AU498131B2 - Production of cephems by cyclization - Google Patents

Production of cephems by cyclization

Info

Publication number
AU498131B2
AU498131B2 AU78498/75A AU7849875A AU498131B2 AU 498131 B2 AU498131 B2 AU 498131B2 AU 78498/75 A AU78498/75 A AU 78498/75A AU 7849875 A AU7849875 A AU 7849875A AU 498131 B2 AU498131 B2 AU 498131B2
Authority
AU
Australia
Prior art keywords
cephems
cyclization
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU78498/75A
Other languages
English (en)
Other versions
AU7849875A (en
Inventor
R. B. and BICKEL H WOODWARD
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Priority claimed from CH269374A external-priority patent/CH601310A5/de
Priority claimed from CH776674A external-priority patent/CH610584A5/de
Publication of AU7849875A publication Critical patent/AU7849875A/en
Application granted granted Critical
Publication of AU498131B2 publication Critical patent/AU498131B2/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C313/02—Sulfinic acids; Derivatives thereof
    • C07C313/04—Sulfinic acids; Esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C07D205/095—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4 and with a nitrogen atom directly attached in position 3
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU78498/75A 1974-02-26 1974-02-24 Production of cephems by cyclization Expired AU498131B2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
CHCH11000/74 1974-01-24
CH269374A CH601310A5 (en) 1974-02-26 1974-02-26 7-Amino-3-hydroxy-2(or 3)-cephem-4-carboxylic acid derivs prepn
CHCH2693/74 1974-02-26
CH776674A CH610584A5 (en) 1974-02-26 1974-06-05 Process for the preparation of 2-(3-amino-2-oxo-4-sulphonylthio-1- azetidinyl)-3-methylenebutyric acid derivatives
CHCH7766/74 1974-06-05
CH1100074 1974-08-12

Publications (2)

Publication Number Publication Date
AU7849875A AU7849875A (en) 1976-08-26
AU498131B2 true AU498131B2 (en) 1979-02-15

Family

ID=27173851

Family Applications (1)

Application Number Title Priority Date Filing Date
AU78498/75A Expired AU498131B2 (en) 1974-02-26 1974-02-24 Production of cephems by cyclization

Country Status (21)

Country Link
JP (1) JPS625919B2 (sv)
AR (1) AR208538A1 (sv)
AT (2) AT337362B (sv)
AU (1) AU498131B2 (sv)
BE (1) BE825919A (sv)
BG (1) BG26201A3 (sv)
CA (2) CA1059988A (sv)
DD (1) DD117074A5 (sv)
DE (1) DE2506330A1 (sv)
DK (2) DK73475A (sv)
ES (2) ES435110A1 (sv)
FI (1) FI66389C (sv)
FR (1) FR2261761B1 (sv)
GB (1) GB1503581A (sv)
HU (1) HU175212B (sv)
IE (1) IE40695B1 (sv)
IL (1) IL46699A (sv)
NL (1) NL7502292A (sv)
NO (1) NO750625L (sv)
NZ (1) NZ176623A (sv)
SE (3) SE431652B (sv)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1044247B (it) * 1974-08-02 1980-03-20 Farmaceutici Italia Intermedi per la sintesi di derivati b lattamici e procedimento per la loro preparazone
JPS5198265A (sv) * 1975-02-17 1976-08-30
CA1136132A (en) * 1975-02-17 1982-11-23 Teruji Tsuji Cyclization to form cephem ring and intermediates therefor
AT342197B (de) * 1975-02-20 1978-03-28 Ciba Geigy Ag Neues verfahren zur herstellung von 3-cephemverbindungen
US4029645A (en) * 1975-11-17 1977-06-14 E. R. Squibb & Sons, Inc. Mercury intermediates useful in the preparation of 2-alkoxy cephalosporins
JPH0639474B2 (ja) * 1983-03-04 1994-05-25 大塚化学株式会社 セファロスポリン化合物の製造法
JPS59228854A (ja) * 1983-06-08 1984-12-22 真井　康博 薬液収納兼即効注出器
GB2152497B (en) * 1983-11-28 1987-08-05 Otsuka Kagaku Kk Process for the preparation of azetidinone derivatives
JPS60237061A (ja) * 1984-05-08 1985-11-25 Otsuka Chem Co Ltd アゼチジノン誘導体の製造法
JPS60126263A (ja) * 1983-12-12 1985-07-05 Otsuka Chem Co Ltd アゼチジノン誘導体の製造法
JPS60115562A (ja) * 1983-11-28 1985-06-22 Otsuka Chem Co Ltd アゼチジノン誘導体の製造法
JPS61178961A (ja) * 1985-02-01 1986-08-11 Otsuka Chem Co Ltd アゼチジノン誘導体の製造法
DE3725375A1 (de) * 1987-07-31 1989-02-09 Bayer Ag Stabile oxapenem-3-carbonsaeuren
JP3195959B2 (ja) * 1991-03-13 2001-08-06 大塚化学株式会社 ３−ヒドロキシセフェム誘導体の製造法
WO2004039813A1 (en) * 2002-11-01 2004-05-13 Orchid Chemicals & Pharmaceuticals Ltd An improved process for the preparation of chloro methyl cephem derivatives
DK2794628T3 (en) 2011-12-20 2017-07-10 Riboscience Llc 4'-AZIDO-3'-FLUORO-SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF HCV RNA REPLICATION
PT2794629T (pt) 2011-12-20 2017-07-20 Riboscience Llc Derivados de nucleósidos substituídos em 2¿-4¿-difluor-2¿-metilo, como inibidores da replicação do arn de vhc (vírus da hepatite c)
MY186547A (en) 2013-05-16 2021-07-26 Riboscience Llc 4?-fluoro-2?-methyl substituted nucleoside derivatives
US20180200280A1 (en) 2013-05-16 2018-07-19 Riboscience Llc 4'-Fluoro-2'-Methyl Substituted Nucleoside Derivatives as Inhibitors of HCV RNA Replication
MA38678A1 (fr) 2013-05-16 2017-07-31 Riboscience Llc Dérivés nucléosidiques 4'-azido, 3'désoxy-3'-fluoro substitués
TW201919649A (zh) 2017-09-21 2019-06-01 美商里伯賽恩斯有限責任公司 作為ｈｃｖ ｒｎａ複製抑制劑之經４′－氟－２′－甲基取代之核苷衍生物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2230372A1 (de) * 1972-06-21 1973-01-11 Fujisawa Pharmaceutical Co Verfahren zur herstellung von oxidierten penam-derivaten
SE428022B (sv) * 1972-06-29 1983-05-30 Ciba Geigy Ag 7beta-amino-cefam-3-on-4-karboxylsyraforeningar till anvendning for framstellning av cefalosporinderivat
AR206201A1 (es) * 1972-06-29 1976-07-07 Ciba Geigy Ag Procedimiento para la obtencion de compuestos de acido 7beta-amino-3-cefem-3-01-4-carboxilico0-substituidos

Also Published As

Publication number Publication date
AU7849875A (en) 1976-08-26
FI66389C (fi) 1984-10-10
BE825919A (fr) 1975-08-25
HU175212B (hu) 1980-06-28
SE438855B (sv) 1985-05-13
DD117074A5 (sv) 1975-12-20
FI66389B (fi) 1984-06-29
DE2506330A1 (de) 1975-09-04
IL46699A (en) 1977-11-30
SE7501317L (sv) 1975-08-27
FR2261761A1 (sv) 1975-09-19
GB1503581A (en) 1978-03-15
CA1059988A (en) 1979-08-07
SE7807811L (sv) 1978-07-13
AR208538A1 (es) 1977-02-15
IL46699A0 (en) 1975-04-25
JPS625919B2 (sv) 1987-02-07
ES435110A1 (es) 1977-03-16
NZ176623A (en) 1978-04-03
DK73475A (sv) 1975-10-20
FR2261761B1 (sv) 1978-08-18
SE438854B (sv) 1985-05-13
AT337362B (de) 1977-06-27
ATA28178A (de) 1978-10-15
AT350068B (de) 1979-05-10
DK348678A (da) 1978-08-07
BG26201A3 (sv) 1979-02-15
SE431652B (sv) 1984-02-20
ES452915A1 (es) 1977-11-01
NL7502292A (nl) 1975-08-28
IE40695B1 (en) 1979-08-01
SE7807810L (sv) 1978-07-13
JPS50129590A (sv) 1975-10-13
NO750625L (sv) 1975-08-27
IE40695L (en) 1975-08-26
FI750503A (sv) 1975-08-27
CA1080713A (en) 1980-07-01
ATA108275A (de) 1976-10-15

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