DE69025375T2 - Verfahren - Google Patents

Verfahren

Info

Publication number
DE69025375T2
DE69025375T2 DE69025375T DE69025375T DE69025375T2 DE 69025375 T2 DE69025375 T2 DE 69025375T2 DE 69025375 T DE69025375 T DE 69025375T DE 69025375 T DE69025375 T DE 69025375T DE 69025375 T2 DE69025375 T2 DE 69025375T2
Authority
DE
Germany
Prior art keywords
fha
pertussis
purified
purification
extraction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69025375T
Other languages
English (en)
Other versions
DE69025375D1 (de
Inventor
Carine Capiau
Pierre Desmons
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline Biologicals SA
Original Assignee
GlaxoSmithKline Biologicals SA
SmithKline Beecham Biologicals SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GlaxoSmithKline Biologicals SA, SmithKline Beecham Biologicals SA filed Critical GlaxoSmithKline Biologicals SA
Application granted granted Critical
Publication of DE69025375D1 publication Critical patent/DE69025375D1/de
Publication of DE69025375T2 publication Critical patent/DE69025375T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K2039/10—Brucella; Bordetella, e.g. Bordetella pertussis; Not used, see subgroups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
DE69025375T 1989-11-06 1990-11-01 Verfahren Expired - Lifetime DE69025375T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43199989A 1989-11-06 1989-11-06

Publications (2)

Publication Number Publication Date
DE69025375D1 DE69025375D1 (de) 1996-03-28
DE69025375T2 true DE69025375T2 (de) 1996-08-01

Family

ID=23714322

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69025375T Expired - Lifetime DE69025375T2 (de) 1989-11-06 1990-11-01 Verfahren

Country Status (16)

Country Link
EP (1) EP0427462B1 (de)
JP (1) JP3148895B2 (de)
KR (1) KR0161281B1 (de)
AT (1) ATE134194T1 (de)
AU (1) AU635083B2 (de)
CA (1) CA2029201C (de)
CY (1) CY1934A (de)
DE (1) DE69025375T2 (de)
DK (1) DK0427462T3 (de)
ES (1) ES2084668T3 (de)
GR (1) GR3019725T3 (de)
HK (1) HK1004555A1 (de)
IE (1) IE71687B1 (de)
NZ (1) NZ235960A (de)
PT (1) PT95789B (de)
ZA (1) ZA908801B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0835663T3 (da) 1992-05-23 2010-02-01 Glaxosmithkline Biolog Sa Kombinerede vacciner omfattende Hepatitis B overfladeantigen og andre antigener
ES2136290T3 (es) * 1994-04-28 1999-11-16 Takeda Chemical Industries Ltd Metodo para separar componentes protectores de bordetella pertussis.
DE19512346C1 (de) * 1995-04-01 1996-06-13 Behringwerke Ag Verfahren zur Reinigung von Filamenthämagglutinin und Pertussis-Toxin
GB0313916D0 (en) 2003-06-16 2003-07-23 Glaxosmithkline Biolog Sa Vaccine composition
WO2013113729A1 (en) 2012-02-01 2013-08-08 Glaxosmithkline Biologicals S.A. Fermentation process
KR102236498B1 (ko) 2013-03-08 2021-04-06 얀센 백신스 앤드 프리벤션 비.브이. 무세포 백일해 백신
CN112513248A (zh) * 2018-03-20 2021-03-16 圣诺菲·帕斯图尔公司 培育博德特氏菌属菌种的方法
KR102362777B1 (ko) * 2018-03-27 2022-02-15 주식회사 녹십자 친화성 크로마토그래피 공정을 포함하는 백일해균 유래 단백질 수득 방법
WO2019189471A1 (ja) * 2018-03-27 2019-10-03 日本精工株式会社 ステアリング装置

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4500639A (en) 1981-10-15 1985-02-19 Teijin Limited Culturing Bordetella in media containing etherified cyclodextrin
JPS59175439A (ja) 1983-03-23 1984-10-04 Teijin Ltd 繊維状赤血球凝集素の製法
CA1213234A (en) 1983-03-30 1986-10-28 Akihiro Ginnaga Method for the production of ha fraction containing protective antigens of bordetella pertussis and pertussis vaccine
JPS6098988A (ja) 1983-11-01 1985-06-01 Chemo Sero Therapeut Res Inst Ｌｐｆ−ｈａの精製法
US4563303A (en) 1984-04-14 1986-01-07 Judicial Foundation The Chemosero-Therapeutic Research Institute Method for purification of filamentous hemagglutinin
GB8601279D0 (en) 1986-01-20 1986-02-26 Public Health Lab Service Purification of pertussis antigens
FR2596413B1 (fr) 1986-03-27 1988-06-10 Merieux Inst Nouveaux milieux de culture de bacteries appartenant au genre bordetella, contenant des derives etherifies de polymeres de d-glucose, et leur application

Also Published As

Publication number Publication date
ATE134194T1 (de) 1996-02-15
PT95789B (pt) 1997-12-31
KR910009283A (ko) 1991-06-28
AU635083B2 (en) 1993-03-11
IE71687B1 (en) 1997-02-26
DE69025375D1 (de) 1996-03-28
AU6584690A (en) 1991-05-09
DK0427462T3 (da) 1996-03-11
JPH03169893A (ja) 1991-07-23
EP0427462B1 (de) 1996-02-14
GR3019725T3 (en) 1996-07-31
ES2084668T3 (es) 1996-05-16
IE903969A1 (en) 1991-05-08
JP3148895B2 (ja) 2001-03-26
HK1004555A1 (en) 1998-11-27
NZ235960A (en) 1993-11-25
ZA908801B (en) 1991-11-27
CA2029201C (en) 2002-07-30
CA2029201A1 (en) 1991-05-07
EP0427462A1 (de) 1991-05-15
PT95789A (pt) 1991-09-13
KR0161281B1 (ko) 1998-12-01
CY1934A (en) 1990-11-01

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