DE2608218C3 - Rifamycin-Derivate, Verfahren zu ihrer Herstellung, sowie dieselben enthaltende pharmazeutische Präparate - Google Patents

Rifamycin-Derivate, Verfahren zu ihrer Herstellung, sowie dieselben enthaltende pharmazeutische Präparate

Info

Publication number
DE2608218C3
DE2608218C3 DE2608218A DE2608218A DE2608218C3 DE 2608218 C3 DE2608218 C3 DE 2608218C3 DE 2608218 A DE2608218 A DE 2608218A DE 2608218 A DE2608218 A DE 2608218A DE 2608218 C3 DE2608218 C3 DE 2608218C3
Authority
DE
Germany
Prior art keywords
cyclopentyl
rifampicin
derivative
processes
mice
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2608218A
Other languages
German (de)
English (en)
Other versions
DE2608218A1 (de
DE2608218B2 (de
Inventor
Vittorio Fino Mornasco Como Arioli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruppo Lepetit SpA
Original Assignee
Gruppo Lepetit SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruppo Lepetit SpA filed Critical Gruppo Lepetit SpA
Publication of DE2608218A1 publication Critical patent/DE2608218A1/de
Publication of DE2608218B2 publication Critical patent/DE2608218B2/de
Application granted granted Critical
Publication of DE2608218C3 publication Critical patent/DE2608218C3/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE2608218A 1975-03-05 1976-02-28 Rifamycin-Derivate, Verfahren zu ihrer Herstellung, sowie dieselben enthaltende pharmazeutische Präparate Expired DE2608218C3 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB10020/75A GB1478563A (en) 1975-03-05 1975-03-05 Rifamycin derivatives

Publications (3)

Publication Number Publication Date
DE2608218A1 DE2608218A1 (de) 1976-09-16
DE2608218B2 DE2608218B2 (de) 1981-02-26
DE2608218C3 true DE2608218C3 (de) 1981-12-10

Family

ID=9959968

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2608218A Expired DE2608218C3 (de) 1975-03-05 1976-02-28 Rifamycin-Derivate, Verfahren zu ihrer Herstellung, sowie dieselben enthaltende pharmazeutische Präparate

Country Status (27)

Country Link
US (1) US4002752A (esLanguage)
JP (1) JPS51113900A (esLanguage)
AR (1) AR210113A1 (esLanguage)
AT (1) AT344896B (esLanguage)
BE (1) BE839255A (esLanguage)
CA (1) CA1057748A (esLanguage)
CH (1) CH610325A5 (esLanguage)
DD (1) DD123888A5 (esLanguage)
DE (1) DE2608218C3 (esLanguage)
DK (1) DK136655B (esLanguage)
ES (1) ES445790A1 (esLanguage)
FI (1) FI59102C (esLanguage)
FR (1) FR2302742A1 (esLanguage)
GB (1) GB1478563A (esLanguage)
HK (1) HK35282A (esLanguage)
HU (1) HU170451B (esLanguage)
IE (1) IE42881B1 (esLanguage)
KE (1) KE3099A (esLanguage)
LU (1) LU74478A1 (esLanguage)
MX (1) MX3737E (esLanguage)
NL (1) NL165745C (esLanguage)
NO (1) NO143796C (esLanguage)
PT (1) PT64866B (esLanguage)
SE (1) SE420728B (esLanguage)
SU (1) SU575030A3 (esLanguage)
YU (1) YU39477B (esLanguage)
ZA (1) ZA761043B (esLanguage)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2812569A1 (de) * 1977-04-20 1978-10-26 Lepetit Spa Neue rifamycinderivate

