DE68915045T2 - Reinigung von Pertussis-Toxinen und Herstellung von Vakzine. - Google Patents
Reinigung von Pertussis-Toxinen und Herstellung von Vakzine.Info
- Publication number
- DE68915045T2 DE68915045T2 DE68915045T DE68915045T DE68915045T2 DE 68915045 T2 DE68915045 T2 DE 68915045T2 DE 68915045 T DE68915045 T DE 68915045T DE 68915045 T DE68915045 T DE 68915045T DE 68915045 T2 DE68915045 T2 DE 68915045T2
- Authority
- DE
- Germany
- Prior art keywords
- fha
- lpf
- medium
- purified
- adsorbing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 201000005702 Pertussis Diseases 0.000 title abstract 3
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
- 239000003053 toxin Substances 0.000 title 1
- 231100000765 toxin Toxicity 0.000 title 1
- 108700012359 toxins Proteins 0.000 title 1
- 108010081690 Pertussis Toxin Proteins 0.000 abstract 9
- 239000002158 endotoxin Substances 0.000 abstract 2
- 229920006008 lipopolysaccharide Polymers 0.000 abstract 2
- 239000002609 medium Substances 0.000 abstract 2
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 abstract 1
- 230000002744 anti-aggregatory effect Effects 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000011109 contamination Methods 0.000 abstract 1
- 239000003431 cross linking reagent Substances 0.000 abstract 1
- 238000003795 desorption Methods 0.000 abstract 1
- 239000003599 detergent Substances 0.000 abstract 1
- 238000002523 gelfiltration Methods 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 abstract 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 abstract 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB888807860A GB8807860D0 (en) | 1988-04-05 | 1988-04-05 | Pertussis vaccine |
Publications (2)
Publication Number | Publication Date |
---|---|
DE68915045D1 DE68915045D1 (de) | 1994-06-09 |
DE68915045T2 true DE68915045T2 (de) | 1994-08-25 |
Family
ID=10634535
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE68915045T Expired - Lifetime DE68915045T2 (de) | 1988-04-05 | 1989-04-05 | Reinigung von Pertussis-Toxinen und Herstellung von Vakzine. |
Country Status (8)
Country | Link |
---|---|
US (1) | US4997915A (de) |
EP (1) | EP0336736B1 (de) |
JP (1) | JPH0789949B2 (de) |
AT (1) | ATE105188T1 (de) |
CA (1) | CA1331134C (de) |
DE (1) | DE68915045T2 (de) |
ES (1) | ES2052909T3 (de) |
GB (1) | GB8807860D0 (de) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8412207D0 (en) * | 1984-05-12 | 1984-06-20 | Wellcome Found | Antigenic preparations |
US5191197A (en) * | 1988-05-11 | 1993-03-02 | Symbol Technologies, Inc. | Arm mounted scanner actuatable by hand movement |
GB8910570D0 (en) | 1989-05-08 | 1989-06-21 | Wellcome Found | Acellular vaccine |
US5391715A (en) * | 1989-11-06 | 1995-02-21 | Smithkline Beecham Biologicals | Method for isolating and purifying bordetella pertussis antigenic factors |
US5578308A (en) * | 1990-02-12 | 1996-11-26 | Capiau; Carine | Glutaraldehyde and formalin detoxified bordetella toxin vaccine |
US6197548B1 (en) | 1990-04-02 | 2001-03-06 | Medeva Pharma Limited | Transformed Pichia expressing the pertactin antigen |
GB9007657D0 (en) * | 1990-04-04 | 1990-05-30 | Connaught Lab | Purification of a pertussis outer membrane protein(omp69) |
IL97985A0 (en) * | 1990-05-07 | 1992-06-21 | North American Vaccine Inc | Improved vaccine compositions |
