ES442262A1 - Procedure for obtaining O-substitute 7-beta-amino-3-cefem-3-ol-4-carboxylic acid compounds. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for obtaining O-substitute 7-beta-amino-3-cefem-3-ol-4-carboxylic acid compounds. (Machine-translation by Google Translate, not legally binding)

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Publication number
ES442262A1
ES442262A1 ES442262A ES442262A ES442262A1 ES 442262 A1 ES442262 A1 ES 442262A1 ES 442262 A ES442262 A ES 442262A ES 442262 A ES442262 A ES 442262A ES 442262 A1 ES442262 A1 ES 442262A1
Authority
ES
Spain
Prior art keywords
formula
group
compound
cephem
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES442262A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH978872A external-priority patent/CH587268A5/en
Priority claimed from CH1872272A external-priority patent/CH605987A5/en
Priority claimed from CH265573A external-priority patent/CH605988A5/en
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES442262A1 publication Critical patent/ES442262A1/en
Expired legal-status Critical Current

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Abstract

Procedure for obtaining 7-amino-3-cephem-3-ol-4-carboxylic acid or substituted compounds of formula **(See formula)** wherein it means hydroxy or a moiety which together with the carbonyl group -C (= O) forms a protected carboxyl group, and R3 means a hydrocarbon moiety, optionally substituted, or an acyl group, or the salts thereof, characterized in that Cephem-3-one compounds of the formula **(See formula)** or a corresponding enol with a double bond at the 2,3 or 3,4 position, is transformed into an enolic derivative with a functionally modified hydroxy group of the formula -O-R3 at the 3 position, or a compound of the formula **(See formula)** wherein R2 and R3 have the meanings indicated above, and R0A signifies a protecting amino group and R0b signifies hydrogen or an acyl moiety, or R0A and R0b together signify a bivalent protecting amino group, the amino group at position 7 is released, or a 2-cephem compound of the formula **(See formula)** the corresponding 3-cephem compound is isomerized, and, if desired, in a compound obtained of formula II, the protected carboxyl group of formula -C (= O) -R2A is transformed into the free carboxyl group or another protected carboxyl group, and/or, if desired, a compound obtained with a salt-forming group is transformed into a salt, or a salt obtained in the free compound or another salt and/or, if desired, a mixture obtained from isomeric compounds is separates into different isomers. (Machine-translation by Google Translate, not legally binding)
ES442262A 1972-06-29 1975-10-31 Procedure for obtaining O-substitute 7-beta-amino-3-cefem-3-ol-4-carboxylic acid compounds. (Machine-translation by Google Translate, not legally binding) Expired ES442262A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH978872A CH587268A5 (en) 1972-06-29 1972-06-29 Substd carboxylic acid derivs - broad spectrum antibiotics and inters
CH1872272A CH605987A5 (en) 1972-12-22 1972-12-22 Substd carboxylic acid derivs
CH265573A CH605988A5 (en) 1973-02-23 1973-02-23 Substd 7-beta-amino ceph-3-em-3-ol 4-carboxylic acids
CH738873 1973-05-23

Publications (1)

Publication Number Publication Date
ES442262A1 true ES442262A1 (en) 1977-07-01

Family

ID=27428471

Family Applications (1)

Application Number Title Priority Date Filing Date
ES442262A Expired ES442262A1 (en) 1972-06-29 1975-10-31 Procedure for obtaining O-substitute 7-beta-amino-3-cefem-3-ol-4-carboxylic acid compounds. (Machine-translation by Google Translate, not legally binding)

Country Status (1)

Country Link
ES (1) ES442262A1 (en)

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