IE40695L - A process for the manufacture of cephem - 3- ol compounds - Google Patents

A process for the manufacture of cephem - 3- ol compounds

Info

Publication number
IE40695L
IE40695L IE750401A IE40175A IE40695L IE 40695 L IE40695 L IE 40695L IE 750401 A IE750401 A IE 750401A IE 40175 A IE40175 A IE 40175A IE 40695 L IE40695 L IE 40695L
Authority
IE
Ireland
Prior art keywords
compounds
protecting group
group
cephem
manufacture
Prior art date
Application number
IE750401A
Other versions
IE40695B1 (en
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH269374A external-priority patent/CH601310A5/en
Priority claimed from CH776674A external-priority patent/CH610584A5/en
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of IE40695L publication Critical patent/IE40695L/en
Publication of IE40695B1 publication Critical patent/IE40695B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C313/02—Sulfinic acids; Derivatives thereof
    • C07C313/04—Sulfinic acids; Esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C07D205/095—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4 and with a nitrogen atom directly attached in position 3
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1503581 Preparation of ceph-2- or -3-em derivatives CIBA-GEIGY AG 24 Feb 1975 [26 Feb 1974 5 June 1974 12 Aug 1974] 7625/75 Heading C2C Compounds IA and IB (R 1 <SP>a</SP> is H or a protecting group; R 1 b is H or acyl; or R 1 <SP>a</SP> and R 1 <SP>b</SP> together form a divalent protecting group; R 2 is OH or a group which with the adjacent -CO- group forms protected carboxyl; and R 3 is H, 1-7C alkyl or a protecting group) and the 1-oxides of the ceph- 3-em compounds are prepared by cyclization of a compound II followed, where necessary, by deprotection and/or other conventional modifications. [GB1503581A]
IE401/75A 1974-02-26 1975-02-25 Process for the manufacture of 7-amino-cephem-3-ol-4 carboxylic acid compounds IE40695B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH269374A CH601310A5 (en) 1974-02-26 1974-02-26 7-Amino-3-hydroxy-2(or 3)-cephem-4-carboxylic acid derivs prepn
CH776674A CH610584A5 (en) 1974-02-26 1974-06-05 Process for the preparation of 2-(3-amino-2-oxo-4-sulphonylthio-1- azetidinyl)-3-methylenebutyric acid derivatives
CH1100074 1974-08-12

Publications (2)

Publication Number Publication Date
IE40695L true IE40695L (en) 1975-08-26
IE40695B1 IE40695B1 (en) 1979-08-01

Family

ID=27173851

Family Applications (1)

Application Number Title Priority Date Filing Date
IE401/75A IE40695B1 (en) 1974-02-26 1975-02-25 Process for the manufacture of 7-amino-cephem-3-ol-4 carboxylic acid compounds

Country Status (21)

Country Link
JP (1) JPS625919B2 (en)
AR (1) AR208538A1 (en)
AT (2) AT337362B (en)
AU (1) AU498131B2 (en)
BE (1) BE825919A (en)
BG (1) BG26201A3 (en)
CA (2) CA1059988A (en)
DD (1) DD117074A5 (en)
DE (1) DE2506330A1 (en)
DK (2) DK73475A (en)
ES (2) ES435110A1 (en)
FI (1) FI66389C (en)
FR (1) FR2261761B1 (en)
GB (1) GB1503581A (en)
HU (1) HU175212B (en)
IE (1) IE40695B1 (en)
IL (1) IL46699A (en)
NL (1) NL7502292A (en)
NO (1) NO750625L (en)
NZ (1) NZ176623A (en)
SE (3) SE431652B (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1044247B (en) * 1974-08-02 1980-03-20 Farmaceutici Italia INTERMEDIATES FOR THE SYNTHESIS OF LACTAMIC DERIVATIVES AND PROCEDURE FOR THEIR PREPARATION
JPS5198265A (en) * 1975-02-17 1976-08-30
CA1136132A (en) * 1975-02-17 1982-11-23 Teruji Tsuji Cyclization to form cephem ring and intermediates therefor
AT342197B (en) * 1975-02-20 1978-03-28 Ciba Geigy Ag NEW PROCESS FOR PRODUCING 3-CEPHEM CONNECTIONS
US4029645A (en) * 1975-11-17 1977-06-14 E. R. Squibb & Sons, Inc. Mercury intermediates useful in the preparation of 2-alkoxy cephalosporins
JPH0639474B2 (en) * 1983-03-04 1994-05-25 大塚化学株式会社 Method for producing cephalosporin compound
JPS59228854A (en) * 1983-06-08 1984-12-22 真井　康博 Chemical liquid injection by compressed gas and chemical liquid storing syringe
JPS60237061A (en) * 1984-05-08 1985-11-25 Otsuka Chem Co Ltd Preparation of azetidinone derivative
JPS60126263A (en) * 1983-12-12 1985-07-05 Otsuka Chem Co Ltd Production of azetidinone derivative
GB2152497B (en) * 1983-11-28 1987-08-05 Otsuka Kagaku Kk Process for the preparation of azetidinone derivatives
JPS60115562A (en) * 1983-11-28 1985-06-22 Otsuka Chem Co Ltd Production of azetidinone derivative
JPS61178961A (en) * 1985-02-01 1986-08-11 Otsuka Chem Co Ltd Production of azetidinone derivative
DE3725375A1 (en) * 1987-07-31 1989-02-09 Bayer Ag STABLE OXAPENEM-3-CARBONSAEURES
JP3195959B2 (en) * 1991-03-13 2001-08-06 大塚化学株式会社 Method for producing 3-hydroxycephem derivative
AU2003269416A1 (en) * 2002-11-01 2004-05-25 Orchid Chemicals And Pharmaceuticals Ltd An improved process for the preparation of chloro methyl cephem derivatives
AU2012357986B2 (en) 2011-12-20 2017-02-02 Riboscience Llc 4'-Azido, 3'-fluoro substituted nucleoside derivatives as inhibitors of HCV RNA replication
AU2012357940B2 (en) 2011-12-20 2017-02-16 Riboscience Llc 2',4'-difluoro-2'-methyl substituted nucleoside derivatives as inhibitors of HCV RNA replication
MA46490A1 (en) 2013-05-16 2021-04-30 Riboscience Llc Substituted 4'- fluoro-2 '- methyl nucleoside derivatives
EA201592185A1 (en) 2013-05-16 2016-05-31 Рибосайенс Ллк 4'-AZIDO, 3'-DEOXY-3'-Fluoro-substituted NUCLEOSIDE DERIVATIVES
US20180200280A1 (en) 2013-05-16 2018-07-19 Riboscience Llc 4'-Fluoro-2'-Methyl Substituted Nucleoside Derivatives as Inhibitors of HCV RNA Replication
AR112702A1 (en) 2017-09-21 2019-11-27 Riboscience Llc 4'-FLUORO-2'-METHYL SUBSTITUTED NUCLEOSIDE DERIVATIVES AS HCV RNA REPLICATION INHIBITORS

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2230372A1 (en) * 1972-06-21 1973-01-11 Fujisawa Pharmaceutical Co Cepham and cephem derivs - useful as antibiotics
SE428022B (en) * 1972-06-29 1983-05-30 Ciba Geigy Ag 7BETA-AMINO-CEFAM-3-ON-4-CARBOXYLIC ACID COMPOUNDS FOR USE FOR THE PRODUCTION OF CEPHALOSPORINE DERIVATIVES
AR206201A1 (en) * 1972-06-29 1976-07-07 Ciba Geigy Ag PROCEDURE FOR OBTAINING ACID COMPOUNDS 7BETA-AMINO-3-CEFEM-3-01-4-CARBOXILICO0-SUBSTITUIDOS

Also Published As

Publication number Publication date
CA1080713A (en) 1980-07-01
AT337362B (en) 1977-06-27
FR2261761B1 (en) 1978-08-18
DE2506330A1 (en) 1975-09-04
FI66389C (en) 1984-10-10
BE825919A (en) 1975-08-25
IL46699A (en) 1977-11-30
IL46699A0 (en) 1975-04-25
SE7807810L (en) 1978-07-13
GB1503581A (en) 1978-03-15
IE40695B1 (en) 1979-08-01
FI750503A (en) 1975-08-27
AU7849875A (en) 1976-08-26
CA1059988A (en) 1979-08-07
ATA28178A (en) 1978-10-15
DK348678A (en) 1978-08-07
DD117074A5 (en) 1975-12-20
FR2261761A1 (en) 1975-09-19
FI66389B (en) 1984-06-29
AR208538A1 (en) 1977-02-15
AU498131B2 (en) 1979-02-15
HU175212B (en) 1980-06-28
JPS625919B2 (en) 1987-02-07
SE7501317L (en) 1975-08-27
ES452915A1 (en) 1977-11-01
SE438854B (en) 1985-05-13
NO750625L (en) 1975-08-27
AT350068B (en) 1979-05-10
DK73475A (en) 1975-10-20
ES435110A1 (en) 1977-03-16
SE438855B (en) 1985-05-13
BG26201A3 (en) 1979-02-15
ATA108275A (en) 1976-10-15
JPS50129590A (en) 1975-10-13
SE431652B (en) 1984-02-20
NZ176623A (en) 1978-04-03
SE7807811L (en) 1978-07-13
NL7502292A (en) 1975-08-28

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