tokio/Tokyo | Fuellmaterial zum fuellen von defekten und hohlraeumen in knochen |
| EP0306018A1 (en) * | 1987-09-04 | 1989-03-08 | Bio-Products, Inc. | Tendon/ligament substitutes composed of long, parallel, non-antigenic tendon/ligament fibers |
| EP0331786A1 (de) * | 1988-03-11 | 1989-09-13 | CHEMOKOL G.b.R. Ing.-Büro für Kollagenprodukte | Verfahren zur Herstellung von Kollagenmembranen für Hämostase, Wundbehandlung und Implantate |
| DE4227681A1 (de) * | 1992-08-21 | 1994-02-24 | Becker & Co Naturinwerk | Wundabdeckungsmaterial auf der Basis von Kollagenfasern |
| EP0621044A3 (en) * | 1993-04-21 | 1995-01-11 | Sangi Kk | Collagen membrane. |
| US5837278A (en) * | 1994-01-06 | 1998-11-17 | Ed Geistlich Sohne Ag Fur Chemische Industrie | Resorbable collagen membrane for use in guided tissue regeneration |
| DE19856668A1 (de) * | 1998-12-09 | 2000-06-15 | Aesculap Ag & Co Kg | Wirkstoffmatrix in Form eines biologisch resorbierbaren porösen Vlieses, Verfahren zu ihrer Herstellung und Verwendung |
| EP1275405A1 (de) * | 2001-07-13 | 2003-01-15 | JOTEC GmbH | Implantat mit poröser Proteinmatrix und Verfahren zu seiner Herstellung |
| EP1442756A3 (en) * | 1996-11-20 | 2004-09-22 | SHIMIZU, Yasuhiko | Collagen material and its production process |
| EP1905464A3 (de) * | 2006-09-05 | 2010-10-06 | JOTEC GmbH | Implantat und Verfahren zu seiner Herstellung |
| EP2098255A3 (de) * | 2008-03-07 | 2011-06-29 | aap Biomaterials GmbH | Verfahren zur herstellung von kollagen-material |
| DE102010032619A1 (de) | 2010-07-29 | 2012-02-02 | Wilo Se | Beschichtungszusammensetzung mit titandioxiderzeugendem Mittel, nanoskalige Beschichtung auf Basis von titandioxid, deren Herstellung, Weiterverarbeitung und Verwendung |
| WO2012030202A1 (es) * | 2010-09-03 | 2012-03-08 | Daniel Gutierrez Carrillo | Proceso de obtención de un extracto rico en colágeno a partir de pieles de animales y dicho extracto |
| WO2012031916A1 (de) * | 2010-09-10 | 2012-03-15 | Gelita Ag | Verfahren zur reduzierung des endotoxingehalts in einem kollagenhaltigen material |
| EP2468307A1 (de) | 2010-12-23 | 2012-06-27 | Dr. Suwelack Skin & Health Care AG | Degradationsstabilisierte, biokompatible Collagenmatrices |
| DE19962090B4 (de) * | 1998-12-22 | 2014-07-17 | Karl Weis | Verfahren zur Herstellung von Formkörpern |
| US11511073B2 (en) | 2018-10-29 | 2022-11-29 | Heraeus Medical Gmbh | Device for temporary local application of fluids |
| US12144971B2 (en) | 2019-09-18 | 2024-11-19 | Heraeus Medical Gmbh | Device for temporarily, locally applying fluids |
| US12383703B2 (en) | 2019-09-18 | 2025-08-12 | Heraeus Medical Gmbh | Device for temporary, local administration of fluids |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19541555C2 (de) * | 1995-11-08 | 1997-09-11 | Henkel Kgaa | Verfahren zur Herstellung wasserunlöslicher, vernetzerfreier Kollagenschwämme |
| DE19748472A1 (de) * | 1997-11-03 | 1999-05-06 | Suwelack Nachf Dr Otto | Vorrichtung zum Gefriertrocknen von Kollagen aus tierischen Rohstoffen und anderen Biomatrices, die aus Polysacchariden gewonnen worden sind und Verfahren zur Herstellung dieser Produkte |
| DE102007000574A1 (de) | 2007-10-25 | 2009-04-30 | FILK Forschungsinstitut für Leder- und Kunstbahnen gGmbH | Biologisch resorbierbares Schwammmaterial und Verfahren zu dessen Herstellung |
| DE102007061710A1 (de) | 2007-12-19 | 2009-06-25 | Kalle Gmbh | Kollagen-Konzentrat, dessen Verwendung sowie Verfahren zu seiner Herstellung |
| DE102008013091B4 (de) * | 2008-03-07 | 2009-11-26 | Aap Biomaterials Gmbh | Verfahren zur Herstellung von Kollagen-Material, Kollagen-Material |
| CN111744052B (zh) * | 2019-03-27 | 2021-07-09 | 厦门大学 | 一种海绵质止血材料的制备方法 |
| EP3854437B1 (de) | 2020-01-27 | 2022-01-19 | Heraeus Medical GmbH | Vorrichtung zur temporären, lokalen applikation von fluiden |
| EP3831426B1 (de) | 2019-12-05 | 2025-07-09 | Heraeus Medical GmbH | Vorrichtung zur lokalen applikation von pharmazeutischen fluiden |
