DK0755403T3 - Fremgangsmåde til adskillelse af beskyttende komponenter fra Bordetalla pertussis - Google Patents
Fremgangsmåde til adskillelse af beskyttende komponenter fra Bordetalla pertussisInfo
- Publication number
- DK0755403T3 DK0755403T3 DK95917474T DK95917474T DK0755403T3 DK 0755403 T3 DK0755403 T3 DK 0755403T3 DK 95917474 T DK95917474 T DK 95917474T DK 95917474 T DK95917474 T DK 95917474T DK 0755403 T3 DK0755403 T3 DK 0755403T3
- Authority
- DK
- Denmark
- Prior art keywords
- pertussis
- bordetella pertussis
- protective components
- components
- bordetella
- Prior art date
Links
- 201000005702 Pertussis Diseases 0.000 title abstract 4
- 230000001681 protective effect Effects 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 241000588832 Bordetella pertussis Species 0.000 abstract 5
- 101710154643 Filamentous hemagglutinin Proteins 0.000 abstract 2
- 108010081690 Pertussis Toxin Proteins 0.000 abstract 2
- 238000000746 purification Methods 0.000 abstract 2
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 abstract 1
- 229910001424 calcium ion Inorganic materials 0.000 abstract 1
- 229910000389 calcium phosphate Inorganic materials 0.000 abstract 1
- 239000001506 calcium phosphate Substances 0.000 abstract 1
- 235000011010 calcium phosphates Nutrition 0.000 abstract 1
- 238000009776 industrial production Methods 0.000 abstract 1
- 108010021711 pertactin Proteins 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
- C07K14/325—Bacillus thuringiensis crystal peptides, i.e. delta-endotoxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Analytical Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9156594 | 1994-04-28 | ||
| PCT/JP1995/000830 WO1995029934A1 (en) | 1994-04-28 | 1995-04-26 | Method of separating protective components of bordetella pertussis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0755403T3 true DK0755403T3 (da) | 2000-02-14 |
Family
ID=14030044
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95917474T DK0755403T3 (da) | 1994-04-28 | 1995-04-26 | Fremgangsmåde til adskillelse af beskyttende komponenter fra Bordetalla pertussis |
Country Status (12)
| Country | Link |
|---|---|
| US (6) | US6051240A (es) |
| EP (1) | EP0755403B1 (es) |
| KR (1) | KR100266556B1 (es) |
| CN (1) | CN1147259A (es) |
| AT (1) | ATE183194T1 (es) |
| AU (1) | AU2352595A (es) |
| CA (1) | CA2188424A1 (es) |
| DE (1) | DE69511392T2 (es) |
| DK (1) | DK0755403T3 (es) |
| ES (1) | ES2136290T3 (es) |
| GR (1) | GR3031481T3 (es) |
| WO (1) | WO1995029934A1 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8910570D0 (en) | 1989-05-08 | 1989-06-21 | Wellcome Found | Acellular vaccine |
| US6444211B2 (en) * | 1991-04-03 | 2002-09-03 | Connaught Laboratories, Inc. | Purification of a pertussis outer membrane protein |
| EP1234580A1 (en) * | 1995-05-04 | 2002-08-28 | Aventis Pasteur Limited | Acellular Pertussis Vaccines and Methods of Preparation Thereof |
| EP2430040A1 (en) | 2009-05-11 | 2012-03-21 | Novartis AG | Antigen purification process for pertactin antigen |
| US8647640B2 (en) * | 2009-06-24 | 2014-02-11 | Richard E. COWART | Vaccine compositions and methods of use to protect against infectious disease |
| CN102443572B (zh) * | 2011-10-21 | 2012-12-19 | 武汉生物制品研究所有限责任公司 | 一种对脱毒后的百日咳疫苗抗原溶液进行纯化的方法 |
| JP2018511655A (ja) * | 2015-03-20 | 2018-04-26 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | ボルデテラ属に対するワクチン接種における使用のための免疫原性組成物 |
| JP6993984B2 (ja) * | 2016-03-29 | 2022-02-03 | アンスティチュ パスツール ドゥ リール | 変異ボルデテラ菌株および使用方法 |
| CN108570098B (zh) * | 2017-12-29 | 2021-09-07 | 武汉生物制品研究所有限责任公司 | 一种百日咳多种抗原成分的分离纯化方法 |
| CN110358802B (zh) * | 2019-08-16 | 2021-06-18 | 长春百克生物科技股份公司 | 一种去除百日咳组分菌毛蛋白2/3内毒素的方法 |
| WO2022114921A1 (ko) * | 2020-11-30 | 2022-06-02 | 주식회사 엘지화학 | 알루미늄 부형제를 이용하여 다가 혼합백신 내 백일해 균 유래 엔도톡신 제거 방법 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5750925A (en) * | 1980-09-12 | 1982-03-25 | Takeda Chem Ind Ltd | Preparation of pertussis toxoid |
