DE3177213D1 - Dns-sequenzen, rekombinante dns-molekuele und verfahren zur herstellung von dem menschlichen fibroblast-interferon. - Google Patents

Dns-sequenzen, rekombinante dns-molekuele und verfahren zur herstellung von dem menschlichen fibroblast-interferon.

Info

Publication number
DE3177213D1
DE3177213D1 DE8181301414T DE3177213T DE3177213D1 DE 3177213 D1 DE3177213 D1 DE 3177213D1 DE 8181301414 T DE8181301414 T DE 8181301414T DE 3177213 T DE3177213 T DE 3177213T DE 3177213 D1 DE3177213 D1 DE 3177213D1
Authority
DE
Germany
Prior art keywords
dna sequences
producing
pst
pbr322
human fibroblast
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Revoked
Application number
DE8181301414T
Other languages
German (de)
English (en)
Inventor
Walter Charles Dr Fiers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biogen Inc
Original Assignee
Biogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26275083&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3177213(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biogen Inc filed Critical Biogen Inc
Application granted granted Critical
Publication of DE3177213D1 publication Critical patent/DE3177213D1/de
Anticipated expiration legal-status Critical
Revoked legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/73—Expression systems using phage (lambda) regulatory sequences
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/22011—Polyomaviridae, e.g. polyoma, SV40, JC
    • C12N2710/22022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE8181301414T 1980-04-03 1981-04-01 Dns-sequenzen, rekombinante dns-molekuele und verfahren zur herstellung von dem menschlichen fibroblast-interferon. Revoked DE3177213D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8011306 1980-04-03
GB8018701 1980-06-06

Publications (1)

Publication Number Publication Date
DE3177213D1 true DE3177213D1 (de) 1990-10-18

Family

ID=26275083

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8181301414T Revoked DE3177213D1 (de) 1980-04-03 1981-04-01 Dns-sequenzen, rekombinante dns-molekuele und verfahren zur herstellung von dem menschlichen fibroblast-interferon.

Country Status (27)

