ES381910A2 - Procedure for the obtaining of carboxylic acids alpha- (fine amino) -alifatics. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the obtaining of carboxylic acids alpha- (fine amino) -alifatics. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES381910A2
ES381910A2 ES381910A ES381910A ES381910A2 ES 381910 A2 ES381910 A2 ES 381910A2 ES 381910 A ES381910 A ES 381910A ES 381910 A ES381910 A ES 381910A ES 381910 A2 ES381910 A2 ES 381910A2
Authority
ES
Spain
Prior art keywords
formula
group
compound
see formula
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES381910A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ES0365215A external-priority patent/ES365215A1/en
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES381910A2 publication Critical patent/ES381910A2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
    • C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
    • C07D207/448—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/02—Preparation by ring-closure or hydrogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Improvements introduced in the object of the main patent No. 365,215, filed on March 25, 1969, by: Procedure for obtaining α- (amino-phenyl) -aliphatic carboxylic acids, of formula: **(See formula)** in which the group (see formula) means a bicyclo alkylene amino group with 1-3 double bonds and with 5-6 ring members in each ring, pH means a phenylene moiety, if substituted, R1 means hydrogen or a lower alkyl group and R2 means hydrogen or a lower alkyl, lower alkenyl, cycloalkyl, cycloalkenyl, cycloalkyl-lower alkyl or cycloalkenyl-lower alkyl group, or functional derivatives or salts thereof, characterized in that a) in a compound of formula, **(See formula)** wherein X1 signifies a moiety transformable into a functionally modified grouping of formula -C (R1) (R2) -C (= O) -OH (IIa), group X1 is transformed into a grouping of formula IIa, or b) in a compound of formula, **(See formula)** or in a functional derivative thereof, where X2 means a transformable residue in the grouping (see formula), X2 transforms into a group (see formula), and, if desired, a compound obtained is transformed, within the defined range, into another compound of the invention and/or, if desired, a free compound obtained is transformed into a salt or a salt obtained in the free compound, and/or, if desired, a mixture of isomers obtained is separated into the different isomers. (Machine-translation by Google Translate, not legally binding)
ES381910A 1969-03-25 1970-07-16 Procedure for the obtaining of carboxylic acids alpha- (fine amino) -alifatics. (Machine-translation by Google Translate, not legally binding) Expired ES381910A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES0365215A ES365215A1 (en) 1969-03-25 1969-03-25 Procedure for obtaining carboxylic acids alpha- (amino-fenil) -alifaticos (Machine-translation by Google Translate, not legally binding)
US84324469A 1969-07-18 1969-07-18

Publications (1)

Publication Number Publication Date
ES381910A2 true ES381910A2 (en) 1973-01-16

Family

ID=25289436

Family Applications (1)

Application Number Title Priority Date Filing Date
ES381910A Expired ES381910A2 (en) 1969-03-25 1970-07-16 Procedure for the obtaining of carboxylic acids alpha- (fine amino) -alifatics. (Machine-translation by Google Translate, not legally binding)

Country Status (8)

Country Link
CH (13) CH577482A5 (en)
ES (1) ES381910A2 (en)
FI (1) FI54106C (en)
NO (1) NO135938C (en)
PL (6) PL116729B1 (en)
SE (1) SE394670B (en)
SU (1) SU520040A3 (en)
ZA (1) ZA704666B (en)

Also Published As

Publication number Publication date
CH605792A5 (en) 1978-10-13
NO135938B (en) 1977-03-21
CH577480A5 (en) 1976-07-15
CH584690A5 (en) 1977-02-15
CH579541A5 (en) 1976-09-15
PL97082B3 (en) 1978-02-28
SU520040A3 (en) 1976-06-30
PL116729B1 (en) 1981-06-30
CH577481A5 (en) 1976-07-15
CH585725A5 (en) 1977-03-15
CH585727A5 (en) 1977-03-15
PL116578B1 (en) 1981-06-30
CH577482A5 (en) 1976-07-15
CH585724A5 (en) 1977-03-15
CH585722A5 (en) 1977-03-15
FI54106C (en) 1978-10-10
PL116504B1 (en) 1981-06-30
CH579548A5 (en) 1976-09-15
FI54106B (en) 1978-06-30
CH585723A5 (en) 1977-03-15
PL99355B1 (en) 1978-07-31
CH585726A5 (en) 1977-03-15
ZA704666B (en) 1971-03-31
SE394670B (en) 1977-07-04
NO135938C (en) 1977-06-29
PL99354B1 (en) 1978-07-31

