DE2821199A1 - Verfahren zur herstellung von jodophor-verbindungen sowie zur stabilisierung jodophor enthaltender pharmazeutischer zusammensetzungen - Google Patents
Verfahren zur herstellung von jodophor-verbindungen sowie zur stabilisierung jodophor enthaltender pharmazeutischer zusammensetzungenInfo
- Publication number
- DE2821199A1 DE2821199A1 DE19782821199 DE2821199A DE2821199A1 DE 2821199 A1 DE2821199 A1 DE 2821199A1 DE 19782821199 DE19782821199 DE 19782821199 DE 2821199 A DE2821199 A DE 2821199A DE 2821199 A1 DE2821199 A1 DE 2821199A1
- Authority
- DE
- Germany
- Prior art keywords
- iodine
- iodide
- ions
- iodophor
- organic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 title claims description 92
- 238000004519 manufacturing process Methods 0.000 title claims description 25
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 3
- 230000000087 stabilizing effect Effects 0.000 title description 4
- 239000011630 iodine Substances 0.000 claims description 118
- 229910052740 iodine Inorganic materials 0.000 claims description 118
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 112
- -1 iodide ions Chemical class 0.000 claims description 60
- XMBWDFGMSWQBCA-UHFFFAOYSA-M iodide Chemical compound [I-] XMBWDFGMSWQBCA-UHFFFAOYSA-M 0.000 claims description 55
- 238000000034 method Methods 0.000 claims description 41
- 230000002070 germicidal effect Effects 0.000 claims description 25
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims description 24
- 238000002360 preparation method Methods 0.000 claims description 20
- 230000008569 process Effects 0.000 claims description 20
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 19
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 19
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 claims description 18
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 16
- 239000000203 mixture Substances 0.000 claims description 16
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims description 14
- JLKDVMWYMMLWTI-UHFFFAOYSA-M potassium iodate Chemical compound [K+].[O-]I(=O)=O JLKDVMWYMMLWTI-UHFFFAOYSA-M 0.000 claims description 13
- 239000001230 potassium iodate Substances 0.000 claims description 13
- 235000006666 potassium iodate Nutrition 0.000 claims description 13
- 229940093930 potassium iodate Drugs 0.000 claims description 13
- 125000002091 cationic group Chemical group 0.000 claims description 12
- 150000002500 ions Chemical class 0.000 claims description 12
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 9
- 239000003795 chemical substances by application Substances 0.000 claims description 9
- 229940069328 povidone Drugs 0.000 claims description 9
- SXDBWCPKPHAZSM-UHFFFAOYSA-M bromate Inorganic materials [O-]Br(=O)=O SXDBWCPKPHAZSM-UHFFFAOYSA-M 0.000 claims description 8
- ZCDOYSPFYFSLEW-UHFFFAOYSA-N chromate(2-) Chemical compound [O-][Cr]([O-])(=O)=O ZCDOYSPFYFSLEW-UHFFFAOYSA-N 0.000 claims description 8
- WQYVRQLZKVEZGA-UHFFFAOYSA-N hypochlorite Inorganic materials Cl[O-] WQYVRQLZKVEZGA-UHFFFAOYSA-N 0.000 claims description 8
- 125000004432 carbon atom Chemical group C* 0.000 claims description 6
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 claims description 6
- 239000004094 surface-active agent Substances 0.000 claims description 6
- 150000004694 iodide salts Chemical class 0.000 claims description 5
- HSZCZNFXUDYRKD-UHFFFAOYSA-M lithium iodide Chemical compound [Li+].[I-] HSZCZNFXUDYRKD-UHFFFAOYSA-M 0.000 claims description 5