NZ239643A (en) * | 1990-09-17 | 1996-05-28 | North American Vaccine Inc | Vaccine containing bacterial polysaccharide protein conjugate and adjuvant (c-nd-che-a-co-b-r) with a long chain alkyl group. |
GB9021004D0 (en) * | 1990-09-27 | 1990-11-07 | Wellcome Found | Acellular vaccines |
US6444211B2 (en) | 1991-04-03 | 2002-09-03 | Connaught Laboratories, Inc. | Purification of a pertussis outer membrane protein |
US5932217A (en) * | 1991-05-03 | 1999-08-03 | The Rockefeller University | Peptides which inhibit adhesion between leukocytes and endothelial cells |
GB9115332D0 (en) * | 1991-07-16 | 1991-08-28 | Connaught Lab | Manipulation of gene copy number in bordetella |
ES2136290T3 (es) * | 1994-04-28 | 1999-11-16 | Takeda Chemical Industries Ltd | Metodo para separar componentes protectores de bordetella pertussis. |
US6764682B1 (en) * | 1994-06-16 | 2004-07-20 | Aventis Pasteur Limited | Adjuvant compositions containing more than one adjuvant |
ES2182971T3 (es) | 1995-05-04 | 2003-03-16 | Aventis Pasteur | Vacunas de pertussis acelulares y metodos de preparacion de las mismas. |
US6696065B1 (en) * | 1995-05-04 | 2004-02-24 | Aventis Pastuer Limited | Acellular pertussis vaccines and methods of preparation thereof |
US6290971B1 (en) | 1995-06-15 | 2001-09-18 | Aventis Pasteur Limited | Adjuvant compositions comprising a mineral salt and another immunostimulating compound |
US7091311B2 (en) * | 1996-06-07 | 2006-08-15 | Smithkline Beecham Corporation | Peptides and compounds that bind to a receptor |
SK283565B6 (sk) | 1996-07-02 | 2003-09-11 | Connaught Laboratories Limited | Multivalentná imunogénna kompozícia a jej použitie |
AU2232399A (en) * | 1998-01-16 | 1999-08-02 | Maxim Pharmaceuticals, Inc. | Recombinant ctb-based vaccines |
PT1542714E (pt) | 2002-09-18 | 2014-06-23 | Janssen Pharmaceuticals Inc | Métodos para aumentar a produção de células estaminais plaquetárias e hematopoiéticas |
DE602004010376T2 (de) * | 2003-03-13 | 2008-10-23 | Glaxosmithkline Biologicals S.A. | Verfahren zur reinigung von bakteriellem cytolysin |
CA2542593A1 (en) * | 2003-10-14 | 2005-04-21 | Kingston Henry Gordon Mills | Filamentous haemagglutinin in the treatment and/or prophylaxis of immune-mediated disorders |
AU2004292547B9 (en) * | 2003-11-20 | 2012-04-26 | Sanofi Pasteur, Inc. | Methods for purifying pertussis toxin and peptides useful therefor |
WO2005117965A1 (en) | 2004-06-04 | 2005-12-15 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Methods for preparing immunogenic conjugates |
CA2677023C (en) * | 2007-02-22 | 2016-08-30 | Baxter International Inc. | Method of purification of hydrophobic proteins |
US20080306610A1 (en) * | 2007-06-07 | 2008-12-11 | Zimmer Orthobiologics, Inc. | Tissue processing for nonimmunogenic implants |
WO2010131111A1 (en) | 2009-05-11 | 2010-11-18 | Novartis Ag | Antigen purification process for pertactin antigen |
US8435305B2 (en) | 2010-08-31 | 2013-05-07 | Zimmer, Inc. | Osteochondral graft delivery device and uses thereof |
US20140234360A1 (en) | 2011-09-30 | 2014-08-21 | The United States of America, as represented by the Secretary, Dept.of Health and Human Services | Influenza vaccine |
KR102236498B1 (ko) | 2013-03-08 | 2021-04-06 | 얀센 백신스 앤드 프리벤션 비.브이. | 무세포 백일해 백신 |