Country Link
US (2) US7588755B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0041313B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JP2687995B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR860001471B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE56471T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU564690B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BG (1) BG60441B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1341604C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DD (1) DD160280A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3177213D1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK170476B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES8302096A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI88175C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR74498B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HK (1) HK160095A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HU193507B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE57069B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL62552A0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IN (1) IN156128B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
LU (1) LU90131I2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MX (1) MX9202946A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (2) NL970018I1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (3) NO811118L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ196706A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PL (1) PL149079B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT72786B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
YU (1) YU45104B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL58765A (en) * 1979-11-21 1986-09-30 Yeda Res & Dev Process for the production of essentially pure messenger rna of human fibroblast interferon and process for the production of interferon beta
US5554513A (en) * 1979-11-21 1996-09-10 Yeda Research & Development Co. Ltd. Production of recombinant human interferon-beta2
US5510472A (en) * 1979-11-21 1996-04-23 Yeda Research And Development Co. Ltd. Production of recombinant human interferon-beta2
DK33181A (da) * 1980-02-06 1981-08-07 Searle & Co Fremgangsmaade til fremstilling af et interferonlignende protein
DE3005843A1 (de) * 1980-02-16 1981-09-10 Hoechst Ag, 6000 Frankfurt Genprodukt eines hoeheren organismus aus einem dieses gen enthaltenden mikroorganismus
EP0041767B1 (en) * 1980-06-06 1993-03-03 Biogen, Inc. Improved vectors and methods for making such vectors and for expressing cloned genes
DE3176011D1 (en) * 1980-06-12 1987-04-23 Japan Found Cancer Plasmid
US4874702A (en) * 1980-09-08 1989-10-17 Biogen, Inc. Vectors and methods for making such vectors and for expressive cloned genes
GR81946B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1980-09-25 1984-12-12 Genentech Inc
ZA816621B (en) * 1980-09-25 1982-09-29 Genentech Inc Microbial production of human fibroblast interferon
IL63327A (en) * 1981-07-16 1985-11-29 Yeda Res & Dev Production of interferon beta1 and alpha-phage recombinants for its production in host bacteria
GB2108510B (en) * 1981-10-03 1984-12-12 Ciba Geigy Ag Dnas, recombinant dnas, hosts containing them, polypeptides and processes for the production thereof
JPS58110600A (ja) * 1981-12-25 1983-07-01 Kyowa Hakko Kogyo Co Ltd ヒトβ型インタ−フエロン遺伝子を含む組みかえ体プラスミド
JPS58141796A (ja) * 1982-02-18 1983-08-23 Kyowa Hakko Kogyo Co Ltd ペプチドの製造法
US4582800A (en) * 1982-07-12 1986-04-15 Hoffmann-La Roche Inc. Novel vectors and method for controlling interferon expression
IL69382A (en) * 1982-08-05 1991-01-31 Carter William Alvin Method of protecting plants against viral pathogens by inserting into plant cells genes encoding polypeptides containing interferon domains
IE56026B1 (en) * 1982-10-19 1991-03-27 Cetus Corp Cysteine-depleted muteins of biologically active proteins
US4588585A (en) * 1982-10-19 1986-05-13 Cetus Corporation Human recombinant cysteine depleted interferon-β muteins
US4737462A (en) * 1982-10-19 1988-04-12 Cetus Corporation Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-β
US4966843A (en) * 1982-11-01 1990-10-30 Cetus Corporation Expression of interferon genes in Chinese hamster ovary cells
GR79124B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1982-12-22 1984-10-02 Genentech Inc
GB8308235D0 (en) * 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4518584A (en) * 1983-04-15 1985-05-21 Cetus Corporation Human recombinant interleukin-2 muteins
DE152483T1 (de) * 1983-08-22 1986-02-27 Kyowa Hakko Kogyo Co., Ltd., Tokio/Tokyo Verfahren zur herstellung von peptiden.
WO1986007093A1 (en) * 1985-05-29 1986-12-04 The Green Cross Corporation Process for preparing heterogenic protein
WO1987000553A1 (en) * 1985-07-16 1987-01-29 The Green Cross Corporation Process for preparing hetero-protein
FR2635113B1 (fr) * 1988-08-05 1992-07-24 Sanofi Sa Procede d'obtention d'interleukine-1 (beta) mature a partir de cellules d'e. coli transformees
FR2686899B1 (fr) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
US5545723A (en) * 1994-03-15 1996-08-13 Biogen Inc. Muteins of IFN-β
KR100711990B1 (ko) 1997-09-23 2007-05-02 렌트슐러 비오테히놀로기 게엠베하 액상 인터페론-베타 제제
US6531122B1 (en) 1999-08-27 2003-03-11 Maxygen Aps Interferon-β variants and conjugates
US7144574B2 (en) 1999-08-27 2006-12-05 Maxygen Aps Interferon β variants and conjugates
US7431921B2 (en) 1999-08-27 2008-10-07 Maxygen Aps Interferon beta-like molecules
JP2003530847A (ja) 2000-04-12 2003-10-21 ヒューマン ゲノム サイエンシズ インコーポレイテッド アルブミン融合タンパク質
ATE432288T1 (de) 2001-02-27 2009-06-15 Maxygen Aps Neue interferon-beta-ähnliche moleküle
WO2005003296A2 (en) 2003-01-22 2005-01-13 Human Genome Sciences, Inc. Albumin fusion proteins
ES2545090T3 (es) 2001-12-21 2015-09-08 Human Genome Sciences, Inc. Proteínas de fusión de albúmina y GCSF
NZ586034A (en) 2004-02-02 2011-10-28 Ambrx Inc Modified human growth hormone polypeptides and their uses
NZ580686A (en) 2007-05-02 2012-11-30 Ambrx Inc Modified interferon beta polypeptides and their uses
DE102009032179A1 (de) 2009-07-07 2011-01-13 Biogenerix Ag Verfahren zur Reinigung von Interferon beta

