DE2457047C3 - Verfahren zur Herstellung eines Derivates der leichten Kette des Tetanustoxins, dessen Verwendung zur Tetanusprophylaxe - Google Patents

Verfahren zur Herstellung eines Derivates der leichten Kette des Tetanustoxins, dessen Verwendung zur Tetanusprophylaxe

Info

Publication number
DE2457047C3
DE2457047C3 DE2457047A DE2457047A DE2457047C3 DE 2457047 C3 DE2457047 C3 DE 2457047C3 DE 2457047 A DE2457047 A DE 2457047A DE 2457047 A DE2457047 A DE 2457047A DE 2457047 C3 DE2457047 C3 DE 2457047C3
Authority
DE
Germany
Prior art keywords
light chain
tetanus
derivative
aldehyde
tetanus toxin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2457047A
Other languages
German (de)
English (en)
Other versions
DE2457047A1 (de
DE2457047B2 (de
Inventor
Torsten B. Dr. 3550 Marburg Helting
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Behringwerke AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke AG filed Critical Behringwerke AG
Priority to DE2457047A priority Critical patent/DE2457047C3/de
Priority to NL7513941A priority patent/NL7513941A/xx
Priority to ES443052A priority patent/ES443052A1/es
Priority to CH1548575A priority patent/CH622701A5/de
Priority to IL48571A priority patent/IL48571A/xx
Priority to LU73900A priority patent/LU73900A1/xx
Priority to AT915575A priority patent/AT342764B/de
Priority to IE2621/75A priority patent/IE42760B1/en
Priority to DK544175A priority patent/DK544175A/da
Priority to SE7513606A priority patent/SE431401B/xx
Priority to US05/637,028 priority patent/US4029765A/en
Priority to CA240,888A priority patent/CA1066621A/en
Priority to AU87167/75A priority patent/AU504575B2/en
Priority to GB49630/75A priority patent/GB1531417A/en
Priority to JP50144567A priority patent/JPS5182719A/ja
Priority to FR7536963A priority patent/FR2293217A1/fr
Priority to BE162406A priority patent/BE836228A/xx
Publication of DE2457047A1 publication Critical patent/DE2457047A1/de
Priority to CA313,399A priority patent/CA1063021A/en
Publication of DE2457047B2 publication Critical patent/DE2457047B2/de
Application granted granted Critical
Publication of DE2457047C3 publication Critical patent/DE2457047C3/de
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/08—Clostridium, e.g. Clostridium tetani
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/825—Bacteria

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
DE2457047A 1974-12-03 1974-12-03 Verfahren zur Herstellung eines Derivates der leichten Kette des Tetanustoxins, dessen Verwendung zur Tetanusprophylaxe Expired DE2457047C3 (de)

Priority Applications (18)

Application Number Priority Date Filing Date Title
DE2457047A DE2457047C3 (de) 1974-12-03 1974-12-03 Verfahren zur Herstellung eines Derivates der leichten Kette des Tetanustoxins, dessen Verwendung zur Tetanusprophylaxe
NL7513941A NL7513941A (nl) 1974-12-03 1975-11-28 Derivaten en tetanustoxinen, hun bereiding en geneesmiddelen met daarin deze derivaten.
ES443052A ES443052A1 (es) 1974-12-03 1975-11-28 Procedimiento para la preparacion de un derivado de la cade-na ligera de la toxina tetanica.
CH1548575A CH622701A5 (enExample) 1974-12-03 1975-11-28
IL48571A IL48571A (en) 1974-12-03 1975-11-30 Modified light chain of the tetanus toxin, process for its preparation and agents containing it
LU73900A LU73900A1 (enExample) 1974-12-03 1975-12-01
US05/637,028 US4029765A (en) 1974-12-03 1975-12-02 Derivatives of the tetanus toxin, process for their preparation and agents containing them
IE2621/75A IE42760B1 (en) 1974-12-03 1975-12-02 Derivatives of the tetanus toxin, process for their preparation and agents containing them
DK544175A DK544175A (da) 1974-12-03 1975-12-02 Derivater af tetanustoksinet, fremgangsmade til deres fremstilling og midler indeholdende disse derivater
SE7513606A SE431401B (sv) 1974-12-03 1975-12-02 Forfarande for framstellning av derivat av tetanustoxinets letta kedja
AT915575A AT342764B (de) 1974-12-03 1975-12-02 Verfahren zur herstellung eines derivates der leichten kette des tetanustoxins
CA240,888A CA1066621A (en) 1974-12-03 1975-12-02 Dialdehyde treatment of tetanus toxin and derivative obtained
AU87167/75A AU504575B2 (en) 1974-12-03 1975-12-02 Tetanus toxin derivatives
JP50144567A JPS5182719A (en) 1974-12-03 1975-12-03 Hashofudokusojudotaino seizohoho
FR7536963A FR2293217A1 (fr) 1974-12-03 1975-12-03 Derives de la toxine du tetanos, leur procede de preparation et leurs applications
BE162406A BE836228A (fr) 1974-12-03 1975-12-03 Derives de la toxine du tetanos, leur procede de preparation et leurs applications
GB49630/75A GB1531417A (en) 1974-12-03 1975-12-03 Derivatives of tetanus toxin process for their preparation and agents containing them
CA313,399A CA1063021A (en) 1974-12-03 1978-10-13 Derivatives of the tetanus toxin, process for their preparation and agents containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2457047A DE2457047C3 (de) 1974-12-03 1974-12-03 Verfahren zur Herstellung eines Derivates der leichten Kette des Tetanustoxins, dessen Verwendung zur Tetanusprophylaxe

