DE2916711A1 - Blutgerinnungsfaktoren und verfahren zu ihrer herstellung - Google Patents
Blutgerinnungsfaktoren und verfahren zu ihrer herstellungInfo
- Publication number
- DE2916711A1 DE2916711A1 DE19792916711 DE2916711A DE2916711A1 DE 2916711 A1 DE2916711 A1 DE 2916711A1 DE 19792916711 DE19792916711 DE 19792916711 DE 2916711 A DE2916711 A DE 2916711A DE 2916711 A1 DE2916711 A1 DE 2916711A1
- Authority
- DE
- Germany
- Prior art keywords
- solution
- factor
- fibrinogen
- factor viii
- plasma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 238000000034 method Methods 0.000 title claims abstract description 60
- 102000015081 Blood Coagulation Factors Human genes 0.000 title claims abstract description 20
- 108010039209 Blood Coagulation Factors Proteins 0.000 title claims abstract description 20
- 239000003114 blood coagulation factor Substances 0.000 title claims abstract description 20
- 230000008569 process Effects 0.000 title abstract description 15
- 238000004519 manufacturing process Methods 0.000 title description 17
- 229940019700 blood coagulation factors Drugs 0.000 title description 6
- 108010051456 Plasminogen Proteins 0.000 claims abstract description 25
- 102000013566 Plasminogen Human genes 0.000 claims abstract description 25
- 102000004411 Antithrombin III Human genes 0.000 claims abstract description 22
- 108090000935 Antithrombin III Proteins 0.000 claims abstract description 22
- 229960005348 antithrombin iii Drugs 0.000 claims abstract description 22
- 230000000087 stabilizing effect Effects 0.000 claims abstract description 9
- 239000000243 solution Substances 0.000 claims description 79
- 108010054218 Factor VIII Proteins 0.000 claims description 52
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 52
- 102000001690 Factor VIII Human genes 0.000 claims description 51
- 108010071289 Factor XIII Proteins 0.000 claims description 29
- 239000004471 Glycine Substances 0.000 claims description 26
- 108010094028 Prothrombin Proteins 0.000 claims description 22
- 150000001413 amino acids Chemical class 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 12
- 239000007864 aqueous solution Substances 0.000 claims description 9
- UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 claims description 8
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- 229940000635 beta-alanine Drugs 0.000 claims description 4
- 229920001542 oligosaccharide Polymers 0.000 claims description 4
- 150000002482 oligosaccharides Chemical class 0.000 claims description 4
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 claims description 2
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims description 2
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims description 2
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- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims description 2
- 229960002743 glutamine Drugs 0.000 claims description 2
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- OQEBBZSWEGYTPG-UHFFFAOYSA-N 3-aminobutanoic acid Chemical compound CC(N)CC(O)=O OQEBBZSWEGYTPG-UHFFFAOYSA-N 0.000 claims 2
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- 229960003692 gamma aminobutyric acid Drugs 0.000 claims 1
- 238000002360 preparation method Methods 0.000 abstract description 34
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- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 14
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- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 12
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 12
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 12
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- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 10
- 102000009123 Fibrin Human genes 0.000 description 10
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- DZBUGLKDJFMEHC-UHFFFAOYSA-N acridine Chemical compound C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 description 8
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- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
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- C12N9/6424—Serine endopeptidases (3.4.21)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
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- C12Y—ENZYMES
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- C12Y—ENZYMES
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- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y10S530/83—Plasma; serum