Family Cites Families (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1645C (da) 1898-06-20 Carl Christensen Lommekniv med et i Skaftet indskydeligt Blad.
US3699222A (en) 1958-03-11 1972-10-17 Nat Res Dev Production of viral interfering substances
US4184917A (en) 1974-04-01 1980-01-22 Sandoz Ltd. Process for producing a structurally modified interferon
NL7404589A (nl) 1974-04-03 1975-10-07 Stichting Rega V Z W Werkwijze voor het stabiliseren van interferon.
GB1521032A (en) * 1974-08-08 1978-08-09 Ici Ltd Biological treatment
US4237224A (en) 1974-11-04 1980-12-02 Board Of Trustees Of The Leland Stanford Jr. University Process for producing biologically functional molecular chimeras
FR2321298A1 (fr) * 1975-08-01 1977-03-18 Anvar Procede de preparation de produits a activite interferon
US4190495A (en) 1976-09-27 1980-02-26 Research Corporation Modified microorganisms and method of preparing and using same
US4264731A (en) 1977-05-27 1981-04-28 The Regents Of The University Of California DNA Joining method
DE2724918A1 (de) 1977-06-02 1978-12-14 Thomae Gmbh Dr K Gewinnung und reinigung von humaninterferon
CS215108B2 (en) 1977-07-15 1982-07-30 Wellcome Found Method of making the interferrone
US4283489A (en) 1977-09-23 1981-08-11 The Regents Of The University Of California Purification of nucleotide sequences suitable for expression in bacteria
ZA782933B (en) 1977-09-23 1979-05-30 Univ California Purification of nucleotide sequences suitable for expression in bacteria
CA1201668A (en) 1977-11-08 1986-03-11 Genentech, Inc. Synthetic dna and method therefor
NL7811042A (nl) 1977-11-08 1979-05-10 Genentech Inc Werkwijze en middel voor het tot uitdrukking brengen van microbieel polypeptide.
IL55890A (en) 1977-11-08 1984-01-31 Genentech Inc Method and means for polypeptide production involving expression of a heterologous gene,and as products therefrom recombinant microbial cloning vehicles containing said gene
DE2759053A1 (de) 1977-12-30 1979-07-12 Uhlin Verfahren zum herstellen von genprodukten von plasmid-dns
FR2422956A1 (fr) 1978-04-13 1979-11-09 Pasteur Institut Procede de detection et de caracterisation d'un acide nucleique ou d'une sequence de celui-ci, et reactif enzymatique pour la mise en oeuvre de ce procede
EP0005476B1 (de) 1978-05-17 1981-12-30 Dr. Karl Thomae GmbH Verfahren zur Herstellung von Humaninterferon
US4322497A (en) 1978-06-02 1982-03-30 Eli Lilly And Company Process for transducing Escherichia coli K12 χ1776
US4411994A (en) 1978-06-08 1983-10-25 The President And Fellows Of Harvard College Protein synthesis
US4307193A (en) 1978-06-09 1981-12-22 Toray Industries, Inc. Method of producing interferon
JPS5519239A (en) 1978-07-28 1980-02-09 Green Cross Corp:The Interferon-producing attractant
FI792481A7 (fi) 1978-08-11 1981-01-01 The Regents Of The Univ Of Enkaroyyttisen proteiinin synteesi mikro-organismia käyttäen.
JPS5561798A (en) 1978-10-30 1980-05-09 Noda Sangyo Kagaku Kenkyusho Preparation of novel recombination dna
JPS5564799A (en) 1978-11-07 1980-05-15 Toray Ind Inc Multi-stage concentration and purification of interferon originated from human fibroblast
IN150740B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1978-11-24 1982-12-04 Hoffmann La Roche
US4241174A (en) 1978-11-24 1980-12-23 Hoffmann-La Roche Inc. Interferon assay
NL8000127A (nl) 1979-01-15 1980-07-17 Harvard College Werkwijze voor het vormen van prokaryotische of eukaryotische proteinen alsmede een daarbij toepasbaar gekoppeld gen.
EP0014050A3 (en) 1979-01-16 1980-10-01 Beecham Group Plc Interferon production
US5326859A (en) * 1979-10-30 1994-07-05 Juridical Foundation, Japanese Foundation For Cancer Research DNA and recombinant plasmid
US5514567A (en) 1979-01-30 1996-05-07 Juridical Foundation, Japanese Foundation For Cancer Research DNA and recombinant plasmid
JPS5663996A (en) 1979-10-30 1981-05-30 Japan Found Cancer Novel recombinant having gene complementary to human interferon messenger rna
JPS56131598A (en) 1980-03-19 1981-10-15 Japan Found Cancer Novel recombinant plasmid having gene of human fibroblastic interferon messenger rna
US4357421A (en) 1979-04-02 1982-11-02 G. D. Searle & Co. Synthetic gene coding for influenza hemagglutinin
FI77877C (fi) 1979-04-20 1989-05-10 Technobiotic Ltd Foerfarande foer framstaellning och rening av human le-formig interferonprotein.
IL57108A (en) 1979-04-22 1981-12-31 Yeda Res & Dev Assay for the quantitative determination of interferon and a kit therefor
US4293652A (en) 1979-05-25 1981-10-06 Cetus Corporation Method for synthesizing DNA sequentially
GB2052516B (en) 1979-06-01 1983-06-29 Searle & Co Plasmid vectors production and use thereof
US4262090A (en) 1979-06-04 1981-04-14 Cetus Corporation Interferon production
