DE2860330D1 - 3,4,5-trihydroxypiperidine derivatives, process for their preparation and medicaments and fodder containing them - Google Patents
3,4,5-trihydroxypiperidine derivatives, process for their preparation and medicaments and fodder containing themInfo
- Publication number
- DE2860330D1 DE2860330D1 DE7878100750T DE2860330T DE2860330D1 DE 2860330 D1 DE2860330 D1 DE 2860330D1 DE 7878100750 T DE7878100750 T DE 7878100750T DE 2860330 T DE2860330 T DE 2860330T DE 2860330 D1 DE2860330 D1 DE 2860330D1
- Authority
- DE
- Germany
- Prior art keywords
- medicaments
- preparation
- fodder containing
- trihydroxypiperidine
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003814 drug Substances 0.000 title 1
- RMCNETIHECSPMZ-UHFFFAOYSA-N piperidine-3,4,5-triol Chemical class OC1CNCC(O)C1O RMCNETIHECSPMZ-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
- C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
- C07H9/04—Cyclic acetals
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
- A23K20/132—Heterocyclic compounds containing only one nitrogen as hetero atom
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
- A23K20/137—Heterocyclic compounds containing two hetero atoms, of which at least one is nitrogen
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/18—Acyclic radicals, substituted by carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Polymers & Plastics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Food Science & Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Animal Husbandry (AREA)
- Diabetes (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Birds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE7878100750T DE2860330D1 (en) | 1977-08-27 | 1978-08-25 | 3,4,5-trihydroxypiperidine derivatives, process for their preparation and medicaments and fodder containing them |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19772738717 DE2738717A1 (de) | 1977-08-27 | 1977-08-27 | N-alkylierte derivate der 5-amino- 5-deoxy-d-glucose, verfahren zu ihrer herstellung und ihre verwendung |
| DE19772758025 DE2758025A1 (de) | 1977-12-24 | 1977-12-24 | Neue derivate von 3,4,5-trihydroxypiperidin, verfahren zu ihrer herstellung und ihre verwendung |
| DE7878100750T DE2860330D1 (en) | 1977-08-27 | 1978-08-25 | 3,4,5-trihydroxypiperidine derivatives, process for their preparation and medicaments and fodder containing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2860330D1 true DE2860330D1 (en) | 1981-03-12 |
Family
ID=25772626
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE7878100750T Expired DE2860330D1 (en) | 1977-08-27 | 1978-08-25 | 3,4,5-trihydroxypiperidine derivatives, process for their preparation and medicaments and fodder containing them |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US4639436A (cg-RX-API-DMAC7.html) |
| EP (1) | EP0000947B2 (cg-RX-API-DMAC7.html) |
| JP (1) | JPS5446786A (cg-RX-API-DMAC7.html) |
| AT (1) | AT373239B (cg-RX-API-DMAC7.html) |
| AU (2) | AU3921478A (cg-RX-API-DMAC7.html) |
| CA (1) | CA1123437A (cg-RX-API-DMAC7.html) |
| DE (1) | DE2860330D1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK152753C (cg-RX-API-DMAC7.html) |
| ES (1) | ES472838A1 (cg-RX-API-DMAC7.html) |
| FI (1) | FI72715C (cg-RX-API-DMAC7.html) |
| GR (1) | GR73065B (cg-RX-API-DMAC7.html) |
| HU (1) | HU182449B (cg-RX-API-DMAC7.html) |
| IE (1) | IE47070B1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL55423A (cg-RX-API-DMAC7.html) |
| IT (1) | IT1111197B (cg-RX-API-DMAC7.html) |
| LU (1) | LU90211I2 (cg-RX-API-DMAC7.html) |
| NL (1) | NL960027I2 (cg-RX-API-DMAC7.html) |
| NO (1) | NO154918C (cg-RX-API-DMAC7.html) |
| PT (1) | PT68474A (cg-RX-API-DMAC7.html) |
Families Citing this family (245)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5943946B2 (ja) * | 1978-04-28 | 1984-10-25 | 日本新薬株式会社 | N−アルケニルモラノリン誘導体 |
| DE2839309A1 (de) * | 1978-09-09 | 1980-03-27 | Bayer Ag | 3,4,5-trihydroxypiperidin-derivate |
| DE2848117A1 (de) * | 1978-11-06 | 1980-05-14 | Bayer Ag | Derivate des 2-hydroxymethyl-3,4,5- trihydroxy-piperidins, ihre herstellung und verwendung zur beeinflussung des kohlenhydrat- und fettstoffwechsels |
| DE2922760A1 (de) * | 1979-06-05 | 1980-12-11 | Bayer Ag | Neue derivate von 3,4,5-trihydroxypiperidin, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel sowie in der tierernaehrung |
| DE2925943A1 (de) * | 1979-06-27 | 1981-01-29 | Bayer Ag | 1-alkadien-2,4-yl-2-hydroxymethyl3,4,5-trihydroxypiperidine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| DE2936240A1 (de) | 1979-09-07 | 1981-03-26 | Bayer Ag, 51373 Leverkusen | Verfahren zur herstellung bekannter und neuer 6-amino-6-desoxy-2,3-0-isopropyliden-(alpha)-l-sorbofuranose-derivate sowie neue zwischenprodukte des verfahrens |
| DE2942365A1 (de) * | 1979-10-19 | 1981-05-14 | Bayer Ag, 5090 Leverkusen | 2-hydroxyalkyl-3,4,5-trihydroxy-(pi)-peridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| JPS56108767A (en) * | 1980-01-28 | 1981-08-28 | Nippon Shinyaku Co Ltd | Bismoranoline derivative |
| JPS56108768A (en) * | 1980-01-28 | 1981-08-28 | Nippon Shinyaku Co Ltd | Cinnamylmoranoline derivative |
| DE3007078A1 (de) * | 1980-02-26 | 1981-09-10 | Bayer Ag, 5090 Leverkusen | Neue derivate von 3,4,5-trihydroxypiperidin, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel sowie in der tierernaehrung |
| DE3038901A1 (de) * | 1980-10-15 | 1982-05-06 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von n-substituierten derivaten des 1-desoxynojirimycins |
| US4634765A (en) * | 1984-12-18 | 1987-01-06 | Merrell Dow Pharmaceuticals Inc. | Homodisaccharide hypoglycemic agents |
| DE3507019A1 (de) * | 1985-02-28 | 1986-08-28 | Bayer Ag, 5090 Leverkusen | Neue derivate von 3,4,5-trihydroxypiperidin, verfahren zu ihrer herstellung und ihre verwendung |
| US5231185A (en) * | 1985-11-19 | 1993-07-27 | Cornell Research Foundation, Inc. | Monosaccharide analog-based glycosidase inhibitors |
| DE3620645A1 (de) * | 1985-12-20 | 1987-07-02 | Bayer Ag | 3-amino-4,5-dihydroxypiperidine, verfahren zu ihrer herstellung und ihre verwendung |
| DE3611841A1 (de) * | 1986-04-09 | 1987-10-15 | Bayer Ag | Verfahren zur herstellung von 1-desoxynojirimycin und dessen n-derivaten |
| DE3737523A1 (de) * | 1987-11-05 | 1989-05-18 | Bayer Ag | Verwendung von substituierten hydroxypiperidinen als antivirale mittel |
| US5192772A (en) * | 1987-12-09 | 1993-03-09 | Nippon Shinyaku Co. Ltd. | Therapeutic agents |
| US4849430A (en) * | 1988-03-09 | 1989-07-18 | Monsanto Company | Method of inhibiting virus |
| PT89266B (pt) * | 1987-12-21 | 1993-11-30 | Monsanto Co | Metodo para a inibicao de virus da imunodeficiencia humana utilizando um derivado n-n-butilo de desoxinojirimicina |
| DE3743749A1 (de) * | 1987-12-23 | 1989-07-13 | Bayer Ag | Arzneimittel enthaltend in kombination interferon und 1-desoxy-piperidinosen, verfahren zu deren herstellung und deren verwendung |
| US5250545A (en) * | 1988-02-12 | 1993-10-05 | Meiji Seika Kaisha, Ltd. | Cancer cell metastasis inhibitor methods |
| EP0345104B1 (en) * | 1988-06-02 | 1995-11-02 | Merrell Dow Pharmaceuticals Inc. | Novel Alpha-glucosidase inhibitors |
| EP0344383A1 (en) * | 1988-06-02 | 1989-12-06 | Merrell Dow Pharmaceuticals Inc. | Novel alpha-Glucosidase inhibitors |
| US4880917A (en) * | 1988-07-01 | 1989-11-14 | Merrell Dow Pharmaceuticals Inc. | Process for hydrolyzing 2,6-dideoxy-2,6-iminoheptononitrile derivatives using trifluoroacetic acid and dinitrogen tetroxide |
| EP0350012A3 (en) * | 1988-07-08 | 1990-09-05 | Meiji Seika Kaisha Ltd. | Antiviral composition |
| US5043416A (en) * | 1988-09-26 | 1991-08-27 | Monsanto Company | Method of inhibiting virus |
| US5003072A (en) * | 1988-11-03 | 1991-03-26 | G. D. Searle & Co. | 1,5-dideoxy-1,5-imino-D-glucitol derivatives |
| US5221746A (en) * | 1988-11-03 | 1993-06-22 | G. D. Searle & Co. | 1,5-dideoxy-1,5-imino-D-glucitol derivatives |
| US5144037A (en) * | 1988-11-03 | 1992-09-01 | G. D. Searle & Co. | 1,5-dideoxy-1,5-imino-d-glucitol derivatives |
| US4876268A (en) * | 1988-11-03 | 1989-10-24 | G. D. Searle & Co. | Antiviral compounds and use thereof |
| US4937357A (en) * | 1988-11-03 | 1990-06-26 | G. D. Searle & Co. | Intermediates for antiviral compounds |
| US5310745A (en) * | 1988-11-03 | 1994-05-10 | G. D. Searle & Co. | Antiviral compounds |
| US4973602A (en) * | 1988-11-03 | 1990-11-27 | G. D. Searle & Co. | Antiviral compounds and a method of use thereas |
| US4957926A (en) * | 1988-12-22 | 1990-09-18 | Monsanto Company | Method of treating herpesviruses |
| EP0389723A1 (en) * | 1989-03-29 | 1990-10-03 | Merrell Dow Pharmaceuticals Inc. | Novel alpha-glucosidase inhibitors |
| US5100797A (en) * | 1989-06-27 | 1992-03-31 | Monsanto Company | Fucosidase inhibitors |
| EP0422307A1 (en) * | 1989-10-10 | 1991-04-17 | Merrell Dow Pharmaceuticals Inc. | Novel alpha-glucosidase inhibitors |
| DE3936295A1 (de) * | 1989-11-01 | 1991-05-02 | Bayer Ag | Verfahren zur herstellung von zwischenprodukten und zur synthese von n-(2-hydroxyethyl)-2-hydroxymethyl-3,4,5-trihydroxypiperidine |
| US5030638A (en) * | 1990-02-26 | 1991-07-09 | G. D. Searle & Co. | Method of antiviral enhancement |
| DE4009561A1 (de) * | 1990-03-24 | 1991-09-26 | Bayer Ag | Neue desoxynojirimycinderivate, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
| US5252587A (en) * | 1990-04-27 | 1993-10-12 | Merrell Dow Pharmaceuticals, Inc. | N-derivatives of 1-deoxy nojirimycin |
| US5536732A (en) * | 1990-04-27 | 1996-07-16 | Merrell Pharmaceuticals Inc. | N-derivatives of 1-deoxy nojirimycin |
| US5151519A (en) * | 1990-05-07 | 1992-09-29 | G. D. Searle & Co. | Process for the preparation of 1,5-(alkylimino)-1,5-dideoxy-d-glucitol and derivatives thereof |
| US5504078A (en) * | 1990-06-08 | 1996-04-02 | Merrell Dow Pharmaceuticals Inc. | α-glucosidase inhibitors |
| WO1992000277A1 (en) * | 1990-06-29 | 1992-01-09 | Nippon Shinyaku Co., Ltd. | Piperidine derivative |
| US5561134A (en) * | 1990-09-25 | 1996-10-01 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties |
| US5273981A (en) * | 1990-10-18 | 1993-12-28 | Monsanto Company | Intramolecular carbamate derivative of 2,3-Di-O-blocked-1,4-dideoxy-4-fluoro-nojirimycins |
| US5128347A (en) * | 1990-10-18 | 1992-07-07 | Monsanto Company | Glycosidase inhibiting 1,4-dideoxy-4-fluoronojirimycin |
| US5216168A (en) * | 1992-04-01 | 1993-06-01 | G. D. Searle & Co. | 2- and 3- amino and azido derivatives of 1,5-iminosugars |
| US5331096A (en) * | 1992-04-01 | 1994-07-19 | G. D. Searle & Co. | 2- and 3-sulfur derivatives of 1,5-iminosugars |
| US5206251A (en) * | 1992-04-01 | 1993-04-27 | G. D. Searle & Co. | 2- and 3- amino and azido derivatives of 1,5-iminosugars |
| US5258518A (en) * | 1992-04-01 | 1993-11-02 | G. D. Searle & Co. | 2-substituted tertiary carbinol derivatives of deoxynojirimycin |
| US5268482A (en) * | 1992-04-01 | 1993-12-07 | G. D. Searle & Co. | 2- and 3-sulfur derivatives of 1,5-iminosugars |
| US5342951A (en) * | 1992-04-01 | 1994-08-30 | G.D. Searle & Co. | 2- and 3-sulfur derivatives of 1,5-iminosugars |
| US5798366A (en) * | 1993-05-13 | 1998-08-25 | Monsanto Company | Method for treatment of CNS-involved lysosomal storage diseases |
| US5399567A (en) * | 1993-05-13 | 1995-03-21 | Monsanto Company | Method of treating cholera |
| US6291657B1 (en) * | 1993-05-13 | 2001-09-18 | Monsanto Company | Deoxygalactonojirimycin derivatives |
| AU1890295A (en) * | 1994-03-09 | 1995-09-25 | Novo Nordisk A/S | Piperidines and pyrrolidines |
| US5863903A (en) * | 1994-03-09 | 1999-01-26 | Novo Nordisk A/S | Use of hydroxy alkyl piperidine and pyrrolidine compounds to treat diabetes |
| US20030100532A1 (en) * | 1997-02-14 | 2003-05-29 | Gary S. Jacob | Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections |
| IL158466A0 (en) * | 1997-04-15 | 2004-05-12 | Csir | Pharmaceutical compositions having appetite suppressant activity |
| JP2001522833A (ja) * | 1997-11-10 | 2001-11-20 | ジー・ディー・サール・アンド・カンパニー | 多剤耐性を治療するためのアルキル化イミノ糖類の使用 |
| CA2319713C (en) | 1998-02-12 | 2012-06-26 | G.D. Searle & Co. | Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds for treating hepatitis virus infections |
| US6689759B1 (en) | 1998-02-12 | 2004-02-10 | G. D. Searle & Co. | Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy |
| KR100620935B1 (ko) | 1998-03-19 | 2006-09-13 | 브리스톨-마이어스스퀴브컴파니 | 용해도가 높은 약물에 대한 2상 서방성 전달 시스템과 방법 |
| US6274597B1 (en) | 1998-06-01 | 2001-08-14 | Mount Sinai School Of Medicine Of New York University | Method of enhancing lysosomal α-Galactosidase A |
| WO2000015229A1 (en) | 1998-09-17 | 2000-03-23 | Bristol-Myers Squibb Company | METHOD FOR TREATING DIABETES EMPLOYING AN aP2 INHIBITOR AND COMBINATION |
| HK1043311A1 (zh) * | 1999-02-12 | 2002-09-13 | G.D. Searle & Co. | 使用替代-1,5-二脱氧-1,5-亚氨基-d-glucitol化合物治疗肝炎病毒感染 |
| EP1173161A2 (en) | 1999-02-12 | 2002-01-23 | G.D. SEARLE & CO. | Glucamine compounds for treating hepatitis virus infections |
| US6548529B1 (en) | 1999-04-05 | 2003-04-15 | Bristol-Myers Squibb Company | Heterocyclic containing biphenyl aP2 inhibitors and method |
| GB0100889D0 (en) * | 2001-01-12 | 2001-02-21 | Oxford Glycosciences Uk Ltd | Compounds |
| HK1046869A1 (zh) | 1999-08-10 | 2003-01-30 | The Chancellor, Masters And Scholars Of The University Of Oxford | 使用长链n烷基化合物及其恶衍生物作为抗病毒成分 |
| GB2355657B (en) * | 1999-10-27 | 2004-07-28 | Phytopharm Plc | Inhibitors Of Gastric Acid Secretion |
| US6586438B2 (en) | 1999-11-03 | 2003-07-01 | Bristol-Myers Squibb Co. | Antidiabetic formulation and method |
| CN1422156A (zh) * | 2000-02-14 | 2003-06-04 | 法马西亚公司 | N-取代的-1,5-二脱氧-1,5-亚氨基-d-葡萄糖醇化合物在治疗肝炎病毒感染中的用途 |
| US6395767B2 (en) | 2000-03-10 | 2002-05-28 | Bristol-Myers Squibb Company | Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV and method |
| GB2363985B (en) * | 2000-06-30 | 2004-09-29 | Phytopharm Plc | Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use |
| SK2102003A3 (en) | 2000-08-07 | 2003-08-05 | Ranbaxy Signature Llc | Liquid formulation of metformin |
| FR2816840B1 (fr) * | 2000-11-17 | 2004-04-09 | Flamel Tech Sa | Medicament a base de microcapsules d'anti-hyperclycemiant a liberation prolongee et son procede de preparation |
| CA2439063A1 (en) * | 2001-03-12 | 2002-09-19 | Novartis Ag | Combination of nateglinide or repaglinide with at least one further antidiabetic compound |
| DE60209343T2 (de) | 2001-04-11 | 2006-10-26 | Bristol-Myers Squibb Co. | Aminosäurekomplexe von c-arylglycosiden zur behandlung von diabetes und verfahren |
| US8101209B2 (en) * | 2001-10-09 | 2012-01-24 | Flamel Technologies | Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles |
| FR2830447B1 (fr) * | 2001-10-09 | 2004-04-16 | Flamel Tech Sa | Forme galenique orale microparticulaire pour la liberation retardee et controlee de principes actifs pharmaceutiques |
| US6806381B2 (en) * | 2001-11-02 | 2004-10-19 | Bristol-Myers Squibb Company | Process for the preparation of aniline-derived thyroid receptor ligands |
| AU2002348276A1 (en) * | 2001-11-16 | 2003-06-10 | Bristol-Myers Squibb Company | Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein |
| FR2833813B1 (fr) * | 2001-12-26 | 2005-08-26 | Phytosynthese | Complement alimentaire destine a l'animal |
| MXPA04009968A (es) | 2002-04-09 | 2004-12-13 | Flamel Tech Sa | Formulacion farmaceutica oral bajo forma de suspension acuosa de microcapsulas que permiten la liberacion modificada de principio (s) activo (s). |
| KR20050005437A (ko) * | 2002-04-09 | 2005-01-13 | 플라멜 테크놀로지스 | 아목시실린의 변형 방출을 위한 마이크로캡슐 수성 현탁액형태의 경구 제약학적 제제 |
| CA2492410C (en) * | 2002-07-17 | 2011-09-13 | Oxford Glycosciences (Uk) Ltd | Piperidinetriol derivatives as inhibitors of glycosylceramidsynthase |
| AU2003246942B2 (en) * | 2002-07-17 | 2009-06-25 | Idorsia Pharmaceuticals Ltd | Piperidinetriol derivatives as inhibitors of glycosylceramide synthase |
| US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
| TW200504021A (en) * | 2003-01-24 | 2005-02-01 | Bristol Myers Squibb Co | Substituted anilide ligands for the thyroid receptor |