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Molecular Biology (AREA)
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- Microbiology (AREA)
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- Biophysics (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
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- Virology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Compounds Of Unknown Constitution (AREA)
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Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19792916711 DE2916711A1 (de) | 1979-04-25 | 1979-04-25 | Blutgerinnungsfaktoren und verfahren zu ihrer herstellung |
| ES490682A ES490682A0 (es) | 1979-04-25 | 1980-04-18 | Procedimiento para la estabilizacion de los factores de coa-gulacion ii,viii,xiii y antitrombina iii |
| DE8080102105T DE3071773D1 (en) | 1979-04-25 | 1980-04-18 | Process for the stabilization of blood clotting factors |
| EP80102105A EP0018561B1 (de) | 1979-04-25 | 1980-04-18 | Verfahren zur Stabilisierung von Blutgerinnungsfaktoren |
| AT80102105T ATE22396T1 (de) | 1979-04-25 | 1980-04-18 | Verfahren zur stabilisierung von blutgerinnungsfaktoren. |
| US06/142,962 US4297344A (en) | 1979-04-25 | 1980-04-23 | Blood coagulation factors and process for their manufacture |
| IL59924A IL59924A (en) | 1979-04-25 | 1980-04-24 | Process for stabilizing blood coagulation factors |
| DK176280A DK155568C (da) | 1979-04-25 | 1980-04-24 | Fremgangsmaade til stabilisering af koagulationsfaktorerne ii, viii, xiii og antithrombin iii samt plasminogen, og saaledes at disse er fibrinogen-fri og fri for risiko for en hepatitis-overfoering |
| JP5609880A JPS55145615A (en) | 1979-04-25 | 1980-04-25 | Blood coagulation factor and its manufacture |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19792916711 DE2916711A1 (de) | 1979-04-25 | 1979-04-25 | Blutgerinnungsfaktoren und verfahren zu ihrer herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2916711A1 true DE2916711A1 (de) | 1980-11-06 |
Family
ID=6069217
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19792916711 Ceased DE2916711A1 (de) | 1979-04-25 | 1979-04-25 | Blutgerinnungsfaktoren und verfahren zu ihrer herstellung |
| DE8080102105T Expired DE3071773D1 (en) | 1979-04-25 | 1980-04-18 | Process for the stabilization of blood clotting factors |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8080102105T Expired DE3071773D1 (en) | 1979-04-25 | 1980-04-18 | Process for the stabilization of blood clotting factors |
Country Status (8)
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1982003871A1 (en) * | 1981-04-27 | 1982-11-11 | Baxter Travenol Lab | Process for making novel blood clotting enzyme compositions |
| WO1982004395A1 (en) * | 1981-06-18 | 1982-12-23 | Erik Gustaf Birger Blombaeck | A process in purification and concentration of the factor viii complex |
| US4640834A (en) * | 1984-03-09 | 1987-02-03 | Immuno Aktiengesellschaft Fur Chemisch-Medizinische Produkte | Method of inactivating reproducible filterable pathogens in blood products as well as a method of producing blood products |
| DE3602688A1 (de) * | 1986-01-30 | 1987-08-06 | Behringwerke Ag | Verfahren zur gewinnung und herstellung eines pasteurisierten praeparates von (alpha)(pfeil abwaerts)2(pfeil abwaerts)-antiplasmin |
| EP0286198B1 (en) * | 1981-04-27 | 1994-12-14 | BAXTER INTERNATIONAL INC. (a Delaware corporation) | Blood clotting enzyme compositions |
| US5410022A (en) * | 1992-04-24 | 1995-04-25 | Immuno Aktiengesellschaft | Method of producing a factor VIII preparation |
| LT3419B (en) | 1990-07-03 | 1995-09-25 | Centre Regional De Transfusion | Composition for stabilizing blood plasma during pasteurization, method of pasteurization and plasma preparing by this method |
| US5614405A (en) * | 1991-06-20 | 1997-03-25 | Immuno Aktiengesellschaft | Method of determining the virus inactivation capacity of an inactivation treatment |
| US5614493A (en) * | 1993-06-18 | 1997-03-25 | Immuno Ag | Use of human protein C for prevention and treatment of depositions of thrombocytes |
| US5639730A (en) * | 1992-12-16 | 1997-06-17 | Immuno Aktiengesellschaft | Method of producing a virus-safe biological preparation |
| AT402788B (de) * | 1993-08-03 | 1997-08-25 | Immuno Ag | Virussichere blutgerinnungsfaktor xiii-präparation |
| US5733884A (en) | 1995-11-07 | 1998-03-31 | Nestec Ltd. | Enteral formulation designed for optimized wound healing |
