ES417353A1 - Procedure for preparing quinoleine derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Procedure for preparing quinoline derivatives, which respond to formula I: **(See formula)** wherein the CF3O radical is in position 5, 6, 7 or 8 on the quinoline nucleus; R represents a radical **(See formula)** wherein A is a straight or branched aliphatic chain, saturated or not, containing from 2 to 7 carbon atoms; represents: either a phenyl radical which may or may not have 1 to 3 substituents chosen from the group consisting of halogen atoms, halogen-methyl, halogen-methoxy and halogen-methylthio radicals and saturated or non-saturated aliphatic radicals of straight or branched chain, containing from 1 to 5 carbon atoms, or an ArA1 residue in which Ar is a phenyl radical that may or may not have 1 to 3 substituents chosen from the group consisting of halogen atoms, the halogen-methyl, halogen-methoxy and halogen-methylthio radicals and straight or branched, saturated or unsaturated aliphatic radicals containing from 1 to 5 carbon atoms, and A1 is a straight or branched aliphatic chain, saturated or not, containing from 1 to 7 carbon atoms, or a radical R2CO in which R2 is either a phenyl radical which may or may not have 1 to 3 substituents chosen from the group consisting of halogen atoms, the halogen radicals- methyl, halogen-methoxy and halogen-m ethylthio and unsaturated, straight-chain or branched aliphatic radicals containing from 1 to 5 carbon atoms, or an ArA2 radical in which Ar has the meaning given above and A2 is a straight or branched, saturated aliphatic chain or not, it contains from 1 to 7 carbon atoms and can be interrupted by a heteroatom such as an oxygen or sulfur atom, or even a radical (see formula) in which Ar has the meaning given above and A3 is either a single bond or a straight or branched aliphatic chain, containing 1 to 4 carbon atoms, as well as their acid addition salts pharmaceutically acceptable organic or mineral; characterized in that a quinoline derivative of formula (II) is reacted **(See formula)** where X is a halogen atom, in particular chlorine, with an anthranilic ester that responds to the formula **(See formula)** where R has the meaning given above. (Machine-translation by Google Translate, not legally binding)