IE45929L - Tetralines. - Google Patents

Tetralines.

Info

Publication number
IE45929L
IE45929L IE772462A IE246277A IE45929L IE 45929 L IE45929 L IE 45929L IE 772462 A IE772462 A IE 772462A IE 246277 A IE246277 A IE 246277A IE 45929 L IE45929 L IE 45929L
Authority
IE
Ireland
Prior art keywords
hydrogen
carbon atoms
alkanoyl
chlorine
alkyl
Prior art date
Application number
IE772462A
Other versions
IE45929B1 (en
Original Assignee
Sandoz Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ltd filed Critical Sandoz Ltd
Publication of IE45929L publication Critical patent/IE45929L/en
Publication of IE45929B1 publication Critical patent/IE45929B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invension provides compounds of formula I, I wherein R1 is, for example, hydrogen or alkanoyl of 1 to 20 carbon atoms; R2 is, for example, hydrogen, hydroxy, alkanoyl of 1 to 20 carbon atoms, CF3SO2NH or CC13SO2NH; R3 is hydrogen or, when R2 is chlorine, R3 may also be chlorine; R4 is, for example, hydrogen, alkyl of 1 to 4 carbon atoms or cycloalkyl of 3 to 8 carbon atoms; and R6 is, for example, hydrogen, alkyl of 1 to 4 carbon atoms or, together with R5, a -(CH2)4-, -(CH2)5 or (CH2)6-group, which compounds possess pharmacological activity, for example in she treatment of cardiac diseases and Parkinson's disease. [CA1105475A]
IE2462/77A 1976-12-07 1977-12-05 Tetralines IE45929B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1535376 1976-12-07
CH8277 1977-01-05

Publications (2)

Publication Number Publication Date
IE45929L true IE45929L (en) 1978-06-07
IE45929B1 IE45929B1 (en) 1982-12-29

Family

ID=25683446

Family Applications (1)

Application Number Title Priority Date Filing Date
IE2462/77A IE45929B1 (en) 1976-12-07 1977-12-05 Tetralines

Country Status (17)

Country Link
JP (1) JPS5384955A (en)
AT (1) AT366361B (en)
CA (1) CA1105475A (en)
DE (1) DE2752659A1 (en)
DK (1) DK527877A (en)
ES (1) ES464747A1 (en)
FI (1) FI773595A (en)
FR (1) FR2373513A1 (en)
GB (1) GB1597140A (en)
IE (1) IE45929B1 (en)
IL (1) IL53533A (en)
NL (1) NL7713364A (en)
NZ (1) NZ185884A (en)
PH (1) PH13932A (en)
PT (1) PT67365B (en)
SE (1) SE7713471L (en)
SU (1) SU927110A3 (en)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4314082A (en) * 1978-07-14 1982-02-02 American Hospital Supply Corporation Derivatives of 2-amino-6,7-dihydroxytetrahydro naphthalene (ADTN)
DE2965841D1 (en) * 1978-07-14 1983-08-18 American Hospital Supply Corp 2-alpha-methyl-dopaminimino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene, its salts, and a process for preparation thereof
DE3062971D1 (en) 1979-09-14 1983-06-09 Sandoz Ag Derivatives of tetraline, their preparation and medicaments containing these compounds
EP0033789B1 (en) * 1980-01-30 1984-03-07 American Hospital Supply Corporation 2-alpha-methyl-dopaminimino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene, its salts, and a process for preparation thereof
SE8004002L (en) * 1980-05-29 1981-11-30 Arvidsson Folke Lars Erik THERAPEUTICALLY APPLICABLE TETRALIN DERIVATIVES
IL65501A (en) * 1981-05-08 1986-04-29 Astra Laekemedel Ab 1-alkyl-2-aminotetralin derivatives,process for their preparation and pharmaceutical compositions containing them
JPS58500714A (en) * 1981-05-11 1983-05-06 ア−ヴイツツソン，フオルケ・ラルス−エリ−ク Therapeutically useful tetralin derivatives 3, processes for the preparation of such compounds and pharmaceutical formulations
US4455317A (en) * 1981-06-23 1984-06-19 American Hospital Supply Corporation Method for treating glaucoma by the topical administration of selectively metabolized beta-blocking agents
US4559359A (en) * 1981-06-23 1985-12-17 American Hospital Supply Corporation Method for treating glaucoma by the topical administration of selectively metabolized beta-blocking agents
US4454154A (en) * 1981-06-23 1984-06-12 American Hospital Supply Corporation Method for treating glaucoma by the topical administration of selectively metabolized beta-blocking agents
US4402974A (en) 1981-06-23 1983-09-06 American Hospital Supply Corporation Method for treating glaucoma by the topical administration of selectively metabolized beta-blocking agents
US4578403A (en) * 1981-06-23 1986-03-25 American Hospital Supply Corporation Method for treating glaucoma by the topical administration of selectively metabolized beta-blocking agents
IT1218322B (en) * 1982-06-10 1990-04-12 Chiesi Farma Spa 1,2,3,4-TETRAIDRONAFTALENE DERIVATIVES, PREPARATION PROCEDURE AND RELATED PHARMACEUTICAL COMPOSITIONS
US4448990A (en) * 1982-11-16 1984-05-15 Eli Lilly And Company Hydroxyaminotetralincarboxamides
US4500545A (en) * 1982-11-16 1985-02-19 Eli Lilly And Company Hydroxyaminotetralincarboxamides
US5177112A (en) * 1983-01-03 1993-01-05 Whitby Research, Inc. Substituted 2-aminotetralins
US4722933A (en) * 1985-12-20 1988-02-02 Nelson Research & Development Co. Substituted 2-aminotetralins
US4564628A (en) * 1983-01-03 1986-01-14 Nelson Research & Development Co. Substituted 2-aminotetralins
US4743618A (en) * 1983-01-03 1988-05-10 Nelson Research & Development Co. Substituted 2-aminotetralins
US4657925A (en) * 1984-08-13 1987-04-14 Nelson Research & Development Co. Method and compositions for reducing the intraocular pressure of mammals
GB2157950B (en) * 1984-05-04 1988-11-02 Nelson Res & Dev Selective d-2 dopamine receptor agonist
CA1331191C (en) 1988-03-25 1994-08-02 Bengt Ronny Andersson Therapeutically useful tetralin derivatives
US5214156A (en) * 1988-03-25 1993-05-25 The Upjohn Company Therapeutically useful tetralin derivatives
US5225596A (en) * 1989-01-09 1993-07-06 The Upjohn Company Halo substituted aminotetralins
JP2931986B2 (en) * 1989-02-17 1999-08-09 武田薬品工業株式会社 Aralkylamine derivatives
SE8901889D0 (en) * 1989-05-26 1989-05-26 Astra Ab NOVEL 8-SUBSTITUTED-2-AMINOTETRALINES
CA2105560A1 (en) * 1991-03-07 1992-09-08 Yoshiaki Muto Trialkylamine derivative and ameliorant for digestive tract movement containing the same
SK282725B6 (en) * 1996-05-31 2002-11-06 Pharmacia & Upjohn Company Aryl substituted cyclic amines as selective dopamine D3 ligands
IT1294931B1 (en) 1997-09-22 1999-04-23 Sigma Tau Ind Farmaceuti DERIVATIVES OF 2-AMINOTETHRALIN PROCEDURE FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, ACTIVE IN THE
AR054363A1 (en) * 2005-05-23 2007-06-20 Astrazeneca Ab COMPOUNDS THAT DISPLAY MODULATORY ACTIVITY IN THE 5-HYDROXY-TRIPTAMINE 6 RECEIVER
KR101478597B1 (en) * 2011-06-27 2015-01-02 산동 루예 파마슈티칼 컴파니 리미티드 Method for industrially preparing nitrogen substituted amino-5,6,7,8-tetrahydronaphthol

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1017359A (en) * 1972-07-03 1977-09-13 Frederic P. Hauck Substituted cyclic polymethylene phenols

Also Published As

Publication number Publication date
GB1597140A (en) 1981-09-03
IL53533A (en) 1982-07-30
FR2373513B1 (en) 1980-08-22
IL53533A0 (en) 1978-03-10
NZ185884A (en) 1980-04-28
JPS5384955A (en) 1978-07-26
PT67365B (en) 1979-09-20
NL7713364A (en) 1978-06-09
DE2752659A1 (en) 1978-06-08
PH13932A (en) 1980-11-04
ES464747A1 (en) 1979-01-01
SU927110A3 (en) 1982-05-07
AT366361B (en) 1982-04-13
SE7713471L (en) 1978-06-08
FR2373513A1 (en) 1978-07-07
PT67365A (en) 1978-01-01
DK527877A (en) 1978-06-08
JPS6214540B2 (en) 1987-04-02
FI773595A (en) 1978-06-08
ATA871977A (en) 1981-08-15
CA1105475A (en) 1981-07-21
IE45929B1 (en) 1982-12-29

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