SE7713471L - NEW ORGANIC ASSOCIATIONS, THEIR PREPARATION AND USE - Google Patents

NEW ORGANIC ASSOCIATIONS, THEIR PREPARATION AND USE

Info

Publication number
SE7713471L
SE7713471L SE7713471A SE7713471A SE7713471L SE 7713471 L SE7713471 L SE 7713471L SE 7713471 A SE7713471 A SE 7713471A SE 7713471 A SE7713471 A SE 7713471A SE 7713471 L SE7713471 L SE 7713471L
Authority
SE
Sweden
Prior art keywords
hydrogen
carbon atoms
preparation
new organic
associations
Prior art date
Application number
SE7713471A
Other languages
Swedish (sv)
Inventor
J Pless
M-P Seiler
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of SE7713471L publication Critical patent/SE7713471L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

Abstract

The invension provides compounds of formula I, I wherein R1 is, for example, hydrogen or alkanoyl of 1 to 20 carbon atoms; R2 is, for example, hydrogen, hydroxy, alkanoyl of 1 to 20 carbon atoms, CF3SO2NH or CC13SO2NH; R3 is hydrogen or, when R2 is chlorine, R3 may also be chlorine; R4 is, for example, hydrogen, alkyl of 1 to 4 carbon atoms or cycloalkyl of 3 to 8 carbon atoms; and R6 is, for example, hydrogen, alkyl of 1 to 4 carbon atoms or, together with R5, a -(CH2)4-, -(CH2)5 or (CH2)6-group, which compounds possess pharmacological activity, for example in she treatment of cardiac diseases and Parkinson's disease.
SE7713471A 1976-12-07 1977-11-29 NEW ORGANIC ASSOCIATIONS, THEIR PREPARATION AND USE SE7713471L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1535376 1976-12-07
CH8277 1977-01-05

Publications (1)

Publication Number Publication Date
SE7713471L true SE7713471L (en) 1978-06-08

Family

ID=25683446

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7713471A SE7713471L (en) 1976-12-07 1977-11-29 NEW ORGANIC ASSOCIATIONS, THEIR PREPARATION AND USE

Country Status (17)

