DE2635843A1 - Injizierbare waessrige acetylsalicylsaeureloesung - Google Patents
Injizierbare waessrige acetylsalicylsaeureloesungInfo
- Publication number
- DE2635843A1 DE2635843A1 DE19762635843 DE2635843A DE2635843A1 DE 2635843 A1 DE2635843 A1 DE 2635843A1 DE 19762635843 DE19762635843 DE 19762635843 DE 2635843 A DE2635843 A DE 2635843A DE 2635843 A1 DE2635843 A1 DE 2635843A1
- Authority
- DE
- Germany
- Prior art keywords
- parts
- weight
- acid
- container
- solution according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002253 acid Substances 0.000 title claims description 8
- -1 ACETYL SALICYL Chemical class 0.000 title description 2
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims description 32
- 229960001138 acetylsalicylic acid Drugs 0.000 claims description 30
- 239000000243 solution Substances 0.000 claims description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 20
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 11
- 239000004472 Lysine Substances 0.000 claims description 11
- 239000004475 Arginine Substances 0.000 claims description 8
- 235000001014 amino acid Nutrition 0.000 claims description 8
- 150000001413 amino acids Chemical class 0.000 claims description 8
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 8
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims description 8
- 238000002347 injection Methods 0.000 claims description 8
- 239000007924 injection Substances 0.000 claims description 8
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 7
- 235000003704 aspartic acid Nutrition 0.000 claims description 7
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims description 7
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims description 6
- 125000002843 carboxylic acid group Chemical group 0.000 claims description 6
- 235000013922 glutamic acid Nutrition 0.000 claims description 6
- 239000004220 glutamic acid Substances 0.000 claims description 6
- 239000000654 additive Substances 0.000 claims description 3
- 230000000996 additive effect Effects 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 2
- BSYNRYMUTXBXSQ-FOQJRBATSA-N 59096-14-9 Chemical compound CC(=O)OC1=CC=CC=C1[14C](O)=O BSYNRYMUTXBXSQ-FOQJRBATSA-N 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 3
- 239000003125 aqueous solvent Substances 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 2
- SJHOBWUQRVIODN-UHFFFAOYSA-N 2-amino-3-(1H-imidazol-5-yl)propanoic acid 2-aminopentanedioic acid Chemical compound OC(=O)C(N)CCC(O)=O.OC(=O)C(N)CC1=CN=CN1 SJHOBWUQRVIODN-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- 235000011054 acetic acid Nutrition 0.000 description 1
- 150000001243 acetic acids Chemical class 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000000721 bacterilogical effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 229940102223 injectable solution Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229940126601 medicinal product Drugs 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/618—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate
- A61K31/621—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate having the hydroxy group in position 2 esterified, e.g. benorylate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7524981A FR2320759A1 (fr) | 1975-08-11 | 1975-08-11 | Solution d'acide acetylsalicylique extemporanee injectable |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2635843A1 true DE2635843A1 (de) | 1977-02-24 |
Family
ID=9158984