| US20040176425A1 (en) * | 2003-01-24 | 2004-09-09 | Washburn William N. | Cycloalkyl containing anilide ligands for the thyroid receptor |
| NZ577031A (en) * | 2003-05-30 | 2010-09-30 | Ranbaxy Lab Ltd | Substituted pyrrole derivatives and their use as HMG-CO inhibitors |
| US7459474B2 (en) * | 2003-06-11 | 2008-12-02 | Bristol-Myers Squibb Company | Modulators of the glucocorticoid receptor and method |
| GB0313677D0 (en) * | 2003-06-13 | 2003-07-16 | Oxford Glycosciences Uk Ltd | Novel compound |
| GB0313678D0 (en) * | 2003-06-13 | 2003-07-16 | Oxford Glycosciences Uk Ltd | Novel compounds |
| US7371759B2 (en) * | 2003-09-25 | 2008-05-13 | Bristol-Myers Squibb Company | HMG-CoA reductase inhibitors and method |
| FR2861991B1 (fr) * | 2003-11-07 | 2008-01-18 | Centre Nat Rech Scient | Utilisation d'inhibiteurs de glucosidase pour une therapie de la mucoviscidose |
| BRPI0416444B8 (pt) | 2003-11-12 | 2021-05-25 | Chiesi Farm Spa | composto de ácido borônico heterocíclico, composição farmacêutica, e, combinação farmacêutica compreendendo o mesmo |
| US7420059B2 (en) * | 2003-11-20 | 2008-09-02 | Bristol-Myers Squibb Company | HMG-CoA reductase inhibitors and method |
| US7501426B2 (en) * | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
| US7262318B2 (en) * | 2004-03-10 | 2007-08-28 | Pfizer, Inc. | Substituted heteroaryl- and phenylsulfamoyl compounds |
| US20050288340A1 (en) * | 2004-06-29 | 2005-12-29 | Pfizer Inc | Substituted heteroaryl- and phenylsulfamoyl compounds |
| US7786163B2 (en) * | 2004-07-12 | 2010-08-31 | Forest Laboratories Holdings Limited (BM) | Constrained cyano compounds |
| US7572805B2 (en) | 2004-07-14 | 2009-08-11 | Bristol-Myers Squibb Company | Pyrrolo(oxo)isoquinolines as 5HT ligands |
| WO2006037069A1 (en) * | 2004-09-28 | 2006-04-06 | Allergan, Inc. | Compositions comprising nb-dnj, ne-dnj or d-glucaro-delta-lactam and their uses for the treatment of pain and other neurological conditions |
| US7517991B2 (en) * | 2004-10-12 | 2009-04-14 | Bristol-Myers Squibb Company | N-sulfonylpiperidine cannabinoid receptor 1 antagonists |
| DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
| EP1811991B1 (en) * | 2004-11-10 | 2018-11-07 | Genzyme Corporation | Treatment of type 2 diabetes using inhibitors of glycosphingolipid synthesis |
| MX2007005137A (es) * | 2004-11-23 | 2007-06-22 | Warner Lambert Co | Derivados del acido 7-(2h-pyrazol-3-il)-3, 5-dihidroxi-heptanoico como inhibidores de hmg co-a reductasa para el tratamiento de lipidemia. |
| WO2006076568A2 (en) | 2005-01-12 | 2006-07-20 | Bristol-Myers Squibb Company | Thiazolopyridines as cannabinoid receptor modulators |
| US7314882B2 (en) * | 2005-01-12 | 2008-01-01 | Bristol-Myers Squibb Company | Bicyclic heterocycles as cannabinoid receptor modulators |
| WO2006076597A1 (en) * | 2005-01-12 | 2006-07-20 | Bristol-Myers Squibb Company | Bicyclic heterocycles as cannabinoid receptor modulators |
| US7317024B2 (en) | 2005-01-13 | 2008-01-08 | Bristol-Myers Squibb Co. | Heterocyclic modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
| US20060160850A1 (en) * | 2005-01-18 | 2006-07-20 | Chongqing Sun | Bicyclic heterocycles as cannabinoid receptor modulators |
| US7238702B2 (en) * | 2005-02-10 | 2007-07-03 | Bristol-Myers Squibb Company | Dihydroquinazolinones as 5HT modulators |
| UA91546C2 (uk) * | 2005-05-03 | 2010-08-10 | Бьорінгер Інгельхайм Інтернаціональ Гмбх | КРИСТАЛІЧНА ФОРМА 1-ХЛОР-4-(β-D-ГЛЮКОПІРАНОЗ-1-ИЛ)-2-[4-((S)-ТЕТРАГІДРОФУРАН-3-ІЛОКСИ)-БЕНЗИЛ]-БЕНЗОЛУ, СПОСІБ ЇЇ ОДЕРЖАННЯ ТА ЇЇ ЗАСТОСУВАННЯ ПРИ ПРИГОТУВАННІ ЛІКАРСЬКИХ ЗАСОБІВ |
| US7772191B2 (en) | 2005-05-10 | 2010-08-10 | Boehringer Ingelheim International Gmbh | Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein |
| JP2008545657A (ja) | 2005-05-17 | 2008-12-18 | アミカス セラピューティックス インコーポレイテッド | 1−デオキシノジリマイシンおよび誘導体を用いるポンペ病の治療方法 |
| CN101228174A (zh) * | 2005-06-08 | 2008-07-23 | 阿米库斯治疗学公司 | 晶体糖组合物及其制备方法 |
| JP2008545800A (ja) * | 2005-06-08 | 2008-12-18 | アミカス セラピューティックス インコーポレイテッド | トリフラート化化合物の安定化 |
| PT2027137E (pt) * | 2005-06-08 | 2015-06-09 | Amicus Therapeutics Inc | Purificação de imino e amino-açúcares |
| US7888381B2 (en) | 2005-06-14 | 2011-02-15 | Bristol-Myers Squibb Company | Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity, and use thereof |
| US7452892B2 (en) * | 2005-06-17 | 2008-11-18 | Bristol-Myers Squibb Company | Triazolopyrimidine cannabinoid receptor 1 antagonists |
| US20060287342A1 (en) * | 2005-06-17 | 2006-12-21 | Mikkilineni Amarendra B | Triazolopyrimidine heterocycles as cannabinoid receptor modulators |
| US7632837B2 (en) * | 2005-06-17 | 2009-12-15 | Bristol-Myers Squibb Company | Bicyclic heterocycles as cannabinoid-1 receptor modulators |
| TW200726765A (en) * | 2005-06-17 | 2007-07-16 | Bristol Myers Squibb Co | Triazolopyridine cannabinoid receptor 1 antagonists |
| US7629342B2 (en) * | 2005-06-17 | 2009-12-08 | Bristol-Myers Squibb Company | Azabicyclic heterocycles as cannabinoid receptor modulators |
| US7317012B2 (en) * | 2005-06-17 | 2008-01-08 | Bristol-Myers Squibb Company | Bicyclic heterocycles as cannabinoind-1 receptor modulators |
| FR2887549B1 (fr) | 2005-06-23 | 2009-07-10 | Centre Nat Rech Scient | Nouveaux composes de la famille des iminosucres, leurs utilisations, notamment pour le traitement de maladies lysosomales, ainsi que leur procede de preparation |
| CA2617102A1 (en) * | 2005-07-28 | 2007-02-08 | Bristol-Myers Squibb Company | Substituted tetrahydro-1h-pyrido[4,3,b]indoles as serotonin receptor agonists and antagonists |
| DE102005035891A1 (de) | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
| US7795436B2 (en) * | 2005-08-24 | 2010-09-14 | Bristol-Myers Squibb Company | Substituted tricyclic heterocycles as serotonin receptor agonists and antagonists |
| US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
| AR056155A1 (es) | 2005-10-26 | 2007-09-19 | Bristol Myers Squibb Co | Antagonistas del receptor 1 de la hormona de concentracion de melanina no basica |
| BRPI0618379A2 (pt) * | 2005-11-08 | 2011-08-30 | Ranbaxy Lab Ltd | processo para preparação do hemi-sal de cálcio do ácido (3r,5r) -7-[2-(4-fluorofenil)-5-isopropil-3-fenil-4-[(4-hidroxime tilfenilamino) carbonil]-pirrol-1-il] -3, 5-diidroxi heptanóico |
| US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| US7592461B2 (en) | 2005-12-21 | 2009-09-22 | Bristol-Myers Squibb Company | Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
| US7553836B2 (en) * | 2006-02-06 | 2009-06-30 | Bristol-Myers Squibb Company | Melanin concentrating hormone receptor-1 antagonists |
| CL2007000667A1 (es) * | 2006-03-14 | 2008-03-14 | Ranbaxi Lab Ltd | Composicion farmaceutica que comprende al acido 7-[2-(4-fluorofenil)-5-isopropil-3-fenil-4-[(4-hidroximetilfenilamino)carbonil]pirrol-1-il]-3,5-dihidroxi-heptanoico o una sal y al menos un agente estabilizante; procedimiento de preparacion, util en e |
| US20070238770A1 (en) * | 2006-04-05 | 2007-10-11 | Bristol-Myers Squibb Company | Process for preparing novel crystalline forms of peliglitazar, novel stable forms produced therein and formulations |
| PE20080697A1 (es) * | 2006-05-03 | 2008-08-05 | Boehringer Ingelheim Int | Derivados de benzonitrilo sustituidos con glucopiranosilo, composiciones farmaceuticas que contienen compuestos de este tipo, su uso y procedimiento para su fabricacion |
| PE20080251A1 (es) * | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
| EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
| NZ600394A (en) | 2006-05-04 | 2014-04-30 | Boehringer Ingelheim Int | Polymorphs of a dpp-iv enzyme inhibitor |
| PT2032134E (pt) * | 2006-05-09 | 2015-10-07 | Genzyme Corp | Métodos de tratamento da doença do fígado gorduroso |
| CN104876855A (zh) * | 2006-05-24 | 2015-09-02 | 联合治疗公司 | 脱氧吉瑞霉素和d-阿拉伯胶素醇类似物及使用方法 |
| CL2007002044A1 (es) * | 2006-07-14 | 2008-06-13 | Ranbaxy Lab Ltd | Polimorfo cristalino de la sal hemicalcica del acido (3r,5r)-7-[2-(4-fluorofenil)-5-isopropil-3-fenil-4-[(4-hidroximetilfenilamino)carbonil]-pirrol-1-il]-3,5-dihidroxiheptanoico; composicion farmaceutica; y uso para el tratamiento de la diabetes, enf |
| GB0614947D0 (en) * | 2006-07-27 | 2006-09-06 | Isis Innovation | Epitope reduction therapy |
| EP2049126A2 (en) * | 2006-08-02 | 2009-04-22 | United Therapeutics Corporation | Liposome treatment of viral infections |
| EP2054076A2 (en) * | 2006-08-21 | 2009-05-06 | United Therapeutics Corporation | Combination therapy for treatment of viral infections |
| EP2099767A1 (en) | 2006-11-01 | 2009-09-16 | Brystol-Myers Squibb Company | Modulators of glucocorticoid receptor, ap-1, and/or nf- b activity and use thereof |
| WO2008057862A2 (en) | 2006-11-01 | 2008-05-15 | Bristol-Myers Squibb Company | MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-ϰB ACTIVITY AND USE THEREOF |
| ATE547394T1 (de) | 2006-12-01 | 2012-03-15 | Bristol Myers Squibb Co | N-((3-benzyl)-2,2-(bis-phenyl)-propan-1- aminderivate als cetp-hemmer für die behandlung von atherosklerose und herz-kreislauf- erkrankungen |
| WO2008110551A1 (en) | 2007-03-12 | 2008-09-18 | Zadec Aps | An anti-diabetic extract of rooibos |
| US8097728B2 (en) * | 2007-04-30 | 2012-01-17 | Philadelphia Health & Education Corporation | Iminosugar compounds with antiflavirus activity |
| EP2594565B1 (en) | 2007-05-31 | 2018-10-24 | Genzyme Corporation | 2-acylaminopropanol-type glucosylceramide synthase inhibitors |
| ES2559319T3 (es) | 2007-06-04 | 2016-02-11 | Synergy Pharmaceuticals Inc. | Agonistas de guanilato cliclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
| US8034782B2 (en) | 2008-07-16 | 2011-10-11 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| US20090011994A1 (en) * | 2007-07-06 | 2009-01-08 | Bristol-Myers Squibb Company | Non-basic melanin concentrating hormone receptor-1 antagonists and methods |
| CL2008002427A1 (es) * | 2007-08-16 | 2009-09-11 | Boehringer Ingelheim Int | Composicion farmaceutica que comprende 1-cloro-4-(b-d-glucopiranos-1-il)-2-[4-((s)-tetrahidrofurano-3-iloxi)bencil]-benceno combinado con 1-[(4-metilquinazolin-2-il)metil]-3-metil-7-(2-butin-1-il)-8-(3-(r)-aminopiperidin-1-il)xantina; y su uso para tratar diabetes mellitus tipo 2. |
| ES2733348T3 (es) * | 2007-08-17 | 2019-11-28 | Boehringer Ingelheim Int | Derivados de purina para uso en el tratamiento de enfermedades relacionadas con FAP |
| BRPI0823522A2 (pt) | 2007-10-05 | 2014-01-07 | Genzyme Corp | Uso de um composto derivado de ceramida |
| WO2009058944A2 (en) | 2007-11-01 | 2009-05-07 | Bristol-Myers Squibb Company | Nonsteroidal compounds useful as modulators of glucocorticoid receptor ap-1 and /or nf- kappa b activity and use thereof |