Country Link
JP (1) JPS5384955A (en)
AT (1) AT366361B (en)
CA (1) CA1105475A (en)
DE (1) DE2752659A1 (en)
DK (1) DK527877A (en)
ES (1) ES464747A1 (en)
FI (1) FI773595A (en)
FR (1) FR2373513A1 (en)
GB (1) GB1597140A (en)
IE (1) IE45929B1 (en)
IL (1) IL53533A (en)
NL (1) NL7713364A (en)
NZ (1) NZ185884A (en)
PH (1) PH13932A (en)
PT (1) PT67365B (en)
SE (1) SE7713471L (en)
SU (1) SU927110A3 (en)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1980000251A1 (en) * 1978-07-14 1980-02-21 American Hospital Supply Corp Derivatives of 2-amino-6,7-dihydroxytetrahydronaphthalene(adtn)
US4314082A (en) * 1978-07-14 1982-02-02 American Hospital Supply Corporation Derivatives of 2-amino-6,7-dihydroxytetrahydro naphthalene (ADTN)
DE3062971D1 (en) 1979-09-14 1983-06-09 Sandoz Ag Derivatives of tetraline, their preparation and medicaments containing these compounds
EP0033789B1 (en) * 1980-01-30 1984-03-07 American Hospital Supply Corporation 2-alpha-methyl-dopaminimino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene, its salts, and a process for preparation thereof
SE8004002L (en) * 1980-05-29 1981-11-30 Arvidsson Folke Lars Erik THERAPEUTICALLY APPLICABLE TETRALIN DERIVATIVES
IL65501A (en) * 1981-05-08 1986-04-29 Astra Laekemedel Ab 1-alkyl-2-aminotetralin derivatives,process for their preparation and pharmaceutical compositions containing them
JPS58500714A (en) * 1981-05-11 1983-05-06 ア−ヴイツツソン，フオルケ・ラルス−エリ−ク Therapeutically useful tetralin derivatives 3, processes for the preparation of such compounds and pharmaceutical formulations
US4402974A (en) 1981-06-23 1983-09-06 American Hospital Supply Corporation Method for treating glaucoma by the topical administration of selectively metabolized beta-blocking agents
US4454154A (en) * 1981-06-23 1984-06-12 American Hospital Supply Corporation Method for treating glaucoma by the topical administration of selectively metabolized beta-blocking agents
US4455317A (en) * 1981-06-23 1984-06-19 American Hospital Supply Corporation Method for treating glaucoma by the topical administration of selectively metabolized beta-blocking agents
US4559359A (en) * 1981-06-23 1985-12-17 American Hospital Supply Corporation Method for treating glaucoma by the topical administration of selectively metabolized beta-blocking agents
US4578403A (en) * 1981-06-23 1986-03-25 American Hospital Supply Corporation Method for treating glaucoma by the topical administration of selectively metabolized beta-blocking agents
IT1218322B (en) * 1982-06-10 1990-04-12 Chiesi Farma Spa 1,2,3,4-TETRAIDRONAFTALENE DERIVATIVES, PREPARATION PROCEDURE AND RELATED PHARMACEUTICAL COMPOSITIONS
US4500545A (en) * 1982-11-16 1985-02-19 Eli Lilly And Company Hydroxyaminotetralincarboxamides
US4448990A (en) * 1982-11-16 1984-05-15 Eli Lilly And Company Hydroxyaminotetralincarboxamides
US4743618A (en) * 1983-01-03 1988-05-10 Nelson Research & Development Co. Substituted 2-aminotetralins
US5177112A (en) * 1983-01-03 1993-01-05 Whitby Research, Inc. Substituted 2-aminotetralins
US4564628A (en) * 1983-01-03 1986-01-14 Nelson Research & Development Co. Substituted 2-aminotetralins
US4657925A (en) * 1984-08-13 1987-04-14 Nelson Research & Development Co. Method and compositions for reducing the intraocular pressure of mammals
US4722933A (en) * 1985-12-20 1988-02-02 Nelson Research & Development Co. Substituted 2-aminotetralins
GB2157950B (en) * 1984-05-04 1988-11-02 Nelson Res & Dev Selective d-2 dopamine receptor agonist
CA1331191C (en) 1988-03-25 1994-08-02 Bengt Ronny Andersson Therapeutically useful tetralin derivatives
US5214156A (en) * 1988-03-25 1993-05-25 The Upjohn Company Therapeutically useful tetralin derivatives
US5225596A (en) * 1989-01-09 1993-07-06 The Upjohn Company Halo substituted aminotetralins
JP2931986B2 (en) * 1989-02-17 1999-08-09 武田薬品工業株式会社 Aralkylamine derivatives
SE8901889D0 (en) * 1989-05-26 1989-05-26 Astra Ab NOVEL 8-SUBSTITUTED-2-AMINOTETRALINES
US5380748A (en) * 1991-03-07 1995-01-10 Zeria Pharmaceutical Co., Ltd. Trialkylamine derivative and ameliorant for digestive tract movement containing the same
CA2255612A1 (en) * 1996-05-31 1997-12-04 Pharmacia & Upjohn Company Aryl substituted cyclic amines as selective dopamine d3 ligands
IT1294931B1 (en) 1997-09-22 1999-04-23 Sigma Tau Ind Farmaceuti DERIVATIVES OF 2-AMINOTETHRALIN PROCEDURE FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, ACTIVE IN THE
AR054363A1 (en) * 2005-05-23 2007-06-20 Astrazeneca Ab COMPOUNDS THAT DISPLAY MODULATORY ACTIVITY IN THE 5-HYDROXY-TRIPTAMINE 6 RECEIVER
AU2012276179B2 (en) * 2011-06-27 2015-09-24 Shan Dong Luye Pharmaceutical Co., Ltd. Method for industrially preparing nitrogen substituted amino-5,6,7,8-tetrahydronaphthol

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1017359A (en) * 1972-07-03 1977-09-13 Frederic P. Hauck Substituted cyclic polymethylene phenols

Also Published As

Publication number Publication date
JPS5384955A (en) 1978-07-26
DK527877A (en) 1978-06-08
NL7713364A (en) 1978-06-09
PT67365B (en) 1979-09-20
FR2373513B1 (en) 1980-08-22
IL53533A0 (en) 1978-03-10
AT366361B (en) 1982-04-13
ATA871977A (en) 1981-08-15
DE2752659A1 (en) 1978-06-08
SU927110A3 (en) 1982-05-07
PT67365A (en) 1978-01-01
CA1105475A (en) 1981-07-21
GB1597140A (en) 1981-09-03
ES464747A1 (en) 1979-01-01
FI773595A (en) 1978-06-08
JPS6214540B2 (en) 1987-04-02
IE45929L (en) 1978-06-07
PH13932A (en) 1980-11-04
FR2373513A1 (en) 1978-07-07
IL53533A (en) 1982-07-30
IE45929B1 (en) 1982-12-29
NZ185884A (en) 1980-04-28

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