WO1981000116A1 (en) 1979-07-05 1981-01-22 United States Res Corp Method for the purification and analysis of interferon
CH648331A5 (de) 1979-07-31 1985-03-15 Hoffmann La Roche Homogenes fibroblasten-interferon und dessen herstellung.
JPS5651995A (en) 1979-10-05 1981-05-09 Green Cross Corp:The Preparation of interferon
NL7907791A (nl) 1979-10-23 1981-04-27 Stichting Rega V Z W Werkwijze voor het zuiveren van interferon.
AU538665B2 (en) * 1979-10-30 1984-08-23 Juridical Foundation, Japanese Foundation For Cancer Research Human interferon dna
IL58765A (en) * 1979-11-21 1986-09-30 Yeda Res & Dev Process for the production of essentially pure messenger rna of human fibroblast interferon and process for the production of interferon beta
EP0030094A1 (en) 1979-11-30 1981-06-10 Beecham Group Plc Calcium enhanced interferon production process
DK170236B1 (da) 1980-01-08 1995-07-10 Biogen Inc Rekombinante DNA-molekyler, fremgangsmåde til fremstilling af et polypeptid af IFN-alfa typen og fremgangsmåde til udvælgelse af DNA-sekvenser, der koder for polypeptider af IFN-alfa typen
DK33181A (da) 1980-02-06 1981-08-07 Searle & Co Fremgangsmaade til fremstilling af et interferonlignende protein
GB2068970B (en) * 1980-02-06 1983-06-22 Searle & Co Recombinant dna technique for the preparation of a protein resembling human interferon
IE51030B1 (en) 1980-02-06 1986-09-17 Searle & Co Recombinant dna technique for the preparation of a protein resembling human interferon
DE3005843A1 (de) * 1980-02-16 1981-09-10 Hoechst Ag, 6000 Frankfurt Genprodukt eines hoeheren organismus aus einem dieses gen enthaltenden mikroorganismus
DE3005897A1 (de) 1980-02-16 1981-09-03 Hoechst Ag, 6000 Frankfurt Genprodukt eines hoeheren organismus aus einem dieses gen enhtaltenden mikroorganismus
JPS57500408A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1980-02-25 1982-03-11
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
ZA811368B (en) 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
US4338397A (en) 1980-04-11 1982-07-06 President And Fellows Of Harvard College Mature protein synthesis
DE3019621C2 (de) 1980-05-22 1982-08-19 Stiftung Deutsches Krebsforschungszentrum, 6900 Heidelberg Verfahren zur Herstellung von Interferon II.
DK220781A (da) 1980-05-22 1981-11-23 Deutsches Krebsforsch Fremgangsmaade til fremstilling af interferon ii og stimulerede kloner til ydfoerelse af frmgangsmaaden
JPS56167624A (en) 1980-05-29 1981-12-23 Toray Ind Inc Method of interferon production
JPS571237A (en) 1980-06-03 1982-01-06 Toshiba Corp Combined integrared circuit device
EP0041767B1 (en) 1980-06-06 1993-03-03 Biogen, Inc. Improved vectors and methods for making such vectors and for expressing cloned genes
DE3176011D1 (en) * 1980-06-12 1987-04-23 Japan Found Cancer Plasmid
JPS575158A (en) 1980-06-12 1982-01-11 Matsushita Electric Works Ltd Automatic resetting circuit for cpu function stopping phenomenon
CH651308A5 (de) 1980-07-01 1985-09-13 Hoffmann La Roche Interferone und deren herstellung.
US4357422A (en) 1980-08-14 1982-11-02 Massachusetts Institute Of Technology Method of enhancing interferon production
US4874702A (en) 1980-09-08 1989-10-17 Biogen, Inc. Vectors and methods for making such vectors and for expressive cloned genes
GR81946B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1980-09-25 1984-12-12 Genentech Inc
US4315852A (en) 1980-11-26 1982-02-16 Schering Corporation Extraction of interferon from bacteria
JPS58201794A (ja) 1982-05-17 1983-11-24 Toray Ind Inc ヒトインターフェロンβの濃縮精製法
US4835256A (en) 1982-09-30 1989-05-30 New York University & Juridical Foundation Human gamma interferon polypeptide having glutamine as the ninth n-terminal amino acid
NZ210501A (en) 1983-12-13 1991-08-27 Kirin Amgen Inc Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence
AU594014B2 (en) 1984-03-21 1990-03-01 Research Corporation Technologies, Inc. Recombinant DNA molecules
NZ212207A (en) 1984-05-31 1991-07-26 Genentech Inc Recombinant lymphotoxin
DE3683080D1 (de) 1985-04-22 1992-02-06 Lilly Co Eli Rekombinante dns-expressionsvektoren und dns-verbindungen.
US4892819A (en) 1985-11-25 1990-01-09 Eli Lilly And Company Recombinant DNA expression vectors and DNA compounds that encode isopenicillin N synthetase from penicillium chrysogenum
DE3781747T2 (de) 1986-08-29 1993-03-18 Tonen Corp Fuer das rinderpestvirus-antigen kodierende dns, ihre herstellung und verwendung.
DE3642096A1 (de) 1986-12-10 1988-06-16 Boehringer Ingelheim Int Pferde-(gamma)-interferon
ES2052630T3 (es) 1987-04-09 1994-07-16 Shionogi & Co Gen reg y proteina codificada por el gen.
ZA887773B (en) 1987-10-26 1989-07-26 Immunex Corp Interleukin-7
US5258287A (en) 1988-03-22 1993-11-02 Genentech, Inc. DNA encoding and methods of production of insulin-like growth factor binding protein BP53
JP3393180B2 (ja) 1998-10-22 2003-04-07 シャープ株式会社 半導体装置の製造方法