Publications (3)

Publication Number Publication Date
DE2457047A1 DE2457047A1 (de) 1976-06-10
DE2457047B2 DE2457047B2 (de) 1979-03-15
DE2457047C3 true DE2457047C3 (de) 1979-10-31

Family

ID=5932347

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2457047A Expired DE2457047C3 (de) 1974-12-03 1974-12-03 Verfahren zur Herstellung eines Derivates der leichten Kette des Tetanustoxins, dessen Verwendung zur Tetanusprophylaxe

Country Status (17)

Country Link
US (1) US4029765A (enExample)
JP (1) JPS5182719A (enExample)
AT (1) AT342764B (enExample)
AU (1) AU504575B2 (enExample)
BE (1) BE836228A (enExample)
CA (1) CA1066621A (enExample)
CH (1) CH622701A5 (enExample)
DE (1) DE2457047C3 (enExample)
DK (1) DK544175A (enExample)
ES (1) ES443052A1 (enExample)
FR (1) FR2293217A1 (enExample)
GB (1) GB1531417A (enExample)
IE (1) IE42760B1 (enExample)
IL (1) IL48571A (enExample)
LU (1) LU73900A1 (enExample)
NL (1) NL7513941A (enExample)
SE (1) SE431401B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4200627A (en) 1976-07-31 1980-04-29 Behringwerke Aktiengesellschaft Atoxic, immunogenic product of tetanus toxin

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4264588A (en) * 1979-05-10 1981-04-28 The Charles River Breeding Laboratories, Inc. Vaccine for Clostridium perfringens type E enterotoxemia of rabbits
JPS5750925A (en) * 1980-09-12 1982-03-25 Takeda Chem Ind Ltd Preparation of pertussis toxoid
US4594336A (en) * 1982-09-28 1986-06-10 Institut Pasteur Thiolated polypeptide compound derived from a tetanus toxin fragment, the process for obtaining and its application
US5252714A (en) * 1990-11-28 1993-10-12 The University Of Alabama In Huntsville Preparation and use of polyethylene glycol propionaldehyde
JP4229341B2 (ja) 1996-03-23 2009-02-25 財団法人阪大微生物病研究会 破傷風毒素の機能的フラグメント抗原及び破傷風ワクチン
US20030138460A1 (en) * 2000-02-08 2003-07-24 Allergan, Inc Methods of treating animals with botulinum toxin pharmaceutical compositions
US8632785B2 (en) * 2000-02-08 2014-01-21 Allergan, Inc. Clostridial toxin pharmaceutical composition containing a gelatin fragment
US20060269575A1 (en) * 2000-02-08 2006-11-30 Allergan, Inc. Botulinum toxin pharmaceutical compositions formulated with recombinant albumin
CA2494241C (en) * 2000-02-08 2011-06-14 Allergan, Inc. Botulinum toxin pharmaceutical compositions
US7780967B2 (en) * 2000-02-08 2010-08-24 Allergan, Inc. Reduced toxicity Clostridial toxin pharmaceutical compositions
US20030118598A1 (en) * 2000-02-08 2003-06-26 Allergan, Inc. Clostridial toxin pharmaceutical compositions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1617344B2 (de) * 1967-05-06 1976-04-08 Behringwerke Ag, 3550 Marburg Verfahren zur herstellung eines tetanus-impfstoffes
US3903262A (en) * 1972-03-13 1975-09-02 Cutter Lab Pharmaceutical compositions comprising intravenously injectable modified serum globulin, its production and use
DE2355094C3 (de) * 1973-11-03 1979-05-23 Behringwerke Ag, 3550 Marburg Verfahren zur Herstellung eines Tetanus-Impfstoffs