| EP4094797B1 (de) | 2021-05-28 | 2023-04-05 | Heraeus Medical GmbH | Vorrichtung zur applikation eines pharmazeutischen fluids |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2734503C2 (de) * | 1977-07-30 | 1984-04-05 | Fa. Carl Freudenberg, 6940 Weinheim | Verfahren zur Herstellung von Kollagenschwamm |
-
1982
- 1982-02-05 DE DE19823203957 patent/DE3203957A1/de active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2734503C2 (de) * | 1977-07-30 | 1984-04-05 | Fa. Carl Freudenberg, 6940 Weinheim | Verfahren zur Herstellung von Kollagenschwamm |
Non-Patent Citations (1)
| Title |
|---|
| Zusätzlich sind zur Einsicht für jedermann bereitzuhalten: Versuchsberichte eingegangen am 12.02.86 und 07.07.88 |
Cited By (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3616365A1 (de) * | 1985-05-15 | 1986-11-20 | Mitsubishi Mining & Cement Co. Ltd., Tokio/Tokyo | Fuellmaterial zum fuellen von defekten und hohlraeumen in knochen |
| EP0306018A1 (en) * | 1987-09-04 | 1989-03-08 | Bio-Products, Inc. | Tendon/ligament substitutes composed of long, parallel, non-antigenic tendon/ligament fibers |
| EP0331786A1 (de) * | 1988-03-11 | 1989-09-13 | CHEMOKOL G.b.R. Ing.-Büro für Kollagenprodukte | Verfahren zur Herstellung von Kollagenmembranen für Hämostase, Wundbehandlung und Implantate |
| DE4227681A1 (de) * | 1992-08-21 | 1994-02-24 | Becker & Co Naturinwerk | Wundabdeckungsmaterial auf der Basis von Kollagenfasern |
| EP0621044A3 (en) * | 1993-04-21 | 1995-01-11 | Sangi Kk | Collagen membrane. |
| US5837278A (en) * | 1994-01-06 | 1998-11-17 | Ed Geistlich Sohne Ag Fur Chemische Industrie | Resorbable collagen membrane for use in guided tissue regeneration |
| EP1442756A3 (en) * | 1996-11-20 | 2004-09-22 | SHIMIZU, Yasuhiko | Collagen material and its production process |
| DE19856668A1 (de) * | 1998-12-09 | 2000-06-15 | Aesculap Ag & Co Kg | Wirkstoffmatrix in Form eines biologisch resorbierbaren porösen Vlieses, Verfahren zu ihrer Herstellung und Verwendung |
| DE19962090B4 (de) * | 1998-12-22 | 2014-07-17 | Karl Weis | Verfahren zur Herstellung von Formkörpern |
| EP1275405A1 (de) * | 2001-07-13 | 2003-01-15 | JOTEC GmbH | Implantat mit poröser Proteinmatrix und Verfahren zu seiner Herstellung |
| US7175852B2 (en) | 2001-07-13 | 2007-02-13 | Jotec Gmbh | Implant and process for producing it |
| EP1905464A3 (de) * | 2006-09-05 | 2010-10-06 | JOTEC GmbH | Implantat und Verfahren zu seiner Herstellung |
| EP2098255A3 (de) * | 2008-03-07 | 2011-06-29 | aap Biomaterials GmbH | Verfahren zur herstellung von kollagen-material |
| DE102010032619A1 (de) | 2010-07-29 | 2012-02-02 | Wilo Se | Beschichtungszusammensetzung mit titandioxiderzeugendem Mittel, nanoskalige Beschichtung auf Basis von titandioxid, deren Herstellung, Weiterverarbeitung und Verwendung |
| WO2012013335A2 (de) | 2010-07-29 | 2012-02-02 | Wilo Se | Beschichtungszusammensetzung mit titandioxiderzeugendem mittel, nanoskalige beschichtung auf basis von titandioxid, deren herstellung, weiterverarbeitung und verwendung |
| WO2012030202A1 (es) * | 2010-09-03 | 2012-03-08 | Daniel Gutierrez Carrillo | Proceso de obtención de un extracto rico en colágeno a partir de pieles de animales y dicho extracto |
| WO2012031916A1 (de) * | 2010-09-10 | 2012-03-15 | Gelita Ag | Verfahren zur reduzierung des endotoxingehalts in einem kollagenhaltigen material |
| EP2468307A1 (de) | 2010-12-23 | 2012-06-27 | Dr. Suwelack Skin & Health Care AG | Degradationsstabilisierte, biokompatible Collagenmatrices |
| EP2789352A1 (de) | 2010-12-23 | 2014-10-15 | MedSkin Solutions Dr. Suwelack AG | Degradationsstabilisierte, biokompatible Collagenmatrices |
| US11511073B2 (en) | 2018-10-29 | 2022-11-29 | Heraeus Medical Gmbh | Device for temporary local application of fluids |
| US12144971B2 (en) | 2019-09-18 | 2024-11-19 | Heraeus Medical Gmbh | Device for temporarily, locally applying fluids |
| US12383703B2 (en) | 2019-09-18 | 2025-08-12 | Heraeus Medical Gmbh | Device for temporary, local administration of fluids |
Also Published As
| Publication number | Publication date |
|---|---|
| DE3203957C2 (enrdf_load_stackoverflow) | 1989-12-07 |
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