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2728869A1 (de) * 1976-06-25 1977-12-29 Antibiotice Iasi Intreprindere Rifamycinen und verfahren zu deren herstellung
GR64108B (en) * 1977-04-15 1980-01-24 Dso Pharmachim Method for the preparation of azomethine-derivatives of rifamycin s.v
GB1594134A (en) * 1977-11-25 1981-07-30 Holco Investment Inc Rifamycins
AU536524B2 (en) * 1979-06-28 1984-05-10 Gruppo Lepetit S.P.A. Water soluble hydrozones of 3-formylifamyan
US4447432A (en) * 1981-11-17 1984-05-08 Farmitalia Carlo Erba S.P.A. Azino rifamycins
US4681938A (en) * 1984-08-27 1987-07-21 Ciba-Geigy Corporation Novel polycyclic hydrazones of rifamycins, their manufacture, and their pharmaceutical compositions for treating tuberculosis
HUT47586A (en) * 1985-10-18 1989-03-28 Ciba Geigy Ag Process for production of substituated 3-/4-benzil-piperazinil/-piphamicins
AU621811B2 (en) * 1987-09-25 1992-03-26 Ciba-Geigy Ag Diacyl derivatives of 4-(trialkylbenzyl)-piperazinyl compounds
GB8816620D0 (en) * 1988-07-13 1988-08-17 Lepetit Spa Rifapentine hydrohalides
CA2082809C (en) * 1990-06-29 1995-10-17 Marino Nebuloni Pure crystalline form of rifapentine
US8404664B2 (en) 2005-08-11 2013-03-26 Targanta Therapeutics, Inc. Phosphonated Rifamycins and uses thereof for the prevention and treatment of bone and joint infections
US8524691B2 (en) 2008-08-13 2013-09-03 The Medicines Company Phosphonated rifamycins and uses thereof for the prevention and treatment of bone and joint infections
RU2496475C2 (ru) 2011-10-26 2013-10-27 Александр Васильевич Иващенко Фармацевтическая композиция и набор для лечения бактериальных инфекций
CN104736152B (zh) 2012-08-13 2018-01-23 阿迪帕姆单人股份公司 包含3‑甲酰基利福霉素sv和3‑甲酰基利福霉素s的3‑(4‑肉桂基‑1‑哌嗪基)氨基衍生物的药物制剂以及它们的制备方法
CN103951677B (zh) * 2014-03-17 2016-04-06 四川省长征药业股份有限公司 利福喷丁的制备方法
WO2022225384A1 (es) * 2021-04-21 2022-10-27 Interquim, S.A. De C.V. Proceso de obtención de rifapentina. con una nueva forma cristalina
CN115047122B (zh) * 2022-06-29 2023-05-02 重庆华邦胜凯制药有限公司 利福喷丁及其合成过程中所产生的杂质的分析方法
CN117186032A (zh) * 2023-09-08 2023-12-08 徐州博康信息化学品有限公司 1-氨基-4-环戊基哌嗪及其中间体的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR208F (esLanguage) * 1964-07-31
AR205434A1 (es) * 1972-03-27 1976-05-07 Lepetit Spa Proceso para la preparacion de 3-acilhidrazonometil rifamicinas sv
GB1392272A (en) * 1972-05-31 1975-04-30 Lepetit Spa 3-formylrifamycin azines

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2812569A1 (de) * 1977-04-20 1978-10-26 Lepetit Spa Neue rifamycinderivate

Also Published As

Publication number Publication date
GB1478563A (en) 1977-07-06
FR2302742A1 (fr) 1976-10-01
US4002752A (en) 1977-01-11
SE7602122L (sv) 1976-09-06
FR2302742B1 (esLanguage) 1979-10-12
DE2608218A1 (de) 1976-09-16
NL165745B (nl) 1980-12-15
PT64866B (en) 1977-07-20
NL165745C (nl) 1981-05-15
DK78476A (esLanguage) 1976-09-06
DK136655C (esLanguage) 1978-04-17
HU170451B (esLanguage) 1977-06-28
CH610325A5 (esLanguage) 1979-04-12
IE42881B1 (en) 1980-11-05
ZA761043B (en) 1977-01-26
BE839255A (fr) 1976-09-06
NO760549L (esLanguage) 1976-09-07
PT64866A (en) 1976-04-01
FI760561A7 (esLanguage) 1976-09-06
FI59102B (fi) 1981-02-27
JPS51113900A (en) 1976-10-07
AT344896B (de) 1978-08-10
YU57276A (en) 1982-06-30
LU74478A1 (esLanguage) 1976-09-01
SE420728B (sv) 1981-10-26
JPS5530797B2 (esLanguage) 1980-08-13
DK136655B (da) 1977-11-07
DE2608218B2 (de) 1981-02-26
NO143796C (no) 1981-04-15
CA1057748A (en) 1979-07-03
HK35282A (en) 1982-08-13
NO143796B (no) 1981-01-05
MX3737E (es) 1981-06-05
YU39477B (en) 1984-12-31
AU1170476A (en) 1977-09-08
NL7602191A (nl) 1976-09-07
KE3099A (en) 1981-02-13
IE42881L (en) 1976-09-05
ATA162876A (de) 1977-12-15
ES445790A1 (es) 1977-06-01
AR210113A1 (es) 1977-06-30
SU575030A3 (ru) 1977-09-30
DD123888A5 (esLanguage) 1977-01-19
FI59102C (fi) 1981-06-10

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Legal Events

Date Code Title Description
8326 Change of the secondary classification
C3 Grant after two publication steps (3rd publication)