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4200627A (en) 1976-07-31 1980-04-29 Behringwerke Aktiengesellschaft Atoxic, immunogenic product of tetanus toxin

Also Published As

Publication number Publication date
LU73900A1 (enExample) 1976-11-11
IE42760L (en) 1976-06-03
DE2457047A1 (de) 1976-06-10
ES443052A1 (es) 1977-07-16
GB1531417A (en) 1978-11-08
AU504575B2 (en) 1979-10-18
FR2293217B1 (enExample) 1978-07-28
JPS5182719A (en) 1976-07-20
CA1066621A (en) 1979-11-20
AU8716775A (en) 1977-06-09
CH622701A5 (enExample) 1981-04-30
FR2293217A1 (fr) 1976-07-02
DE2457047B2 (de) 1979-03-15
NL7513941A (nl) 1976-06-08
IL48571A0 (en) 1976-01-30
DK544175A (da) 1976-06-04
IL48571A (en) 1980-02-29
BE836228A (fr) 1976-06-03
IE42760B1 (en) 1980-10-08
ATA915575A (de) 1977-08-15
SE431401B (sv) 1984-02-06
SE7513606L (sv) 1976-06-04
US4029765A (en) 1977-06-14
AT342764B (de) 1978-04-25

Similar Documents

Publication Publication Date Title
DE68915045T2 (de) Reinigung von Pertussis-Toxinen und Herstellung von Vakzine.
DE2430356C2 (enExample)
DE2457047C3 (de) Verfahren zur Herstellung eines Derivates der leichten Kette des Tetanustoxins, dessen Verwendung zur Tetanusprophylaxe
DE3032488C2 (enExample)
EP0124506A2 (de) Verfahren zur Inaktivierung von vermehrungsfähigen Krankheitserregern
DE2433883A1 (de) Geschuetztes polypeptid, im wesentlichen nicht immunogene, enzymisch aktive substanz sowie verfahren zum weitgehenden unterdruekken der immunogenizitaet eines polypeptids
DE2322552A1 (de) Verfahren zum trennen eines polypeptids von mikroorganismen
DE60315827T2 (de) Verbesserte polysaccharid- und glykokonjugat-vakzine
CH639854A5 (de) Gefriergetrocknetes natives gammaglobulin-praeparat zur intravenoesen verabreichung und verfahren zu seiner herstellug.
DE3785157T2 (de) Verfahren zur herstellung von toxoid.
DE1951256C3 (de) Verfahren zur Herstellung eines formalinisierten Allergens und dieses Allergen enthaltende Mitte!
CH628246A5 (de) Verfahren zur herstellung eines schuetzenden pertussis-antigens.
DE2355094C3 (de) Verfahren zur Herstellung eines Tetanus-Impfstoffs
DE2448530C3 (de) Verfahren zum Herstellen von Derivaten des Diphtherietoxins und diese enthaltende Mittel
DE19831061A1 (de) Herstellung von Proteinpräparationen mit verringertem Aggregatgehalt
DE69416983T2 (de) Zederpollen-Proteine und ihre Verwendung
DE3779914T2 (de) Neue lectine, abgeleitet von bakteriellen haaren.
DE2404265C3 (de) Verfahren zum Abreichen von Immunglobulinen
WO1997025352A1 (de) VERFAHREN ZUR TRENNUNG VON IgG und IgA
WO1991004275A1 (de) Neue proteine geeignet zur bekämpfung von krankheiten sowie zum schutz von weidevieh gegen zecken
DE2634584C3 (de) Atoxisches, immunogenes Produkt aus Tetanus-Toxin
DE2321951C2 (de) Verfahren zur Herstellung einer Diphtherie-Vaccine
DE2039223B2 (de) Parenteral injizierbares pharmazeutisches Präparat mit einem Gehalt an einem parenteral vertraglichen Trägermaterial und einem Desensibilisierungsmittel gegen Allergien
DE2510987C2 (de) Verfahren zur Herstellung eines Tetanusimpfstoffes
DE2815758C3 (de) Peptidkomplexe aus DNS-haltigen Organismen

Legal Events

Date Code Title Description
BI Miscellaneous see part 2
C3 Grant after two publication steps (3rd publication)
8339 Ceased/non-payment of the annual fee