DE68915045D1 - Reinigung von Pertussis-Toxinen und Herstellung von Vakzine. - Google Patents

Reinigung von Pertussis-Toxinen und Herstellung von Vakzine.

Info

Publication number
DE68915045D1
DE68915045D1 DE68915045T DE68915045T DE68915045D1 DE 68915045 D1 DE68915045 D1 DE 68915045D1 DE 68915045 T DE68915045 T DE 68915045T DE 68915045 T DE68915045 T DE 68915045T DE 68915045 D1 DE68915045 D1 DE 68915045D1
Authority
DE
Germany
Prior art keywords
fha
lpf
medium
purified
adsorbing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE68915045T
Other languages
English (en)
Other versions
DE68915045T2 (de
Inventor
Larry U L Tan
Gail Jackson
Dirk Alkema
Po S Wah
Rafaat Emil Fahmy Fahim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Pasteur Ltd
Original Assignee
Connaught Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Connaught Laboratories Ltd filed Critical Connaught Laboratories Ltd
Application granted granted Critical
Publication of DE68915045D1 publication Critical patent/DE68915045D1/de
Publication of DE68915045T2 publication Critical patent/DE68915045T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE68915045T 1988-04-05 1989-04-05 Reinigung von Pertussis-Toxinen und Herstellung von Vakzine. Expired - Lifetime DE68915045T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888807860A GB8807860D0 (en) 1988-04-05 1988-04-05 Pertussis vaccine

Publications (2)

Publication Number Publication Date
DE68915045D1 true DE68915045D1 (de) 1994-06-09
DE68915045T2 DE68915045T2 (de) 1994-08-25

Family

ID=10634535

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68915045T Expired - Lifetime DE68915045T2 (de) 1988-04-05 1989-04-05 Reinigung von Pertussis-Toxinen und Herstellung von Vakzine.

Country Status (8)

