DE69511392D1 - Verfahren zur trennung von protektiven verbindungen aus bordetella pertussis - Google Patents
Verfahren zur trennung von protektiven verbindungen aus bordetella pertussisInfo
- Publication number
- DE69511392D1 DE69511392D1 DE69511392T DE69511392T DE69511392D1 DE 69511392 D1 DE69511392 D1 DE 69511392D1 DE 69511392 T DE69511392 T DE 69511392T DE 69511392 T DE69511392 T DE 69511392T DE 69511392 D1 DE69511392 D1 DE 69511392D1
- Authority
- DE
- Germany
- Prior art keywords
- pertussis
- bordetella pertussis
- components
- bordetella
- separated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 241000588832 Bordetella pertussis Species 0.000 title abstract 6
- 230000001681 protective effect Effects 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 201000005702 Pertussis Diseases 0.000 abstract 3
- 101710154643 Filamentous hemagglutinin Proteins 0.000 abstract 2
- 108010081690 Pertussis Toxin Proteins 0.000 abstract 2
- 238000000746 purification Methods 0.000 abstract 2
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 abstract 1
- 229910001424 calcium ion Inorganic materials 0.000 abstract 1
- 229910000389 calcium phosphate Inorganic materials 0.000 abstract 1
- 239000001506 calcium phosphate Substances 0.000 abstract 1
- 235000011010 calcium phosphates Nutrition 0.000 abstract 1
- 238000009776 industrial production Methods 0.000 abstract 1
- 108010021711 pertactin Proteins 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
- C07K14/325—Bacillus thuringiensis crystal peptides, i.e. delta-endotoxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9156594 | 1994-04-28 | ||
| PCT/JP1995/000830 WO1995029934A1 (en) | 1994-04-28 | 1995-04-26 | Method of separating protective components of bordetella pertussis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69511392D1 true DE69511392D1 (de) | 1999-09-16 |
| DE69511392T2 DE69511392T2 (de) | 2000-03-23 |
Family
ID=14030044
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69511392T Expired - Fee Related DE69511392T2 (de) | 1994-04-28 | 1995-04-26 | Verfahren zur trennung von protektiven verbindungen aus bordetella pertussis |
Country Status (12)
| Country | Link |
|---|---|
| US (6) | US6051240A (de) |
| EP (1) | EP0755403B1 (de) |
| KR (1) | KR100266556B1 (de) |
| CN (1) | CN1147259A (de) |
| AT (1) | ATE183194T1 (de) |
| AU (1) | AU2352595A (de) |
| CA (1) | CA2188424A1 (de) |
| DE (1) | DE69511392T2 (de) |
| DK (1) | DK0755403T3 (de) |
| ES (1) | ES2136290T3 (de) |
| GR (1) | GR3031481T3 (de) |
| WO (1) | WO1995029934A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8910570D0 (en) | 1989-05-08 | 1989-06-21 | Wellcome Found | Acellular vaccine |
| US6444211B2 (en) * | 1991-04-03 | 2002-09-03 | Connaught Laboratories, Inc. | Purification of a pertussis outer membrane protein |
| EP1233022B1 (de) * | 1995-05-04 | 2015-12-09 | Aventis Pasteur Limited | Verfahren zur Herstellung von Komponenten azellulären Pertussis-Impfstoffen |
| US8574589B2 (en) * | 2009-05-11 | 2013-11-05 | Novartis Ag | Antigen purification process for pertactin antigen |
| WO2011005587A1 (en) * | 2009-06-24 | 2011-01-13 | University Of Dubuque | Vaccine compositions and methods of use to protect against infectious disease |
| CN102443572B (zh) * | 2011-10-21 | 2012-12-19 | 武汉生物制品研究所有限责任公司 | 一种对脱毒后的百日咳疫苗抗原溶液进行纯化的方法 |
| JP2018511655A (ja) * | 2015-03-20 | 2018-04-26 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | ボルデテラ属に対するワクチン接種における使用のための免疫原性組成物 |
| CN114767718A (zh) * | 2016-03-29 | 2022-07-22 | 里尔巴斯德研究所 | 突变型博德特氏菌属菌株及其使用方法 |
| CN108570098B (zh) * | 2017-12-29 | 2021-09-07 | 武汉生物制品研究所有限责任公司 | 一种百日咳多种抗原成分的分离纯化方法 |
| CN110358802B (zh) * | 2019-08-16 | 2021-06-18 | 长春百克生物科技股份公司 | 一种去除百日咳组分菌毛蛋白2/3内毒素的方法 |
| KR20220076405A (ko) * | 2020-11-30 | 2022-06-08 | 주식회사 엘지화학 | 알루미늄 부형제를 이용하여 다가 혼합백신 내 백일해 균 유래 엔도톡신 제거 방법 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5750925A (en) * | 1980-09-12 | 1982-03-25 | Takeda Chem Ind Ltd | Preparation of pertussis toxoid |