Similar Documents

Publication Publication Date Title
GB1431323A (en) Aminonaphthalenesulphonic acids
ES401968A1 (en) Total steroid synthesis employing substituted isoxazole derivatives
ES381910A2 (en) Procedure for the obtaining of carboxylic acids alpha- (fine amino) -alifatics. (Machine-translation by Google Translate, not legally binding)
ES446802A1 (en) Triamines
ES8506706A1 (en) Substituted thiazolidinylic esters of mineral acids.
ES327297A1 (en) Procedure for the obtaining of compounds derived from quinazoline. (Machine-translation by Google Translate, not legally binding)
ES365215A1 (en) Procedure for obtaining carboxylic acids alpha- (amino-fenil) -alifaticos (Machine-translation by Google Translate, not legally binding)
ES406013A1 (en) Synthesis of alpha-(carbo(5-indanyloxy)) benzylpenicillin
ES394504A1 (en) Cycloalkyl(f)(l)benzopyrans
ES310125A1 (en) Procedure for the preparation of fenantrenic derivatives. (Machine-translation by Google Translate, not legally binding)
ES313320A1 (en) Procedure for the obtaining of new pyrimidinic compounds. (Machine-translation by Google Translate, not legally binding)
ES459871A1 (en) Salts of aliphatic-thioethylamines
ES419803A1 (en) A procedure for the preparation of 3-alkyl-3-cefem-4-carboxylic acids. (Machine-translation by Google Translate, not legally binding)
ES416412A1 (en) Process for the obtaining of 7 - amino - 3 - cegem - 3 - ol - 4 - carboxylic or substitute acid compounds. (Machine-translation by Google Translate, not legally binding)
ES377601A2 (en) Procedure for the obtaining of carboxylic acids - (amino-phenyl) - aliphatic. (Machine-translation by Google Translate, not legally binding)
ES349893A1 (en) Procedure for the obtaining of tricioclic fenoxicarboxilic acids. (Machine-translation by Google Translate, not legally binding)
ES405195A3 (en) Procedure for the preparation of combinations type acid 3, 4, 5-trial-coxibenzoil-aminoalcano-carboxilico and their salts. (Machine-translation by Google Translate, not legally binding)
ES391895A1 (en) Procedure for the obtaining of acilaminic compounds. (Machine-translation by Google Translate, not legally binding)
ES399151A1 (en) Procedure for obtaining 4-piperidone-quetal derivatives, its preparation and its use as stabilizers. (Machine-translation by Google Translate, not legally binding)
ES442262A1 (en) Procedure for obtaining O-substitute 7-beta-amino-3-cefem-3-ol-4-carboxylic acid compounds. (Machine-translation by Google Translate, not legally binding)
ES324363A1 (en) Procedure for the obtaining of benzoxacepine derivatives. (Machine-translation by Google Translate, not legally binding)
ES451084A1 (en) N,n-diethyl-4-(2,4-dinitro-6-alkylsulfonylphenylazo)-2-alkoxy-5-alkyl-carbonylaminoanilines
ES316379A1 (en) Procedure for the preparation of a biocidal agent. (Machine-translation by Google Translate, not legally binding)
GB1273241A (en) Heterobicyclic amino acids
ES373176A1 (en) Procedure for the obtaining of acid - o - desacetil-7n-acilamino-cefaloesporaicos. (Machine-translation by Google Translate, not legally binding)

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20100528