| ES2620743T3 (es) | 2008-02-18 | 2017-06-29 | Vida Pharma Limited | Tratamiento de enfermedad de utilización de la energía |
| EP2282723A2 (en) * | 2008-03-26 | 2011-02-16 | University of Oxford | Endoplasmic reticulum targeting liposomes |
| AR071175A1 (es) | 2008-04-03 | 2010-06-02 | Boehringer Ingelheim Int | Composicion farmaceutica que comprende un inhibidor de la dipeptidil-peptidasa-4 (dpp4) y un farmaco acompanante |
| PE20091928A1 (es) * | 2008-05-29 | 2009-12-31 | Bristol Myers Squibb Co | Tienopirimidinas hidroxisustituidas como antagonistas de receptor-1 de hormona concentradora de melanina no basicos |
| PE20100156A1 (es) * | 2008-06-03 | 2010-02-23 | Boehringer Ingelheim Int | Tratamiento de nafld |
| EP2328910B1 (en) | 2008-06-04 | 2014-08-06 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| EP2320886B1 (en) | 2008-07-28 | 2017-06-28 | Genzyme Corporation | Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease |
| UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
| KR20190016601A (ko) | 2008-08-06 | 2019-02-18 | 베링거 인겔하임 인터내셔날 게엠베하 | 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료 |
| CA2735562C (en) * | 2008-08-15 | 2017-10-17 | Boehringer Ingelheim International Gmbh | Dpp-4 inhibitors for wound healing |
| MX2011002558A (es) | 2008-09-10 | 2011-04-26 | Boehringer Ingelheim Int | Terapia de combinacion para el tratamiento de diabetes y estados relacionados. |
| CA2738768C (en) * | 2008-10-03 | 2017-10-31 | Genzyme Corporation | 2-acylaminopropoanol-type glucosylceramide synthase inhibitors |
| US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
| EA021377B9 (ru) | 2008-12-09 | 2015-09-30 | Джилид Сайэнс, Инк. | Модуляторы толл-подобных рецепторов |
| CA2745037C (en) | 2008-12-23 | 2020-06-23 | Boehringer Ingelheim International Gmbh | Salt forms of 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8(3-(r)-amino-piperidin-1-yl)-xanthine |
| AR074990A1 (es) | 2009-01-07 | 2011-03-02 | Boehringer Ingelheim Int | Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina |
| KR101921934B1 (ko) * | 2009-02-13 | 2018-11-26 | 베링거 인겔하임 인터내셔날 게엠베하 | 글루코피라노실 디페닐메탄 유도체를 포함하는 약제학적 조성물, 이들의 약제학적 용량형, 이들의 제조방법 및 환자에서의 개선된 당 조절을 위한 이들의 용도 |
| AU2010212867B2 (en) | 2009-02-13 | 2013-05-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition comprising a SGLT2 inhibitor, a DPP-IV inhibitor and optionally a further antidiabetic agent and uses thereof |
| CN106420740A (zh) | 2009-02-23 | 2017-02-22 | 伊莫根特病毒学有限责任公司 | 亚氨基糖以及治疗病毒性疾病的方法 |
| US20100222384A1 (en) * | 2009-02-24 | 2010-09-02 | United Therapeutics Corporation | Iminosugars and methods of treating arenaviral infections |
| JP2012522015A (ja) | 2009-03-27 | 2012-09-20 | ブリストル−マイヤーズ スクイブ カンパニー | Dpp−iv阻害剤を用いて主要有害心血管事象を予防する方法 |
| CA2757026A1 (en) * | 2009-03-27 | 2010-09-30 | The Chancellor, Masters And Scholars Of The University Of Oxford | Cholesterol level lowering liposomes |
| WO2010144759A1 (en) | 2009-06-12 | 2010-12-16 | United Therapeutics Corporation | Iminosugars and methods of treating bunyaviral and togaviral diseases |
| CN102625796B (zh) * | 2009-09-04 | 2015-03-11 | 联合治疗公司 | 治疗正粘病毒感染的方法 |
| CN102595895A (zh) * | 2009-09-04 | 2012-07-18 | 联合治疗公司 | 亚氨基糖以及治疗丝状病毒性疾病的方法 |
| CN102625801B (zh) * | 2009-09-04 | 2015-09-09 | 联合治疗公司 | 治疗痘病毒感染的方法 |
| EP2483286B1 (en) * | 2009-09-30 | 2016-07-13 | Boehringer Ingelheim International GmbH | Method for the preparation of a crystalline form of 1-chloro-4-(beta-d-glucopyranos-1-yl)-2-(4-((s)-tetrahydrofuran-3-yloxy)benzyl)benzene |
| IN2012DN02751A (cg-RX-API-DMAC7.html) | 2009-09-30 | 2015-09-18 | Boehringer Ingelheim Int | |
| US10610489B2 (en) * | 2009-10-02 | 2020-04-07 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, pharmaceutical dosage form, process for their preparation, methods for treating and uses thereof |
| CN102753161A (zh) | 2009-11-27 | 2012-10-24 | 贝林格尔.英格海姆国际有限公司 | 基因型糖尿病患者利用dpp-iv抑制剂例如利拉利汀的治疗 |
| CN107961377B (zh) | 2010-05-05 | 2022-11-22 | 勃林格殷格翰国际有限公司 | 组合疗法 |
| US20130072519A1 (en) | 2010-05-21 | 2013-03-21 | Edward Lee Conn | 2-phenyl benzoylamides |
| MX2012014247A (es) | 2010-06-24 | 2013-01-18 | Boehringer Ingelheim Int | Terapia para la diabetes. |
| US10940159B2 (en) | 2010-07-09 | 2021-03-09 | James Trinca Green | Combination immediate/delayed release delivery system for short half-life pharmaceuticals including remogliflozin |
| JP5769710B2 (ja) * | 2010-07-22 | 2015-08-26 | ビオフェルミン製薬株式会社 | 脂質代謝改善剤、脂質代謝改善作用増強剤、抗肥満剤及び抗肥満作用増強剤 |
| US20130156720A1 (en) | 2010-08-27 | 2013-06-20 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| AR083878A1 (es) | 2010-11-15 | 2013-03-27 | Boehringer Ingelheim Int | Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento |
| US20130345392A1 (en) | 2011-03-04 | 2013-12-26 | Pfizer Inc | Edn3-like peptides and uses thereof |
| UY33937A (es) | 2011-03-07 | 2012-09-28 | Boehringer Ingelheim Int | Composiciones farmacéuticas que contienen inhibidores de dpp-4 y/o sglt-2 y metformina |
| PL2731947T3 (pl) | 2011-07-15 | 2019-07-31 | Boehringer Ingelheim International Gmbh | Podstawiona dimeryczna pochodna chinazoliny, sposób jej wytwarzania i jej zastosowanie w kompozycjach farmaceutycznych do leczenia cukrzycy typu I i II |
| US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
| US20150050371A1 (en) | 2012-03-09 | 2015-02-19 | Biotropics Malaysia Berhad | Extract Formulations of Rhodamnia Cinerea And Uses Thereof |
| US9192617B2 (en) | 2012-03-20 | 2015-11-24 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| US20130303554A1 (en) | 2012-05-14 | 2013-11-14 | Boehringer Ingelheim International Gmbh | Use of a dpp-4 inhibitor in sirs and/or sepsis |
| US20130303462A1 (en) | 2012-05-14 | 2013-11-14 | Boehringer Ingelheim International Gmbh | Use of a dpp-4 inhibitor in podocytes related disorders and/or nephrotic syndrome |
| WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
| US9499482B2 (en) | 2012-09-05 | 2016-11-22 | Bristol-Myers Squibb Company | Pyrrolone or pyrrolidinone melanin concentrating hormone receptor-1 antagonists |
| EP2892896B1 (en) | 2012-09-05 | 2016-06-29 | Bristol-Myers Squibb Company | Pyrrolone or pyrrolidinone melanin concentrating hormore receptor-1 antagonists |
| US9486433B2 (en) | 2012-10-12 | 2016-11-08 | Mochida Pharmaceuticals Co. Ltd. | Compositions and methods for treating non-alcoholic steatohepatitis |
| ITMI20122090A1 (it) | 2012-12-06 | 2014-06-07 | Dipharma Francis Srl | Sintesi di un inibitore delle glicosiltransferasi |
| ITMI20130083A1 (it) | 2013-01-22 | 2014-07-23 | Dipharma Francis Srl | Imminozucchero in forma cristallina |
| SG11201507288UA (en) | 2013-03-15 | 2015-10-29 | Mochida Pharm Co Ltd | Compositions and methods for treating non-alcoholic steatohepatitis |
| US10441560B2 (en) | 2013-03-15 | 2019-10-15 | Mochida Pharmaceutical Co., Ltd. | Compositions and methods for treating non-alcoholic steatohepatitis |
| AU2014235215A1 (en) | 2013-03-15 | 2015-10-01 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| WO2014151200A2 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| CA2812519A1 (en) | 2013-04-05 | 2014-10-05 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| US20140303098A1 (en) | 2013-04-05 | 2014-10-09 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| US20140303097A1 (en) | 2013-04-05 | 2014-10-09 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| US11813275B2 (en) | 2013-04-05 | 2023-11-14 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| AU2014255381A1 (en) | 2013-04-17 | 2015-10-08 | Pfizer Inc. | N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases |
| HK1215378A1 (zh) | 2013-04-18 | 2016-08-26 | 勃林格殷格翰国际有限公司 | 药物组合物、治疗方法及其用途 |
| BR112015030326A2 (pt) | 2013-06-05 | 2017-08-29 | Synergy Pharmaceuticals Inc | Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos |
| US9593113B2 (en) | 2013-08-22 | 2017-03-14 | Bristol-Myers Squibb Company | Imide and acylurea derivatives as modulators of the glucocorticoid receptor |
| WO2015128453A1 (en) | 2014-02-28 | 2015-09-03 | Boehringer Ingelheim International Gmbh | Medical use of a dpp-4 inhibitor |
| TWI733652B (zh) | 2014-07-11 | 2021-07-21 | 美商基利科學股份有限公司 | 用於治療HIV之toll樣受體調節劑 |
| ES2901114T3 (es) | 2014-08-29 | 2022-03-21 | Tes Pharma S R L | Inhibidores de ácido alfa-amino-beta-carboximucónico semialdehído descarboxilasa |
| SI3194401T1 (sl) | 2014-09-16 | 2020-12-31 | Gilead Sciences, Inc. | Trdne oblike modulatorja toličnega receptorja |
| WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
| US9718777B2 (en) | 2014-12-11 | 2017-08-01 | Navinta, Llc | Process for the preparation of high purity miglustat |
| ITUB20150176A1 (it) | 2015-04-17 | 2016-10-17 | Dipharma Francis Srl | Sintesi di un azazucchero e i suoi intermedi |
| BR112018072298A2 (pt) | 2016-05-02 | 2019-02-12 | Florida State University Research Foundation, Inc. | tratamento de infecções pelo vírus da zika usando inibidores da alfa-glicosidase |
| CA3022202A1 (en) | 2016-06-10 | 2017-12-14 | Boehringer Ingelheim International Gmbh | Combinations of linagliptin and metformin |
| MX2019004321A (es) | 2016-10-14 | 2019-06-12 | Tes Pharma S R L | Inhibidores de la acido alfa-amino-beta-carboximuconico semialdehido descarboxilasa. |
| KR20250097990A (ko) | 2016-11-10 | 2025-06-30 | 베링거 인겔하임 인터내셔날 게엠베하 | 약제학적 조성물, 치료 방법 및 이의 용도 |
| IL283182B2 (en) | 2018-11-20 | 2025-10-01 | Tes Pharma S R L | Alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase inhibitors |
| DK3911648T3 (da) | 2019-01-18 | 2025-01-13 | Astrazeneca Ab | 6'-[[(1s,3s)-3-[[5-(difluormethoxy)-2-pyrimidinyl]amino]cyclopentyl]amino][1(2h),3'-bipyridin]-2-on som pcsk9-hæmmer og fremgangsmåder til anvendelse deraf |
| EP4106752A4 (en) | 2020-02-21 | 2024-03-20 | Florida State University Research Foundation, Inc. | TREATMENT OF HUMAN CORONAVIRUS INFECTIONS USING ALPHA-GLUCOSIDASE-GLYCOPROTEIN PROCESSING INHIBITORS |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1555654A (en) * | 1977-06-25 | 1979-11-14 | Exxon Research Engineering Co | Agricultural burner apparatus |
| US4065562A (en) * | 1975-12-29 | 1977-12-27 | Nippon Shinyaku Co., Ltd. | Method and composition for reducing blood glucose levels |
| DE2660486C2 (de) * | 1975-12-29 | 1984-03-08 | Nippon Shinyaku Co., Ltd., Kyoto | Verwendung von 2-Hydroxymethyl-3,4,5-trihydroxypiperidin als Arzneimittel |
| GB2020278B (en) * | 1978-05-03 | 1983-02-23 | Nippon Shinyaku Co Ltd | Moranoline dervitives |
| JPS5943948B2 (ja) * | 1978-07-06 | 1984-10-25 | 日本新薬株式会社 | 置換モラノリン誘導体 |
| DE2830469A1 (de) * | 1978-07-11 | 1980-01-24 | Bayer Ag | Herstellung von l-desoxy-nojirimycin und n-substituierten derivaten |
| JPS5943948A (ja) * | 1982-09-03 | 1984-03-12 | Toyota Motor Corp | 可変ベンチユリ型気化器 |
-
1978
- 1978-08-09 NO NO782713A patent/NO154918C/no unknown
- 1978-08-23 US US05/936,280 patent/US4639436A/en not_active Expired - Lifetime
- 1978-08-24 PT PT68474A patent/PT68474A/pt unknown
- 1978-08-24 IL IL55423A patent/IL55423A/xx active IP Right Grant
- 1978-08-24 AU AU39214/78A patent/AU3921478A/en active Pending
- 1978-08-24 GR GR57073A patent/GR73065B/el unknown
- 1978-08-25 DK DK377678A patent/DK152753C/da not_active IP Right Cessation
- 1978-08-25 IE IE1716/78A patent/IE47070B1/en not_active IP Right Cessation
- 1978-08-25 EP EP78100750A patent/EP0000947B2/de not_active Expired
- 1978-08-25 AT AT0621778A patent/AT373239B/de not_active IP Right Cessation
- 1978-08-25 JP JP10297478A patent/JPS5446786A/ja active Granted
- 1978-08-25 CA CA310,084A patent/CA1123437A/en not_active Expired
- 1978-08-25 IT IT27067/78A patent/IT1111197B/it active
- 1978-08-25 DE DE7878100750T patent/DE2860330D1/de not_active Expired
- 1978-08-25 FI FI782607A patent/FI72715C/fi not_active IP Right Cessation
- 1978-08-25 ES ES472838A patent/ES472838A1/es not_active Expired
- 1978-08-25 HU HU78BA3696A patent/HU182449B/hu unknown
- 1978-08-28 AU AU39304/78A patent/AU520686B2/en not_active Expired
-
1979
- 1979-09-20 US US06/077,507 patent/US4260622A/en not_active Expired - Lifetime
-
1996
- 1996-10-21 NL NL960027C patent/NL960027I2/nl unknown
-
1998
- 1998-02-04 LU LU90211C patent/LU90211I2/fr unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE2860330D1 (en) | 3,4,5-trihydroxypiperidine derivatives, process for their preparation and medicaments and fodder containing them | |
| DE2960222D1 (en) | Phenoxyalkylcarboxylic-acid derivatives, process for their preparation and medicaments containing them | |
| DE2860900D1 (en) | Triphenylalkene derivatives, process for their preparation and pharmaceutical compositions containing them | |
| DE3065026D1 (en) | Phenylsulphonamide derivatives, a process for their preparation and their use as medicines | |
| IL56115A (en) | 14-deoxy-14-glycoside-mutilin derivatives,process for their preparation and pharmaceutical and veterinary compositions containing them | |
| DE2963321D1 (en) | 1-benzoyl-2-pyrrolidinone derivative, processes for its preparation and medicaments containing it | |
| DE3067830D1 (en) | Trans-quinazoline derivatives, processes for their preparation, intermediates and medicaments containing these derivatives | |
| DE2861361D1 (en) | 1-n-acylated-4-o-glycosyl-6-o-glycosyl-1,3-diaminocyclitol derivatives, process for their preparation and pharmaceutical compositions containing them | |
| DE2961983D1 (en) | Pyrrolidine-2-methanol derivatives, process for their preparation and medicaments containing them | |
| DE3067264D1 (en) | Indole derivatives, process for their preparation and medicaments containing them | |
| IL52611A (en) | 2-benzylpyrrolidines,process for their preparation and medicaments containing them | |
| IL54069A (en) | 14,15-dihydro-20,21-dinoreburnamenin-14-ol derivatives,process for preparing them and pharmaceutical compositions containing them | |
| IL55862A0 (en) | Novel 6-oxygenated-3,20-dioxo-pregnane derivatives, process for the preparation thereof, and pharmaceutical compositionss containing them | |
| DE2860111D1 (en) | New bispidine derivatives, process for their preparation and medicinal preparations containing them | |
| ZA784471B (en) | Derivatives of 1,3-diphenoxypropane-2-on,process for their preparation,medicaments thereof,and their use as medicaments | |
| DE3060894D1 (en) | Benzimidazolone derivatives, process for their preparation and pharmaceutical compositions containing them | |
| DE2964198D1 (en) | Indanamine derivatives, process for their preparation and medicaments containing them | |
| DE2860928D1 (en) | 2,4-diamino-5-benzyl-pyrimidines, process for their preparation and medicines containing them | |
| GB1538705A (en) | 1,4-dihydropyridine-sugar derivatives process for their preparation and their use as medicaments | |
| DE2861767D1 (en) | Cephalosprin derivatives, process for their preparation and pharmaceutical compositions containing them | |
| IL54111A (en) | 3,6-disubstituted-1,2,4-triazine-5-one-derivatives,process for their preparation and pharmaceutical compositions containing them | |
| IL54517A (en) | 3,5-disubstituted-1h-1,2,4-triazole derivatives and process for their preparation | |
| HK96984A (en) | Glucofuranosyl-nitrosourea derivatives,processes for their preparation and medicaments containing them | |
| DE3065906D1 (en) | Pyridine derivatives, process for their preparation and medicaments containing them | |
| DE2860614D1 (en) | N-benzylpyrimidinyl-amidines, process for their preparation and medicines containing them |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| V448 | Application of spc |
Free format text: PRODUCT NAME: MIGLITOL; REGISTRATION NO/DATE: 39092.00.00, 39092.01.00; 19970130 Spc suppl protection certif: 197 75 013 Filing date: 19970314 |
|
| V457 | Spc granted |
Free format text: PRODUCT NAME: MIGLITOL; REGISTRATION NO/DATE: 39092.00.00, 39092.01.00; 19970130 Spc suppl protection certif: 197 75 013 Filing date: 19970314 |
|
| V464 | Spc expired |
Free format text: PRODUCT NAME: MIGLITOL; REGISTRATION NO/DATE: 39092.00.00, 39092.01.00; 19970130 Spc suppl protection certif: 197 75 013 Filing date: 19970314 |