Country Link
US (1) US4997915A (de)
EP (1) EP0336736B1 (de)
JP (1) JPH0789949B2 (de)
AT (1) ATE105188T1 (de)
CA (1) CA1331134C (de)
DE (1) DE68915045T2 (de)
ES (1) ES2052909T3 (de)
GB (1) GB8807860D0 (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8412207D0 (en) * 1984-05-12 1984-06-20 Wellcome Found Antigenic preparations
US5191197A (en) * 1988-05-11 1993-03-02 Symbol Technologies, Inc. Arm mounted scanner actuatable by hand movement
GB8910570D0 (en) 1989-05-08 1989-06-21 Wellcome Found Acellular vaccine
US5391715A (en) * 1989-11-06 1995-02-21 Smithkline Beecham Biologicals Method for isolating and purifying bordetella pertussis antigenic factors
US5578308A (en) * 1990-02-12 1996-11-26 Capiau; Carine Glutaraldehyde and formalin detoxified bordetella toxin vaccine
US6197548B1 (en) 1990-04-02 2001-03-06 Medeva Pharma Limited Transformed Pichia expressing the pertactin antigen
GB9007657D0 (en) * 1990-04-04 1990-05-30 Connaught Lab Purification of a pertussis outer membrane protein(omp69)
IL97985A0 (en) * 1990-05-07 1992-06-21 North American Vaccine Inc Improved vaccine compositions
NZ239643A (en) * 1990-09-17 1996-05-28 North American Vaccine Inc Vaccine containing bacterial polysaccharide protein conjugate and adjuvant (c-nd-che-a-co-b-r) with a long chain alkyl group.
GB9021004D0 (en) * 1990-09-27 1990-11-07 Wellcome Found Acellular vaccines
US6444211B2 (en) 1991-04-03 2002-09-03 Connaught Laboratories, Inc. Purification of a pertussis outer membrane protein
US5932217A (en) * 1991-05-03 1999-08-03 The Rockefeller University Peptides which inhibit adhesion between leukocytes and endothelial cells
GB9115332D0 (en) * 1991-07-16 1991-08-28 Connaught Lab Manipulation of gene copy number in bordetella
ES2136290T3 (es) * 1994-04-28 1999-11-16 Takeda Chemical Industries Ltd Metodo para separar componentes protectores de bordetella pertussis.
US6764682B1 (en) 1994-06-16 2004-07-20 Aventis Pasteur Limited Adjuvant compositions containing more than one adjuvant
US6696065B1 (en) * 1995-05-04 2004-02-24 Aventis Pastuer Limited Acellular pertussis vaccines and methods of preparation thereof
CA2433502A1 (en) 1995-05-04 1996-11-07 Aventis Pasteur Limited Acellular pertussis vaccines and methods of preparation thereof
US6290971B1 (en) 1995-06-15 2001-09-18 Aventis Pasteur Limited Adjuvant compositions comprising a mineral salt and another immunostimulating compound
US7091311B2 (en) * 1996-06-07 2006-08-15 Smithkline Beecham Corporation Peptides and compounds that bind to a receptor
CN100408095C (zh) 1996-07-02 2008-08-06 康诺特实验室有限公司 多价dtp-polio疫苗
AU2232399A (en) * 1998-01-16 1999-08-02 Maxim Pharmaceuticals, Inc. Recombinant ctb-based vaccines
DK1542714T3 (da) 2002-09-18 2014-05-26 Janssen Pharmaceuticals Inc Fremgangsmåder til forøgelse af produktion af blodplader og hæmatopoietiske stamceller
CA2518669C (en) * 2003-03-13 2014-07-29 Glaxosmithkline Biologicals S.A. Purification process
US20070190078A1 (en) * 2003-10-14 2007-08-16 Mills Kingston H G Filamentous haemagglutinin in the treatment and/or prophylaxis of immune-mediated disorders
EP1692313A2 (de) * 2003-11-20 2006-08-23 Sanofi Pasteur Inc. Verfahren zur aufreinigung von pertussistoxin sowie dafür geeignete peptide
AU2005249571B9 (en) 2004-06-04 2011-01-20 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Methods for preparing immunogenic conjugates
US8293876B2 (en) 2007-02-22 2012-10-23 Baxter International Inc. Method of purification of hydrophobic proteins
US20080306610A1 (en) * 2007-06-07 2008-12-11 Zimmer Orthobiologics, Inc. Tissue processing for nonimmunogenic implants
EP2430040A1 (de) 2009-05-11 2012-03-21 Novartis AG Antigenaufreinigungs­verfahren für pertactinantigen
US8435305B2 (en) 2010-08-31 2013-05-07 Zimmer, Inc. Osteochondral graft delivery device and uses thereof
WO2013049535A2 (en) 2011-09-30 2013-04-04 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Influenza vaccine
BR112015021523A8 (pt) 2013-03-08 2021-06-29 Crucell Holland Bv composição de uma vacina contra a tosse convulsa acelular, e, usos da composição e de antígenos da bordetella pertussis
US11602559B2 (en) 2016-10-03 2023-03-14 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services HIV-1 Env fusion peptide immunogens and their use
US11202824B2 (en) 2016-10-31 2021-12-21 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Peptide fragments from filoviruses and their uses
US11235056B2 (en) 2017-03-24 2022-02-01 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Glycan-masked engineered outer domains of HIV-1 gp120 and their use
EP3697440A1 (de) 2017-10-16 2020-08-26 The United States of America, as represented by the Secretary, Department of Health and Human Services Rekombinante hiv-1-hüllproteine und deren verwendung
US20210353740A1 (en) 2018-09-23 2021-11-18 The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic Hiv-1 env fusion peptide nanoparticle carrier conjugates and their use
CA3117390A1 (en) 2018-10-22 2020-04-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Recombinant gp120 protein with v1-loop deletion
CA3228275A1 (en) 2021-08-03 2023-02-09 Genoveffa Franchini Hiv-1 vaccination and samt-247 microbicide to prevent hiv-1 infection
WO2023192835A1 (en) 2022-03-27 2023-10-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Base-covered hiv-1 envelope ectodomains and their use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5750925A (en) * 1980-09-12 1982-03-25 Takeda Chem Ind Ltd Preparation of pertussis toxoid
CA1213234A (en) * 1983-03-30 1986-10-28 Akihiro Ginnaga Method for the production of ha fraction containing protective antigens of bordetella pertussis and pertussis vaccine
US4563303A (en) * 1984-04-14 1986-01-07 Judicial Foundation The Chemosero-Therapeutic Research Institute Method for purification of filamentous hemagglutinin
JPS6176422A (ja) * 1984-09-22 1986-04-18 Chemo Sero Therapeut Res Inst 百日ぜきコンポ−ネントワクチンおよび百日ぜき・ジフテリア・破傷風混合ワクチンの製造方法
GB8601279D0 (en) * 1986-01-20 1986-02-26 Public Health Lab Service Purification of pertussis antigens
US4705686A (en) * 1986-05-09 1987-11-10 American Cyanamid Process for the preparation of acellular Bordetalla pertussis vaccine
FR2601250B1 (fr) * 1986-07-08 1989-12-01 Pasteur Institut Procede de preparation de fractions antigeniques exocellulaires de bordetella pertussis et vaccin contre la coqueluche contenant de telles fractions.

Also Published As

Publication number Publication date
DE68915045T2 (de) 1994-08-25
EP0336736B1 (de) 1994-05-04
ATE105188T1 (de) 1994-05-15
ES2052909T3 (es) 1994-07-16
CA1331134C (en) 1994-08-02
JPH0231689A (ja) 1990-02-01
GB8807860D0 (en) 1988-05-05
US4997915A (en) 1991-03-05
JPH0789949B2 (ja) 1995-10-04
EP0336736A1 (de) 1989-10-11

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