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19762635843 Pending DE2635843A1 (de) | 1975-08-11 | 1976-08-10 | Injizierbare waessrige acetylsalicylsaeureloesung |
Country Status (10)
| Country | Link |
|---|---|
| JP (1) | JPS5241212A (OSRAM) |
| AU (1) | AU1673776A (OSRAM) |
| BE (1) | BE845038A (OSRAM) |
| DE (1) | DE2635843A1 (OSRAM) |
| ES (1) | ES450583A1 (OSRAM) |
| FR (1) | FR2320759A1 (OSRAM) |
| GB (1) | GB1525765A (OSRAM) |
| NL (1) | NL7608951A (OSRAM) |
| SE (1) | SE7608909L (OSRAM) |
| ZA (1) | ZA764781B (OSRAM) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3148082A1 (de) * | 1980-12-04 | 1982-06-16 | Eliane Marie-Therese Paris Lauzanne-Morelle | Zusammensetzung zur aeusseren anwendung beim menschen, tier oder an pflanzen |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6021570B2 (ja) * | 1978-07-04 | 1985-05-28 | 三共株式会社 | ド−パ類の高濃度製剤の製法 |
| GB8929076D0 (en) * | 1989-12-22 | 1990-02-28 | Scras | Treatment of shock by blocking agents of edrf effect or formation |
| GB9200114D0 (en) * | 1992-01-04 | 1992-02-26 | Scras | Dual inhibitors of no synthase and cyclooxygenase |
| DE602006005423D1 (de) * | 2005-06-29 | 2009-04-16 | Verisfield Uk Ltd | Pharmazeutische Zusammensetzungen von Risperidon in wässriger Lösung |
| CN101380329B (zh) * | 2008-10-29 | 2010-11-17 | 海南本创医药科技有限公司 | 一种精氨酸阿司匹林及其粉针剂的制备方法 |
| WO2010130396A2 (en) * | 2009-05-11 | 2010-11-18 | King Saud University | Preparation of acetyl salicylic acid/glutamic acid complex for oral administration |
| CN102531969A (zh) * | 2011-12-28 | 2012-07-04 | 蚌埠丰原医药科技发展有限公司 | 一种无菌l-精氨酸的制备方法 |
| CN117982446A (zh) * | 2016-06-28 | 2024-05-07 | 阿萨德股份有限公司 | 双组分组合物 |
| US11096949B2 (en) * | 2017-05-30 | 2021-08-24 | Rhoshan Pharmaceuticals, Inc. | In-vial deposition of a stable, sterile and crystalline O-acetyl salicylic acid |
| EP3501523A1 (en) | 2017-12-22 | 2019-06-26 | Asamedic AS | Two-component compositions comprising acetyl salicylic acid and a carbonate salt |
| EP3501522A1 (en) | 2017-12-22 | 2019-06-26 | Asamedic AS | Compositions comprising acetylsalicylic acid and a phosphate salt |
| WO2023198294A1 (en) | 2022-04-14 | 2023-10-19 | Hyloris Developments Sa | Acetyl salicylic acid composition for intravenous administration, its storage, production and use |
-
1975
- 1975-08-11 FR FR7524981A patent/FR2320759A1/fr active Granted
-
1976
- 1976-08-09 ZA ZA764781A patent/ZA764781B/xx unknown
- 1976-08-09 ES ES450583A patent/ES450583A1/es not_active Expired
- 1976-08-10 DE DE19762635843 patent/DE2635843A1/de active Pending
- 1976-08-10 BE BE2055232A patent/BE845038A/xx unknown
- 1976-08-10 SE SE7608909A patent/SE7608909L/xx unknown
- 1976-08-11 AU AU16737/76A patent/AU1673776A/en not_active Expired
- 1976-08-11 GB GB33481/76A patent/GB1525765A/en not_active Expired
- 1976-08-11 NL NL7608951A patent/NL7608951A/xx not_active Application Discontinuation
- 1976-08-11 JP JP51095886A patent/JPS5241212A/ja active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3148082A1 (de) * | 1980-12-04 | 1982-06-16 | Eliane Marie-Therese Paris Lauzanne-Morelle | Zusammensetzung zur aeusseren anwendung beim menschen, tier oder an pflanzen |
Also Published As
| Publication number | Publication date |
|---|---|
| SE7608909L (sv) | 1977-02-12 |
| NL7608951A (nl) | 1977-02-15 |
| JPS5241212A (en) | 1977-03-30 |
| FR2320759A1 (fr) | 1977-03-11 |
| FR2320759B1 (OSRAM) | 1979-09-14 |
| ZA764781B (en) | 1977-07-27 |
| AU1673776A (en) | 1978-02-16 |
| GB1525765A (en) | 1978-09-20 |
| ES450583A1 (es) | 1978-02-01 |
| BE845038A (fr) | 1976-12-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OHJ | Non-payment of the annual fee |