DE2946723C2 - Verfahren zur Herstellung von Mikroorganismen enthaltenden Mikrokugeln - Google Patents

Verfahren zur Herstellung von Mikroorganismen enthaltenden Mikrokugeln

Info

Publication number
DE2946723C2
DE2946723C2 DE2946723A DE2946723A DE2946723C2 DE 2946723 C2 DE2946723 C2 DE 2946723C2 DE 2946723 A DE2946723 A DE 2946723A DE 2946723 A DE2946723 A DE 2946723A DE 2946723 C2 DE2946723 C2 DE 2946723C2
Authority
DE
Germany
Prior art keywords
fat
process according
microspheres
dispersion
temperature
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2946723A
Other languages
German (de)
English (en)
Other versions
DE2946723A1 (de
Inventor
Marcel Tolochenaz Bühler
Alfred Orbe Schrenk
Tomaso Lausanne Sozzi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Societe des Produits Nestle SA
Original Assignee
Societe des Produits Nestle SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe des Produits Nestle SA filed Critical Societe des Produits Nestle SA
Publication of DE2946723A1 publication Critical patent/DE2946723A1/de
Application granted granted Critical
Publication of DE2946723C2 publication Critical patent/DE2946723C2/de
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/745—Bifidobacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
DE2946723A 1978-12-05 1979-11-20 Verfahren zur Herstellung von Mikroorganismen enthaltenden Mikrokugeln Expired DE2946723C2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1239278A CH637297A5 (fr) 1978-12-05 1978-12-05 Microbille comprenant un microorganisme et son procede de fabrication.

Publications (2)

Publication Number Publication Date
DE2946723A1 DE2946723A1 (de) 1980-06-19
DE2946723C2 true DE2946723C2 (de) 1987-04-09

Family

ID=4382571

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2946723A Expired DE2946723C2 (de) 1978-12-05 1979-11-20 Verfahren zur Herstellung von Mikroorganismen enthaltenden Mikrokugeln

Country Status (10)

Country Link
US (1) US4332790A ( )
AU (1) AU526326B2 ( )
BE (1) BE880027A ( )
CH (1) CH637297A5 ( )
DE (1) DE2946723C2 ( )
ES (1) ES486575A1 ( )
FR (2) FR2443247A1 ( )
IT (1) IT1164075B ( )
MX (1) MX6497E ( )
SE (1) SE447540B ( )

Cited By (2)

* Cited by examiner, † Cited by third party
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DE102004004030A1 (de) * 2004-01-27 2005-08-18 Mars Inc. Nahrungsmittelerzeugnis und Verfahren zu dessen Herstellung
DE102012008271A1 (de) 2012-04-23 2013-10-24 Human Nutrition Gmbh Kleingebäck zur Unterstützung der Gewichtsreduktion