Also Published As

Publication number Publication date
YU45104B (en) 1992-03-10
IE810756L (en) 1981-10-03
JP2687995B2 (ja) 1997-12-08
US7588755B1 (en) 2009-09-15
ATE56471T1 (de) 1990-09-15
GR74498B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1984-06-28
FI88175C (fi) 1993-04-13
EP0041313B1 (en) 1990-09-12
US7635466B1 (en) 2009-12-22
NL970032I2 (nl) 1997-12-01
HU193507B (en) 1987-10-28
NO850734L (no) 1981-10-05
LU90131I2 (fr) 1997-11-26
BG60441B2 (bg) 1995-03-31
IL62552A0 (en) 1981-06-29
HK160095A (en) 1995-10-20
YU85981A (en) 1984-04-30
NO811118L (no) 1981-10-05
ES500966A0 (es) 1982-12-16
FI811008L (fi) 1981-10-04
DD160280A5 (de) 1983-05-25
PL230484A1 (en) 1983-07-18
PT72786A (en) 1981-05-01
NZ196706A (en) 1988-01-08
AU564690B2 (en) 1987-08-20
DK170476B1 (da) 1995-09-11
IN156128B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1985-05-18
ES8302096A1 (es) 1982-12-16
JPS56154499A (en) 1981-11-30
EP0041313A2 (en) 1981-12-09
KR860001471B1 (ko) 1986-09-26
NL970032I1 (nl) 1997-10-01
NO850735L (no) 1981-10-05
KR830005354A (ko) 1983-08-13
EP0041313A3 (en) 1982-08-18
AU6897981A (en) 1981-10-08
IE57069B1 (en) 1992-04-22
PT72786B (en) 1983-01-10
DK148581A (da) 1981-10-04
PL149079B1 (en) 1990-01-31
NL970018I1 (nl) 1997-06-02
MX9202946A (es) 1992-07-01
FI88175B (fi) 1992-12-31
CA1341604C (en) 2010-05-04

