DE2905877A1 - Neue aminopropanolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel - Google Patents

Neue aminopropanolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Info

Publication number
DE2905877A1
DE2905877A1 DE19792905877 DE2905877A DE2905877A1 DE 2905877 A1 DE2905877 A1 DE 2905877A1 DE 19792905877 DE19792905877 DE 19792905877 DE 2905877 A DE2905877 A DE 2905877A DE 2905877 A1 DE2905877 A1 DE 2905877A1
Authority
DE
Germany
Prior art keywords
deep
group
radical
hydrogen
propoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19792905877
Other languages
German (de)
English (en)
Inventor
Wolfgang Dr Med Bartsch
Karl Prof Dr Med Dietmann
Walter-Gunar Dr Rer Nat Friebe
Helmut Michel
Carl Heinz Dr Rer Nat Ross
Fritz Dr Phil Wiedemann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Priority to DE19792905877 priority Critical patent/DE2905877A1/de
Priority to US06/117,190 priority patent/US4346093A/en
Priority to CA000345099A priority patent/CA1134827A/en
Priority to IL59352A priority patent/IL59352A/xx
Priority to FI800408A priority patent/FI66371C/fi
Priority to AU55410/80A priority patent/AU531282B2/en
Priority to SU802878004A priority patent/SU1243622A3/ru
Priority to DD80219037A priority patent/DD148774A5/de
Priority to AT80100719T priority patent/ATE2190T1/de
Priority to EP80100719A priority patent/EP0014951B1/de
Priority to DE8080100719T priority patent/DE3061555D1/de
Priority to CS801055A priority patent/CS227305B2/cs
Priority to DK65380A priority patent/DK65380A/da
Priority to HU80350A priority patent/HU184719B/hu
Priority to ZA00800894A priority patent/ZA80894B/xx
Priority to ES488657A priority patent/ES488657A1/es
Priority to JP1671180A priority patent/JPS55120559A/ja
Publication of DE2905877A1 publication Critical patent/DE2905877A1/de
Priority to CS806605A priority patent/CS227313B2/cs
Priority to CS806604A priority patent/CS227312B2/cs
Priority to CS814336A priority patent/CS227327B2/cs
Priority to HK44/86A priority patent/HK4486A/xx
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D249/18—Benzotriazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Indole Compounds (AREA)
DE19792905877 1979-02-16 1979-02-16 Neue aminopropanolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel Withdrawn DE2905877A1 (de)

Priority Applications (21)

Application Number Priority Date Filing Date Title
DE19792905877 DE2905877A1 (de) 1979-02-16 1979-02-16 Neue aminopropanolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US06/117,190 US4346093A (en) 1979-02-16 1980-01-31 Heterocyclic oxypropanolamine compounds and pharmaceutical compositions
CA000345099A CA1134827A (en) 1979-02-16 1980-02-05 Heterocyclic oxypropanolamine derivatives
IL59352A IL59352A (en) 1979-02-16 1980-02-10 Heterocyclic oxypropanolamine derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
FI800408A FI66371C (fi) 1979-02-16 1980-02-11 Foerfarande foer framstaellning av heterocykliska oxipropanolaminderivater
AU55410/80A AU531282B2 (en) 1979-02-16 1980-02-11 Heterocyclic oxypropanolamine derivatives
SU802878004A SU1243622A3 (ru) 1979-02-16 1980-02-11 Способ получени производных аминопропанола или их солей
DD80219037A DD148774A5 (de) 1979-02-16 1980-02-13 Verfahren zur herstellung von aminopropanolderivaten
AT80100719T ATE2190T1 (de) 1979-02-16 1980-02-13 Heterocyclische oxypropanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel.
EP80100719A EP0014951B1 (de) 1979-02-16 1980-02-13 Heterocyclische Oxypropanolamin-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE8080100719T DE3061555D1 (en) 1979-02-16 1980-02-13 Heterocyclic oxypropanolamine derivatives, process for their preparation and medicines containing these compounds
CS801055A CS227305B2 (en) 1979-02-16 1980-02-15 Method of preparing heterocyclic oxypropanolamine derivatives
DK65380A DK65380A (da) 1979-02-16 1980-02-15 Heterocycloske oxypropanolaminderivater fremgangsmaader til deres fremstilling og laegemidler indeholdende disse forbindelser
HU80350A HU184719B (en) 1979-02-16 1980-02-15 Process for the preparation of heterocyclic oxy-propanolamine derivatives
ZA00800894A ZA80894B (en) 1979-02-16 1980-02-15 Heterocyclic oxypropanolamine derivatives
ES488657A ES488657A1 (es) 1979-02-16 1980-02-15 Procedimiento para la preparacion de derivados de aminopro- panol
JP1671180A JPS55120559A (en) 1979-02-16 1980-02-15 Heterocyclic oxypropanolamine derivative*its manufacture and drug containing it and having vasolidating and betaaintercepting activity
CS806605A CS227313B2 (cs) 1979-02-16 1980-09-30 Způsob přípravy heterocyklických oxypropanolaminových derivátů
CS806604A CS227312B2 (cs) 1979-02-16 1980-09-30 Způsob přípravy heterocyklických oxypropanolaminových derivátů
CS814336A CS227327B2 (cs) 1979-02-16 1981-06-10 Způsob přípravy heterocyklických oxypropanolaminových derivátů
HK44/86A HK4486A (en) 1979-02-16 1986-01-23 Heterocyclic oxypropanolamine derivatives,process for their preparation and medicines containing these compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19792905877 DE2905877A1 (de) 1979-02-16 1979-02-16 Neue aminopropanolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Publications (1)

