DE3035467A1 - Enzymatisches verfahren zur herstellung von (beta)-lactamantibiotika und acylverbindungen zur durchfuehrung des verfahrens - Google Patents
Enzymatisches verfahren zur herstellung von (beta)-lactamantibiotika und acylverbindungen zur durchfuehrung des verfahrensInfo
- Publication number
- DE3035467A1 DE3035467A1 DE19803035467 DE3035467A DE3035467A1 DE 3035467 A1 DE3035467 A1 DE 3035467A1 DE 19803035467 DE19803035467 DE 19803035467 DE 3035467 A DE3035467 A DE 3035467A DE 3035467 A1 DE3035467 A1 DE 3035467A1
- Authority
- DE
- Germany
- Prior art keywords
- acid
- hydrogen atom
- general formula
- acylase
- enzyme
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000000034 method Methods 0.000 title claims description 46
- 230000008569 process Effects 0.000 title claims description 18
- 230000002255 enzymatic effect Effects 0.000 title claims description 9
- 239000003782 beta lactam antibiotic agent Substances 0.000 title claims description 6
- 150000003855 acyl compounds Chemical class 0.000 title claims 2
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- -1 β-lactam compound Chemical class 0.000 claims description 31
- 239000002253 acid Substances 0.000 claims description 26
- 239000000203 mixture Substances 0.000 claims description 25
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- 125000002252 acyl group Chemical group 0.000 claims description 10
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- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- JFALSRSLKYAFGM-UHFFFAOYSA-N uranium(0) Chemical compound [U] JFALSRSLKYAFGM-UHFFFAOYSA-N 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
- C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11926079A JPS5645196A (en) | 1979-09-19 | 1979-09-19 | Enzymatic synthesis of beta-lactam antibacterial agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3035467A1 true DE3035467A1 (de) | 1981-04-09 |
Family
ID=14756922
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19803035467 Withdrawn DE3035467A1 (de) | 1979-09-19 | 1980-09-19 | Enzymatisches verfahren zur herstellung von (beta)-lactamantibiotika und acylverbindungen zur durchfuehrung des verfahrens |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US4340672A (enExample) |
| JP (1) | JPS5645196A (enExample) |
| DE (1) | DE3035467A1 (enExample) |
| FR (1) | FR2465708A1 (enExample) |
| GB (1) | GB2058776B (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3362280D1 (en) * | 1982-06-25 | 1986-04-03 | Merck & Co Inc | Process for producing thienamycin employing streptromyces cattleya cells immobilized to kieselguhr |
| ES2036149A6 (es) * | 1989-12-12 | 1993-05-01 | Consejo Superior Investigacion | Procedimiento de sintesis de antibioticos semiestaticos en sistemas termodinamicamente controlados agua-cosolventes organicos miscibles apolares con el empleo de penicilina g acilasa. |
| DK0536671T3 (da) * | 1991-10-07 | 1996-08-12 | Hoechst Ag | Carboxylsyreester-beskyttelsesgrupper, en fremgangsmåde til deres fremstilling, kobling til funktionelle grupper samt deres anvendelser |
| DE69626842D1 (de) * | 1995-12-08 | 2003-04-24 | Dsm Nv | Verfahren zur herstellung eines anitibiotkums |
| TW555855B (en) * | 1996-07-26 | 2003-10-01 | Bristol Myers Squibb Co | Synthesis of beta-lactam antibacterials using soluble side chain esters and enzyme acylase |
| JP4833498B2 (ja) * | 2000-10-03 | 2011-12-07 | ミラリ バイオサイエンシズ，インコーポレーテッド | 指向性マイクロ波化学のための方法および組成物 |
| US20040209303A1 (en) * | 2000-10-03 | 2004-10-21 | Martin Mark T. | Methods and compositions for directed microwave chemistry |
| US7348182B2 (en) * | 2000-10-03 | 2008-03-25 | Mirari Biosciences, Inc. | Directed microwave chemistry |
| US20030044884A1 (en) * | 2000-10-11 | 2003-03-06 | Usher John J. | Synthesis of beta-lactam antibacterials using soluble side chain esters and enzyme acylase |
| EP1394262A1 (en) * | 2002-08-30 | 2004-03-03 | Bioferma Murcia, S.A. | An enzymatic process for preparing beta-lactams |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5011475B1 (enExample) * | 1969-10-16 | 1975-05-01 | ||
| JPS5417030B2 (enExample) * | 1972-12-06 | 1979-06-27 | ||
| JPS51133488A (en) * | 1975-05-14 | 1976-11-19 | Shionogi & Co Ltd | Process for producing antibiotics enzymatically |
-
1979
- 1979-09-19 JP JP11926079A patent/JPS5645196A/ja active Pending
-
1980
- 1980-09-18 FR FR8020117A patent/FR2465708A1/fr active Granted
- 1980-09-19 DE DE19803035467 patent/DE3035467A1/de not_active Withdrawn
- 1980-09-19 GB GB8030372A patent/GB2058776B/en not_active Expired
- 1980-09-19 US US06/188,869 patent/US4340672A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5645196A (en) | 1981-04-24 |
| GB2058776A (en) | 1981-04-15 |
| FR2465708B1 (enExample) | 1983-02-18 |
| US4340672A (en) | 1982-07-20 |
| FR2465708A1 (fr) | 1981-03-27 |
| GB2058776B (en) | 1984-02-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8141 | Disposal/no request for examination |