| US4729957A (en) * | 1984-12-13 | 1988-03-08 | The United States Of America As Represented By The Department Of Health And Human Services | Process for manufacture of L-asparaginase from erwinia chrysanthemi |
| GB8512972D0 (en) * | 1985-05-22 | 1985-06-26 | Univ Glasgow | Vaccine production |
| GB8601279D0 (en) * | 1986-01-20 | 1986-02-26 | Public Health Lab Service | Purification of pertussis antigens |
| CA1337859C (en) * | 1987-04-24 | 1996-01-02 | Masashi Chazono | Method for culturing bordetella pertussis, a pertussis toxoid and a pertussis vaccine |
| US5101019A (en) * | 1987-05-22 | 1992-03-31 | Takeda Chemical Industries, Ltd. | Method for removing pertussis endotoxin, a pertussis toxoid and its production |
| GB8807860D0 (en) * | 1988-04-05 | 1988-05-05 | Connaught Lab | Pertussis vaccine |
| US5101014A (en) * | 1989-02-10 | 1992-03-31 | United States Of America | Process for the purification of a 69,000 da outer membrane protein of Bordetella pertussis |
| ES2084668T3 (es) * | 1989-11-06 | 1996-05-16 | Smithkline Beecham Biolog | Procedimiento. |
| US5276142A (en) * | 1989-12-11 | 1994-01-04 | American Cyanamid Company | Process for purification of a 69000 dalton antigenic protein from Bordetella pertussis |
| GB9007657D0 (en) * | 1990-04-04 | 1990-05-30 | Connaught Lab | Purification of a pertussis outer membrane protein(omp69) |
| IT1248735B (it) * | 1990-06-21 | 1995-01-26 | Sclavo Spa | Vaccini acellulari contro la pertosse |
| EP0484621A3 (en) * | 1990-07-11 | 1992-08-26 | American Cyanamid Company | Efficacious vaccines against bordetella pertussis comprising a combination of individually purified pertussis antigens |
| ES2194841T3 (es) * | 1991-11-15 | 2003-12-01 | Pfizer | Procedimiento de produccion de vacunas bacterianas gram negativas. |
| EP1234580A1 (en) * | 1995-05-04 | 2002-08-28 | Aventis Pasteur Limited | Acellular Pertussis Vaccines and Methods of Preparation Thereof |
| US6696065B1 (en) * | 1995-05-04 | 2004-02-24 | Aventis Pastuer Limited | Acellular pertussis vaccines and methods of preparation thereof |
-
1995
- 1995-04-26 DE DE69511392T patent/DE69511392T2/de not_active Expired - Fee Related
- 1995-04-26 AU AU23525/95A patent/AU2352595A/en not_active Abandoned
- 1995-04-26 ES ES95917474T patent/ES2136290T3/es not_active Expired - Lifetime
- 1995-04-26 WO PCT/JP1995/000830 patent/WO1995029934A1/en active IP Right Grant
- 1995-04-26 US US08/530,373 patent/US6051240A/en not_active Expired - Lifetime
- 1995-04-26 DK DK95917474T patent/DK0755403T3/da active
- 1995-04-26 KR KR1019960706030A patent/KR100266556B1/ko not_active IP Right Cessation
- 1995-04-26 CA CA002188424A patent/CA2188424A1/en not_active Abandoned
- 1995-04-26 AT AT95917474T patent/ATE183194T1/de active
- 1995-04-26 EP EP95917474A patent/EP0755403B1/en not_active Expired - Lifetime
- 1995-04-26 CN CN95192782A patent/CN1147259A/zh active Pending
-
1999
- 1999-07-08 US US09/349,712 patent/US20020119161A1/en not_active Abandoned
- 1999-10-08 GR GR990402573T patent/GR3031481T3/el unknown
-
2002
- 2002-07-30 US US10/206,989 patent/US20030133941A1/en not_active Abandoned
-
2005
- 2005-04-14 US US11/105,540 patent/US20050180987A1/en not_active Abandoned
-
2007
- 2007-10-24 US US11/877,789 patent/US20090068228A1/en not_active Abandoned
-
2009
- 2009-08-27 US US12/461,925 patent/US20100055134A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR970702874A (ko) | 1997-06-10 |
| US20020119161A1 (en) | 2002-08-29 |
| EP0755403B1 (en) | 1999-08-11 |
| DE69511392D1 (de) | 1999-09-16 |
| CA2188424A1 (en) | 1995-11-09 |
| ES2136290T3 (es) | 1999-11-16 |
| DE69511392T2 (de) | 2000-03-23 |
| WO1995029934A1 (en) | 1995-11-09 |
| US20050180987A1 (en) | 2005-08-18 |
| US20090068228A1 (en) | 2009-03-12 |
| ATE183194T1 (de) | 1999-08-15 |
| US20030133941A1 (en) | 2003-07-17 |
| AU2352595A (en) | 1995-11-29 |
| US20100055134A1 (en) | 2010-03-04 |
| US6051240A (en) | 2000-04-18 |
| CN1147259A (zh) | 1997-04-09 |
| EP0755403A1 (en) | 1997-01-29 |
| GR3031481T3 (en) | 2000-01-31 |
| KR100266556B1 (ko) | 2000-09-15 |
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