Publication Number Publication Date
DE2905877A1 true DE2905877A1 (de) 1980-08-28

Family

ID=6063044

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19792905877 Withdrawn DE2905877A1 (de) 1979-02-16 1979-02-16 Neue aminopropanolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE8080100719T Expired DE3061555D1 (en) 1979-02-16 1980-02-13 Heterocyclic oxypropanolamine derivatives, process for their preparation and medicines containing these compounds

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE8080100719T Expired DE3061555D1 (en) 1979-02-16 1980-02-13 Heterocyclic oxypropanolamine derivatives, process for their preparation and medicines containing these compounds

Country Status (17)

Country Link
US (1) US4346093A (cg-RX-API-DMAC10.html)
EP (1) EP0014951B1 (cg-RX-API-DMAC10.html)
JP (1) JPS55120559A (cg-RX-API-DMAC10.html)
AT (1) ATE2190T1 (cg-RX-API-DMAC10.html)
AU (1) AU531282B2 (cg-RX-API-DMAC10.html)
CA (1) CA1134827A (cg-RX-API-DMAC10.html)
CS (1) CS227305B2 (cg-RX-API-DMAC10.html)
DD (1) DD148774A5 (cg-RX-API-DMAC10.html)
DE (2) DE2905877A1 (cg-RX-API-DMAC10.html)
DK (1) DK65380A (cg-RX-API-DMAC10.html)
ES (1) ES488657A1 (cg-RX-API-DMAC10.html)
FI (1) FI66371C (cg-RX-API-DMAC10.html)
HK (1) HK4486A (cg-RX-API-DMAC10.html)
HU (1) HU184719B (cg-RX-API-DMAC10.html)
IL (1) IL59352A (cg-RX-API-DMAC10.html)
SU (1) SU1243622A3 (cg-RX-API-DMAC10.html)
ZA (1) ZA80894B (cg-RX-API-DMAC10.html)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0045910A1 (de) * 1980-08-08 1982-02-17 Roche Diagnostics GmbH Indolderivate und Verfahren zu ihrer Herstellung
US4338330A (en) 1979-05-04 1982-07-06 Continental Pharma Benzimidazole derivatives, their use, and compositions containing these derivatives
WO1996022290A1 (en) * 1995-01-17 1996-07-25 Eli Lilly And Company Compounds having effects on serotonin-related systems
US6172073B1 (en) 1995-01-17 2001-01-09 Eli Lilly And Company Compounds having effects on serotonin-related systems
WO2003011210A3 (en) * 2001-07-31 2007-10-25 Astrazeneca Ab Arylheteroalkylamine derivatives and their use as inhibitors of nitric oxide synthase

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD150456A5 (de) * 1979-03-01 1981-09-02 Ciba Geigy Ag Verfahren zur herstellung von derivaten des 3-amino-1,2-propandiols
EP0034116A3 (en) * 1980-02-11 1981-09-02 Berlex Laboratories, Inc. N-(3-phenoxy-2-hydroxypropyl)benzimidazole-1-alkanamines
DE3030047A1 (de) * 1980-08-08 1982-03-11 Boehringer Mannheim Gmbh, 6800 Mannheim Neue aminopropanol-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3131146A1 (de) * 1981-08-06 1983-02-24 Boehringer Mannheim Gmbh, 6800 Mannheim Neue heteroaryloxypropanolamine, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
FR2523964B1 (fr) * 1982-03-23 1985-09-27 Sanofi Sa Nouveaux derives de la tryptamine actifs notamment sur le systeme cardiovasculaire et procede pour leur preparation
DE3310891A1 (de) * 1983-03-25 1984-09-27 Boehringer Mannheim Gmbh, 6800 Mannheim Neue indolinon-(2)-derivate, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und zwischenprodukte
US4562200A (en) * 1983-06-30 1985-12-31 American Home Products Corporation 5(Indolyl) and 5(2,3-dihydroindolyl) substituted aminoethanols and their use as anti-hypertensives
EP0179808B1 (en) * 1984-04-09 1991-10-30 The Du Pont Merck Pharmaceutical Company Pharmaceutical composition suitable for treatment or prophylaxis of cardiac disorders
DE3540149A1 (de) * 1985-11-13 1987-05-14 Boehringer Mannheim Gmbh Verwendung von 1-(benztriazol-4-yloxy)3-(2-(2-methoxyphenoxy) -ethylamino)-2-propanol als antiglaukommittel, optisch aktive r und s isomere dieser substanz, verfahren zur herstellung derselben sowie arzneimittel, die diese substanzen enthalten
DE68917024D1 (de) * 1988-05-24 1994-09-01 Kirin Brewery 4(1H)-Chinolonderivate.
EP0550507A1 (en) * 1990-09-13 1993-07-14 Beecham Group p.l.c. Indole ureas as 5 ht receptor antagonist
EP0711284A1 (en) * 1993-07-31 1996-05-15 Smithkline Beecham Plc 2-benzoheterocyclyloxy or thiopropanolamine derivatives with adreno receptor agonist activity
ZA967892B (en) * 1995-09-21 1998-03-18 Lilly Co Eli Selective β3 adrenergic agonists.
US5808080A (en) * 1996-09-05 1998-09-15 Eli Lilly And Company Selective β3 adrenergic agonists
ES2171839T3 (es) 1996-09-05 2002-09-16 Lilly Co Eli Analogos de carbazol como agonistas adrenergicos selectivos de beta3.
FR2756286A1 (fr) * 1996-11-27 1998-05-29 Pf Medicament Amino alcools aromatiques, leur preparation et leurs applications comme medicaments
CO5011072A1 (es) * 1997-12-05 2001-02-28 Lilly Co Eli Etanolaminas pirazinil substituidas como agfonistas de los receptores
WO2001036390A1 (en) * 1999-11-15 2001-05-25 Eli Lilly And Company Indazolyloxy propanolamines for improving livestock production
TW593278B (en) * 2001-01-23 2004-06-21 Wyeth Corp 1-aryl-or 1-alkylsulfonylbenzazole derivatives as 5-hydroxytryptamine-6 ligands
AU2017263657A1 (en) * 2016-05-13 2018-11-29 The Board Of Trustees Of The Leland Stanford Junior University Adrenergic receptor modulating compounds and methods of using the same
GB202213163D0 (en) * 2022-09-08 2022-10-26 Cambridge Entpr Ltd Novel compounds, compositions and therapeutic uses thereof

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1948507U (de) 1961-12-08 1966-10-27 Leslie Edward Soderquist Reifenpresse.
DE2230426A1 (de) 1971-06-24 1973-01-11 Sandoz Ag Verfahren zur herstellung neuer heterocyclischer verbindungen
DE2508251A1 (de) 1975-02-26 1976-09-09 Boehringer Mannheim Gmbh Neue derivate des indols, verfahren zu deren herstellung sowie diese enthaltende arzneimittel
DE2700193A1 (de) 1976-01-08 1977-07-14 Ciba Geigy Ag Veraetherte hydroxy-benzodiheterocyclen
DE2619164A1 (de) 1976-04-30 1977-11-17 Boehringer Mannheim Gmbh Indazolyl-(4)-oxy-propanolamine und verfahren zu ihrer herstellung
DE2626890A1 (de) 1976-06-16 1977-12-29 Boehringer Mannheim Gmbh Neue derivate des indols, verfahren zu deren herstellung sowie diese enthaltende arzneimittel
DE2651574A1 (de) 1976-11-12 1978-05-18 Boehringer Mannheim Gmbh Ein neues aminopropanol-derivat und verfahren zu dessen herstellung

