ES450666A1 - Aminomethylbenzocycloheptene derivatives - Google Patents
Aminomethylbenzocycloheptene derivativesInfo
- Publication number
- ES450666A1 ES450666A1 ES450666A ES450666A ES450666A1 ES 450666 A1 ES450666 A1 ES 450666A1 ES 450666 A ES450666 A ES 450666A ES 450666 A ES450666 A ES 450666A ES 450666 A1 ES450666 A1 ES 450666A1
- Authority
- ES
- Spain
- Prior art keywords
- radical
- hydrogen atom
- formula
- carbon
- atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
A process for the preparation of the new aminomethylbenzocyclheptene derivatives, as well as their addition salts with mineral or organic acids, said derivatives responding to general formula I: **(See formula)** where X represents a hydrogen atom or a halogen atom with the exception of fluorine, said halogen atom being in position 2 or 4 on the phenyl nucleus, R represents a hydrogen atom, an alcohol radical containing from 1 to 3 carbon atoms, a phenyl radical, if appropriate substituted by a fluorine or chlorine atom, a methyl or methoxy radical, a benzyl radical or R represents with Y a benzylidene radical, and represents a hydrogen atom or, with R, a benzylidene radical, or Y forms a carbon-carbon double bond with Z, Z represents a hydrogen atom or forms a carbon-carbon double bond with Y, R1 and R2, identical or different, represent a hydrogen atom or a methyl radical, it being understood that when R1 and R2 represent a hydrogen atom, R also represents a hydrogen atom, said process being characterized by the fact that a product of formula II is dehydrated: **(See formula)** in which X, R, R1 and R2 have the meaning already indicated, to obtain a product of the formula: **(See formula)** where X, R1 and R2 have the meaning indicated above, R represents a hydrogen atom, an alcohol radical containing from 1 to 3 carbon atoms, a phenyl radical, if appropriate substituted by a fluorine atom or chlorine, a methyl or methoxy radical, a benzyl radical, or R represents with Y'a benzylidene radical, Y' represents with R a benzylidene radical or forms with Z'a carbon-carbon double bond, Z' represents a hydrogen atom or forms with Y'a carbon-carbon double bond, and by the fact that either the latter is isolated and, if desired, salified, or said product of formula I' is reduced to obtain the product of formula: **(See formula)** where X, R, R1 and R2 have the meaning already indicated, after which the latter is isolated and, if desired, salified. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7525398A FR2320734A1 (en) | 1975-08-14 | 1975-08-14 | NEW DERIVATIVES OF AMINOMETHYL BENZOCYCLOHEPTENE AND THEIR SALTS, METHOD OF PREPARATION AND APPLICATION AS MEDICINAL PRODUCTS OF THESE PRODUCTS |
Publications (1)
Publication Number | Publication Date |
---|---|
ES450666A1 true ES450666A1 (en) | 1977-07-16 |
Family
ID=9159099
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES450666A Expired ES450666A1 (en) | 1975-08-14 | 1976-08-13 | Aminomethylbenzocycloheptene derivatives |
Country Status (17)
Country | Link |
---|---|
JP (1) | JPS5223061A (en) |
AT (1) | AT348979B (en) |
AU (1) | AU504224B2 (en) |
BE (1) | BE845189A (en) |
DD (1) | DD126265A5 (en) |
DE (1) | DE2636432A1 (en) |
DK (1) | DK365676A (en) |
ES (1) | ES450666A1 (en) |
FI (1) | FI762280A (en) |
FR (1) | FR2320734A1 (en) |
GB (1) | GB1520579A (en) |
IL (1) | IL50179A (en) |
LU (1) | LU75604A1 (en) |
NL (1) | NL7609090A (en) |
PT (1) | PT65474B (en) |
SE (1) | SE7609041L (en) |
ZA (1) | ZA764669B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5354775B2 (en) | 2005-06-14 | 2013-11-27 | ベイラー ユニバーシティ | Combretastatin analogs with tubulin binding activity |
-
1975
- 1975-08-14 FR FR7525398A patent/FR2320734A1/en active Granted
-
1976
- 1976-07-30 IL IL50179A patent/IL50179A/en unknown
- 1976-08-03 ZA ZA764669A patent/ZA764669B/en unknown
- 1976-08-10 FI FI762280A patent/FI762280A/fi not_active Application Discontinuation
- 1976-08-12 SE SE7609041A patent/SE7609041L/en unknown
- 1976-08-13 LU LU75604A patent/LU75604A1/xx unknown
- 1976-08-13 JP JP51096175A patent/JPS5223061A/en active Pending
- 1976-08-13 AT AT605876A patent/AT348979B/en active
- 1976-08-13 PT PT65474A patent/PT65474B/en unknown
- 1976-08-13 AU AU16838/76A patent/AU504224B2/en not_active Expired
- 1976-08-13 DD DD194325A patent/DD126265A5/xx unknown
- 1976-08-13 GB GB33820/76A patent/GB1520579A/en not_active Expired
- 1976-08-13 DE DE19762636432 patent/DE2636432A1/en not_active Withdrawn
- 1976-08-13 ES ES450666A patent/ES450666A1/en not_active Expired
- 1976-08-13 BE BE169813A patent/BE845189A/en unknown
- 1976-08-13 DK DK365676A patent/DK365676A/en unknown
- 1976-08-16 NL NL7609090A patent/NL7609090A/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
PT65474A (en) | 1976-09-01 |
AT348979B (en) | 1979-03-12 |
DD126265A5 (en) | 1977-07-06 |
DK365676A (en) | 1977-02-15 |
FR2320734B1 (en) | 1979-01-05 |
GB1520579A (en) | 1978-08-09 |
FI762280A (en) | 1977-02-15 |
PT65474B (en) | 1978-07-04 |
NL7609090A (en) | 1977-02-16 |
AU504224B2 (en) | 1979-10-04 |
ATA605876A (en) | 1978-08-15 |
AU1683876A (en) | 1978-02-16 |
DE2636432A1 (en) | 1977-02-24 |
SE7609041L (en) | 1977-02-15 |
ZA764669B (en) | 1977-09-28 |
IL50179A0 (en) | 1976-09-30 |
LU75604A1 (en) | 1977-04-21 |
FR2320734A1 (en) | 1977-03-11 |
IL50179A (en) | 1979-10-31 |
JPS5223061A (en) | 1977-02-21 |
BE845189A (en) | 1977-02-14 |
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