- 239000003381 stabilizer Substances 0.000 claims description 5
- 239000003945 anionic surfactant Substances 0.000 claims description 4
- 239000012459 cleaning agent Substances 0.000 claims description 4
- 230000001590 oxidative effect Effects 0.000 claims description 4
- 230000006641 stabilisation Effects 0.000 claims description 4
- 238000011105 stabilization Methods 0.000 claims description 4
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims description 4
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 3
- UNMYWSMUMWPJLR-UHFFFAOYSA-L Calcium iodide Chemical compound [Ca+2].[I-].[I-] UNMYWSMUMWPJLR-UHFFFAOYSA-L 0.000 claims description 2
- 229910001640 calcium iodide Inorganic materials 0.000 claims description 2
- 229940046413 calcium iodide Drugs 0.000 claims description 2
- BLQJIBCZHWBKSL-UHFFFAOYSA-L magnesium iodide Chemical compound [Mg+2].[I-].[I-] BLQJIBCZHWBKSL-UHFFFAOYSA-L 0.000 claims description 2
- 229910001641 magnesium iodide Inorganic materials 0.000 claims description 2
- 230000009972 noncorrosive effect Effects 0.000 claims description 2
- 229920001451 polypropylene glycol Polymers 0.000 claims description 2
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims description 2
- 235000009518 sodium iodide Nutrition 0.000 claims description 2
- 229910002651 NO3 Inorganic materials 0.000 claims 2
- ROOXNKNUYICQNP-UHFFFAOYSA-N ammonium persulfate Chemical compound [NH4+].[NH4+].[O-]S(=O)(=O)OOS([O-])(=O)=O ROOXNKNUYICQNP-UHFFFAOYSA-N 0.000 claims 2
- 229910001919 chlorite Inorganic materials 0.000 claims 2
- 229910052619 chlorite group Inorganic materials 0.000 claims 2
- 239000000356 contaminant Substances 0.000 claims 2
- XZXYQEHISUMZAT-UHFFFAOYSA-N 2-[(2-hydroxy-5-methylphenyl)methyl]-4-methylphenol Chemical compound CC1=CC=C(O)C(CC=2C(=CC=C(C)C=2)O)=C1 XZXYQEHISUMZAT-UHFFFAOYSA-N 0.000 claims 1
- 101100165798 Arabidopsis thaliana CYP86A1 gene Proteins 0.000 claims 1
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical class NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 1
- 125000002877 alkyl aryl group Chemical group 0.000 claims 1
- 229940107816 ammonium iodide Drugs 0.000 claims 1
- 229910001870 ammonium persulfate Inorganic materials 0.000 claims 1
- 239000007859 condensation product Substances 0.000 claims 1
- 150000002462 imidazolines Chemical class 0.000 claims 1
- 229940006461 iodide ion Drugs 0.000 description 48
- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 description 32
- 229920000153 Povidone-iodine Polymers 0.000 description 29
- 229960001621 povidone-iodine Drugs 0.000 description 29
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 26
- 239000000243 solution Substances 0.000 description 24
- 239000000047 product Substances 0.000 description 23
- 238000006243 chemical reaction Methods 0.000 description 21
- ICIWUVCWSCSTAQ-UHFFFAOYSA-M iodate Chemical compound [O-]I(=O)=O ICIWUVCWSCSTAQ-UHFFFAOYSA-M 0.000 description 18
- 239000000126 substance Substances 0.000 description 17
- 229940005633 iodate ion Drugs 0.000 description 15
- 239000003599 detergent Substances 0.000 description 13
- 230000015572 biosynthetic process Effects 0.000 description 12
- 239000002904 solvent Substances 0.000 description 12
- 229910052739 hydrogen Inorganic materials 0.000 description 11
- 239000001257 hydrogen Substances 0.000 description 11
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 10
- 125000000129 anionic group Chemical group 0.000 description 10
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 10
- 229910052708 sodium Inorganic materials 0.000 description 10
- 239000011734 sodium Substances 0.000 description 10
- 238000007792 addition Methods 0.000 description 9
- 229920000642 polymer Polymers 0.000 description 8
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 7
- 239000002736 nonionic surfactant Substances 0.000 description 7
- 238000003756 stirring Methods 0.000 description 7
- 230000000845 anti-microbial effect Effects 0.000 description 6
- 239000007864 aqueous solution Substances 0.000 description 6
- 235000019441 ethanol Nutrition 0.000 description 6
- 239000012535 impurity Substances 0.000 description 6
- JRKICGRDRMAZLK-UHFFFAOYSA-L peroxydisulfate Chemical compound [O-]S(=O)(=O)OOS([O-])(=O)=O JRKICGRDRMAZLK-UHFFFAOYSA-L 0.000 description 6
- 239000000825 pharmaceutical preparation Substances 0.000 description 6
- 229920001983 poloxamer Polymers 0.000 description 6
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 6
- 230000002588 toxic effect Effects 0.000 description 6
- 230000032683 aging Effects 0.000 description 5
- QBWCMBCROVPCKQ-UHFFFAOYSA-M chlorite Chemical compound [O-]Cl=O QBWCMBCROVPCKQ-UHFFFAOYSA-M 0.000 description 5
- 229940005993 chlorite ion Drugs 0.000 description 5
- 230000007423 decrease Effects 0.000 description 5
- 238000004090 dissolution Methods 0.000 description 5
- 239000002798 polar solvent Substances 0.000 description 5
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 4
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 4
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
- 239000005642 Oleic acid Substances 0.000 description 4
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 4
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 4
- 230000002378 acidificating effect Effects 0.000 description 4
- 239000000654 additive Substances 0.000 description 4
- 230000000996 additive effect Effects 0.000 description 4
- 150000001298 alcohols Chemical class 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- 238000004140 cleaning Methods 0.000 description 4
- 238000011109 contamination Methods 0.000 description 4
- 239000012153 distilled water Substances 0.000 description 4
- ICIWUVCWSCSTAQ-UHFFFAOYSA-N iodic acid Chemical compound OI(=O)=O ICIWUVCWSCSTAQ-UHFFFAOYSA-N 0.000 description 4
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 150000002894 organic compounds Chemical class 0.000 description 4
- 229920000151 polyglycol Polymers 0.000 description 4
- 239000010695 polyglycol Substances 0.000 description 4
- 229910052700 potassium Inorganic materials 0.000 description 4
- 239000011591 potassium Substances 0.000 description 4
- 238000001228 spectrum Methods 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- 238000003786 synthesis reaction Methods 0.000 description 4
- 229940104261 taurate Drugs 0.000 description 4
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 4
- 239000012085 test solution Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 238000004448 titration Methods 0.000 description 4
- 231100000331 toxic Toxicity 0.000 description 4
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- 230000001988 toxicity Effects 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 3
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 239000003125 aqueous solvent Substances 0.000 description 3
- 239000000969 carrier Substances 0.000 description 3
- SPCNPOWOBZQWJK-UHFFFAOYSA-N dimethoxy-(2-propan-2-ylsulfanylethylsulfanyl)-sulfanylidene-$l^{5}-phosphane Chemical compound COP(=S)(OC)SCCSC(C)C SPCNPOWOBZQWJK-UHFFFAOYSA-N 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 150000002431 hydrogen Chemical class 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 239000003960 organic solvent Substances 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 229910001961 silver nitrate Inorganic materials 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
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- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
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- REYJJPSVUYRZGE-UHFFFAOYSA-N Octadecylamine Chemical compound CCCCCCCCCCCCCCCCCCN REYJJPSVUYRZGE-UHFFFAOYSA-N 0.000 description 2
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- 125000000217 alkyl group Chemical group 0.000 description 2
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- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 2
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- 235000019345 sodium thiosulphate Nutrition 0.000 description 2
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 2
- 231100000563 toxic property Toxicity 0.000 description 2
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- 238000007086 side reaction Methods 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- VOXBATAAGDVURT-UHFFFAOYSA-M sodium;2-[cyclohexyl(hexadecanoyl)amino]ethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCCCCC(=O)N(CCS([O-])(=O)=O)C1CCCCC1 VOXBATAAGDVURT-UHFFFAOYSA-M 0.000 description 1
- PWWJJDVDTKXWOF-UHFFFAOYSA-M sodium;2-[hexadecanoyl(methyl)amino]ethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCCCCC(=O)N(C)CCS([O-])(=O)=O PWWJJDVDTKXWOF-UHFFFAOYSA-M 0.000 description 1
- IZWPGJFSBABFGL-GMFCBQQYSA-M sodium;2-[methyl-[(z)-octadec-9-enoyl]amino]ethanesulfonate Chemical compound [Na+].CCCCCCCC\C=C/CCCCCCCC(=O)N(C)CCS([O-])(=O)=O IZWPGJFSBABFGL-GMFCBQQYSA-M 0.000 description 1
- 230000003330 sporicidal effect Effects 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
- DHCDFWKWKRSZHF-UHFFFAOYSA-N sulfurothioic S-acid Chemical compound OS(O)(=O)=S DHCDFWKWKRSZHF-UHFFFAOYSA-N 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229930192474 thiophene Natural products 0.000 description 1
- 150000003577 thiophenes Chemical class 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 238000005292 vacuum distillation Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/18—Iodine; Compounds thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/12—Iodine, e.g. iodophors; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Wood Science & Technology (AREA)
- Agronomy & Crop Science (AREA)
- Dentistry (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/797,094 US4113857A (en) | 1977-05-16 | 1977-05-16 | Process for the preparation of iodophor compounds and methods for stabilizing iodophor pharmaceutical compositions containing the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE2821199A1 true DE2821199A1 (de) | 1978-11-23 |
| DE2821199C2 DE2821199C2 (enrdf_load_stackoverflow) | 1989-08-24 |
Family
ID=25169886
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19782821199 Granted DE2821199A1 (de) | 1977-05-16 | 1978-05-13 | Verfahren zur herstellung von jodophor-verbindungen sowie zur stabilisierung jodophor enthaltender pharmazeutischer zusammensetzungen |
Country Status (21)
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3034290A1 (de) * | 1979-09-21 | 1981-04-02 | West Agro-Chemical, Inc., Westwood, Kan. | Germizide, jodhaltige zusammensetzungen |
| DE3313655A1 (de) * | 1983-03-02 | 1984-09-06 | Euro-Celtique S.A., Luxembourg | Pharmazeutisches jodophor-praeparat |
| DE4013118A1 (de) * | 1989-04-28 | 1990-10-31 | Harbor Ucla Med Ct Res Educat | Povidon-iod-mittel zur ophthalmischen antimikrobiellen prophylaxe bei neugeborenen |
| EP0448288A1 (en) * | 1990-03-21 | 1991-09-25 | Euroceltique S.A. | Pharmaceutical iodine compositions |
| EP0496546A1 (en) * | 1991-01-22 | 1992-07-29 | Becton, Dickinson and Company | Iodophor composition with increased stability |
| WO2000057703A1 (en) * | 1999-03-26 | 2000-10-05 | Ecolab Inc. | Antimicrobial and antiviral compositions containing an oxidizing species |
| WO2000078150A1 (en) * | 1999-06-21 | 2000-12-28 | Symbollon Corporation | Iodine germicides that continuously generate free molecular iodine |
| US6534075B1 (en) | 1999-03-26 | 2003-03-18 | Ecolab Inc. | Antimicrobial and antiviral compositions and treatments for food surfaces |
| US6855328B2 (en) | 2002-03-28 | 2005-02-15 | Ecolab Inc. | Antimicrobial and antiviral compositions containing an oxidizing species |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE7902893L (sv) * | 1979-04-02 | 1980-10-03 | Astra Chem Prod Ab | Desinfektionsmedel |
| US4323557A (en) * | 1979-07-31 | 1982-04-06 | Minnesota Mining & Manufacturing Company | Pressure-sensitive adhesive containing iodine |
| US4310509A (en) * | 1979-07-31 | 1982-01-12 | Minnesota Mining And Manufacturing Company | Pressure-sensitive adhesive having a broad spectrum antimicrobial therein |
| US4481167A (en) * | 1980-04-11 | 1984-11-06 | The Dow Chemical Company | Sanitizing complexes of polyoxazolines or polyoxazines and polyhalide anions |
| EP0094219A1 (en) * | 1982-05-07 | 1983-11-16 | Diversey Corporation | Germicidal iodine compositions |
| ATE23094T1 (de) * | 1982-05-25 | 1986-11-15 | Edward Sturdy Wilson | Iodophore. |
| US4521403A (en) * | 1983-01-20 | 1985-06-04 | Simon Gilbert I | Chemotherapeutic method for treating periodontal disease |
| IL70972A (en) * | 1983-03-02 | 1987-10-30 | Euro Celtique Sa | Method of producing standardized iodophor preparations and iodophor preparations produced thereby |
| US4792445A (en) * | 1983-11-04 | 1988-12-20 | Mario Flores Rivera | Highly stable free iodine iodophor compositions, process for preparing same and process for using same |
| US4567036A (en) * | 1983-12-30 | 1986-01-28 | Simon Gilbert I | Chemotherapeutic method for treating periodontal disease, and composition therefore |
| US4575491A (en) * | 1984-05-31 | 1986-03-11 | Euroceltique, S.A. | Method of controlling and determining germicidal activity |
| US4946673A (en) * | 1984-05-31 | 1990-08-07 | Euroceltique, S.A. | Iodine-containing germicidal preparations and method of controlling germicidal activity |
| US4923677A (en) * | 1985-08-07 | 1990-05-08 | Roy T. Witkin | Chemical sterilization |
| US4997625A (en) * | 1985-08-07 | 1991-03-05 | Simon Gilbert I | Chemical sterilization |
| US4684519A (en) * | 1986-04-09 | 1987-08-04 | Gaf Corporation | Method of preparing a polyvinylpyrrolidone-halogen complex of improved stability |
| US4842858A (en) * | 1987-03-03 | 1989-06-27 | Gaf Corporation | Polymeric halophors |
| US4830851A (en) * | 1987-03-03 | 1989-05-16 | Gaf Corporation | Polymeric halophors |