EP4070815A1 (de) | 2016-10-03 | 2022-10-12 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Hiv-1-env-fusionspeptid-immunogene und deren verwendung |
US11202824B2 (en) | 2016-10-31 | 2021-12-21 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Peptide fragments from filoviruses and their uses |
WO2018176031A1 (en) | 2017-03-24 | 2018-09-27 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Glycan-masked engineered outer domains of hiv-1 gp120 and their use |
EP3697440A1 (de) | 2017-10-16 | 2020-08-26 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Rekombinante hiv-1-hüllproteine und deren verwendung |
US20210353740A1 (en) | 2018-09-23 | 2021-11-18 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic | Hiv-1 env fusion peptide nanoparticle carrier conjugates and their use |
EP3870703A1 (de) | 2018-10-22 | 2021-09-01 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Rekombinantes gp120-protein mit v1-schleifendeletion |
AU2022323509A1 (en) | 2021-08-03 | 2024-02-08 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Hiv-1 vaccination and samt-247 microbicide to prevent hiv-1 infection |
WO2023192835A1 (en) | 2022-03-27 | 2023-10-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Base-covered hiv-1 envelope ectodomains and their use |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5750925A (en) * | 1980-09-12 | 1982-03-25 | Takeda Chem Ind Ltd | Preparation of pertussis toxoid |
CA1213234A (en) * | 1983-03-30 | 1986-10-28 | Akihiro Ginnaga | Method for the production of ha fraction containing protective antigens of bordetella pertussis and pertussis vaccine |
US4563303A (en) * | 1984-04-14 | 1986-01-07 | Judicial Foundation The Chemosero-Therapeutic Research Institute | Method for purification of filamentous hemagglutinin |
JPS6176422A (ja) * | 1984-09-22 | 1986-04-18 | Chemo Sero Therapeut Res Inst | 百日ぜきコンポ−ネントワクチンおよび百日ぜき・ジフテリア・破傷風混合ワクチンの製造方法 |
GB8601279D0 (en) * | 1986-01-20 | 1986-02-26 | Public Health Lab Service | Purification of pertussis antigens |
US4705686A (en) * | 1986-05-09 | 1987-11-10 | American Cyanamid | Process for the preparation of acellular Bordetalla pertussis vaccine |
FR2601250B1 (fr) * | 1986-07-08 | 1989-12-01 | Pasteur Institut | Procede de preparation de fractions antigeniques exocellulaires de bordetella pertussis et vaccin contre la coqueluche contenant de telles fractions. |
-
1988
- 1988-04-05 GB GB888807860A patent/GB8807860D0/en active Pending
-
1989
- 1989-04-04 CA CA000595622A patent/CA1331134C/en not_active Expired - Lifetime
- 1989-04-05 DE DE68915045T patent/DE68915045T2/de not_active Expired - Lifetime
- 1989-04-05 ES ES89303369T patent/ES2052909T3/es not_active Expired - Lifetime
- 1989-04-05 AT AT8989303369T patent/ATE105188T1/de not_active IP Right Cessation
- 1989-04-05 JP JP1084926A patent/JPH0789949B2/ja not_active Expired - Lifetime
- 1989-04-05 EP EP89303369A patent/EP0336736B1/de not_active Expired - Lifetime
- 1989-04-06 US US07/333,964 patent/US4997915A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US4997915A (en) | 1991-03-05 |
GB8807860D0 (en) | 1988-05-05 |
CA1331134C (en) | 1994-08-02 |
ATE105188T1 (de) | 1994-05-15 |
ES2052909T3 (es) | 1994-07-16 |
EP0336736A1 (de) | 1989-10-11 |
EP0336736B1 (de) | 1994-05-04 |
DE68915045D1 (de) | 1994-06-09 |
JPH0231689A (ja) | 1990-02-01 |
JPH0789949B2 (ja) | 1995-10-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |