DE2946723C2 - Verfahren zur Herstellung von Mikroorganismen enthaltenden Mikrokugeln - Google Patents

Verfahren zur Herstellung von Mikroorganismen enthaltenden Mikrokugeln

Info

Publication number
DE2946723C2
DE2946723C2 DE2946723A DE2946723A DE2946723C2 DE 2946723 C2 DE2946723 C2 DE 2946723C2 DE 2946723 A DE2946723 A DE 2946723A DE 2946723 A DE2946723 A DE 2946723A DE 2946723 C2 DE2946723 C2 DE 2946723C2
Authority
DE
Germany
Prior art keywords
fat
process according
microspheres
dispersion
temperature
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2946723A
Other languages
German (de)
English (en)
Other versions
DE2946723A1 (de
Inventor
Marcel Tolochenaz Bühler
Alfred Orbe Schrenk
Tomaso Lausanne Sozzi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Societe des Produits Nestle SA
Original Assignee
Societe des Produits Nestle SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe des Produits Nestle SA filed Critical Societe des Produits Nestle SA
Publication of DE2946723A1 publication Critical patent/DE2946723A1/de
Application granted granted Critical
Publication of DE2946723C2 publication Critical patent/DE2946723C2/de
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/745—Bifidobacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
DE2946723A 1978-12-05 1979-11-20 Verfahren zur Herstellung von Mikroorganismen enthaltenden Mikrokugeln Expired DE2946723C2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1239278A CH637297A5 (fr) 1978-12-05 1978-12-05 Microbille comprenant un microorganisme et son procede de fabrication.

Publications (2)

Publication Number Publication Date
DE2946723A1 DE2946723A1 (de) 1980-06-19
DE2946723C2 true DE2946723C2 (de) 1987-04-09

Family

ID=4382571

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2946723A Expired DE2946723C2 (de) 1978-12-05 1979-11-20 Verfahren zur Herstellung von Mikroorganismen enthaltenden Mikrokugeln

Country Status (10)

Country Link
US (1) US4332790A (fr)
AU (1) AU526326B2 (fr)
BE (1) BE880027A (fr)
CH (1) CH637297A5 (fr)
DE (1) DE2946723C2 (fr)
ES (1) ES486575A1 (fr)
FR (2) FR2443247A1 (fr)
IT (1) IT1164075B (fr)
MX (1) MX6497E (fr)
SE (1) SE447540B (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004004030A1 (de) * 2004-01-27 2005-08-18 Mars Inc. Nahrungsmittelerzeugnis und Verfahren zu dessen Herstellung
DE102012008271A1 (de) 2012-04-23 2013-10-24 Human Nutrition Gmbh Kleingebäck zur Unterstützung der Gewichtsreduktion

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US5597564A (en) * 1986-08-28 1997-01-28 Enzacor Properties Limited Method of administering a microgranular preparation to the intestinal region of animals
US5356625A (en) * 1986-08-28 1994-10-18 Enzacor Properties Limited Microgranular preparation useful in the delivery of biologically active materials to the intestinal regions of animals
US6024983A (en) * 1986-10-24 2000-02-15 Southern Research Institute Composition for delivering bioactive agents for immune response and its preparation
AU640349B2 (en) * 1988-08-02 1993-08-26 Borody, Thomas J Dr Treatment of gastro-intestinal disorders
EP0433299B1 (fr) * 1988-08-02 1998-05-06 Gastro Services Pty. Limited (ACN 002 994 890) Traitement de troubles gastro-intestinaux
US5443826A (en) * 1988-08-02 1995-08-22 Borody; Thomas J. Treatment of gastro-intestinal disorders with a fecal composition or a composition of bacteroides and E. Coli
EP0550436A1 (fr) * 1989-11-06 1993-07-14 Alkermes Controlled Therapeutics, Inc. Microspheres de proteines et leurs procedes d'utilisation
US5213810A (en) * 1990-03-30 1993-05-25 American Cyanamid Company Stable compositions for parenteral administration and method of making same
JP2573892B2 (ja) * 1990-12-31 1997-01-22 パイオニア ハイ−ブレッド インターナショナル，インコーポレイテッド 回転ディスクミクロカプセル化法により得た、脂肪酸をカプセル化剤とする乾燥菌体
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US5599556A (en) * 1991-12-31 1997-02-04 Abbott Laboratories Prolamine coatings for taste masking
DE69223615T2 (de) * 1992-07-06 1998-04-09 Nestle Sa Lactobacillus Acidophilus enthaltende Antigastritis-Mittel
DK0768375T4 (da) * 1992-07-06 2002-09-16 Nestle Sa Mælkesyrebakterier
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US5733568A (en) * 1993-12-03 1998-03-31 Lafor Laboratories Limited Micro-encapsulated lactobacilli for medical applications
EP0858267A1 (fr) * 1995-11-02 1998-08-19 Ed. Haas Nährmittel Gesellschaft m.b.H. Formulations a effet probiotique
ATE298363T1 (de) * 1996-07-09 2005-07-15 Nestle Sa Verfahren zur sprühtrocknung
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US20020035071A1 (en) * 1997-07-08 2002-03-21 Josef Pitha Mimicking the metabolic effects of caloric restriction by administration of glucose antimetabolites
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NZ523741A (en) * 2000-06-26 2004-10-29 Martek Biosciences Corp Improved methods of incorporating polyunsaturated fatty acids in milk
AUPQ899700A0 (en) 2000-07-25 2000-08-17 Borody, Thomas Julius Probiotic recolonisation therapy
US20050266069A1 (en) * 2002-09-06 2005-12-01 Simmons Donald L Stable probiotic microsphere compositions and their methods of preparation
US7517681B2 (en) * 2003-01-29 2009-04-14 Biogaia Ab Selection and use of lactic acid bacteria for reducing dental caries and bacteria causing dental caries
US20050100559A1 (en) * 2003-11-07 2005-05-12 The Procter & Gamble Company Stabilized compositions comprising a probiotic
US8877178B2 (en) * 2003-12-19 2014-11-04 The Iams Company Methods of use of probiotic bifidobacteria for companion animals
US7785635B1 (en) 2003-12-19 2010-08-31 The Procter & Gamble Company Methods of use of probiotic lactobacilli for companion animals
US8894991B2 (en) * 2003-12-19 2014-11-25 The Iams Company Canine probiotic Lactobacilli
US20050158294A1 (en) * 2003-12-19 2005-07-21 The Procter & Gamble Company Canine probiotic Bifidobacteria pseudolongum
US20050152884A1 (en) * 2003-12-19 2005-07-14 The Procter & Gamble Company Canine probiotic Bifidobacteria globosum
JP4938006B2 (ja) * 2005-05-31 2012-05-23 ザ・アイムス・カンパニー ネコ科動物プロバイオティク・ビフィドバクテリア
JP4938005B2 (ja) * 2005-05-31 2012-05-23 ザ・アイムス・カンパニー ネコ科動物プロバイオティックであるラクトバシラス
US8221809B2 (en) * 2006-06-22 2012-07-17 Martek Biosciences Corporation Encapsulated labile compound compositions and methods of making the same
WO2008093303A2 (fr) 2007-02-01 2008-08-07 The Iams Company Procédé de réduction de l'inflammation et du stress chez un mammifère
BE1018007A5 (fr) * 2008-02-21 2010-03-02 Van Lidth De Jeude Jehan Lienart Enrobage de microorganismes.
US9771199B2 (en) 2008-07-07 2017-09-26 Mars, Incorporated Probiotic supplement, process for making, and packaging
AU2010209436A1 (en) * 2009-01-27 2011-08-18 Probiotical S.P.A. Chocolate flavoured probiotic supplement
IT1400821B1 (it) * 2009-03-09 2013-07-02 Probiotical Spa Sospensione oleosa contenente batteri probiotici per uso pediatrico
ES2382263T3 (es) 2009-05-11 2012-06-06 Nestec S.A. Prevención y tratamiento de la diarrea alérgica
US10104903B2 (en) 2009-07-31 2018-10-23 Mars, Incorporated Animal food and its appearance
TR201807143T4 (tr) 2009-08-25 2018-06-21 Nestec Sa Bifidobacterium longum ve fonksiyonel gastrointestinal bozukluklar.
IT1398648B1 (it) * 2010-03-09 2013-03-08 Probiotical Spa Prodotto alimentare comprendente batteri probiotici rivestiti con un rivestimento di origine vegetale.
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IT1403661B1 (it) 2011-01-28 2013-10-31 Probiotical Spa Composizione effervescente in forma solida per uso in applicazioni vaginali per il trattamento di infezioni vaginali.
BR112013022927A2 (pt) 2011-03-09 2016-12-06 Univ Minnesota composição, métodos para substituir ou suplementar ou modificar uma microbiota do cólon de um sujeito, e para tratar um sujeito, e, uso de uma composição
WO2012123770A1 (fr) * 2011-03-17 2012-09-20 Probiotical S.P.A. Bactéries probiotiques ayant une activité antioxydante et leur utilisation
ITMI20110792A1 (it) 2011-05-09 2012-11-10 Probiotical Spa Ceppi di batteri appartenenti al genere bifidobacterium per uso nel trattamento della ipercolesterolemia.
ITMI20110791A1 (it) 2011-05-09 2012-11-10 Probiotical Spa Ceppi di batteri in grado di metabolizzare gli ossalati.
ITMI20110793A1 (it) 2011-05-09 2012-11-10 Probiotical Spa Ceppi di batteri probiotici e composizione sinbiotica contenente gli stessi destinata alla alimentazione dei neonati.
ITRM20110477A1 (it) 2011-09-09 2013-03-10 Giovanni Mogna Composizione comprendente n-acetilcisteina e/o lisozima microincapsulato gastroprotetto in associazione con batteri probiotici in grado di ripristinare l'effetto barriera proprio dello stomaco che viene perso durante il trattamento farmacologico dell
ITMI20111718A1 (it) 2011-09-23 2013-03-24 Probiotical Spa Un materiale impermeabile alla umidita e allo ossigeno per confezionare prodotti dietetici, cosmetici e specialita medicinali.
WO2013176774A1 (fr) 2012-05-25 2013-11-28 Arizona Board Of Regents Marqueurs de microbiome et thérapies pour troubles du spectre autistique
CN103690490B (zh) * 2012-08-23 2017-11-17 尼奥克斯(文莱)控股有限公司 基于微囊化化学试剂延时产生一氧化氮的系统和方法
ITMI20130793A1 (it) 2013-05-14 2014-11-15 Probiotical Spa Composizione comprendente batteri lattici per uso nel trattamento preventivo e/o curativo delle cistiti ricorrenti.
WO2016183577A1 (fr) 2015-05-14 2016-11-17 Crestovo Llc Compositions permettant la transplantation de flore fécale et méthodes de préparation et d'utilisation de ces dernières, et dispositifs pour leur administration
ES2909456T3 (es) 2015-05-22 2022-05-06 Univ Arizona State Métodos para tratar el trastorno del espectro autista y síntomas asociados
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US11213549B2 (en) 2016-10-11 2022-01-04 Finch Therapeutics Holdings Llc Compositions and method for treating primary sclerosing cholangitis and related disorders
US10092601B2 (en) 2016-10-11 2018-10-09 Crestovo Holdings Llc Compositions and methods for treating multiple sclerosis and related disorders
US11026978B2 (en) 2016-10-11 2021-06-08 Finch Therapeutics Holdings Llc Compositions and methods for treating multiple sclerosis and related disorders
WO2018187464A1 (fr) 2017-04-05 2018-10-11 Crestovo Holdings Llc Compositions et méthodes pour traiter la diverticulite et des troubles associés
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004004030A1 (de) * 2004-01-27 2005-08-18 Mars Inc. Nahrungsmittelerzeugnis und Verfahren zu dessen Herstellung
DE102012008271A1 (de) 2012-04-23 2013-10-24 Human Nutrition Gmbh Kleingebäck zur Unterstützung der Gewichtsreduktion

Also Published As

Publication number Publication date
FR2443279B1 (fr) 1984-04-06
FR2443247B1 (fr) 1983-04-29
IT7950976A0 (it) 1979-12-03
DE2946723A1 (de) 1980-06-19
BE880027A (fr) 1980-05-14
SE447540B (sv) 1986-11-24
CH637297A5 (fr) 1983-07-29
US4332790A (en) 1982-06-01
MX6497E (es) 1985-06-21
IT1164075B (it) 1987-04-08
SE7909492L (sv) 1980-06-06
ES486575A1 (es) 1980-10-01
FR2443247A1 (fr) 1980-07-04
AU526326B2 (en) 1983-01-06
AU5329879A (en) 1980-07-10
FR2443279A1 (fr) 1980-07-04

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