ES452915A1 - Process for the manufacture of 7-beta-amino-cephem-3-ol-4-carboxylic acid compounds - Google Patents

Process for the manufacture of 7-beta-amino-cephem-3-ol-4-carboxylic acid compounds

Info

Publication number
ES452915A1
ES452915A1 ES452915A ES452915A ES452915A1 ES 452915 A1 ES452915 A1 ES 452915A1 ES 452915 A ES452915 A ES 452915A ES 452915 A ES452915 A ES 452915A ES 452915 A1 ES452915 A1 ES 452915A1
Authority
ES
Spain
Prior art keywords
group
transformed
formula
compound
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES452915A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH269374A external-priority patent/CH601310A5/en
Priority claimed from CH776674A external-priority patent/CH610584A5/en
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES452915A1 publication Critical patent/ES452915A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C313/02—Sulfinic acids; Derivatives thereof
    • C07C313/04—Sulfinic acids; Esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C07D205/095—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4 and with a nitrogen atom directly attached in position 3
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Process for obtaining derivatives of 2- (3-amino-2-oxo-4-thio-1-azetidinyl) -3-hydrox-crotonic acid derivatives of the formula **(See formula)** where it means hydrogen or a protecting amino group RA1, means hydrogen or an acyl group Ac, or RA1 and together represent a bivalent protecting amino group and RA2 means, hydroxy or, together with the carbonyl group -C (= 0) -, a group protector of carboxyl function, Ro3 means lower chyl or a protective hydroxy group and Y means an exit group, as well as its salts, characterized in that in a compound of formula **(See formula)** where Ra1, Rb1, RA2 and Y have the meaning indicated above, the enolic group is transformed by etherization into a -OR03 group and, if desired, into a compound obtained of formula II, where Y signifies the group -S-R4, where R4 signifies an aromatic heterocyclic moiety, optionally substituted, with up to 15.9 carbon atoms, and at least one ring nitrogen atom and optionally one further ring hetero atom, whose moiety is linked to one of its ring carbon atoms, which is linked to the ring nitrogen atom by a double bond, with the thio group -S-, the group -S-R4 is transformed into a group - SO2-R5 or -S-SO2-R5, where R5 means an aliphatic, cycloaliphatic, araliphatic or aromatic hydrocarbon residue, optionally substituted with up to 18 carbon atoms, and/or, if desired, within the definition of the final products, a compound obtained is transformed into another compound, and/or, if desired, a compound obtained with a salt-forming group is transformed into a salt or a salt obtained in the free compound or in another salt and/or if you want a mixture of isomers obtained is separated into the different isomers. (Machine-translation by Google Translate, not legally binding)
ES452915A 1974-02-26 1976-11-02 Process for the manufacture of 7-beta-amino-cephem-3-ol-4-carboxylic acid compounds Expired ES452915A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH269374A CH601310A5 (en) 1974-02-26 1974-02-26 7-Amino-3-hydroxy-2(or 3)-cephem-4-carboxylic acid derivs prepn
CH776674A CH610584A5 (en) 1974-02-26 1974-06-05 Process for the preparation of 2-(3-amino-2-oxo-4-sulphonylthio-1- azetidinyl)-3-methylenebutyric acid derivatives
CH1100074 1974-08-12

Publications (1)

Publication Number Publication Date
ES452915A1 true ES452915A1 (en) 1977-11-01

Family

ID=27173851

Family Applications (2)

Application Number Title Priority Date Filing Date
ES435110A Expired ES435110A1 (en) 1974-02-26 1975-02-26 Process for the manufacture of 7-beta-amino-cephem-3-ol-4-carboxylic acid compounds
ES452915A Expired ES452915A1 (en) 1974-02-26 1976-11-02 Process for the manufacture of 7-beta-amino-cephem-3-ol-4-carboxylic acid compounds

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES435110A Expired ES435110A1 (en) 1974-02-26 1975-02-26 Process for the manufacture of 7-beta-amino-cephem-3-ol-4-carboxylic acid compounds

Country Status (21)