| EP0844254A3 (en) * | 1996-11-20 | 1999-05-12 | The Green Cross Corporation | Method for producing antithrombin-III, method for purifying it, and preparation containing it |
| US6737405B2 (en) | 2000-05-08 | 2004-05-18 | Aventis Behring Gmbh | Stabilized protein preparation and process for its preparation |
| US7084250B2 (en) | 2000-01-28 | 2006-08-01 | Sanofi-Aventis Deutschland Gmbh | Process for the preparation of acetyl-amidiniophenylalanyl-cyclohexylglycyl-pyridinioalaninamides |
| WO2010052879A1 (ja) | 2008-11-04 | 2010-05-14 | あすか製薬株式会社 | 卵胞刺激ホルモン含有水性組成物 |
| RU2556804C2 (ru) * | 2013-12-17 | 2015-07-20 | Федеральное государственное бюджетное учреждение Гематологический научный центр Министерства здравоохранения РФ | Способ получения концентрата фибриногена |
Families Citing this family (125)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0035204B2 (en) * | 1980-03-05 | 1991-05-22 | Miles Inc. | Pasteurized therapeutically active protein compositions |
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| US4640834A (en) * | 1984-03-09 | 1987-02-03 | Immuno Aktiengesellschaft Fur Chemisch-Medizinische Produkte | Method of inactivating reproducible filterable pathogens in blood products as well as a method of producing blood products |
| DE3602688A1 (de) * | 1986-01-30 | 1987-08-06 | Behringwerke Ag | Verfahren zur gewinnung und herstellung eines pasteurisierten praeparates von (alpha)(pfeil abwaerts)2(pfeil abwaerts)-antiplasmin |
| LT3419B (en) | 1990-07-03 | 1995-09-25 | Centre Regional De Transfusion | Composition for stabilizing blood plasma during pasteurization, method of pasteurization and plasma preparing by this method |
| US5614405A (en) * | 1991-06-20 | 1997-03-25 | Immuno Aktiengesellschaft | Method of determining the virus inactivation capacity of an inactivation treatment |
| US5864016A (en) * | 1991-06-20 | 1999-01-26 | Immuno Aktiengesellschaft | Blood product, a method of producing the same and a method of determining the virus inactivation capacity of an inactivation treatment |
| US5410022A (en) * | 1992-04-24 | 1995-04-25 | Immuno Aktiengesellschaft | Method of producing a factor VIII preparation |
| US5639730A (en) * | 1992-12-16 | 1997-06-17 | Immuno Aktiengesellschaft | Method of producing a virus-safe biological preparation |
| US5733885A (en) * | 1992-12-16 | 1998-03-31 | Immuno Aktiengesellschaft | Method of producing a virus-safe biological preparation |
| US5614493A (en) * | 1993-06-18 | 1997-03-25 | Immuno Ag | Use of human protein C for prevention and treatment of depositions of thrombocytes |
| AT402788B (de) * | 1993-08-03 | 1997-08-25 | Immuno Ag | Virussichere blutgerinnungsfaktor xiii-präparation |
| US5733884A (en) | 1995-11-07 | 1998-03-31 | Nestec Ltd. | Enteral formulation designed for optimized wound healing |
| EP0844254A3 (en) * | 1996-11-20 | 1999-05-12 | The Green Cross Corporation | Method for producing antithrombin-III, method for purifying it, and preparation containing it |
| US7084250B2 (en) | 2000-01-28 | 2006-08-01 | Sanofi-Aventis Deutschland Gmbh | Process for the preparation of acetyl-amidiniophenylalanyl-cyclohexylglycyl-pyridinioalaninamides |
| US6737405B2 (en) | 2000-05-08 | 2004-05-18 | Aventis Behring Gmbh | Stabilized protein preparation and process for its preparation |
| WO2010052879A1 (ja) | 2008-11-04 | 2010-05-14 | あすか製薬株式会社 | 卵胞刺激ホルモン含有水性組成物 |
| US8329649B2 (en) | 2008-11-04 | 2012-12-11 | Aska Pharmaceutical Co., Ltd. | Aqueous composition containing follicle-stimulating hormone and histidine |
| RU2556804C2 (ru) * | 2013-12-17 | 2015-07-20 | Федеральное государственное бюджетное учреждение Гематологический научный центр Министерства здравоохранения РФ | Способ получения концентрата фибриногена |
Also Published As
| Publication number | Publication date |
|---|---|
| IL59924A (en) | 1983-06-15 |
| DE3071773D1 (en) | 1986-10-30 |
| JPS6254286B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1987-11-13 |
| JPS55145615A (en) | 1980-11-13 |
| EP0018561A2 (de) | 1980-11-12 |
| DK176280A (da) | 1980-10-26 |
| IL59924A0 (en) | 1980-06-30 |
| ES8100884A1 (es) | 1980-12-01 |
| EP0018561B1 (de) | 1986-09-24 |
| DK155568B (da) | 1989-04-24 |
| DK155568C (da) | 1989-10-09 |
| ATE22396T1 (de) | 1986-10-15 |
| US4297344A (en) | 1981-10-27 |
| ES490682A0 (es) | 1980-12-01 |
| EP0018561A3 (en) | 1981-10-21 |
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|---|---|---|---|
| 8110 | Request for examination paragraph 44 | ||
| 8131 | Rejection |