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CH483423A (de) * 1967-05-29 1969-12-31 Sandoz Ag Verfahren zur Herstellung einer neuen Indolverbindung
US3699123A (en) * 1970-03-24 1972-10-17 Sandoz Ltd 4-(3-amino-2-hydroxy-propoxy) indole derivatives
CH532040A (de) * 1970-03-24 1972-12-31 Sandoz Ag Verfahren zur Herstellung neuer Indolderivate
US3751429A (en) * 1970-03-24 1973-08-07 Sandoz Ltd 4-(3-amino-2-substituted propoxy)indole derivatives
CH536839A (de) * 1970-03-24 1973-05-15 Sandoz Ag Verfahren zur Herstellung einer neuen Indolverbindung
US4189494A (en) * 1975-11-06 1980-02-19 Sandoz Ltd. Reducing free fatty acid of the blood and suppressing appetite
NZ187066A (en) * 1977-05-03 1981-02-11 Hoffmann La Roche 4-(3-substitutedamino-2-hydroxypropoxy)-benzimidazolidin-2-(ones or thiones)
US4235919A (en) * 1977-07-21 1980-11-25 Sandoz Ltd. 1-(Indol-4-yloxy)-3-(2-substituted amino)-2-propanols and pharmaceutical use thereof
DE2830211A1 (de) * 1977-07-21 1979-02-01 Sandoz Ag Substituierte indol-derivate, ihre herstellung und verwendung
DE2801980A1 (de) * 1978-01-18 1979-07-19 Boehringer Mannheim Gmbh 4-hydroxy-2-benzimidazolin-thion- derivate, verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel
EP0003758A1 (de) * 1978-02-09 1979-09-05 Ciba-Geigy Ag Verätherte Hydroxy-benzodiheterocyclen und ihre Säureadditionssalze, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1948507U (de) 1961-12-08 1966-10-27 Leslie Edward Soderquist Reifenpresse.
DE2230426A1 (de) 1971-06-24 1973-01-11 Sandoz Ag Verfahren zur herstellung neuer heterocyclischer verbindungen
DE2508251A1 (de) 1975-02-26 1976-09-09 Boehringer Mannheim Gmbh Neue derivate des indols, verfahren zu deren herstellung sowie diese enthaltende arzneimittel
DE2700193A1 (de) 1976-01-08 1977-07-14 Ciba Geigy Ag Veraetherte hydroxy-benzodiheterocyclen
DE2619164A1 (de) 1976-04-30 1977-11-17 Boehringer Mannheim Gmbh Indazolyl-(4)-oxy-propanolamine und verfahren zu ihrer herstellung
DE2626890A1 (de) 1976-06-16 1977-12-29 Boehringer Mannheim Gmbh Neue derivate des indols, verfahren zu deren herstellung sowie diese enthaltende arzneimittel
DE2651574A1 (de) 1976-11-12 1978-05-18 Boehringer Mannheim Gmbh Ein neues aminopropanol-derivat und verfahren zu dessen herstellung

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
C.W. Huffmann, J. Org. Chem. 23, 727 (1958)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4338330A (en) 1979-05-04 1982-07-06 Continental Pharma Benzimidazole derivatives, their use, and compositions containing these derivatives
EP0045910A1 (de) * 1980-08-08 1982-02-17 Roche Diagnostics GmbH Indolderivate und Verfahren zu ihrer Herstellung
WO1996022290A1 (en) * 1995-01-17 1996-07-25 Eli Lilly And Company Compounds having effects on serotonin-related systems
US5576321A (en) * 1995-01-17 1996-11-19 Eli Lilly And Company Compounds having effects on serotonin-related systems
EA000620B1 (ru) * 1995-01-17 1999-12-29 Эли Лилли Энд Компани Соединения, оказывающие влияние на системы, связанные с серотонином
US6172073B1 (en) 1995-01-17 2001-01-09 Eli Lilly And Company Compounds having effects on serotonin-related systems
WO2003011210A3 (en) * 2001-07-31 2007-10-25 Astrazeneca Ab Arylheteroalkylamine derivatives and their use as inhibitors of nitric oxide synthase

Also Published As

Publication number Publication date
FI66371C (fi) 1984-10-10
IL59352A0 (en) 1980-05-30
HK4486A (en) 1986-01-31
FI66371B (fi) 1984-06-29
JPS55120559A (en) 1980-09-17
DD148774A5 (de) 1981-06-10
EP0014951B1 (de) 1983-01-12
CS227305B2 (en) 1984-04-16
SU1243622A3 (ru) 1986-07-07
EP0014951A3 (en) 1981-02-04
AU5541080A (en) 1980-08-21
FI800408A7 (fi) 1980-08-17
EP0014951A2 (de) 1980-09-03
DK65380A (da) 1980-08-17
ES488657A1 (es) 1980-09-16
DE3061555D1 (en) 1983-02-17
US4346093A (en) 1982-08-24
HU184719B (en) 1984-10-29
CA1134827A (en) 1982-11-02
IL59352A (en) 1985-01-31
ZA80894B (en) 1981-09-30
ATE2190T1 (de) 1983-01-15
JPS6348864B2 (cg-RX-API-DMAC10.html) 1988-09-30
AU531282B2 (en) 1983-08-18

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