KR920008194A - 테이코플라닌 회수 방법 - Google Patents

테이코플라닌 회수 방법 Download PDF

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Publication number
KR920008194A
KR920008194A KR1019910017055A KR910017055A KR920008194A KR 920008194 A KR920008194 A KR 920008194A KR 1019910017055 A KR1019910017055 A KR 1019910017055A KR 910017055 A KR910017055 A KR 910017055A KR 920008194 A KR920008194 A KR 920008194A
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South Korea
Prior art keywords
teicoplanin
broth
filtration
temperature
filtered
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KR1019910017055A
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English (en)
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KR0184644B1 (ko
Inventor
지안안토니오 아나클레토
판조네 지안바티스타
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레나토 스가르비
그루포 레페티트 에스. 피. 에이.
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Publication of KR920008194A publication Critical patent/KR920008194A/ko
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Publication of KR0184644B1 publication Critical patent/KR0184644B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Peptides Or Proteins (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Polyamides (AREA)

Abstract

내용 없음

Description

테이코플라닌 회수방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. a) 여과하는 동안 pH를 10 이상 및 온도를 테이코플라닌의 에피머화를 필수적으로 피하는 온도에서 일정하게 유지하면서 균사체를 브로쓰로부터 여과시켜 분리하고, b)테이코플라닌 A2를 여과된 브로쓰로부터 분리하는 것으로 이루어지는 전배양 발효 브로쓰로부터 테이코플라닌 A2를 추출하는 방법.
  2. 제1항에 있어서, 여과를 pH 10.5 내지 11.5 바람직하게는 pH 11에서 수행함을 특징으로 하는 방법.
  3. 제1항 또는 제2항에 있어서, 여과가 수행되는 온도가 용액의 빙점 내지 실온, 바람직하게는 5℃ 내지 10℃임을 특징으로 하는 방법.
  4. 제1항 내지 제3항 중 어느 한 항에 있어서, 여과된 브로쓰로 부터의 테이코플라닌 A2의 분리를, 여과된 용액을 테이코플라닌 활성을 흡착할 수 있는 폴리아미드 칼럼 크로마토그래피 수지와 접촉시키고, 이 수지를 수용액으로부터 분리시키고, 물 및 1이상의 혼화성 유기 용매의 용액 혼합물은 용출시킴으로써 수행함을 특징으로 하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910017055A 1990-10-01 1991-09-30 테이코플라닌 회수 방법 KR0184644B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP90118778.1 1990-10-01
EP90118778 1990-10-01

Publications (2)

Publication Number Publication Date
KR920008194A true KR920008194A (ko) 1992-05-27
KR0184644B1 KR0184644B1 (ko) 1999-04-01

Family

ID=8204557

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910017055A KR0184644B1 (ko) 1990-10-01 1991-09-30 테이코플라닌 회수 방법

Country Status (11)

Country Link
US (1) US5486465A (ko)
EP (1) EP0479086B1 (ko)
JP (1) JP3083369B2 (ko)
KR (1) KR0184644B1 (ko)
AT (1) ATE127477T1 (ko)
CA (1) CA2052455C (ko)
DE (1) DE69112750T2 (ko)
DK (1) DK0479086T3 (ko)
ES (1) ES2076436T3 (ko)
GR (1) GR3018019T3 (ko)
IE (1) IE71672B1 (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100434109B1 (ko) * 2001-10-29 2004-06-04 씨제이 주식회사 테이코플라닌의 정제방법

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8621912D0 (en) * 1986-09-11 1986-10-15 Lepetit Spa Increasing ratio of components of anti-biotic complex
US6218505B1 (en) 1996-04-23 2001-04-17 Biosearch Italia S.P.A. Chemical process for preparing amide derivatives of antibiotic A 40926
KR100321304B1 (ko) * 1999-04-16 2002-03-18 박호군 테이코플라닌의 정제방법
KR100459289B1 (ko) * 2002-05-30 2004-12-03 이연제약주식회사 발효액으로부터 테이코플라닌ａ₂의 회수방법
KR100476818B1 (ko) 2002-07-19 2005-03-17 종근당바이오 주식회사 테이코플라닌 에이 투 정제 방법
KR100474653B1 (ko) 2004-04-16 2005-03-14 동국제약 주식회사 타이코플라닌의 고순도 생산방법
CN101031582B (zh) 2004-10-27 2012-10-24 克利亚制药股份公司 糖肽类的纯化
JP5851766B2 (ja) 2011-08-29 2016-02-03 オリンパス株式会社 携帯機器
EP2592089A1 (en) 2011-11-11 2013-05-15 LEK Pharmaceuticals d.d. Process of purification of teicoplanin
EP2592090A1 (en) 2011-11-11 2013-05-15 LEK Pharmaceuticals d.d. Process of purification of teicoplanin

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1496386A (en) * 1975-03-05 1977-12-30 Lepetit Spa Antibiotics
US4696817A (en) * 1983-10-11 1987-09-29 The Dow Chemical Company Extraction of teichomycin A2 from whole culture fermentation broth
GB8608798D0 (en) * 1986-04-11 1986-05-14 Lepetit Spa Recovery of glycopeptide antibiotics from aqueous solutions
US4742045A (en) * 1986-07-30 1988-05-03 Smithkline Beckman Corporation Glycopeptide antibiotics

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100434109B1 (ko) * 2001-10-29 2004-06-04 씨제이 주식회사 테이코플라닌의 정제방법

Also Published As

Publication number Publication date
IE913432A1 (en) 1992-04-08
DK0479086T3 (da) 1995-10-23
ATE127477T1 (de) 1995-09-15
EP0479086A2 (en) 1992-04-08
CA2052455C (en) 2001-08-28
EP0479086A3 (en) 1992-10-21
DE69112750D1 (de) 1995-10-12
DE69112750T2 (de) 1996-09-19
US5486465A (en) 1996-01-23
EP0479086B1 (en) 1995-09-06
IE71672B1 (en) 1997-02-26
GR3018019T3 (en) 1996-02-29
KR0184644B1 (ko) 1999-04-01
ES2076436T3 (es) 1995-11-01
CA2052455A1 (en) 1992-04-02
JP3083369B2 (ja) 2000-09-04
JPH04264099A (ja) 1992-09-18

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