DE2752659A1 - Neue tetralinderivate, ihre herstellung und verwendung - Google Patents
Neue tetralinderivate, ihre herstellung und verwendungInfo
- Publication number
- DE2752659A1 DE2752659A1 DE19772752659 DE2752659A DE2752659A1 DE 2752659 A1 DE2752659 A1 DE 2752659A1 DE 19772752659 DE19772752659 DE 19772752659 DE 2752659 A DE2752659 A DE 2752659A DE 2752659 A1 DE2752659 A1 DE 2752659A1
- Authority
- DE
- Germany
- Prior art keywords
- group
- hydrogen
- carbon atoms
- alkyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH1535376 | 1976-12-07 | ||
CH8277 | 1977-01-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE2752659A1 true DE2752659A1 (de) | 1978-06-08 |
Family
ID=25683446
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19772752659 Ceased DE2752659A1 (de) | 1976-12-07 | 1977-11-25 | Neue tetralinderivate, ihre herstellung und verwendung |
Country Status (17)
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1981003491A1 (en) * | 1980-05-29 | 1981-12-10 | Astra Laekemedel Ab | Therapeutically useful tetralin derivatives |
WO1982004042A1 (en) * | 1981-05-11 | 1982-11-25 | Folke Lars Erik Arvidsson | Therapeutically useful tetralin derivatives iii,processes for preparation and pharmaceutical preparations for such compounds |
US4410519A (en) | 1979-09-14 | 1983-10-18 | Sandoz Ltd. | Tetraline derivatives, their production and pharmaceutical compositions containing them |
DE3320936A1 (de) * | 1982-06-10 | 1983-12-22 | Chiesi Farmaceutici S.P.A., Parma | 1,2,3,4-tetrahydronaphthalinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
US4876284A (en) * | 1981-05-08 | 1989-10-24 | Per Arvid Emil Carlsson | 1-alkyl-2-aminotetralin derivatives |
EP0399982A1 (en) * | 1989-05-26 | 1990-11-28 | Astra Aktiebolag | Novel 8-substituted-2-amino-tetralines |
WO1997045403A1 (en) * | 1996-05-31 | 1997-12-04 | Pharmacia & Upjohn Company | Aryl substituted cyclic amines as selective dopamine d3 ligands |
WO1999015494A1 (en) * | 1997-09-22 | 1999-04-01 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | 2-aminotetralines, a process for their preparation, and pharmaceutical compositions, for the prevention and therapeutic treatment of inflammatory and/or autoimmune pathologies |
WO2006126939A1 (en) * | 2005-05-23 | 2006-11-30 | Astrazeneca Ab | Novel 8-sulfonylamino-3 aminosubstituted chroman or tetrahydronaphtalene derivatives modulating the 5ht6 receptor |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4314082A (en) * | 1978-07-14 | 1982-02-02 | American Hospital Supply Corporation | Derivatives of 2-amino-6,7-dihydroxytetrahydro naphthalene (ADTN) |
DE2965841D1 (en) * | 1978-07-14 | 1983-08-18 | American Hospital Supply Corp | 2-alpha-methyl-dopaminimino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene, its salts, and a process for preparation thereof |
EP0033789B1 (en) * | 1980-01-30 | 1984-03-07 | American Hospital Supply Corporation | 2-alpha-methyl-dopaminimino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene, its salts, and a process for preparation thereof |
US4455317A (en) * | 1981-06-23 | 1984-06-19 | American Hospital Supply Corporation | Method for treating glaucoma by the topical administration of selectively metabolized beta-blocking agents |
US4559359A (en) * | 1981-06-23 | 1985-12-17 | American Hospital Supply Corporation | Method for treating glaucoma by the topical administration of selectively metabolized beta-blocking agents |
US4454154A (en) * | 1981-06-23 | 1984-06-12 | American Hospital Supply Corporation | Method for treating glaucoma by the topical administration of selectively metabolized beta-blocking agents |
US4402974A (en) | 1981-06-23 | 1983-09-06 | American Hospital Supply Corporation | Method for treating glaucoma by the topical administration of selectively metabolized beta-blocking agents |
US4578403A (en) * | 1981-06-23 | 1986-03-25 | American Hospital Supply Corporation | Method for treating glaucoma by the topical administration of selectively metabolized beta-blocking agents |
US4448990A (en) * | 1982-11-16 | 1984-05-15 | Eli Lilly And Company | Hydroxyaminotetralincarboxamides |
US4500545A (en) * | 1982-11-16 | 1985-02-19 | Eli Lilly And Company | Hydroxyaminotetralincarboxamides |
US5177112A (en) * | 1983-01-03 | 1993-01-05 | Whitby Research, Inc. | Substituted 2-aminotetralins |
US4722933A (en) * | 1985-12-20 | 1988-02-02 | Nelson Research & Development Co. | Substituted 2-aminotetralins |
US4564628A (en) * | 1983-01-03 | 1986-01-14 | Nelson Research & Development Co. | Substituted 2-aminotetralins |
US4743618A (en) * | 1983-01-03 | 1988-05-10 | Nelson Research & Development Co. | Substituted 2-aminotetralins |
US4657925A (en) * | 1984-08-13 | 1987-04-14 | Nelson Research & Development Co. | Method and compositions for reducing the intraocular pressure of mammals |
GB2157950B (en) * | 1984-05-04 | 1988-11-02 | Nelson Res & Dev | Selective d-2 dopamine receptor agonist |
CA1331191C (en) | 1988-03-25 | 1994-08-02 | Bengt Ronny Andersson | Therapeutically useful tetralin derivatives |
US5214156A (en) * | 1988-03-25 | 1993-05-25 | The Upjohn Company | Therapeutically useful tetralin derivatives |
US5225596A (en) * | 1989-01-09 | 1993-07-06 | The Upjohn Company | Halo substituted aminotetralins |
JP2931986B2 (ja) * | 1989-02-17 | 1999-08-09 | 武田薬品工業株式会社 | アラルキルアミン誘導体 |
CA2105560A1 (en) * | 1991-03-07 | 1992-09-08 | Yoshiaki Muto | Trialkylamine derivative and ameliorant for digestive tract movement containing the same |
KR101478597B1 (ko) * | 2011-06-27 | 2015-01-02 | 산동 루예 파마슈티칼 컴파니 리미티드 | 질소 치환 아미노-5,6,7,8-테트라하이드로나프톨의 공업화 제조방법 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1017359A (en) * | 1972-07-03 | 1977-09-13 | Frederic P. Hauck | Substituted cyclic polymethylene phenols |
-
1977
- 1977-11-25 DE DE19772752659 patent/DE2752659A1/de not_active Ceased
- 1977-11-28 DK DK527877A patent/DK527877A/da not_active Application Discontinuation
- 1977-11-28 FI FI773595A patent/FI773595A/fi not_active Application Discontinuation
- 1977-11-29 SE SE7713471A patent/SE7713471L/xx not_active Application Discontinuation
- 1977-12-02 NL NL7713364A patent/NL7713364A/xx not_active Application Discontinuation
- 1977-12-05 PT PT67365A patent/PT67365B/pt unknown
- 1977-12-05 IL IL53533A patent/IL53533A/xx unknown
- 1977-12-05 GB GB50477/77A patent/GB1597140A/en not_active Expired
- 1977-12-05 ES ES464747A patent/ES464747A1/es not_active Expired
- 1977-12-05 IE IE2462/77A patent/IE45929B1/en unknown
- 1977-12-06 JP JP14648577A patent/JPS5384955A/ja active Granted
- 1977-12-06 NZ NZ185884A patent/NZ185884A/xx unknown
- 1977-12-06 AT AT0871977A patent/AT366361B/de not_active IP Right Cessation
- 1977-12-06 FR FR7736662A patent/FR2373513A1/fr active Granted
- 1977-12-06 SU SU772549950A patent/SU927110A3/ru active
- 1977-12-06 CA CA292,457A patent/CA1105475A/en not_active Expired
- 1977-12-07 PH PH20543A patent/PH13932A/en unknown
Non-Patent Citations (10)
Title |
---|
Chem.Abstr.78 (1973), 119348v * |
J.Chem.Soc.(C) 1967, 288 * |
J.Med.Chem.12 (1969), 487 * |
J.Med.Chem.15 (1972), 348 * |
J.Med.Chem.16 (1973), 804 * |
J.Med.Chem.17 (1974), 565 * |
J.Med.Chem.18 (1975), 1212 * |
J.Med.Chem.18 (1975), 362 * |
J.Med.Chem.19 (1976), 547 * |
J.Med.Chem.19 (1976), 99 * |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4410519A (en) | 1979-09-14 | 1983-10-18 | Sandoz Ltd. | Tetraline derivatives, their production and pharmaceutical compositions containing them |
WO1981003491A1 (en) * | 1980-05-29 | 1981-12-10 | Astra Laekemedel Ab | Therapeutically useful tetralin derivatives |
US4876284A (en) * | 1981-05-08 | 1989-10-24 | Per Arvid Emil Carlsson | 1-alkyl-2-aminotetralin derivatives |
WO1982004042A1 (en) * | 1981-05-11 | 1982-11-25 | Folke Lars Erik Arvidsson | Therapeutically useful tetralin derivatives iii,processes for preparation and pharmaceutical preparations for such compounds |
DE3320936A1 (de) * | 1982-06-10 | 1983-12-22 | Chiesi Farmaceutici S.P.A., Parma | 1,2,3,4-tetrahydronaphthalinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
WO1990014330A1 (en) * | 1989-05-26 | 1990-11-29 | Aktiebolaget Astra | Novel 8-substituted-2-aminotetralines |
EP0399982A1 (en) * | 1989-05-26 | 1990-11-28 | Astra Aktiebolag | Novel 8-substituted-2-amino-tetralines |
US5635537A (en) * | 1989-05-26 | 1997-06-03 | Astra Aktiebolag | 8-substituted-2-aminotetralins |
WO1997045403A1 (en) * | 1996-05-31 | 1997-12-04 | Pharmacia & Upjohn Company | Aryl substituted cyclic amines as selective dopamine d3 ligands |
US6084130A (en) * | 1996-05-31 | 2000-07-04 | Pharmacia & Upjohn Company | Aryl substituted bicyclic amines as selective dopamine D3 ligands |
WO1999015494A1 (en) * | 1997-09-22 | 1999-04-01 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | 2-aminotetralines, a process for their preparation, and pharmaceutical compositions, for the prevention and therapeutic treatment of inflammatory and/or autoimmune pathologies |
US6849663B2 (en) | 1997-09-22 | 2005-02-01 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | 2-Aminotetralines, a process for their preparation, and pharmaceutical compositions, for the prevention and therapeutic treatment of inflammatory and/or autoimmune pathologies |
US7041703B2 (en) | 1997-09-22 | 2006-05-09 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | 2-aminotetralines and pharmaceutical compositions for the prevention and therapeutic treatment of inflammatory and/or autoimmune pathologies |
WO2006126939A1 (en) * | 2005-05-23 | 2006-11-30 | Astrazeneca Ab | Novel 8-sulfonylamino-3 aminosubstituted chroman or tetrahydronaphtalene derivatives modulating the 5ht6 receptor |
Also Published As
Publication number | Publication date |
---|---|
GB1597140A (en) | 1981-09-03 |
IL53533A (en) | 1982-07-30 |
FR2373513B1 (US20020095090A1-20020718-M00002.png) | 1980-08-22 |
IL53533A0 (en) | 1978-03-10 |
NZ185884A (en) | 1980-04-28 |
JPS5384955A (en) | 1978-07-26 |
IE45929L (en) | 1978-06-07 |
PT67365B (fr) | 1979-09-20 |
NL7713364A (nl) | 1978-06-09 |
PH13932A (en) | 1980-11-04 |
ES464747A1 (es) | 1979-01-01 |
SU927110A3 (ru) | 1982-05-07 |
AT366361B (de) | 1982-04-13 |
SE7713471L (sv) | 1978-06-08 |
FR2373513A1 (fr) | 1978-07-07 |
PT67365A (fr) | 1978-01-01 |
DK527877A (da) | 1978-06-08 |
JPS6214540B2 (US20020095090A1-20020718-M00002.png) | 1987-04-02 |
FI773595A (fi) | 1978-06-08 |
ATA871977A (de) | 1981-08-15 |
CA1105475A (en) | 1981-07-21 |
IE45929B1 (en) | 1982-12-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
OI | Miscellaneous see part 1 | ||
8110 | Request for examination paragraph 44 | ||
8131 | Rejection |