DE2619667C2 - Pharmazeutisches Mittel - Google Patents

Pharmazeutisches Mittel

Info

Publication number
DE2619667C2
DE2619667C2 DE2619667A DE2619667A DE2619667C2 DE 2619667 C2 DE2619667 C2 DE 2619667C2 DE 2619667 A DE2619667 A DE 2619667A DE 2619667 A DE2619667 A DE 2619667A DE 2619667 C2 DE2619667 C2 DE 2619667C2
Authority
DE
Germany
Prior art keywords
solution
salt
process step
precipitate
concentrations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2619667A
Other languages
German (de)
English (en)
Other versions
DE2619667A1 (de
Inventor
Jacques Durand
Lucien Castres Dussourd d'Hinterland
Gerard Castres Normier
Lucien Toulouse Pradayrol
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre SA
Original Assignee
Pierre Fabre SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre SA filed Critical Pierre Fabre SA
Publication of DE2619667A1 publication Critical patent/DE2619667A1/de
Application granted granted Critical
Publication of DE2619667C2 publication Critical patent/DE2619667C2/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE2619667A 1975-05-05 1976-05-04 Pharmazeutisches Mittel Expired DE2619667C2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7513932A FR2310133A2 (fr) 1975-05-05 1975-05-05 Nouveau medicament comportant un activateur du plasminogene perfectionne

Publications (2)

Publication Number Publication Date
DE2619667A1 DE2619667A1 (de) 1976-11-18
DE2619667C2 true DE2619667C2 (de) 1984-12-06

Family

ID=9154824

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2619667A Expired DE2619667C2 (de) 1975-05-05 1976-05-04 Pharmazeutisches Mittel

Country Status (6)

Country Link
US (1) US4083961A (Direct)
BE (1) BE841251R (Direct)
DE (1) DE2619667C2 (Direct)
ES (1) ES447803A2 (Direct)
FR (1) FR2310133A2 (Direct)
GB (1) GB1551275A (Direct)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2462165A2 (fr) * 1973-12-03 1981-02-13 Fabre Sa Pierre Procede perfectionne de preparation d'activateur du plasminogene
GB2121050B (en) * 1979-07-05 1986-03-26 Genentech Inc Preparation of functional human urokinase proteins
CA1154671A (fr) * 1979-07-27 1983-10-04 Lucien D. D'hinterland Separation d'un activateur tissulaire du plasminogene
FR2483234A2 (fr) * 1980-05-29 1981-12-04 Fabre Sa Pierre Composition ophtalmique contenant un activateur du plasminogene
NL8003402A (nl) * 1980-06-11 1982-01-04 Leuven Res & Dev Vzw Nieuwe plasminogeen-activator en farmaceutisch preparaat met trombolytische werking.
US5112755A (en) * 1982-04-15 1992-05-12 Genentech, Inc. Preparation of functional human urokinase proteins
FI831484L (fi) * 1982-05-05 1983-11-06 Genentech Inc Plasminogen aktivator foer maenskovaevnad
GR79202B (Direct) * 1982-05-05 1984-10-22 Genentech Inc
US4853330A (en) * 1983-04-07 1989-08-01 Genentech, Inc. Human tissue plasminogen activator
KR840004781A (ko) * 1982-05-05 1984-10-24 월터 에이치·드레거 인체의 조직 플라스미노겐 활성화제
US4766075A (en) * 1982-07-14 1988-08-23 Genentech, Inc. Human tissue plasminogen activator
US5185259A (en) * 1982-05-05 1993-02-09 Genentech, Inc. Truncated human tissue plasminogen activator
JPS59196824A (ja) * 1983-04-21 1984-11-08 Kowa Co 吸着防止剤
EP0156169B1 (en) * 1984-02-29 1991-12-18 Asahi Kasei Kogyo Kabushiki Kaisha An aqueous solution of a tissue plasminogen activator dissolved therein at an increased concentration and a method
DE3512908A1 (de) * 1985-04-11 1986-10-23 Behringwerke Ag, 3550 Marburg Gewebe-plasminogenaktivator (t-pa) enthaltendes mittel
US5120715A (en) * 1988-12-12 1992-06-09 Takeda Chemical Industries, Ltd. Method for purifying fibroblast growth factor protein
US6207151B1 (en) * 1989-09-21 2001-03-27 Mitsui Chemicals Inc. Aqueous solution of t-PA
JP2520975B2 (ja) * 1989-09-21 1996-07-31 三井東圧化学株式会社 組織プラスミノ―ゲンアクチベ―タ―若しくはその誘導体を含有する血栓溶解剤
US5288489A (en) * 1991-08-28 1994-02-22 Orion Therapeutic Systems, Inc. Fibrinolysis and fibrinogenolysis treatment
AU2006200638B2 (en) * 1999-10-01 2007-11-01 Amgen Inc. Pharmaceutical compositions of fibrinolytic agent
US6440414B1 (en) * 1999-10-01 2002-08-27 Amgen Inc. Pharmaceutical compositions of fibrinolytic agent
AU2004201694B2 (en) * 1999-10-01 2006-03-02 Amgen Inc. Pharmaceutical compositions of fibrinolytic agent
US6261820B1 (en) * 1999-10-01 2001-07-17 Amgen Inc. Fibronolytically active polypeptide
US7033776B2 (en) * 1999-12-17 2006-04-25 Amgen Inc. Method for treatment of indwelling catheter occlusion using fibrinolytic metalloproteinases

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2153200A1 (en) * 1971-09-24 1973-05-04 Choay Sa Stable,pyrogen-free urokinase prepns - from human urine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NICHTS-ERMITTELT

Also Published As

Publication number Publication date
DE2619667A1 (de) 1976-11-18
FR2310133B2 (Direct) 1978-12-01
BE841251R (fr) 1976-10-28
FR2310133A2 (fr) 1976-12-03
GB1551275A (en) 1979-08-30
ES447803A2 (es) 1977-07-01
US4083961A (en) 1978-04-11

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Legal Events

Date Code Title Description
8126 Change of the secondary classification

Ipc: A61K 31/715

8128 New person/name/address of the agent

Representative=s name: BARTELS, H. HELD, M., DIPL.-ING. DR.-ING., PAT.-AN

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8340 Patent of addition ceased/non-payment of fee of main patent