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US5356625A (en) * 1986-08-28 1994-10-18 Enzacor Properties Limited Microgranular preparation useful in the delivery of biologically active materials to the intestinal regions of animals
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US5443826A (en) 1988-08-02 1995-08-22 Borody; Thomas J. Treatment of gastro-intestinal disorders with a fecal composition or a composition of bacteroides and E. Coli
DE68928665T2 (de) * 1988-08-02 1998-11-12 Gastro Services Pty Ltd Behandlung von gastro-intestinalen krankheiten
EP0550436A1 (en) * 1989-11-06 1993-07-14 Alkermes Controlled Therapeutics, Inc. Protein microspheres and methods of using them
US5213810A (en) * 1990-03-30 1993-05-25 American Cyanamid Company Stable compositions for parenteral administration and method of making same
US5292657A (en) * 1990-12-31 1994-03-08 Pioneer Hi-Bred International, Inc. Process for preparing rotary disc fatty acid microspheres of microorganisms
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DE69223615T2 (de) * 1992-07-06 1998-04-09 Nestle Sa Lactobacillus Acidophilus enthaltende Antigastritis-Mittel
EP0654273A1 (en) * 1993-11-18 1995-05-24 Harry H. Leveen Pharmaceutical product and method for treatment
US5733568A (en) * 1993-12-03 1998-03-31 Lafor Laboratories Limited Micro-encapsulated lactobacilli for medical applications
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DK0818529T3 (da) * 1996-07-09 2005-10-17 Nestle Sa Fremgangsmåde til spraytörring
US20020035071A1 (en) * 1997-07-08 2002-03-21 Josef Pitha Mimicking the metabolic effects of caloric restriction by administration of glucose antimetabolites
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US20050266069A1 (en) * 2002-09-06 2005-12-01 Simmons Donald L Stable probiotic microsphere compositions and their methods of preparation
US7517681B2 (en) * 2003-01-29 2009-04-14 Biogaia Ab Selection and use of lactic acid bacteria for reducing dental caries and bacteria causing dental caries
US20050100559A1 (en) * 2003-11-07 2005-05-12 The Procter & Gamble Company Stabilized compositions comprising a probiotic
US20050152884A1 (en) * 2003-12-19 2005-07-14 The Procter & Gamble Company Canine probiotic Bifidobacteria globosum
US8894991B2 (en) 2003-12-19 2014-11-25 The Iams Company Canine probiotic Lactobacilli
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US20050158294A1 (en) * 2003-12-19 2005-07-21 The Procter & Gamble Company Canine probiotic Bifidobacteria pseudolongum
US8877178B2 (en) * 2003-12-19 2014-11-04 The Iams Company Methods of use of probiotic bifidobacteria for companion animals
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US8221809B2 (en) * 2006-06-22 2012-07-17 Martek Biosciences Corporation Encapsulated labile compound compositions and methods of making the same
JP5799299B2 (ja) 2007-02-01 2015-10-21 ザ・アイムス・カンパニーＴｈｅ Ｉａｍｓ Ｃｏｍｐａｎｙ ブドウ糖代謝拮抗物質、アボカド又はアボカド抽出物を使用する、哺乳動物における炎症及びストレスの低下方法
BE1018007A5 (fr) * 2008-02-21 2010-03-02 Van Lidth De Jeude Jehan Lienart Enrobage de microorganismes.
US9771199B2 (en) 2008-07-07 2017-09-26 Mars, Incorporated Probiotic supplement, process for making, and packaging
SI2381799T1 (sl) * 2009-01-27 2018-12-31 Probiotical S.P.A. Probiotični dodatek z okusom čokolade
IT1400821B1 (it) * 2009-03-09 2013-07-02 Probiotical Spa Sospensione oleosa contenente batteri probiotici per uso pediatrico
ATE546149T1 (de) 2009-05-11 2012-03-15 Nestec Sa Prävention und behandlung von allergischer diarrhöe
US10104903B2 (en) 2009-07-31 2018-10-23 Mars, Incorporated Animal food and its appearance
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MX344831B (es) 2010-08-04 2017-01-04 Borody Thomas J Composiciones para el transplante floral fecal y metodos para elaborar y utilzar las mismas y dispositivos para suministrar las mismas.
IT1403661B1 (it) 2011-01-28 2013-10-31 Probiotical Spa Composizione effervescente in forma solida per uso in applicazioni vaginali per il trattamento di infezioni vaginali.
EP4129312A1 (en) 2011-03-09 2023-02-08 Regents Of The University Of Minnesota Compositions and methods for transplantation of colon microbiota
PL2685994T3 (pl) * 2011-03-17 2016-05-31 Probiotical Spa Bakterie probiotyczne wykazujące aktywność przeciwutleniającą i ich zastosowanie
ITMI20110791A1 (it) 2011-05-09 2012-11-10 Probiotical Spa Ceppi di batteri in grado di metabolizzare gli ossalati.
ITMI20110792A1 (it) 2011-05-09 2012-11-10 Probiotical Spa Ceppi di batteri appartenenti al genere bifidobacterium per uso nel trattamento della ipercolesterolemia.
ITMI20110793A1 (it) 2011-05-09 2012-11-10 Probiotical Spa Ceppi di batteri probiotici e composizione sinbiotica contenente gli stessi destinata alla alimentazione dei neonati.
ITRM20110477A1 (it) 2011-09-09 2013-03-10 Giovanni Mogna Composizione comprendente n-acetilcisteina e/o lisozima microincapsulato gastroprotetto in associazione con batteri probiotici in grado di ripristinare l'effetto barriera proprio dello stomaco che viene perso durante il trattamento farmacologico dell
ITMI20111718A1 (it) 2011-09-23 2013-03-24 Probiotical Spa Un materiale impermeabile alla umidita e allo ossigeno per confezionare prodotti dietetici, cosmetici e specialita medicinali.
US9719144B2 (en) 2012-05-25 2017-08-01 Arizona Board Of Regents Microbiome markers and therapies for autism spectrum disorders
CN103622917B (zh) * 2012-08-23 2017-12-29 尼奥克斯(文莱)控股有限公司 基于微囊化亚硝酸盐和酸化水凝胶的延时产生一氧化氮的系统和方法
ITMI20130793A1 (it) 2013-05-14 2014-11-15 Probiotical Spa Composizione comprendente batteri lattici per uso nel trattamento preventivo e/o curativo delle cistiti ricorrenti.
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KR102358879B1 (ko) 2015-05-22 2022-02-08 아리조나 보드 오브 리젠츠 온 비하프 오브 아리조나 스테이트 유니버시티 자폐 스펙트럼 장애 및 관련된 증상을 치료하는 방법
US20170360848A1 (en) 2016-06-15 2017-12-21 Arizona Board Of Regents On Behalf Of Arizona State University Methods for treating autism spectrum disorder and associated symptoms
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004004030A1 (de) * 2004-01-27 2005-08-18 Mars Inc. Nahrungsmittelerzeugnis und Verfahren zu dessen Herstellung
DE102012008271A1 (de) 2012-04-23 2013-10-24 Human Nutrition Gmbh Kleingebäck zur Unterstützung der Gewichtsreduktion

Also Published As

Publication number Publication date
AU5329879A (en) 1980-07-10
IT1164075B (it) 1987-04-08
DE2946723A1 (de) 1980-06-19
FR2443279A1 (fr) 1980-07-04
CH637297A5 (fr) 1983-07-29
FR2443247B1 ( ) 1983-04-29
US4332790A (en) 1982-06-01
BE880027A (fr) 1980-05-14
FR2443247A1 (fr) 1980-07-04
FR2443279B1 ( ) 1984-04-06
IT7950976A0 (it) 1979-12-03
SE447540B (sv) 1986-11-24
SE7909492L (sv) 1980-06-06
AU526326B2 (en) 1983-01-06
MX6497E (es) 1985-06-21
ES486575A1 (es) 1980-10-01

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