DE2506330A1 - Verfahren zur herstellung von enolderivaten - Google Patents

Verfahren zur herstellung von enolderivaten

Info

Publication number
DE2506330A1
DE2506330A1 DE19752506330 DE2506330A DE2506330A1 DE 2506330 A1 DE2506330 A1 DE 2506330A1 DE 19752506330 DE19752506330 DE 19752506330 DE 2506330 A DE2506330 A DE 2506330A DE 2506330 A1 DE2506330 A1 DE 2506330A1
Authority
DE
Germany
Prior art keywords
group
acid
formula
methoxy
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE19752506330
Other languages
German (de)
English (en)
Inventor
Hans Dr Bickel
Robert Burns Prof Dr Woodward
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH269374A external-priority patent/CH601310A5/de
Priority claimed from CH776674A external-priority patent/CH610584A5/de
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of DE2506330A1 publication Critical patent/DE2506330A1/de
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C313/02—Sulfinic acids; Derivatives thereof
    • C07C313/04—Sulfinic acids; Esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C07D205/095—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4 and with a nitrogen atom directly attached in position 3
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE19752506330 1974-02-26 1975-02-14 Verfahren zur herstellung von enolderivaten Ceased DE2506330A1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH269374A CH601310A5 (en) 1974-02-26 1974-02-26 7-Amino-3-hydroxy-2(or 3)-cephem-4-carboxylic acid derivs prepn
CH776674A CH610584A5 (en) 1974-02-26 1974-06-05 Process for the preparation of 2-(3-amino-2-oxo-4-sulphonylthio-1- azetidinyl)-3-methylenebutyric acid derivatives
CH1100074 1974-08-12

Publications (1)

Publication Number Publication Date
DE2506330A1 true DE2506330A1 (de) 1975-09-04

Family

ID=27173851

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19752506330 Ceased DE2506330A1 (de) 1974-02-26 1975-02-14 Verfahren zur herstellung von enolderivaten

Country Status (21)

Country Link
JP (1) JPS625919B2 (sv)
AR (1) AR208538A1 (sv)
AT (2) AT337362B (sv)
AU (1) AU498131B2 (sv)
BE (1) BE825919A (sv)
BG (1) BG26201A3 (sv)
CA (2) CA1059988A (sv)
DD (1) DD117074A5 (sv)
DE (1) DE2506330A1 (sv)
DK (2) DK73475A (sv)
ES (2) ES435110A1 (sv)
FI (1) FI66389C (sv)
FR (1) FR2261761B1 (sv)
GB (1) GB1503581A (sv)
HU (1) HU175212B (sv)
IE (1) IE40695B1 (sv)
IL (1) IL46699A (sv)
NL (1) NL7502292A (sv)
NO (1) NO750625L (sv)
NZ (1) NZ176623A (sv)
SE (3) SE431652B (sv)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3725375A1 (de) * 1987-07-31 1989-02-09 Bayer Ag Stabile oxapenem-3-carbonsaeuren
US9108999B2 (en) 2011-12-20 2015-08-18 Riboscience Llc 2′, 4′-difluoro-2′-methyl substituted nucleoside derivatives as inhibitors of HCV RNA replication
US9249176B2 (en) 2013-05-16 2016-02-02 Riboscience Llc 4′-azido, 3′-deoxy-3′-fluoro substituted nucleoside derivatives as inhibitors of HCV RNA replication
US9708357B2 (en) 2011-12-20 2017-07-18 Riboscience, LLC 4′-azido, 3′-fluoro substituted nucleoside derivatives as inhibitors of HCV RNA replication
US9895442B2 (en) 2013-05-16 2018-02-20 Riboscience Llc 4′-fluoro-2′-methyl substituted nucleoside derivatives as inhibitors of HCV RNA replication
US10682369B2 (en) 2017-09-21 2020-06-16 Riboscience Llc 4′-fluoro-2′-methyl substituted nucleoside derivatives as inhibitors of HCV RNA replication
US10953030B2 (en) 2013-05-16 2021-03-23 Riboscience Llc 4′-fluoro-2′-methyl substituted nucleoside derivatives as inhibitors of HCV RNA replication

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1044247B (it) * 1974-08-02 1980-03-20 Farmaceutici Italia Intermedi per la sintesi di derivati b lattamici e procedimento per la loro preparazone
JPS5198265A (sv) * 1975-02-17 1976-08-30
CA1136132A (en) * 1975-02-17 1982-11-23 Teruji Tsuji Cyclization to form cephem ring and intermediates therefor
AT342197B (de) * 1975-02-20 1978-03-28 Ciba Geigy Ag Neues verfahren zur herstellung von 3-cephemverbindungen
US4029645A (en) * 1975-11-17 1977-06-14 E. R. Squibb & Sons, Inc. Mercury intermediates useful in the preparation of 2-alkoxy cephalosporins
JPH0639474B2 (ja) * 1983-03-04 1994-05-25 大塚化学株式会社 セファロスポリン化合物の製造法
JPS59228854A (ja) * 1983-06-08 1984-12-22 真井　康博 薬液収納兼即効注出器
GB2152497B (en) * 1983-11-28 1987-08-05 Otsuka Kagaku Kk Process for the preparation of azetidinone derivatives
JPS60237061A (ja) * 1984-05-08 1985-11-25 Otsuka Chem Co Ltd アゼチジノン誘導体の製造法
JPS60126263A (ja) * 1983-12-12 1985-07-05 Otsuka Chem Co Ltd アゼチジノン誘導体の製造法
JPS60115562A (ja) * 1983-11-28 1985-06-22 Otsuka Chem Co Ltd アゼチジノン誘導体の製造法
JPS61178961A (ja) * 1985-02-01 1986-08-11 Otsuka Chem Co Ltd アゼチジノン誘導体の製造法
JP3195959B2 (ja) * 1991-03-13 2001-08-06 大塚化学株式会社 ３−ヒドロキシセフェム誘導体の製造法
WO2004039813A1 (en) * 2002-11-01 2004-05-13 Orchid Chemicals & Pharmaceuticals Ltd An improved process for the preparation of chloro methyl cephem derivatives