Similar Documents

Publication Publication Date Title
DE3177213D1 (de) Dns-sequenzen, rekombinante dns-molekuele und verfahren zur herstellung von dem menschlichen fibroblast-interferon.
DE3872273D1 (de) Verfahren zur herstellung und verwendung von kohlenstoffmolekularsieben.
DE3577208D1 (de) Verfahren zur herstellung von tetrafluorethylenpolymerisathaltigen, flammwidrigen polycarbonatformmassen.
DE3675385D1 (de) Verfahren zur herstellung von linearen alpha-olefinen.
DK346385D0 (da) Genetiske sekvenser, hermed kodede interferon-peptider af type i og organismer, der producerer disse
DE68907959D1 (de) Einstufiges verfahren zur herstellung von methyl-tert.-butylether.
ATE87335T1 (de) Methode fuer selektiven zuwachs des anteils der gewoenlichen hauptkomponente des antibiotischen komplexes a/16686.
DE3777516D1 (de) Verfahren zur erzeugung von kohlendioxyd und wasserstoff.
DE3674048D1 (de) Verfahren zur herstellung von imidaten.
DE58900327D1 (de) Verfahren zur herstellung von perfluoralkylgruppen enthaltenden silylaethern und alkoholen.
DE3667960D1 (de) Verfahren zur herstellung von halogen-magnesium-alanat und dessen verwendung.
DE3689008D1 (de) Verfahren zur Herstellung und Reinigung von alpha-Interferon.
DE3769164D1 (de) Verfahren zur herstellung von flaechigem halbzeug.
DE3761088D1 (de) Verbessertes verfahren zur herstellung von p-cymol und homologen alkylbenzolen.
DE3667287D1 (de) Verfahren zur herstellung von bis(dialkylphenyl)pentaerythritoldiphosphiten.
DE3574932D1 (de) Verwendung von 1,4 bisubstituierten anthrachinonen zur herstellung von immunsuppressiva.
DE58901794D1 (de) Verfahren zur herstellung von tert.-olefinen.
DE68920358D1 (de) Verfahren zur Herstellung von Schwefelwasserstoff.
ATA180785A (de) Verfahren zur herstellung von oxazino-(5,6-c)-1,2-benzothiazin-6,6-dioxid
ATA129088A (de) Verfahren zur herstellung eines gebrannten, feuerfesten magnesiasteins auf der grundlage von sintermagnesia und feinverteiltem zirkonsilikat
ATA296587A (de) Verfahren zur herstellung von in alpha, omegastellung durch funktionelle gruppen substituierten homo- und copolymeren
ATE62895T1 (de) Verfahren zur herstellung von kohlenstoffmolekularsieben.
ATE9005T1 (de) Dns-sequenzen, rekombinante dns-molekuele und verfahren zur herstellung von dem menschlichen interferon-alpha aehnlichen polypeptiden.
DE3575085D1 (de) Kobaltkatalysatoren, verwendbar bei der herstellung von kohlenwasserstoffen, ausgehend von synthesegas oder methanol und verfahren unter verwendung dieser katalysatoren.

Legal Events

Date Code Title Description
8328 Change in the person/name/address of the agent

Free format text: VOSSIUS, V., DIPL.-CHEM. DR.RER.NAT. TAUCHNER, P., DIPL.-CHEM. DR.RER.NAT. HEUNEMANN, D., DIPL.-PHYS. DR.RER.NAT. RAUH, P., DIPL.-CHEM. DR.RER.NAT. HERMANN, G., DIPL.-PHYS. DR.RER.NAT. SCHMIDT, J., DIPL.-ING. JAENICHEN, H., DIPL.-BIOL. DR.RER.NAT., PAT.-ANWAELTE, 8000 MUENCHEN

8328 Change in the person/name/address of the agent

Free format text: VOSSIUS, V., DIPL.-CHEM. DR.RER.NAT. TAUCHNER, P., DIPL.-CHEM. DR.RER.NAT. HEUNEMANN, D., DIPL.-PHYS. DR.RER.NAT. RAUH, P., DIPL.-CHEM. DR.RER.NAT. HERMANN, G., DIPL.-PHYS. DR.RER.NAT. SCHMIDT, J., DIPL.-ING. JAENICHEN, H., DIPL.-BIOL. DR.RER.NAT., PAT.-ANWAELTE TREMMEL, H., RECHTSANW., 8000 MUENCHEN

8363 Opposition against the patent
V448 Application of spc

Free format text: PRODUCT NAME: INTERFERON SS-1A "AVONEX"; REGISTRATION NO/DATE: EU/1/97/033/001, 19970313

Spc suppl protection certif: 197 75 079

Filing date: 19970911

8331 Complete revocation
V457 Spc granted

Free format text: PRODUCT NAME: INTERFERON SS-1A "AVONEX"; REGISTRATION NO/DATE: EU/1/97/033/001, 19970313

Spc suppl protection certif: 197 75 079

Filing date: 19970911

V465 Spc lapsed due to nonpayment of the annual fee

Free format text: PRODUCT NAME: INTERFERON SS-1A "AVONEX"; REGISTRATION NO/DATE: EU/1/97/033/001, 19970313

Spc suppl protection certif: 197 75 079

Filing date: 19970911