Country Link
JP (1) JPS625919B2 (en)
AR (1) AR208538A1 (en)
AT (2) AT337362B (en)
AU (1) AU498131B2 (en)
BE (1) BE825919A (en)
BG (1) BG26201A3 (en)
CA (2) CA1059988A (en)
DD (1) DD117074A5 (en)
DE (1) DE2506330A1 (en)
DK (2) DK73475A (en)
ES (2) ES435110A1 (en)
FI (1) FI66389C (en)
FR (1) FR2261761B1 (en)
GB (1) GB1503581A (en)
HU (1) HU175212B (en)
IE (1) IE40695B1 (en)
IL (1) IL46699A (en)
NL (1) NL7502292A (en)
NO (1) NO750625L (en)
NZ (1) NZ176623A (en)
SE (3) SE431652B (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1044247B (en) * 1974-08-02 1980-03-20 Farmaceutici Italia INTERMEDIATES FOR THE SYNTHESIS OF LACTAMIC DERIVATIVES AND PROCEDURE FOR THEIR PREPARATION
JPS5198265A (en) * 1975-02-17 1976-08-30
CA1136132A (en) * 1975-02-17 1982-11-23 Teruji Tsuji Cyclization to form cephem ring and intermediates therefor
AT342197B (en) * 1975-02-20 1978-03-28 Ciba Geigy Ag NEW PROCESS FOR PRODUCING 3-CEPHEM CONNECTIONS
US4029645A (en) * 1975-11-17 1977-06-14 E. R. Squibb & Sons, Inc. Mercury intermediates useful in the preparation of 2-alkoxy cephalosporins
JPH0639474B2 (en) * 1983-03-04 1994-05-25 大塚化学株式会社 Method for producing cephalosporin compound
JPS59228854A (en) * 1983-06-08 1984-12-22 真井　康博 Chemical liquid injection by compressed gas and chemical liquid storing syringe
JPS60115562A (en) * 1983-11-28 1985-06-22 Otsuka Chem Co Ltd Production of azetidinone derivative
GB2152497B (en) * 1983-11-28 1987-08-05 Otsuka Kagaku Kk Process for the preparation of azetidinone derivatives
JPS60237061A (en) * 1984-05-08 1985-11-25 Otsuka Chem Co Ltd Preparation of azetidinone derivative
JPS60126263A (en) * 1983-12-12 1985-07-05 Otsuka Chem Co Ltd Production of azetidinone derivative
JPS61178961A (en) * 1985-02-01 1986-08-11 Otsuka Chem Co Ltd Production of azetidinone derivative
DE3725375A1 (en) * 1987-07-31 1989-02-09 Bayer Ag STABLE OXAPENEM-3-CARBONSAEURES
JP3195959B2 (en) * 1991-03-13 2001-08-06 大塚化学株式会社 Method for producing 3-hydroxycephem derivative
JP2006507289A (en) * 2002-11-01 2006-03-02 オーキッド ケミカルズ アンド ファーマシューティカルズ リミテッド Improved process for preparing chloromethylcephem derivatives
EA024297B1 (en) 2011-12-20 2016-09-30 Рибосайенс Ллк 2',4'-difluoro-2'-methyl substituted nucleoside derivatives as inhibitors of hcv rna replication
US9708357B2 (en) 2011-12-20 2017-07-18 Riboscience, LLC 4′-azido, 3′-fluoro substituted nucleoside derivatives as inhibitors of HCV RNA replication
US20180200280A1 (en) 2013-05-16 2018-07-19 Riboscience Llc 4'-Fluoro-2'-Methyl Substituted Nucleoside Derivatives as Inhibitors of HCV RNA Replication
PE20160120A1 (en) 2013-05-16 2016-02-24 Riboscience Llc DERIVATIVES OF NUCLEOSIDE 4'-FLUORO-2'-METHYL SUBSTITUTED
BR112015028765A2 (en) 2013-05-16 2017-07-25 Riboscience Llc 4'-azido, 3'-deoxy-3'-fluoro substituted nucleoside derivatives
KR20200056420A (en) 2017-09-21 2020-05-22 리보사이언스 엘엘씨 4'-fluoro-2'-methyl substituted nucleoside derivatives as inhibitors of HCV RNA replication

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2230372A1 (en) * 1972-06-21 1973-01-11 Fujisawa Pharmaceutical Co Cepham and cephem derivs - useful as antibiotics
SE428022B (en) * 1972-06-29 1983-05-30 Ciba Geigy Ag 7BETA-AMINO-CEFAM-3-ON-4-CARBOXYLIC ACID COMPOUNDS FOR USE FOR THE PRODUCTION OF CEPHALOSPORINE DERIVATIVES
AR206201A1 (en) * 1972-06-29 1976-07-07 Ciba Geigy Ag PROCEDURE FOR OBTAINING ACID COMPOUNDS 7BETA-AMINO-3-CEFEM-3-01-4-CARBOXILICO0-SUBSTITUIDOS

Also Published As

Publication number Publication date
FR2261761B1 (en) 1978-08-18
IL46699A0 (en) 1975-04-25
BG26201A3 (en) 1979-02-15
IE40695B1 (en) 1979-08-01
ATA108275A (en) 1976-10-15
SE7501317L (en) 1975-08-27
SE7807811L (en) 1978-07-13
ES435110A1 (en) 1977-03-16
DD117074A5 (en) 1975-12-20
DK348678A (en) 1978-08-07
JPS50129590A (en) 1975-10-13
AT350068B (en) 1979-05-10
NO750625L (en) 1975-08-27
AR208538A1 (en) 1977-02-15
HU175212B (en) 1980-06-28
FI66389C (en) 1984-10-10
SE438855B (en) 1985-05-13
AT337362B (en) 1977-06-27
DE2506330A1 (en) 1975-09-04
CA1080713A (en) 1980-07-01
NL7502292A (en) 1975-08-28
BE825919A (en) 1975-08-25
NZ176623A (en) 1978-04-03
SE7807810L (en) 1978-07-13
CA1059988A (en) 1979-08-07
AU7849875A (en) 1976-08-26
SE431652B (en) 1984-02-20
JPS625919B2 (en) 1987-02-07
IE40695L (en) 1975-08-26
FI66389B (en) 1984-06-29
GB1503581A (en) 1978-03-15
FI750503A (en) 1975-08-27
SE438854B (en) 1985-05-13
ATA28178A (en) 1978-10-15
FR2261761A1 (en) 1975-09-19
IL46699A (en) 1977-11-30
AU498131B2 (en) 1979-02-15
DK73475A (en) 1975-10-20

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