JPS5645196A - Enzymatic synthesis of beta-lactam antibacterial agent - Google Patents

Enzymatic synthesis of beta-lactam antibacterial agent

Info

Publication number
JPS5645196A
JPS5645196A JP11926079A JP11926079A JPS5645196A JP S5645196 A JPS5645196 A JP S5645196A JP 11926079 A JP11926079 A JP 11926079A JP 11926079 A JP11926079 A JP 11926079A JP S5645196 A JPS5645196 A JP S5645196A
Authority
JP
Japan
Prior art keywords
formula
antibacterial agent
lactam antibacterial
beta
enzymatic synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP11926079A
Other languages
English (en)
Inventor
Eiji Kondo
Takashi Mitsuki
Tamio Fujiwara
Tatsunosuke Muneyuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Priority to JP11926079A priority Critical patent/JPS5645196A/ja
Priority to FR8020117A priority patent/FR2465708A1/fr
Priority to US06/188,869 priority patent/US4340672A/en
Priority to GB8030372A priority patent/GB2058776B/en
Priority to DE19803035467 priority patent/DE3035467A1/de
Publication of JPS5645196A publication Critical patent/JPS5645196A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
JP11926079A 1979-09-19 1979-09-19 Enzymatic synthesis of beta-lactam antibacterial agent Pending JPS5645196A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP11926079A JPS5645196A (en) 1979-09-19 1979-09-19 Enzymatic synthesis of beta-lactam antibacterial agent
FR8020117A FR2465708A1 (fr) 1979-09-19 1980-09-18 Procede de synthese de penicillines et de cephalosporines par action d'une amidoacylase, et esters en tant que sources de groupes acyles pour cette synthese
US06/188,869 US4340672A (en) 1979-09-19 1980-09-19 Enzymatic synthesis of β-lactam antibacterials
GB8030372A GB2058776B (en) 1979-09-19 1980-09-19 Esters and their use in the synthesis of -lactam antibacterial compounds
DE19803035467 DE3035467A1 (de) 1979-09-19 1980-09-19 Enzymatisches verfahren zur herstellung von (beta)-lactamantibiotika und acylverbindungen zur durchfuehrung des verfahrens

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11926079A JPS5645196A (en) 1979-09-19 1979-09-19 Enzymatic synthesis of beta-lactam antibacterial agent

Publications (1)

Publication Number Publication Date
JPS5645196A true JPS5645196A (en) 1981-04-24

Family

ID=14756922

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11926079A Pending JPS5645196A (en) 1979-09-19 1979-09-19 Enzymatic synthesis of beta-lactam antibacterial agent

Country Status (5)

Country Link
US (1) US4340672A (ja)
JP (1) JPS5645196A (ja)
DE (1) DE3035467A1 (ja)
FR (1) FR2465708A1 (ja)
GB (1) GB2058776B (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5439806A (en) * 1991-10-07 1995-08-08 Hoechst Aktiengesellschaft Carboxylate protective groups, a process for their preparation, their coupling to a functional group, and their use

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0097888B1 (en) * 1982-06-25 1986-02-26 Merck & Co. Inc. Process for producing thienamycin employing streptromyces cattleya cells immobilized to kieselguhr
ES2036149A6 (es) * 1989-12-12 1993-05-01 Consejo Superior Investigacion Procedimiento de sintesis de antibioticos semiestaticos en sistemas termodinamicamente controlados agua-cosolventes organicos miscibles apolares con el empleo de penicilina g acilasa.
KR100455252B1 (ko) * 1995-12-08 2005-01-15 디에스엠 기스트 베.파우. 항생제제조방법
TW555855B (en) * 1996-07-26 2003-10-01 Bristol Myers Squibb Co Synthesis of beta-lactam antibacterials using soluble side chain esters and enzyme acylase
US20040209303A1 (en) * 2000-10-03 2004-10-21 Martin Mark T. Methods and compositions for directed microwave chemistry
US7348182B2 (en) * 2000-10-03 2008-03-25 Mirari Biosciences, Inc. Directed microwave chemistry
EP1330532B1 (en) * 2000-10-03 2011-12-14 Mirari Biosciences, Inc. Methods and compositions for directed microwave chemistry
US20030044884A1 (en) * 2000-10-11 2003-03-06 Usher John J. Synthesis of beta-lactam antibacterials using soluble side chain esters and enzyme acylase
EP1394262A1 (en) * 2002-08-30 2004-03-03 Bioferma Murcia, S.A. An enzymatic process for preparing beta-lactams

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5011475B1 (ja) * 1969-10-16 1975-05-01
JPS5417030B2 (ja) * 1972-12-06 1979-06-27
JPS51133488A (en) * 1975-05-14 1976-11-19 Shionogi & Co Ltd Process for producing antibiotics enzymatically

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5439806A (en) * 1991-10-07 1995-08-08 Hoechst Aktiengesellschaft Carboxylate protective groups, a process for their preparation, their coupling to a functional group, and their use

Also Published As

Publication number Publication date
FR2465708A1 (fr) 1981-03-27
US4340672A (en) 1982-07-20
GB2058776B (en) 1984-02-29
FR2465708B1 (ja) 1983-02-18
GB2058776A (en) 1981-04-15
DE3035467A1 (de) 1981-04-09

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