| US4729957A (en) * | 1984-12-13 | 1988-03-08 | The United States Of America As Represented By The Department Of Health And Human Services | Process for manufacture of L-asparaginase from erwinia chrysanthemi |
| GB8512972D0 (en) * | 1985-05-22 | 1985-06-26 | Univ Glasgow | Vaccine production |
| GB8601279D0 (en) * | 1986-01-20 | 1986-02-26 | Public Health Lab Service | Purification of pertussis antigens |
| CA1337859C (en) * | 1987-04-24 | 1996-01-02 | Masashi Chazono | Method for culturing bordetella pertussis, a pertussis toxoid and a pertussis vaccine |
| US5101019A (en) * | 1987-05-22 | 1992-03-31 | Takeda Chemical Industries, Ltd. | Method for removing pertussis endotoxin, a pertussis toxoid and its production |
| GB8807860D0 (en) * | 1988-04-05 | 1988-05-05 | Connaught Lab | Pertussis vaccine |
| US5101014A (en) * | 1989-02-10 | 1992-03-31 | United States Of America | Process for the purification of a 69,000 da outer membrane protein of Bordetella pertussis |
| CY1934A (en) * | 1989-11-06 | 1990-11-01 | Smithkline Beecham Biolog | Process |
| US5276142A (en) * | 1989-12-11 | 1994-01-04 | American Cyanamid Company | Process for purification of a 69000 dalton antigenic protein from Bordetella pertussis |
| GB9007657D0 (en) * | 1990-04-04 | 1990-05-30 | Connaught Lab | Purification of a pertussis outer membrane protein(omp69) |
| IT1248735B (it) * | 1990-06-21 | 1995-01-26 | Sclavo Spa | Vaccini acellulari contro la pertosse |
| EP0484621A3 (en) * | 1990-07-11 | 1992-08-26 | American Cyanamid Company | Efficacious vaccines against bordetella pertussis comprising a combination of individually purified pertussis antigens |
| CA2123222C (en) * | 1991-11-15 | 2001-02-27 | Donald A. Dearwester | Gram-negative bacterial vaccines |
| US6696065B1 (en) * | 1995-05-04 | 2004-02-24 | Aventis Pastuer Limited | Acellular pertussis vaccines and methods of preparation thereof |
| EP1233022B1 (de) * | 1995-05-04 | 2015-12-09 | Aventis Pasteur Limited | Verfahren zur Herstellung von Komponenten azellulären Pertussis-Impfstoffen |
-
1995
- 1995-04-26 DE DE69511392T patent/DE69511392T2/de not_active Expired - Fee Related
- 1995-04-26 US US08/530,373 patent/US6051240A/en not_active Expired - Lifetime
- 1995-04-26 EP EP95917474A patent/EP0755403B1/de not_active Expired - Lifetime
- 1995-04-26 AT AT95917474T patent/ATE183194T1/de active
- 1995-04-26 CN CN95192782A patent/CN1147259A/zh active Pending
- 1995-04-26 ES ES95917474T patent/ES2136290T3/es not_active Expired - Lifetime
- 1995-04-26 CA CA002188424A patent/CA2188424A1/en not_active Abandoned
- 1995-04-26 DK DK95917474T patent/DK0755403T3/da active
- 1995-04-26 WO PCT/JP1995/000830 patent/WO1995029934A1/en active IP Right Grant
- 1995-04-26 AU AU23525/95A patent/AU2352595A/en not_active Abandoned
- 1995-04-26 KR KR1019960706030A patent/KR100266556B1/ko not_active IP Right Cessation
-
1999
- 1999-07-08 US US09/349,712 patent/US20020119161A1/en not_active Abandoned
- 1999-10-08 GR GR990402573T patent/GR3031481T3/el unknown
-
2002
- 2002-07-30 US US10/206,989 patent/US20030133941A1/en not_active Abandoned
-
2005
- 2005-04-14 US US11/105,540 patent/US20050180987A1/en not_active Abandoned
-
2007
- 2007-10-24 US US11/877,789 patent/US20090068228A1/en not_active Abandoned
-
2009
- 2009-08-27 US US12/461,925 patent/US20100055134A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP0755403A1 (de) | 1997-01-29 |
| KR100266556B1 (ko) | 2000-09-15 |
| WO1995029934A1 (en) | 1995-11-09 |
| AU2352595A (en) | 1995-11-29 |
| DK0755403T3 (da) | 2000-02-14 |
| US20050180987A1 (en) | 2005-08-18 |
| GR3031481T3 (en) | 2000-01-31 |
| ES2136290T3 (es) | 1999-11-16 |
| ATE183194T1 (de) | 1999-08-15 |
| US20020119161A1 (en) | 2002-08-29 |
| EP0755403B1 (de) | 1999-08-11 |
| US20030133941A1 (en) | 2003-07-17 |
| DE69511392T2 (de) | 2000-03-23 |
| KR970702874A (ko) | 1997-06-10 |
| US6051240A (en) | 2000-04-18 |
| CN1147259A (zh) | 1997-04-09 |
| US20100055134A1 (en) | 2010-03-04 |
| US20090068228A1 (en) | 2009-03-12 |
| CA2188424A1 (en) | 1995-11-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |