ES2136290T3 - Metodo para separar componentes protectores de bordetella pertussis. - Google Patents

Metodo para separar componentes protectores de bordetella pertussis.

Info

Publication number
ES2136290T3
ES2136290T3 ES95917474T ES95917474T ES2136290T3 ES 2136290 T3 ES2136290 T3 ES 2136290T3 ES 95917474 T ES95917474 T ES 95917474T ES 95917474 T ES95917474 T ES 95917474T ES 2136290 T3 ES2136290 T3 ES 2136290T3
Authority
ES
Spain
Prior art keywords
bordetella pertussis
components
pertussis
protective
protective components
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95917474T
Other languages
English (en)
Inventor
Akihiro Suehara
Eiji Yamamoto
Shigeo Fujii
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of ES2136290T3 publication Critical patent/ES2136290T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
    • C07K14/325—Bacillus thuringiensis crystal peptides, i.e. delta-endotoxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

PARA PROPORCIONAR UN METODO EFICIENTE DE SEPARACION DE COMPONENTES PROTECTORES DE BORDETELLA PERTUSSIS. EN BASE A LAS DIFERENCIAS DE ADSORBABILIDAD DEL GEL DE FOSFATO CALCICO FORMADO POR ADICION DE IONES CALCIO AL CULTIVO DE BORDETELLA PERTUSSIS EN PRESENCIA DE EXCESO DE IONES DE FOSFATO, LOS COMPONENTES PROTECTORES DE LA BORDETELLA PERTUSSIS SON SEPARADOS DEL CULTIVO DE BORDETELLA PERTUSSIS. TRADICIONALMENTE, LOS COMPUESTOS PROTECTORES DE LA BORDETELLA PERTUSSIS HAN SIDO SEPARADOS USANDO METODOS DE PURIFICACION DIFERENTES PARA LOS RESPECTIVOS COMPONENTES. DE ACUERDO CON LA PRESENTE INVENCION, EL USO DE LOS MISMOS MEDIOS DE PURIFICACION PARA TODOS LOS COMPONENTES HACE POSIBLE PURIFICAR CADA COMPONENTE CON ALTA EFICIENCIA Y UNA ALTA VELOCIDAD DE RECUPERACION, UN ASPECTO MUY VENTAJOSO PARA LA PRODUCCION INDUSTRIAL. TAMBIEN ES POSIBLE PRODUCIR EFICIENTEMENTE UNA VACUNA MEJORADA DE COMPONENTES DE PERTUSSIS PURIFICADOS QUE COMPRENDE UNA COMBINACION EFECTIVA DE HEMAGLUTININA FILAMENTOSA PERTUSSIS(FAH), PERTACTINA (PRN, 69K-OMP), PERTUSSIS FIMBRIOSA (FIM) Y TOXINA PERTUSSIS (PT)
ES95917474T 1994-04-28 1995-04-26 Metodo para separar componentes protectores de bordetella pertussis. Expired - Lifetime ES2136290T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9156594 1994-04-28

Publications (1)

Publication Number Publication Date
ES2136290T3 true ES2136290T3 (es) 1999-11-16

Family

ID=14030044

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95917474T Expired - Lifetime ES2136290T3 (es) 1994-04-28 1995-04-26 Metodo para separar componentes protectores de bordetella pertussis.

Country Status (12)