| KR970002580B1 (ko) * | 1987-07-01 | 1997-03-06 | 노바파암 리서어치 프로프라이어터리 리미티드 | 살균제 조성물 |
| US5409697A (en) * | 1987-07-01 | 1995-04-25 | Novapharm Research Pty. Ltd. | Biocidal composition |
| US4935248A (en) * | 1988-07-28 | 1990-06-19 | Albert L. Jacobs | Antimicrobial veterinary compositions and methods |
| US5066497A (en) * | 1988-07-28 | 1991-11-19 | Albert L. Jacobs, Jr. | Antimicrobial veterinary compositions and methods |
| US4904480A (en) * | 1988-09-19 | 1990-02-27 | Becton, Dickinson And Company | Radiation compatible iodine formulation |
| US4996048A (en) * | 1988-11-30 | 1991-02-26 | Euroceltique, S.A. | Stabilizing packaged iodophor and minimizing leaching of iodine through packaging |
| US4865752A (en) * | 1988-12-05 | 1989-09-12 | Jacobs Albert L | Separation and filtration membranes and their regeneration |
| US4978527A (en) * | 1989-04-10 | 1990-12-18 | Minnesota Mining And Manufacturing Company | Film-forming emulsion containing iodine and methods of use |
| IE63315B1 (en) * | 1989-04-24 | 1995-04-05 | Becton Dickinson Co | Radiation sterilizable antimicrobial ointment and process to manufacture |
| US5019380A (en) * | 1990-04-27 | 1991-05-28 | Bausch & Lomb Incorporated | Novel antimicrobial compositions and process for preparing the same |
| US5261353A (en) * | 1990-11-05 | 1993-11-16 | Stevenson Dale V | Udder care plus indicator |
| US5229027A (en) * | 1991-03-20 | 1993-07-20 | Colgate-Palmolive Company | Aqueous liquid automatic dishwashing detergent composition comprising hypochlorite bleach and an iodate or iodide hypochlorite bleach stabilizer |
| US5130124A (en) * | 1991-05-01 | 1992-07-14 | Isp Investments Inc. | Stabilized, aqueous, film-forming antimicrobial compositions of hydrogen peroxide |
| US5180061A (en) * | 1991-09-09 | 1993-01-19 | Becton, Dickinson And Company | Stable iodophor in polyurethane foam |
| US5152987A (en) * | 1991-10-08 | 1992-10-06 | Isp Investments Inc. | Process for preparing water-insoluble PVP-iodine product |
| AU2511392A (en) * | 1991-10-08 | 1993-05-03 | Isp Investments Inc. | Process for preparing pvp-iodine product |
| ES2155066T3 (es) * | 1992-03-27 | 2001-05-01 | Unilever Nv | Produccion de yodoforos. |
| US5616348A (en) * | 1992-09-18 | 1997-04-01 | West Agro, Inc. | Germicidal detergent-iodine compositions including polyvinyl pyrrolidone and compatible nonionic surfactant complexors |
| GB9306296D0 (en) * | 1993-03-26 | 1993-05-19 | Diversey Corp | Improved iodophors,production and use thereof |
| US5863556A (en) * | 1993-08-20 | 1999-01-26 | Euro-Celtique, S.A. | Preparations for the external application of antiseptic agents and/or agents promoting the healing of wounds |
| JP3005484U (ja) * | 1994-06-21 | 1994-12-20 | 昌弘 米田 | 紙製包装用箱 |
| AU2215197A (en) * | 1996-03-22 | 1997-10-10 | Viatro Corp. | Medical waste solidifier and microbicidal composition |
| US6203484B1 (en) | 1997-03-24 | 2001-03-20 | Basf Corporation | Methods for disinfecting wastes |
| DE29923848U1 (de) * | 1998-05-27 | 2001-04-12 | Euroceltique S.A., Luxemburg/Luxembourg | Präparate zur Anwendung von entzündungshemmenden, insbesondere antiseptischen Wirkstoffen und/oder die Wundheilung fördernden Wirkstoffen in den oberen Atemwegen und/oder dem Ohr |
| US6231830B1 (en) * | 1999-03-04 | 2001-05-15 | George Madray | Method of making molecular chlorine dioxide |
| US7300667B1 (en) | 1999-05-27 | 2007-11-27 | Euro-Celtique, S.A. | Preparations for the application of anti-inflammatory, especially antiseptic agents and/or agents promoting the healing of wounds, to the lower respiratory tract |
| US7297344B1 (en) | 1999-05-27 | 2007-11-20 | Euro-Celtique, S.A. | Preparations for the promotion of wound healing in the upper respiratory tract and/or ear |
| ATE340561T1 (de) | 1999-05-27 | 2006-10-15 | Euro Celtique Sa | Verwendung von antiseptika zur herstellung von arzneimitteln zur prophylaxe und behandlung von entzündungen im korperinneren des menschen |
| EP1628911B1 (en) * | 2003-05-12 | 2011-12-07 | Diversey, Inc. | Preparation of and dispensing chlorine dioxide |
| ES2292874T3 (es) * | 2003-05-19 | 2008-03-16 | Euro-Celtique S.A. | Composiciones liposomales secas de pvp-yodo. |
| JP2006206480A (ja) * | 2005-01-27 | 2006-08-10 | Nippo Kagaku Kk | 水性組成物 |
| US20090003931A1 (en) * | 2007-06-28 | 2009-01-01 | Off The Wall Products, Llc | Control barrier with light assembly |
| WO2012153741A1 (ja) * | 2011-05-10 | 2012-11-15 | 株式会社ネオス | ヨウ素－β－シクロデキストリン包接化合物溶液 |
| TW201808311A (zh) | 2011-09-16 | 2018-03-16 | 遠景生物製藥股份有限公司 | 安定之普維酮-碘組成物 |
| US10034899B2 (en) | 2013-11-27 | 2018-07-31 | BioPharmX, Inc. | Solid oral dosage form for breast symptoms |
| CN104069070A (zh) * | 2014-06-27 | 2014-10-01 | 深圳市格易通消毒药械科技有限公司 | 一种具有高效杀菌消毒作用的聚维酮碘粉剂及其制备方法 |
| WO2016175727A1 (en) * | 2015-04-27 | 2016-11-03 | Aydin Kimya Sanayi Ve Ticaret Anonim Sirketi | Production method of iodophor based antimicrobial hydrogel |
| EP3777537A4 (en) * | 2018-04-03 | 2022-01-05 | Honbusankei Co., Ltd. | MANUFACTURING PROCESS FOR OBTAINING A NEW COMPOSITION OF CHLORINE OXIDE FROM DEGRADED HYPOCHLORITE |
| IL275909B (en) * | 2020-03-23 | 2021-05-31 | Iocure Inc | An iodine preparation for the treatment of pathogens in the respiratory system |
| CN111632192B (zh) * | 2020-06-19 | 2021-09-24 | 浙江大学 | 兼具抗菌、促成骨分化及矿化的载碘钛合金植入物及其制备方法 |
| CN114208820B (zh) * | 2021-11-24 | 2022-10-21 | 佛山市正典生物技术有限公司 | 一种含有砜和/或亚砜的含碘消毒剂及其制备方法和用途 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2438594A1 (de) * | 1974-08-10 | 1976-02-26 | Basf Ag | Desinfektionsmittel |
| US3966090A (en) * | 1969-02-17 | 1976-06-29 | Dart Industries Inc. | Package for dispensing an antiseptic composition |
| DE2537303A1 (de) * | 1975-06-02 | 1976-12-23 | Flow Pharma Inc | Waessrige loesung fuer die verteilung von jod in einem jodophor und deren verwendung |
| DE2540170A1 (de) * | 1975-09-10 | 1977-03-17 | Basf Ag | Verfahren zur herstellung von waessrigen polyvinylpyrrolidon-jod- loesungen |
| DE2718395A1 (de) * | 1976-04-28 | 1977-11-17 | Landstingens Inkopscentral | Vorrichtung zur zeitweiligen befestigung eines kuenstlichen gliedmasses, insbesondere unterschenkelprothese |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3028300A (en) * | 1960-09-13 | 1962-04-03 | West Laboratories Inc | Germicidal compositions and methods for preparing the same |
| US3039916A (en) * | 1961-03-27 | 1962-06-19 | West Laboratories Inc | Anionic iodine complexes |
| US3367877A (en) * | 1965-02-03 | 1968-02-06 | West Laboratories Inc | Detergent-hydriodic acid compositions |
| US3644650A (en) * | 1969-06-26 | 1972-02-22 | Chemed Corp | Solutions of germicidal iodine complexes |
-
1977
- 1977-05-16 US US05/797,094 patent/US4113857A/en not_active Expired - Lifetime
-
1978
- 1978-03-29 NO NO781082A patent/NO153833C/no unknown
- 1978-03-30 DK DK140778A patent/DK156983C/da not_active IP Right Cessation
- 1978-03-30 FI FI780963A patent/FI61609C/fi not_active IP Right Cessation
- 1978-04-03 IL IL54419A patent/IL54419A/xx unknown
- 1978-04-03 PT PT67861A patent/PT67861B/pt unknown
- 1978-04-03 CA CA300,344A patent/CA1099728A/en not_active Expired
- 1978-04-06 SE SE7803912A patent/SE443700B/sv not_active IP Right Cessation
- 1978-04-10 ZA ZA00782026A patent/ZA782026B/xx unknown
- 1978-04-10 AU AU34918/78A patent/AU519505B2/en not_active Expired
- 1978-04-10 NL NLAANVRAGE7803770,A patent/NL185705C/xx not_active IP Right Cessation
- 1978-04-13 IN IN411/CAL/78A patent/IN148864B/en unknown
- 1978-04-14 CH CH403178A patent/CH639278A5/de not_active IP Right Cessation
- 1978-04-18 GB GB15162/78A patent/GB1580596A/en not_active Expired
- 1978-04-26 BE BE187119A patent/BE866395A/xx not_active IP Right Cessation
- 1978-04-27 NZ NZ187097A patent/NZ187097A/xx unknown
- 1978-04-28 JP JP5016578A patent/JPS53148540A/ja active Granted
- 1978-05-03 ES ES469385A patent/ES469385A1/es not_active Expired
- 1978-05-12 FR FR7814266A patent/FR2390963A1/fr active Granted
- 1978-05-12 AT AT347678A patent/AT362082B/de not_active IP Right Cessation
- 1978-05-13 DE DE19782821199 patent/DE2821199A1/de active Granted
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| US3966090A (en) * | 1969-02-17 | 1976-06-29 | Dart Industries Inc. | Package for dispensing an antiseptic composition |
| DE2438594A1 (de) * | 1974-08-10 | 1976-02-26 | Basf Ag | Desinfektionsmittel |
| DE2537303A1 (de) * | 1975-06-02 | 1976-12-23 | Flow Pharma Inc | Waessrige loesung fuer die verteilung von jod in einem jodophor und deren verwendung |
| DE2540170A1 (de) * | 1975-09-10 | 1977-03-17 | Basf Ag | Verfahren zur herstellung von waessrigen polyvinylpyrrolidon-jod- loesungen |
| DE2718395A1 (de) * | 1976-04-28 | 1977-11-17 | Landstingens Inkopscentral | Vorrichtung zur zeitweiligen befestigung eines kuenstlichen gliedmasses, insbesondere unterschenkelprothese |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3034290A1 (de) * | 1979-09-21 | 1981-04-02 | West Agro-Chemical, Inc., Westwood, Kan. | Germizide, jodhaltige zusammensetzungen |
| DE3313655A1 (de) * | 1983-03-02 | 1984-09-06 | Euro-Celtique S.A., Luxembourg | Pharmazeutisches jodophor-praeparat |
| DE4013118A1 (de) * | 1989-04-28 | 1990-10-31 | Harbor Ucla Med Ct Res Educat | Povidon-iod-mittel zur ophthalmischen antimikrobiellen prophylaxe bei neugeborenen |
| DE4013118C2 (de) * | 1989-04-28 | 1998-04-09 | Res & Education Inst Inc | Verwendung von Povidon-Iod zur ophthalmischen antimikrobiellen Prophylaxe bei Neugeborenen |
| EP0448288A1 (en) * | 1990-03-21 | 1991-09-25 | Euroceltique S.A. | Pharmaceutical iodine compositions |
| EP0496546A1 (en) * | 1991-01-22 | 1992-07-29 | Becton, Dickinson and Company | Iodophor composition with increased stability |
| WO2000057703A1 (en) * | 1999-03-26 | 2000-10-05 | Ecolab Inc. | Antimicrobial and antiviral compositions containing an oxidizing species |
| US6436445B1 (en) | 1999-03-26 | 2002-08-20 | Ecolab Inc. | Antimicrobial and antiviral compositions containing an oxidizing species |
| US6534075B1 (en) | 1999-03-26 | 2003-03-18 | Ecolab Inc. | Antimicrobial and antiviral compositions and treatments for food surfaces |
| WO2000078150A1 (en) * | 1999-06-21 | 2000-12-28 | Symbollon Corporation | Iodine germicides that continuously generate free molecular iodine |
| US6855328B2 (en) | 2002-03-28 | 2005-02-15 | Ecolab Inc. | Antimicrobial and antiviral compositions containing an oxidizing species |
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