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2230372A1 (de) * 1972-06-21 1973-01-11 Fujisawa Pharmaceutical Co Verfahren zur herstellung von oxidierten penam-derivaten
DE2331148A1 (de) * 1972-06-29 1974-01-17 Ciba Geigy Ag Oxoverbindungen
DE2331133A1 (de) * 1972-06-29 1974-01-17 Ciba Geigy Ag Enolderivate

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2230372A1 (de) * 1972-06-21 1973-01-11 Fujisawa Pharmaceutical Co Verfahren zur herstellung von oxidierten penam-derivaten
DE2331148A1 (de) * 1972-06-29 1974-01-17 Ciba Geigy Ag Oxoverbindungen
DE2331133A1 (de) * 1972-06-29 1974-01-17 Ciba Geigy Ag Enolderivate

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3725375A1 (de) * 1987-07-31 1989-02-09 Bayer Ag Stabile oxapenem-3-carbonsaeuren
US9108999B2 (en) 2011-12-20 2015-08-18 Riboscience Llc 2′, 4′-difluoro-2′-methyl substituted nucleoside derivatives as inhibitors of HCV RNA replication
US9708357B2 (en) 2011-12-20 2017-07-18 Riboscience, LLC 4′-azido, 3′-fluoro substituted nucleoside derivatives as inhibitors of HCV RNA replication
US9249176B2 (en) 2013-05-16 2016-02-02 Riboscience Llc 4′-azido, 3′-deoxy-3′-fluoro substituted nucleoside derivatives as inhibitors of HCV RNA replication
US9694028B2 (en) 2013-05-16 2017-07-04 Riboscience Llc 4′-azido, 3′-deoxy-3′-fluoro substituted nucleoside derivatives as inhibitors of HCV RNA replication
US9895442B2 (en) 2013-05-16 2018-02-20 Riboscience Llc 4′-fluoro-2′-methyl substituted nucleoside derivatives as inhibitors of HCV RNA replication
US10953030B2 (en) 2013-05-16 2021-03-23 Riboscience Llc 4′-fluoro-2′-methyl substituted nucleoside derivatives as inhibitors of HCV RNA replication
US10682369B2 (en) 2017-09-21 2020-06-16 Riboscience Llc 4′-fluoro-2′-methyl substituted nucleoside derivatives as inhibitors of HCV RNA replication
US11351186B2 (en) 2017-09-21 2022-06-07 Riboscience Llc 4′-fluoro-2′-methyl substituted nucleoside derivatives as inhibitors of HCV RNA replication

Also Published As

Publication number Publication date
AU7849875A (en) 1976-08-26
FI66389C (fi) 1984-10-10
BE825919A (fr) 1975-08-25
HU175212B (hu) 1980-06-28
SE438855B (sv) 1985-05-13
DD117074A5 (sv) 1975-12-20
FI66389B (fi) 1984-06-29
IL46699A (en) 1977-11-30
SE7501317L (sv) 1975-08-27
FR2261761A1 (sv) 1975-09-19
GB1503581A (en) 1978-03-15
CA1059988A (en) 1979-08-07
SE7807811L (sv) 1978-07-13
AR208538A1 (es) 1977-02-15
IL46699A0 (en) 1975-04-25
JPS625919B2 (sv) 1987-02-07
ES435110A1 (es) 1977-03-16
NZ176623A (en) 1978-04-03
DK73475A (sv) 1975-10-20
FR2261761B1 (sv) 1978-08-18
SE438854B (sv) 1985-05-13
AT337362B (de) 1977-06-27
ATA28178A (de) 1978-10-15
AT350068B (de) 1979-05-10
AU498131B2 (en) 1979-02-15
DK348678A (da) 1978-08-07
BG26201A3 (sv) 1979-02-15
SE431652B (sv) 1984-02-20
ES452915A1 (es) 1977-11-01
NL7502292A (nl) 1975-08-28
IE40695B1 (en) 1979-08-01
SE7807810L (sv) 1978-07-13
JPS50129590A (sv) 1975-10-13
NO750625L (sv) 1975-08-27
IE40695L (en) 1975-08-26
FI750503A (sv) 1975-08-27
CA1080713A (en) 1980-07-01
ATA108275A (de) 1976-10-15

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
8125 Change of the main classification

Ipc: C07D205/08

8126 Change of the secondary classification

Ipc: C07D501/26

8128 New person/name/address of the agent

Representative=s name: REDIES, B., DIPL.-CHEM. DR.RER.NAT., PAT.-ANW., 40

8131 Rejection