Country Link
US (6) US6051240A (es)
EP (1) EP0755403B1 (es)
KR (1) KR100266556B1 (es)
CN (1) CN1147259A (es)
AT (1) ATE183194T1 (es)
AU (1) AU2352595A (es)
CA (1) CA2188424A1 (es)
DE (1) DE69511392T2 (es)
DK (1) DK0755403T3 (es)
ES (1) ES2136290T3 (es)
GR (1) GR3031481T3 (es)
WO (1) WO1995029934A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8910570D0 (en) 1989-05-08 1989-06-21 Wellcome Found Acellular vaccine
US6444211B2 (en) * 1991-04-03 2002-09-03 Connaught Laboratories, Inc. Purification of a pertussis outer membrane protein
EP1234579A1 (en) * 1995-05-04 2002-08-28 Aventis Pasteur Limited Acellular Pertussis Vaccines and Methods of Preparation Thereof
WO2010131111A1 (en) 2009-05-11 2010-11-18 Novartis Ag Antigen purification process for pertactin antigen
US8647640B2 (en) * 2009-06-24 2014-02-11 Richard E. COWART Vaccine compositions and methods of use to protect against infectious disease
CN102443572B (zh) * 2011-10-21 2012-12-19 武汉生物制品研究所有限责任公司 一种对脱毒后的百日咳疫苗抗原溶液进行纯化的方法
WO2016154010A1 (en) * 2015-03-20 2016-09-29 Makidon Paul Immunogenic compositions for use in vaccination against bordetella
CN109069535B (zh) * 2016-03-29 2022-03-18 里尔巴斯德研究所 突变型博德特氏菌属菌株及其使用方法
CN108570098B (zh) * 2017-12-29 2021-09-07 武汉生物制品研究所有限责任公司 一种百日咳多种抗原成分的分离纯化方法
CN110358802B (zh) * 2019-08-16 2021-06-18 长春百克生物科技股份公司 一种去除百日咳组分菌毛蛋白2/3内毒素的方法
WO2022114921A1 (ko) * 2020-11-30 2022-06-02 주식회사 엘지화학 알루미늄 부형제를 이용하여 다가 혼합백신 내 백일해 균 유래 엔도톡신 제거 방법

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5750925A (en) * 1980-09-12 1982-03-25 Takeda Chem Ind Ltd Preparation of pertussis toxoid
US4729957A (en) * 1984-12-13 1988-03-08 The United States Of America As Represented By The Department Of Health And Human Services Process for manufacture of L-asparaginase from erwinia chrysanthemi
GB8512972D0 (en) * 1985-05-22 1985-06-26 Univ Glasgow Vaccine production
GB8601279D0 (en) * 1986-01-20 1986-02-26 Public Health Lab Service Purification of pertussis antigens
CA1337859C (en) * 1987-04-24 1996-01-02 Masashi Chazono Method for culturing bordetella pertussis, a pertussis toxoid and a pertussis vaccine
US5101019A (en) * 1987-05-22 1992-03-31 Takeda Chemical Industries, Ltd. Method for removing pertussis endotoxin, a pertussis toxoid and its production
GB8807860D0 (en) * 1988-04-05 1988-05-05 Connaught Lab Pertussis vaccine
US5101014A (en) * 1989-02-10 1992-03-31 United States Of America Process for the purification of a 69,000 da outer membrane protein of Bordetella pertussis
DE69025375T2 (de) * 1989-11-06 1996-08-01 Smithkline Beecham Biolog Verfahren
US5276142A (en) * 1989-12-11 1994-01-04 American Cyanamid Company Process for purification of a 69000 dalton antigenic protein from Bordetella pertussis
GB9007657D0 (en) * 1990-04-04 1990-05-30 Connaught Lab Purification of a pertussis outer membrane protein(omp69)
IT1248735B (it) * 1990-06-21 1995-01-26 Sclavo Spa Vaccini acellulari contro la pertosse
EP0484621A3 (en) * 1990-07-11 1992-08-26 American Cyanamid Company Efficacious vaccines against bordetella pertussis comprising a combination of individually purified pertussis antigens
CA2123222C (en) * 1991-11-15 2001-02-27 Donald A. Dearwester Gram-negative bacterial vaccines
US6696065B1 (en) * 1995-05-04 2004-02-24 Aventis Pastuer Limited Acellular pertussis vaccines and methods of preparation thereof
EP1234579A1 (en) * 1995-05-04 2002-08-28 Aventis Pasteur Limited Acellular Pertussis Vaccines and Methods of Preparation Thereof

Also Published As

Publication number Publication date
DE69511392T2 (de) 2000-03-23
US20030133941A1 (en) 2003-07-17
GR3031481T3 (en) 2000-01-31
EP0755403A1 (en) 1997-01-29
CN1147259A (zh) 1997-04-09
DK0755403T3 (da) 2000-02-14
US20020119161A1 (en) 2002-08-29
US6051240A (en) 2000-04-18
EP0755403B1 (en) 1999-08-11
KR100266556B1 (ko) 2000-09-15
CA2188424A1 (en) 1995-11-09
US20100055134A1 (en) 2010-03-04
WO1995029934A1 (en) 1995-11-09
US20090068228A1 (en) 2009-03-12
DE69511392D1 (de) 1999-09-16
KR970702874A (ko) 1997-06-10
AU2352595A (en) 1995-11-29
US20050180987A1 (en) 2005-08-18
ATE183194T1 (de) 1999-08-15

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